TWI850539B - 顆粒及使用其之製劑 - Google Patents
顆粒及使用其之製劑 Download PDFInfo
- Publication number
- TWI850539B TWI850539B TW110108516A TW110108516A TWI850539B TW I850539 B TWI850539 B TW I850539B TW 110108516 A TW110108516 A TW 110108516A TW 110108516 A TW110108516 A TW 110108516A TW I850539 B TWI850539 B TW I850539B
- Authority
- TW
- Taiwan
- Prior art keywords
- polymer
- molten component
- raw material
- granules
- molten
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Glanulating (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202062988083P | 2020-03-11 | 2020-03-11 | |
| US62/988,083 | 2020-03-11 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW202200118A TW202200118A (zh) | 2022-01-01 |
| TWI850539B true TWI850539B (zh) | 2024-08-01 |
Family
ID=77670617
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW110108516A TWI850539B (zh) | 2020-03-11 | 2021-03-10 | 顆粒及使用其之製劑 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20230014578A1 (https=) |
| EP (1) | EP4119129A4 (https=) |
| JP (2) | JP7487290B2 (https=) |
| KR (1) | KR20220123689A (https=) |
| CN (1) | CN115209876A (https=) |
| TW (1) | TWI850539B (https=) |
| WO (1) | WO2021182467A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7817300B2 (ja) * | 2023-02-14 | 2026-02-18 | 沢井製薬株式会社 | コーティング顆粒、コーティング顆粒を含む製剤及びそれらの製造方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2915653B2 (ja) * | 1991-11-14 | 1999-07-05 | 第一製薬株式会社 | マスクされた粒状物 |
| JP3265680B2 (ja) * | 1992-03-12 | 2002-03-11 | 大正製薬株式会社 | 経口製剤用組成物 |
| US5965161A (en) * | 1994-11-04 | 1999-10-12 | Euro-Celtique, S.A. | Extruded multi-particulates |
| UA80393C2 (uk) * | 2000-12-07 | 2007-09-25 | Алтана Фарма Аг | Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці |
| JP4310605B2 (ja) * | 2001-05-25 | 2009-08-12 | 大塚製薬株式会社 | 医薬用組成物 |
| KR100913281B1 (ko) * | 2002-02-21 | 2009-08-21 | 오츠카 세이야쿠 가부시키가이샤 | 서방 제제 및 그의 제조 방법 |
| JP4779970B2 (ja) * | 2004-06-03 | 2011-09-28 | 大正製薬株式会社 | 経口製剤およびその製造方法 |
| JP5905872B2 (ja) * | 2010-04-07 | 2016-04-20 | ルピン・リミテッド | タペンタドールの制御放出医薬組成物 |
| FR2999937B1 (fr) * | 2012-12-21 | 2015-01-09 | Sanofi Sa | Unite solide a haute teneur en fexofenadine et son procede de preparation |
| JP2015054822A (ja) * | 2013-09-10 | 2015-03-23 | ニプロ株式会社 | クロピドグレル含有錠剤およびその製造方法 |
| WO2017196712A1 (en) * | 2016-05-09 | 2017-11-16 | Dispersol Technologies, Llc | Improved drug formulations |
| JP2018083809A (ja) * | 2016-11-16 | 2018-05-31 | 沢井製薬株式会社 | シロドシン含有粒子の製造方法及びシロドシン含有口腔内崩壊錠の製造方法 |
| JP6895779B2 (ja) * | 2017-03-17 | 2021-06-30 | 東和薬品株式会社 | アジルサルタン含有固形医薬組成物 |
-
2021
- 2021-03-09 KR KR1020227026916A patent/KR20220123689A/ko not_active Ceased
- 2021-03-09 WO PCT/JP2021/009284 patent/WO2021182467A1/ja not_active Ceased
- 2021-03-09 EP EP21766854.0A patent/EP4119129A4/en active Pending
- 2021-03-09 JP JP2022507218A patent/JP7487290B2/ja active Active
- 2021-03-09 CN CN202180017989.5A patent/CN115209876A/zh active Pending
- 2021-03-10 TW TW110108516A patent/TWI850539B/zh active
-
2022
- 2022-09-12 US US17/942,333 patent/US20230014578A1/en active Pending
-
2024
- 2024-02-28 JP JP2024029031A patent/JP2024063111A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP4119129A1 (en) | 2023-01-18 |
| WO2021182467A1 (ja) | 2021-09-16 |
| EP4119129A4 (en) | 2024-01-24 |
| KR20220123689A (ko) | 2022-09-08 |
| JP2024063111A (ja) | 2024-05-10 |
| CN115209876A (zh) | 2022-10-18 |
| JP7487290B2 (ja) | 2024-05-20 |
| JPWO2021182467A1 (https=) | 2021-09-16 |
| TW202200118A (zh) | 2022-01-01 |
| US20230014578A1 (en) | 2023-01-19 |
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