CN114340601A - 掩盖了令人不快的味道的颗粒剂及其制造方法 - Google Patents

掩盖了令人不快的味道的颗粒剂及其制造方法 Download PDF

Info

Publication number
CN114340601A
CN114340601A CN202080059661.5A CN202080059661A CN114340601A CN 114340601 A CN114340601 A CN 114340601A CN 202080059661 A CN202080059661 A CN 202080059661A CN 114340601 A CN114340601 A CN 114340601A
Authority
CN
China
Prior art keywords
active ingredient
particles
unpleasant taste
coated
granules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202080059661.5A
Other languages
English (en)
Chinese (zh)
Inventor
野村达雄
安泽亨
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nobelpharma Co ltd
Original Assignee
Nobelpharma Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nobelpharma Co ltd filed Critical Nobelpharma Co ltd
Publication of CN114340601A publication Critical patent/CN114340601A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN202080059661.5A 2019-09-25 2020-09-24 掩盖了令人不快的味道的颗粒剂及其制造方法 Pending CN114340601A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2019-173744 2019-09-25
JP2019173744 2019-09-25
PCT/JP2020/035883 WO2021060304A1 (ja) 2019-09-25 2020-09-24 不快な味がマスクされた顆粒剤及びその製造方法

Publications (1)

Publication Number Publication Date
CN114340601A true CN114340601A (zh) 2022-04-12

Family

ID=75164923

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080059661.5A Pending CN114340601A (zh) 2019-09-25 2020-09-24 掩盖了令人不快的味道的颗粒剂及其制造方法

Country Status (8)

Country Link
US (1) US20230016901A1 (https=)
EP (1) EP4035733A4 (https=)
JP (3) JP6905781B1 (https=)
CN (1) CN114340601A (https=)
AU (1) AU2020352037A1 (https=)
CA (1) CA3153004A1 (https=)
TW (1) TWI865615B (https=)
WO (1) WO2021060304A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2020352037A1 (en) * 2019-09-25 2022-04-21 Nobelpharma Co., Ltd. Granule having masked unpleasant taste and method for producing same
TR2022010921A2 (tr) * 2022-07-01 2024-01-22 Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi Tadı maskelenmiş bir çinko katı bileşimi.

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1874759A (zh) * 2003-10-29 2006-12-06 盐野义制药株式会社 不愉快味道改善了的包覆制剂的制造方法
JP2007031292A (ja) * 2005-07-22 2007-02-08 Hamari Chemicals Ltd 亜鉛化合物含有組成物およびその製造方法
JP2008081448A (ja) * 2006-09-28 2008-04-10 Kowa Pharmaceutical Co Ltd 酒石酸ゾルピデムの苦味マスキング速放性粒子
CN101495097A (zh) * 2006-07-26 2009-07-29 旭化成化学株式会社 球形素颗粒及其制造方法
US20120189696A1 (en) * 2009-10-09 2012-07-26 Asahi Kasei Chemicals Corporation Coating film, and granules and tablets each utilizing same
CN103096880A (zh) * 2010-09-13 2013-05-08 大鹏药品工业株式会社 不愉快味道被掩蔽的含药膜包覆的颗粒

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2542122B2 (ja) * 1990-04-18 1996-10-09 旭化成工業株式会社 球状核、球形顆粒およびその製造方法
JP3985907B2 (ja) 1996-01-18 2007-10-03 旭化成ケミカルズ株式会社 フィルムコーティング粒剤の製造方法
JP2000053563A (ja) 1998-08-07 2000-02-22 Bayer Yakuhin Ltd 苦味がマスクされた速放性細粒剤
CN102048734B (zh) * 2005-05-26 2013-11-20 大日本住友制药株式会社 药物组合物
AU2010325746B2 (en) * 2009-12-02 2016-02-25 Adare Pharmaceuticals S.R.L. Fexofenadine microcapsules and compositions containing them
CN102018658B (zh) * 2010-07-16 2014-03-12 钟术光 一种控释制剂及其制备方法
AU2020352037A1 (en) * 2019-09-25 2022-04-21 Nobelpharma Co., Ltd. Granule having masked unpleasant taste and method for producing same

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1874759A (zh) * 2003-10-29 2006-12-06 盐野义制药株式会社 不愉快味道改善了的包覆制剂的制造方法
JP2007031292A (ja) * 2005-07-22 2007-02-08 Hamari Chemicals Ltd 亜鉛化合物含有組成物およびその製造方法
CN101495097A (zh) * 2006-07-26 2009-07-29 旭化成化学株式会社 球形素颗粒及其制造方法
US20090196934A1 (en) * 2006-07-26 2009-08-06 Asahi Kasei Chemicals Corporation Spherical elementary granule and method for production thereof
JP2008081448A (ja) * 2006-09-28 2008-04-10 Kowa Pharmaceutical Co Ltd 酒石酸ゾルピデムの苦味マスキング速放性粒子
US20120189696A1 (en) * 2009-10-09 2012-07-26 Asahi Kasei Chemicals Corporation Coating film, and granules and tablets each utilizing same
CN103096880A (zh) * 2010-09-13 2013-05-08 大鹏药品工业株式会社 不愉快味道被掩蔽的含药膜包覆的颗粒

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
卫生部: "《中华药典》", 内政部卫生署, pages: 752 *

Also Published As

Publication number Publication date
EP4035733A1 (en) 2022-08-03
TWI865615B (zh) 2024-12-11
JPWO2021060304A1 (ja) 2021-10-07
CA3153004A1 (en) 2021-04-01
JP6905781B1 (ja) 2021-07-21
WO2021060304A1 (ja) 2021-04-01
TW202128143A (zh) 2021-08-01
JP2025107467A (ja) 2025-07-17
US20230016901A1 (en) 2023-01-19
EP4035733A4 (en) 2024-01-10
AU2020352037A1 (en) 2022-04-21
JP2021138775A (ja) 2021-09-16
JP7715378B2 (ja) 2025-07-30

Similar Documents

Publication Publication Date Title
EP2276472B1 (en) Compositions comprising weakly basic drugs and controlled-release dosage forms
ES2347968T3 (es) Preparacion solida que se disgrega rapidamente.
RU2490012C2 (ru) Системы доставки лекарственного средства, содержащие слабощелочной селективный 5-ht3, серотониновый блокатор и органические кислоты
KR101032289B1 (ko) 미세과립
US10441585B2 (en) Formulations containing nalbuphine and uses thereof
KR20140007364A (ko) 구강내 붕괴정
JP2013189455A (ja) 弱塩基性薬および有機酸を含む薬物送達系
JP2025107467A (ja) 不快な味がマスクされた顆粒剤及びその製造方法
CN101754754B (zh) 含有包覆的含药物的颗粒的可分散药片及其制备方法
KR102568681B1 (ko) 네포팜을 포함하는 경구 붕해 약학 조성물 및 그 제조 방법
JP7316777B2 (ja) 光安定性に優れたシロドシン含有経口固形製剤
WO2004066991A1 (ja) タムスロシンまたはその塩の腸溶性徐放微粒子およびその製造法
WO2002034268A1 (en) Sustained-release preparation containing 5-acetyl-4,6-dimethyl-2-[2-[4-(2-methoxyphenyl)piperazinyl]ethylamino]pyrimidine trihydrochloride as active ingredient
HK40068436A (en) Granule having masked unpleasant taste and method for producing same
JP2011093882A (ja) 不快味マスキング粒子及びこれを含有する経口製剤
AU2002229678B2 (en) Ribavirin granulate for producing coated tablets
JP6427634B1 (ja) 光安定性に優れたシロドシン含有経口固形製剤
CN110664779A (zh) 一种头孢呋辛酯颗粒及其制备方法
JPH05163163A (ja) 有核製剤
CN104434858A (zh) 一种盐酸氨溴索渗透泵控释片药物组合物

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40068436

Country of ref document: HK