TWI849231B - 聚乙二醇化介白素-11之組合物及方法 - Google Patents

聚乙二醇化介白素-11之組合物及方法 Download PDF

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TWI849231B
TWI849231B TW109132750A TW109132750A TWI849231B TW I849231 B TWI849231 B TW I849231B TW 109132750 A TW109132750 A TW 109132750A TW 109132750 A TW109132750 A TW 109132750A TW I849231 B TWI849231 B TW I849231B
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interleukin
polyethylene glycol
pegylated
i40ny
contemplated
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TW109132750A
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Chinese (zh)
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TW202103728A (zh
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游國明
桂林 朱
文遜 霍
耀南 劉
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香港商南沙生物科技（香港）有限公司
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    • A—HUMAN NECESSITIES
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
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    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • A—HUMAN NECESSITIES
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2073—IL-11
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5431—IL-11
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
TW109132750A 2015-03-03 2016-03-01 聚乙二醇化介白素-11之組合物及方法 TWI849231B (zh)

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US201562127748P 2015-03-03 2015-03-03
US62/127,748 2015-03-03

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TW202103728A TW202103728A (zh) 2021-02-01
TWI849231B true TWI849231B (zh) 2024-07-21

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TW105106142A TWI708611B (zh) 2015-03-03 2016-03-01 聚乙二醇化介白素-１１之組合物及方法

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EP (1) EP3265479A4 (cg-RX-API-DMAC7.html)
JP (2) JP6937984B2 (cg-RX-API-DMAC7.html)
CN (1) CN107849108A (cg-RX-API-DMAC7.html)
HK (1) HK1246306A1 (cg-RX-API-DMAC7.html)
TW (2) TWI849231B (cg-RX-API-DMAC7.html)
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JP6937984B2 (ja) * 2015-03-03 2021-09-22 ナンシャ・バイオロジックス・（ホンコン）・リミテッドＮａｎｓｈａ Ｂｉｏｌｏｇｉｃｓ （Ｈｏｎｇ Ｋｏｎｇ） Ｌｉｍｉｔｅｄ ペグ化ｉｌ−１１の組成物および方法
WO2023055081A1 (ko) * 2021-09-28 2023-04-06 한양대학교 산학협력단 암 치료용 글리시리진-분지형 폴리에틸렌글리콜 컨쥬게이트
CN118388578B (zh) * 2024-04-01 2025-01-24 北京大学口腔医学院 一种用于聚乙二醇化蛋白质的方法、非共价聚乙二醇化蛋白及含有其的蛋白质药物和应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5824784A (en) * 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
US7495087B2 (en) 1997-07-14 2009-02-24 Bolder Biotechnology, Inc. Cysteine muteins in the C-D loop of human interleukin-11
CN1316436A (zh) * 2000-04-06 2001-10-10 赵剑 水溶性缓释重组蛋白质的制备方法
PL380269A1 (pl) * 2002-12-26 2007-01-08 Mountain View Pharmaceuticals, Inc. Koniugaty polimerowe cytokin, czynników wzrostu, hormonów polipeptydowych i ich antagonistów o zachowanej zdolności do wiązania receptora
JP2005281302A (ja) * 2004-03-03 2005-10-13 Astellas Pharma Inc 修飾インターロイキン−１１及びそれを含有する医薬組成物
WO2005085283A1 (ja) * 2004-03-03 2005-09-15 Yamanouchi Pharmaceutical Co., Ltd. 修飾インターロイキン−１１及びそれを含有する医薬組成物
JP5602738B2 (ja) * 2008-08-25 2014-10-08 ビロメッド カンパニー， リミテッド インターロイキン−１１類似体を含む生体ポリマー結合体
CA2764449A1 (en) * 2009-06-03 2010-12-09 Regado Biosciences, Inc. Nucleic acid modulators of glycoprotein vi
EP2478066B1 (en) * 2009-09-18 2017-04-26 Protherics Medicines Development Limited Bab triblock polymers having improved release characteristics
US8927488B2 (en) * 2010-05-17 2015-01-06 Cebix, Inc. Pegylated C-peptide
US9023791B2 (en) 2010-11-19 2015-05-05 Novartis Ag Fibroblast growth factor 21 mutations
WO2013020079A2 (en) * 2011-08-04 2013-02-07 Nektar Therapeutics Conjugates of an il-11 moiety and a polymer
WO2014008242A1 (en) * 2012-07-03 2014-01-09 The Trustees Of Columbia University In The City Of New York The use of interleukin-11 to protect against ischemia and reperfusion injury
US8963121B2 (en) * 2012-12-07 2015-02-24 Micron Technology, Inc. Vertical solid-state transducers and high voltage solid-state transducers having buried contacts and associated systems and methods
US20160000901A1 (en) 2013-03-05 2016-01-07 Shifa Biomedical Compositions and Methods for the Production of Virus-Like Particles
CN109498815B (zh) * 2013-12-30 2022-07-22 江苏众红生物工程创药研究院有限公司 重组人激肽释放酶的化学修饰物及其应用
JP6937984B2 (ja) * 2015-03-03 2021-09-22 ナンシャ・バイオロジックス・（ホンコン）・リミテッドＮａｎｓｈａ Ｂｉｏｌｏｇｉｃｓ （Ｈｏｎｇ Ｋｏｎｇ） Ｌｉｍｉｔｅｄ ペグ化ｉｌ−１１の組成物および方法

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JP2021176875A (ja) 2021-11-11
EP3265479A4 (en) 2018-11-14
TWI708611B (zh) 2020-11-01
US20190365908A1 (en) 2019-12-05
TW202103728A (zh) 2021-02-01
US10881739B2 (en) 2021-01-05
HK1246306A1 (zh) 2018-09-07
TW201703793A (zh) 2017-02-01
EP3265479A1 (en) 2018-01-10
US20180036418A1 (en) 2018-02-08
US20190365909A1 (en) 2019-12-05
US20210268117A1 (en) 2021-09-02
US10946103B2 (en) 2021-03-16
JP2018508580A (ja) 2018-03-29
JP6937984B2 (ja) 2021-09-22
WO2016140983A1 (en) 2016-09-09
US10335492B2 (en) 2019-07-02
CN107849108A (zh) 2018-03-27
US11931417B2 (en) 2024-03-19

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