JP6905781B1 - 不快な味がマスクされた顆粒剤及びその製造方法 - Google Patents

不快な味がマスクされた顆粒剤及びその製造方法 Download PDF

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JP6905781B1
JP6905781B1 JP2021503619A JP2021503619A JP6905781B1 JP 6905781 B1 JP6905781 B1 JP 6905781B1 JP 2021503619 A JP2021503619 A JP 2021503619A JP 2021503619 A JP2021503619 A JP 2021503619A JP 6905781 B1 JP6905781 B1 JP 6905781B1
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active ingredient
particles
unpleasant taste
production method
coating
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Japanese (ja)
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JPWO2021060304A1 (ja
Inventor
野村　達雄
達雄 野村
亨 安澤
亨 安澤
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Nobelpharma Co Ltd
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Nobelpharma Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2021503619A 2019-09-25 2020-09-24 不快な味がマスクされた顆粒剤及びその製造方法 Active JP6905781B1 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2021102118A JP7715378B2 (ja) 2019-09-25 2021-06-21 不快な味がマスクされた顆粒剤及びその製造方法
JP2025081181A JP2025107467A (ja) 2019-09-25 2025-05-14 不快な味がマスクされた顆粒剤及びその製造方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2019173744 2019-09-25
JP2019173744 2019-09-25
PCT/JP2020/035883 WO2021060304A1 (ja) 2019-09-25 2020-09-24 不快な味がマスクされた顆粒剤及びその製造方法

Related Child Applications (1)

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JP2021102118A Division JP7715378B2 (ja) 2019-09-25 2021-06-21 不快な味がマスクされた顆粒剤及びその製造方法

Publications (2)

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JP6905781B1 true JP6905781B1 (ja) 2021-07-21
JPWO2021060304A1 JPWO2021060304A1 (ja) 2021-10-07

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JP2021503619A Active JP6905781B1 (ja) 2019-09-25 2020-09-24 不快な味がマスクされた顆粒剤及びその製造方法
JP2021102118A Active JP7715378B2 (ja) 2019-09-25 2021-06-21 不快な味がマスクされた顆粒剤及びその製造方法
JP2025081181A Pending JP2025107467A (ja) 2019-09-25 2025-05-14 不快な味がマスクされた顆粒剤及びその製造方法

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JP2021102118A Active JP7715378B2 (ja) 2019-09-25 2021-06-21 不快な味がマスクされた顆粒剤及びその製造方法
JP2025081181A Pending JP2025107467A (ja) 2019-09-25 2025-05-14 不快な味がマスクされた顆粒剤及びその製造方法

Country Status (8)

Country Link
US (1) US20230016901A1 (https=)
EP (1) EP4035733A4 (https=)
JP (3) JP6905781B1 (https=)
CN (1) CN114340601A (https=)
AU (1) AU2020352037A1 (https=)
CA (1) CA3153004A1 (https=)
TW (1) TWI865615B (https=)
WO (1) WO2021060304A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021138775A (ja) * 2019-09-25 2021-09-16 ノーベルファーマ株式会社 不快な味がマスクされた顆粒剤及びその製造方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR2022010921A2 (tr) * 2022-07-01 2024-01-22 Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi Tadı maskelenmiş bir çinko katı bileşimi.

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007031292A (ja) * 2005-07-22 2007-02-08 Hamari Chemicals Ltd 亜鉛化合物含有組成物およびその製造方法
WO2008013197A1 (fr) * 2006-07-26 2008-01-31 Asahi Kasei Chemicals Corporation Granulé brut sphérique et son procédé de fabrication
WO2011043370A1 (ja) * 2009-10-09 2011-04-14 旭化成ケミカルズ株式会社 コーティングフィルム、及びそれを用いた顆粒、錠剤

Family Cites Families (10)

* Cited by examiner, † Cited by third party
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JP2542122B2 (ja) * 1990-04-18 1996-10-09 旭化成工業株式会社 球状核、球形顆粒およびその製造方法
JP3985907B2 (ja) 1996-01-18 2007-10-03 旭化成ケミカルズ株式会社 フィルムコーティング粒剤の製造方法
JP2000053563A (ja) 1998-08-07 2000-02-22 Bayer Yakuhin Ltd 苦味がマスクされた速放性細粒剤
KR101168189B1 (ko) * 2003-10-29 2012-07-25 시오노기세이야쿠가부시키가이샤 불쾌미를 개선한 피복 제제의 제조 방법
CN102048734B (zh) * 2005-05-26 2013-11-20 大日本住友制药株式会社 药物组合物
JP2008081448A (ja) * 2006-09-28 2008-04-10 Kowa Pharmaceutical Co Ltd 酒石酸ゾルピデムの苦味マスキング速放性粒子
AU2010325746B2 (en) * 2009-12-02 2016-02-25 Adare Pharmaceuticals S.R.L. Fexofenadine microcapsules and compositions containing them
CN102018658B (zh) * 2010-07-16 2014-03-12 钟术光 一种控释制剂及其制备方法
JP5823401B2 (ja) * 2010-09-13 2015-11-25 大鵬薬品工業株式会社 不快な味が遮蔽された薬物含有膜被覆粒子
AU2020352037A1 (en) * 2019-09-25 2022-04-21 Nobelpharma Co., Ltd. Granule having masked unpleasant taste and method for producing same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007031292A (ja) * 2005-07-22 2007-02-08 Hamari Chemicals Ltd 亜鉛化合物含有組成物およびその製造方法
WO2008013197A1 (fr) * 2006-07-26 2008-01-31 Asahi Kasei Chemicals Corporation Granulé brut sphérique et son procédé de fabrication
WO2011043370A1 (ja) * 2009-10-09 2011-04-14 旭化成ケミカルズ株式会社 コーティングフィルム、及びそれを用いた顆粒、錠剤

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
日本医薬品添加剤協会 訳編: " 「酢酸亜鉛」", 改訂 医薬品添加物ハンドブック, JPN6020045881, 28 February 2007 (2007-02-28), pages 340 - 341, ISSN: 0004468568 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021138775A (ja) * 2019-09-25 2021-09-16 ノーベルファーマ株式会社 不快な味がマスクされた顆粒剤及びその製造方法
JP2025107467A (ja) * 2019-09-25 2025-07-17 ノーベルファーマ株式会社 不快な味がマスクされた顆粒剤及びその製造方法

Also Published As

Publication number Publication date
EP4035733A1 (en) 2022-08-03
CN114340601A (zh) 2022-04-12
TWI865615B (zh) 2024-12-11
JPWO2021060304A1 (ja) 2021-10-07
CA3153004A1 (en) 2021-04-01
WO2021060304A1 (ja) 2021-04-01
TW202128143A (zh) 2021-08-01
JP2025107467A (ja) 2025-07-17
US20230016901A1 (en) 2023-01-19
EP4035733A4 (en) 2024-01-10
AU2020352037A1 (en) 2022-04-21
JP2021138775A (ja) 2021-09-16
JP7715378B2 (ja) 2025-07-30

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