TWI823866B - 用於抑制類血管生成素蛋白-3(ANGPTL3)表現的RNAi藥劑及組合物及使用方法 - Google Patents
用於抑制類血管生成素蛋白-3(ANGPTL3)表現的RNAi藥劑及組合物及使用方法 Download PDFInfo
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- TWI823866B TWI823866B TW107132397A TW107132397A TWI823866B TW I823866 B TWI823866 B TW I823866B TW 107132397 A TW107132397 A TW 107132397A TW 107132397 A TW107132397 A TW 107132397A TW I823866 B TWI823866 B TW I823866B
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/343—Spatial arrangement of the modifications having patterns, e.g. ==--==--==--
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- C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
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- C12N2310/351—Conjugate
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
- C12N2310/3521—Methyl
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/353—Nature of the modification linked to the nucleic acid via an atom other than carbon
- C12N2310/3533—Halogen
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Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762558819P | 2017-09-14 | 2017-09-14 | |
| US62/558,819 | 2017-09-14 | ||
| US201762583919P | 2017-11-09 | 2017-11-09 | |
| US62/583,919 | 2017-11-09 | ||
| US201862651284P | 2018-04-02 | 2018-04-02 | |
| US62/651,284 | 2018-04-02 | ||
| US201862694976P | 2018-07-07 | 2018-07-07 | |
| US62/694,976 | 2018-07-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201922264A TW201922264A (zh) | 2019-06-16 |
| TWI823866B true TWI823866B (zh) | 2023-12-01 |
Family
ID=65630620
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW107132397A TWI823866B (zh) | 2017-09-14 | 2018-09-14 | 用於抑制類血管生成素蛋白-3(ANGPTL3)表現的RNAi藥劑及組合物及使用方法 |
| TW112143652A TWI887846B (zh) | 2017-09-14 | 2018-09-14 | 用於抑制類血管生成素蛋白-3 (ANGPTL3)表現的RNAi藥劑及組合物及使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW112143652A TWI887846B (zh) | 2017-09-14 | 2018-09-14 | 用於抑制類血管生成素蛋白-3 (ANGPTL3)表現的RNAi藥劑及組合物及使用方法 |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US10995335B2 (enExample) |
| EP (1) | EP3681513A4 (enExample) |
| JP (3) | JP7281452B2 (enExample) |
| KR (2) | KR20250004009A (enExample) |
| CN (2) | CN117701562A (enExample) |
| AU (2) | AU2018331383B2 (enExample) |
| BR (1) | BR112020003126A2 (enExample) |
| CA (1) | CA3074320A1 (enExample) |
| CL (1) | CL2020000666A1 (enExample) |
| CO (1) | CO2020001740A2 (enExample) |
| EC (1) | ECSP20018305A (enExample) |
| IL (2) | IL273173B1 (enExample) |
| JO (1) | JOP20200050A1 (enExample) |
| MX (1) | MX2020001912A (enExample) |
| MY (1) | MY200087A (enExample) |
| NZ (1) | NZ763275A (enExample) |
| PE (1) | PE20201287A1 (enExample) |
| PH (1) | PH12020500309A1 (enExample) |
| SG (1) | SG11201912188RA (enExample) |
| TN (1) | TN2020000038A1 (enExample) |
| TW (2) | TWI823866B (enExample) |
| UY (1) | UY37881A (enExample) |
| WO (1) | WO2019055633A1 (enExample) |
| ZA (1) | ZA202103669B (enExample) |
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2839573A1 (en) | 2011-06-21 | 2012-12-27 | Alnylam Pharmaceuticals, Inc. | Angiopoietin-like 3 (angptl3) irna compositions and methods of use thereof |
| TWI862799B (zh) | 2015-04-13 | 2024-11-21 | 美商阿尼拉製藥公司 | 類血管生成素3(ANGPTL3)iRNA組成物及其用途方法 |
| IL300869A (en) * | 2016-09-02 | 2023-04-01 | Arrowhead Pharmaceuticals Inc | Ligands containing a targeting factor, preparations containing them and their uses |
| KR102513982B1 (ko) | 2017-03-17 | 2023-03-27 | 가부시키가이샤 엠엠에이지 | 식물병 방제제 |
| EP4219713A3 (en) | 2017-04-05 | 2023-08-16 | Silence Therapeutics GmbH | Products and compositions |
| WO2021030522A1 (en) | 2019-08-13 | 2021-02-18 | Alnylam Pharmaceuticals, Inc. | SMALL RIBOSOMAL PROTEIN SUBUNIT 25 (RPS25) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF |
| CA3155921A1 (en) | 2019-11-01 | 2021-05-06 | Alnylam Pharmaceuticals, Inc. | HUNTINGTINE (HTT) TARGETING RNAI AGENT COMPOSITIONS AND METHODS OF USE THEREOF |
| TW202526019A (zh) | 2019-11-13 | 2025-07-01 | 美商阿尼拉製藥公司 | 用於治療血管收縮素原相關病症之方法及組成物 |
| IL293824A (en) | 2019-12-13 | 2022-08-01 | Alnylam Pharmaceuticals Inc | Compositions of RNA material (c9orf72) human chromosome 9 open reading frame 72 and methods of using them |
| WO2021126734A1 (en) | 2019-12-16 | 2021-06-24 | Alnylam Pharmaceuticals, Inc. | Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof |
| CA3171654A1 (en) | 2020-02-18 | 2021-08-26 | Alnylam Pharmaceuticals, Inc. | Apolipoprotein c3 (apoc3) irna compositions and methods of use thereof |
| EP4114947A1 (en) | 2020-03-05 | 2023-01-11 | Alnylam Pharmaceuticals, Inc. | Complement component c3 irna compositions and methods of use thereof for treating or preventing complement component c3-associated diseases |
| JP2023516095A (ja) | 2020-03-06 | 2023-04-17 | アルナイラム ファーマシューティカルズ, インコーポレイテッド | ケトヘキソキナーゼ(KHK)iRNA組成物およびその使用方法 |
| EP4121534A1 (en) | 2020-03-18 | 2023-01-25 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for treating subjects having a heterozygous alanine-glyoxylate aminotransferase gene (agxt) variant |
| AU2021236674B2 (en) * | 2020-03-18 | 2025-03-06 | Dicerna Pharmaceuticals, Inc. | Compositions and methods for inhibiting ANGPTL3 expression |
| AU2021242321B2 (en) * | 2020-03-26 | 2025-09-04 | Arrowhead Pharmaceuticals, Inc. | RNAi agents for inhibiting expression of PNPLA3, pharmaceutical compositions thereof, and methods of use |
| EP4127168A1 (en) | 2020-03-26 | 2023-02-08 | Alnylam Pharmaceuticals, Inc. | Coronavirus irna compositions and methods of use thereof |
| EP4133076A1 (en) | 2020-04-07 | 2023-02-15 | Alnylam Pharmaceuticals, Inc. | Angiotensin-converting enzyme 2 (ace2) irna compositions and methods of use thereof |
| WO2021206922A1 (en) | 2020-04-07 | 2021-10-14 | Alnylam Pharmaceuticals, Inc. | Transmembrane serine protease 2 (tmprss2) irna compositions and methods of use thereof |
| CN115955972A (zh) | 2020-04-27 | 2023-04-11 | 阿尔尼拉姆医药品有限公司 | 载脂蛋白E(APOE)iRNA剂组合物及其使用方法 |
| KR20230017789A (ko) | 2020-04-30 | 2023-02-06 | 알닐람 파마슈티칼스 인코포레이티드 | 보체 인자 B (CFB) iRNA 조성물 및 이의 사용 방법 |
| EP4162050A1 (en) | 2020-06-09 | 2023-04-12 | Alnylam Pharmaceuticals, Inc. | Rnai compositions and methods of use thereof for delivery by inhalation |
| BR112022024420A2 (pt) | 2020-06-18 | 2023-01-17 | Alnylam Pharmaceuticals Inc | Composições de irna de xantina desidrogenase (xdh) e métodos de uso das mesmas |
| WO2022066847A1 (en) | 2020-09-24 | 2022-03-31 | Alnylam Pharmaceuticals, Inc. | Dipeptidyl peptidase 4 (dpp4) irna compositions and methods of use thereof |
| EP4223875A1 (en) * | 2020-09-30 | 2023-08-09 | Nanopeptide (Qingdao) Biotechnology Ltd. | Sirna of angiopoietin-like 3 (angptl3) and use thereof |
| TW202229552A (zh) | 2020-10-05 | 2022-08-01 | 美商艾拉倫製藥股份有限公司 | G蛋白-偶合受體75(GPR75)iRNA組成物及其使用方法 |
| EP4229200A1 (en) * | 2020-10-16 | 2023-08-23 | Sanofi | Novel rna compositions and methods for inhibiting angptl3 |
| WO2022087329A1 (en) | 2020-10-23 | 2022-04-28 | Alnylam Pharmaceuticals, Inc. | Mucin 5b (muc5b) irna compositions and methods of use thereof |
| MX2023005490A (es) | 2020-11-13 | 2023-05-23 | Alnylam Pharmaceuticals Inc | Composiciones de acido ribonucleico de interferencia (arni) del factor de coagulacion v (f5) y sus metodos de uso. |
| WO2022125490A1 (en) | 2020-12-08 | 2022-06-16 | Alnylam Pharmaceuticals, Inc. | Coagulation factor x (f10) irna compositions and methods of use thereof |
| EP4274896A1 (en) | 2021-01-05 | 2023-11-15 | Alnylam Pharmaceuticals, Inc. | Complement component 9 (c9) irna compositions and methods of use thereof |
| AU2022220704A1 (en) | 2021-02-12 | 2022-08-18 | Alnylam Pharmaceuticals, Inc. | Superoxide dismutase 1 (sod1) irna compositions and methods of use thereof for treating or preventing superoxide dismutase 1- (sod1-) associated neurodegenerative diseases |
| JP2024509783A (ja) | 2021-02-25 | 2024-03-05 | アルナイラム ファーマシューティカルズ, インコーポレイテッド | プリオンタンパク質(prnp)irna組成物およびその使用方法 |
| BR112023016645A2 (pt) | 2021-02-26 | 2023-11-14 | Alnylam Pharmaceuticals Inc | Composições de irna de ceto-hexoquinase (khk) e métodos de uso das mesmas |
| IL305414A (en) | 2021-03-04 | 2023-10-01 | Alnylam Pharmaceuticals Inc | Angiopoietin-like 3 (ANGPTL3) IRNA compositions and methods of using them |
| WO2022192519A1 (en) | 2021-03-12 | 2022-09-15 | Alnylam Pharmaceuticals, Inc. | Glycogen synthase kinase 3 alpha (gsk3a) irna compositions and methods of use thereof |
| EP4314296A2 (en) | 2021-03-29 | 2024-02-07 | Alnylam Pharmaceuticals, Inc. | Huntingtin (htt) irna agent compositions and methods of use thereof |
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