JP7281452B2 - アンジオポエチン様3(ANGPTL3)の発現を阻害するためのRNAi剤および組成物、ならびに使用方法 - Google Patents
アンジオポエチン様3(ANGPTL3)の発現を阻害するためのRNAi剤および組成物、ならびに使用方法 Download PDFInfo
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- JP7281452B2 JP7281452B2 JP2020514926A JP2020514926A JP7281452B2 JP 7281452 B2 JP7281452 B2 JP 7281452B2 JP 2020514926 A JP2020514926 A JP 2020514926A JP 2020514926 A JP2020514926 A JP 2020514926A JP 7281452 B2 JP7281452 B2 JP 7281452B2
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023028733A JP7660154B2 (ja) | 2017-09-14 | 2023-02-27 | アンジオポエチン様3(ANGPTL3)の発現を阻害するためのRNAi剤および組成物、ならびに使用方法 |
| JP2025058240A JP2025092670A (ja) | 2017-09-14 | 2025-03-31 | アンジオポエチン様3(ANGPTL3)の発現を阻害するためのRNAi剤および組成物、ならびに使用方法 |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762558819P | 2017-09-14 | 2017-09-14 | |
| US62/558,819 | 2017-09-14 | ||
| US201762583919P | 2017-11-09 | 2017-11-09 | |
| US62/583,919 | 2017-11-09 | ||
| US201862651284P | 2018-04-02 | 2018-04-02 | |
| US62/651,284 | 2018-04-02 | ||
| US201862694976P | 2018-07-07 | 2018-07-07 | |
| US62/694,976 | 2018-07-07 | ||
| PCT/US2018/050848 WO2019055633A1 (en) | 2017-09-14 | 2018-09-13 | RNAI AGENTS AND COMPOSITIONS FOR INHIBITING ANALOGUE EXPRESSION OF ANGIOPOIETIN 3 (ANGPTL3) AND METHODS OF USE |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023028733A Division JP7660154B2 (ja) | 2017-09-14 | 2023-02-27 | アンジオポエチン様3(ANGPTL3)の発現を阻害するためのRNAi剤および組成物、ならびに使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020534268A JP2020534268A (ja) | 2020-11-26 |
| JP2020534268A5 JP2020534268A5 (enExample) | 2021-10-14 |
| JP7281452B2 true JP7281452B2 (ja) | 2023-05-25 |
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Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020514926A Active JP7281452B2 (ja) | 2017-09-14 | 2018-09-13 | アンジオポエチン様3(ANGPTL3)の発現を阻害するためのRNAi剤および組成物、ならびに使用方法 |
| JP2023028733A Active JP7660154B2 (ja) | 2017-09-14 | 2023-02-27 | アンジオポエチン様3(ANGPTL3)の発現を阻害するためのRNAi剤および組成物、ならびに使用方法 |
| JP2025058240A Pending JP2025092670A (ja) | 2017-09-14 | 2025-03-31 | アンジオポエチン様3(ANGPTL3)の発現を阻害するためのRNAi剤および組成物、ならびに使用方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023028733A Active JP7660154B2 (ja) | 2017-09-14 | 2023-02-27 | アンジオポエチン様3(ANGPTL3)の発現を阻害するためのRNAi剤および組成物、ならびに使用方法 |
| JP2025058240A Pending JP2025092670A (ja) | 2017-09-14 | 2025-03-31 | アンジオポエチン様3(ANGPTL3)の発現を阻害するためのRNAi剤および組成物、ならびに使用方法 |
Country Status (24)
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|---|---|
| US (2) | US10995335B2 (enExample) |
| EP (1) | EP3681513A4 (enExample) |
| JP (3) | JP7281452B2 (enExample) |
| KR (2) | KR20250004009A (enExample) |
| CN (2) | CN111343994B (enExample) |
| AU (2) | AU2018331383B2 (enExample) |
| BR (1) | BR112020003126A2 (enExample) |
| CA (1) | CA3074320A1 (enExample) |
| CL (1) | CL2020000666A1 (enExample) |
| CO (1) | CO2020001740A2 (enExample) |
| EC (1) | ECSP20018305A (enExample) |
| IL (2) | IL273173B1 (enExample) |
| JO (1) | JOP20200050A1 (enExample) |
| MX (1) | MX2020001912A (enExample) |
| MY (1) | MY200087A (enExample) |
| NZ (1) | NZ763275A (enExample) |
| PE (1) | PE20201287A1 (enExample) |
| PH (1) | PH12020500309A1 (enExample) |
| SG (1) | SG11201912188RA (enExample) |
| TN (1) | TN2020000038A1 (enExample) |
| TW (2) | TWI887846B (enExample) |
| UY (1) | UY37881A (enExample) |
| WO (1) | WO2019055633A1 (enExample) |
| ZA (1) | ZA202103669B (enExample) |
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102232287B1 (ko) | 2011-06-21 | 2021-03-29 | 알닐람 파마슈티칼스 인코포레이티드 | 안지오포이에틴-유사 3(ANGPTL3) iRNA 조성물 및 그 사용 방법 |
| TWI723986B (zh) | 2015-04-13 | 2021-04-11 | 美商阿尼拉製藥公司 | 類血管生成素3(ANGPTL3)iRNA組成物及其用途方法 |
| US10294474B2 (en) * | 2016-09-02 | 2019-05-21 | Arrowhead Pharmaceuticals, Inc. | Targeting ligands |
| AU2018235654B2 (en) | 2017-03-17 | 2021-11-18 | Mitsui Chemicals Crop & Life Solutions, Inc. | Plant disease control agent |
| IL321221A (en) | 2017-04-05 | 2025-07-01 | Silence Therapeutics Gmbh | Products and compositions |
| EP4013870A1 (en) | 2019-08-13 | 2022-06-22 | Alnylam Pharmaceuticals, Inc. | Small ribosomal protein subunit 25 (rps25) irna agent compositions and methods of use thereof |
| CA3155921A1 (en) | 2019-11-01 | 2021-05-06 | Alnylam Pharmaceuticals, Inc. | HUNTINGTINE (HTT) TARGETING RNAI AGENT COMPOSITIONS AND METHODS OF USE THEREOF |
| CN114981431A (zh) | 2019-11-13 | 2022-08-30 | 阿尔尼拉姆医药品有限公司 | 用于治疗血管紧张素原(agt)相关病症的方法和组合物 |
| BR112022011417A2 (pt) | 2019-12-13 | 2022-08-30 | Alnylam Pharmaceuticals Inc | Composições do agente de irna da fase de leitura aberta 72 do cromossomo humano 9 (c9orf72) e métodos de uso das mesmas |
| TW202138559A (zh) | 2019-12-16 | 2021-10-16 | 美商阿尼拉製藥公司 | 含類PATATIN磷脂酶結構域3(PNPLA3)iRNA組成物及其使用方法 |
| JP7735288B2 (ja) | 2020-02-18 | 2025-09-08 | アルナイラム ファーマシューティカルズ, インコーポレイテッド | アポリポタンパク質C3(APOC3)iRNA組成物およびその使用法 |
| EP4114947A1 (en) | 2020-03-05 | 2023-01-11 | Alnylam Pharmaceuticals, Inc. | Complement component c3 irna compositions and methods of use thereof for treating or preventing complement component c3-associated diseases |
| EP4114948A1 (en) | 2020-03-06 | 2023-01-11 | Alnylam Pharmaceuticals, Inc. | Ketohexokinase (khk) irna compositions and methods of use thereof |
| WO2021188611A1 (en) | 2020-03-18 | 2021-09-23 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for treating subjects having a heterozygous alanine-glyoxylate aminotransferase gene (agxt) variant |
| IL296549A (en) * | 2020-03-18 | 2022-11-01 | Dicerna Pharmaceuticals Inc | Compositions and methods for inhibiting angptl3 expression |
| JP2023519274A (ja) | 2020-03-26 | 2023-05-10 | アルナイラム ファーマシューティカルズ, インコーポレイテッド | コロナウイルスiRNA組成物およびその使用方法 |
| KR20220158011A (ko) * | 2020-03-26 | 2022-11-29 | 애로우헤드 파마슈티컬스 인코포레이티드 | PNPLA3의 발현을 억제하기 위한 RNAi 작용제, 이의 약제학적 조성물, 및 사용 방법 |
| WO2021206917A1 (en) | 2020-04-07 | 2021-10-14 | Alnylam Pharmaceuticals, Inc. | ANGIOTENSIN-CONVERTING ENZYME 2 (ACE2) iRNA COMPOSITIONS AND METHODS OF USE THEREOF |
| EP4133077A1 (en) | 2020-04-07 | 2023-02-15 | Alnylam Pharmaceuticals, Inc. | Transmembrane serine protease 2 (tmprss2) irna compositions and methods of use thereof |
| EP4143319A1 (en) | 2020-04-27 | 2023-03-08 | Alnylam Pharmaceuticals, Inc. | Apolipoprotein e (apoe) irna agent compositions and methods of use thereof |
| CN116096381A (zh) | 2020-04-30 | 2023-05-09 | 阿尔尼拉姆医药品有限公司 | 补体因子B(CFB)iRNA组合物及其使用方法 |
| EP4162050A1 (en) | 2020-06-09 | 2023-04-12 | Alnylam Pharmaceuticals, Inc. | Rnai compositions and methods of use thereof for delivery by inhalation |
| WO2021257782A1 (en) | 2020-06-18 | 2021-12-23 | Alnylam Pharmaceuticals, Inc. | XANTHINE DEHYDROGENASE (XDH) iRNA COMPOSITIONS AND METHODS OF USE THEREOF |
| EP4217489A1 (en) | 2020-09-24 | 2023-08-02 | Alnylam Pharmaceuticals, Inc. | Dipeptidyl peptidase 4 (dpp4) irna compositions and methods of use thereof |
| EP4331608A1 (en) * | 2020-09-30 | 2024-03-06 | Nanopeptide (Qingdao) Biotechnology Ltd. | Target ligand |
| WO2022076291A1 (en) | 2020-10-05 | 2022-04-14 | Alnylam Pharmaceuticals, Inc. | G protein-coupled receptor 75 (gpr75) irna compositions and methods of use thereof |
| EP4229200A1 (en) * | 2020-10-16 | 2023-08-23 | Sanofi | Novel rna compositions and methods for inhibiting angptl3 |
| EP4232582A1 (en) | 2020-10-23 | 2023-08-30 | Alnylam Pharmaceuticals, Inc. | Mucin 5b (muc5b) irna compositions and methods of use thereof |
| EP4244355A1 (en) | 2020-11-13 | 2023-09-20 | Alnylam Pharmaceuticals, Inc. | Coagulation factor v (f5) irna compositions and methods of use thereof |
| EP4259795A1 (en) | 2020-12-08 | 2023-10-18 | Alnylam Pharmaceuticals, Inc. | Coagulation factor x (f10) irna compositions and methods of use thereof |
| WO2022150260A1 (en) | 2021-01-05 | 2022-07-14 | Alnylam Pharmaceuticals, Inc. | COMPLEMENT COMPONENT 9 (C9) iRNA COMPOSITIONS AND METHODS OF USE THEREOF |
| WO2022174000A2 (en) | 2021-02-12 | 2022-08-18 | Alnylam Pharmaceuticals, Inc. | Superoxide dismutase 1 (sod1) irna compositions and methods of use thereof for treating or preventing superoxide dismutase 1- (sod1-) associated neurodegenerative diseases |
| CN117222739A (zh) | 2021-02-25 | 2023-12-12 | 阿尔尼拉姆医药品有限公司 | 朊病毒蛋白(prnp)irna组合物和其使用方法 |
| AU2022226098A1 (en) | 2021-02-26 | 2023-08-24 | Alnylam Pharmaceuticals, Inc. | KETOHEXOKINASE (KHK) iRNA COMPOSITIONS AND METHODS OF USE THEREOF |
| JP2024508896A (ja) | 2021-03-04 | 2024-02-28 | アルナイラム ファーマシューティカルズ, インコーポレイテッド | アンジオポエチン様3(ANGPTL3)iRNA組成物およびその使用方法 |
| EP4305169A1 (en) | 2021-03-12 | 2024-01-17 | Alnylam Pharmaceuticals, Inc. | Glycogen synthase kinase 3 alpha (gsk3a) irna compositions and methods of use thereof |
| TW202305134A (zh) | 2021-03-29 | 2023-02-01 | 美商艾拉倫製藥股份有限公司 | 杭丁頓蛋白(HTT)iRNA劑組成物及其使用方法 |
| EP4314293A1 (en) | 2021-04-01 | 2024-02-07 | Alnylam Pharmaceuticals, Inc. | Proline dehydrogenase 2 (prodh2) irna compositions and methods of use thereof |
| IL307926A (en) | 2021-04-26 | 2023-12-01 | Alnylam Pharmaceuticals Inc | Transmembrane assemblies, serine 6 ((TMPRSS6 IRNA) and methods of using them |
| EP4330396A1 (en) | 2021-04-29 | 2024-03-06 | Alnylam Pharmaceuticals, Inc. | Signal transducer and activator of transcription factor 6 (stat6) irna compositions and methods of use thereof |
| JP2024522068A (ja) | 2021-05-18 | 2024-06-11 | アルナイラム ファーマシューティカルズ, インコーポレイテッド | ナトリウム-グルコース共輸送体2(sglt2)irna組成物およびその使用方法 |
| WO2022256395A1 (en) | 2021-06-02 | 2022-12-08 | Alnylam Pharmaceuticals, Inc. | Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof |
| TW202308663A (zh) | 2021-06-04 | 2023-03-01 | 美商艾拉倫製藥股份有限公司 | 人類染色體9開讀框72(C9ORF72)iRNA劑組成物及其使用方法 |
| AR126070A1 (es) | 2021-06-08 | 2023-09-06 | Alnylam Pharmaceuticals Inc | Composiciones y métodos para tratar o prevenir la enfermedad de stargardt y/o trastornos asociados con la proteína transportadora de retinol 4 (rbp4) |
| MX2023015489A (es) | 2021-06-30 | 2024-01-19 | Alnylam Pharmaceuticals Inc | Metodos y composiciones para tratar un trastorno asociado al angiotensinogeno (agt). |
| EP4373934A1 (en) | 2021-07-19 | 2024-05-29 | Alnylam Pharmaceuticals, Inc. | Methods and compositions for treating subjects having or at risk of developing a non-primary hyperoxaluria disease or disorder |
| KR20240036041A (ko) | 2021-07-21 | 2024-03-19 | 알닐람 파마슈티칼스 인코포레이티드 | 대사 장애-연관 표적 유전자 iRNA 조성물 및 이의 사용 방법 |
| TW202325312A (zh) | 2021-07-23 | 2023-07-01 | 美商艾拉倫製藥股份有限公司 | β-鏈蛋白(CTNNB1)iRNA組成物及其使用方法 |
| EP4377458A1 (en) | 2021-07-29 | 2024-06-05 | Alnylam Pharmaceuticals, Inc. | 3-hydroxy-3-methylglutaryl-coa reductase (hmgcr) irna compositions and methods of use thereof |
| CA3227852A1 (en) | 2021-08-03 | 2023-02-09 | Alnylam Pharmaceuticals, Inc. | Transthyretin (ttr) irna compositions and methods of use thereof |
| IL310295A (en) | 2021-08-04 | 2024-03-01 | Alnylam Pharmaceuticals Inc | iRNA compositions and methods for silencing angiotensinogen (AGT) |
| JP2024534766A (ja) | 2021-08-13 | 2024-09-26 | アルナイラム ファーマシューティカルズ, インコーポレイテッド | 第XII因子(F12)iRNA組成物およびその使用方法 |
| EP4401742A2 (en) | 2021-09-17 | 2024-07-24 | Alnylam Pharmaceuticals, Inc. | Irna compositions and methods for silencing complement component 3 (c3) |
| CN118159654A (zh) | 2021-09-20 | 2024-06-07 | 阿尔尼拉姆医药品有限公司 | 抑制素亚基βE(INHBE)调节剂组合物及其使用方法 |
| IL310929A (en) * | 2021-09-23 | 2024-04-01 | Shanghai Argo Biopharmaceutical Co Ltd | Preparations and methods for inhibiting expression of angiopoietin-like protein 3 |
| CN118369427A (zh) | 2021-10-15 | 2024-07-19 | 阿尔尼拉姆医药品有限公司 | 肝外递送irna组合物及其使用方法 |
| EP4423272A2 (en) | 2021-10-29 | 2024-09-04 | Alnylam Pharmaceuticals, Inc. | Huntingtin (htt) irna agent compositions and methods of use thereof |
| CA3234636A1 (en) | 2021-10-29 | 2023-05-04 | Alnylam Pharmaceuticals, Inc. | Complement factor b (cfb) irna compositions and methods of use thereof |
| TW202329987A (zh) * | 2021-11-29 | 2023-08-01 | 大陸商上海舶望製藥有限公司 | 用於抑制乙型肝炎病毒(hbv)蛋白表達的組合物和方法 |
| WO2023122656A1 (en) | 2021-12-22 | 2023-06-29 | Regeneron Pharmaceuticals, Inc. | Treatment of kidney diseases with angiopoietin like 3 (angptl3) inhibitors |
| WO2023134705A1 (zh) * | 2022-01-11 | 2023-07-20 | 上海金中锘美生物医药科技有限公司 | 抑制angptl3表达的rna干扰剂及其用途 |
| WO2023141314A2 (en) | 2022-01-24 | 2023-07-27 | Alnylam Pharmaceuticals, Inc. | Heparin sulfate biosynthesis pathway enzyme irna agent compositions and methods of use thereof |
| JP2025511854A (ja) * | 2022-04-08 | 2025-04-16 | アローヘッド ファーマシューティカルズ インコーポレイテッド | 非アルコール性脂肪肝疾患の治療 |
| WO2024027518A1 (zh) * | 2022-08-04 | 2024-02-08 | 北京福元医药股份有限公司 | 用于抑制angptl3基因表达的双链核糖核酸及其修饰物、缀合物和用途 |
| CN119585431A (zh) * | 2022-08-08 | 2025-03-07 | 大睿生物医药科技(上海)有限公司 | 调控ANGPTL3基因活性的siRNA分子 |
| CN120077130A (zh) | 2022-08-18 | 2025-05-30 | 阿尔尼拉姆医药品有限公司 | 通用非靶向sirna组合物及其使用方法 |
| KR20250054795A (ko) * | 2022-08-22 | 2025-04-23 | 애로우헤드 파마슈티컬스 인코포레이티드 | Angptl3-관련 질환 및 장애의 치료 방법 |
| JP2025537256A (ja) | 2022-11-10 | 2025-11-14 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | アンジオポエチン様3(angptl3)阻害剤と溶質担体ファミリー5メンバー2(slc5a2)阻害剤の組み合わせによる腎疾患の治療 |
| WO2024164008A1 (en) * | 2023-02-03 | 2024-08-08 | Sirnaomics, Inc. | Products and compositions |
| WO2024188173A1 (zh) * | 2023-03-10 | 2024-09-19 | 苏州瑞博生物技术股份有限公司 | 一种核酸、含有该核酸的组合物与缀合物及其用途 |
| WO2024220746A2 (en) | 2023-04-21 | 2024-10-24 | Flagship Pioneering Innovations Vii, Llc | Rnai agents targeting fatty acid synthase and related methods |
| WO2024240212A1 (zh) * | 2023-05-24 | 2024-11-28 | 云合智药(苏州)生物科技有限公司 | 用于抑制angptl3表达的rnai剂及其应用 |
| CN118599845A (zh) * | 2023-06-27 | 2024-09-06 | 施能康医药科技(苏州)有限公司 | 靶向人血管生成素样蛋白3的核酸及其用途 |
| WO2025034422A1 (en) | 2023-08-04 | 2025-02-13 | Alnylam Pharmaceuticals, Inc. | Methods and compositions for treating ctnnb1-associated disorders |
| CN119040325B (zh) * | 2023-09-18 | 2025-07-18 | 广州必贝特医药股份有限公司 | 用于同时抑制两个靶基因表达的siRNA、药物及其应用 |
| WO2025064660A2 (en) | 2023-09-21 | 2025-03-27 | Alnylam Pharmaceuticals, Inc. | Activin a receptor type 1c (acvr1c) irna compositions and methods of use thereof |
| WO2025096970A2 (en) * | 2023-11-03 | 2025-05-08 | Basecure Therapeutics Llc | Modified oligonucleotides and methods of use thereof |
| WO2025169133A1 (en) | 2024-02-09 | 2025-08-14 | Astrazeneca Ab | Double-stranded rnai agents and compositions for reducing expression of angiopoietin-like 3 (angptl3) and methods of use thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014524738A (ja) | 2011-06-21 | 2014-09-25 | アルナイラム ファーマシューティカルズ, インコーポレイテッド | アンジオポエチン様3(ANGPTL3)iRNA組成物及びその使用方法 |
| WO2016168286A1 (en) | 2015-04-13 | 2016-10-20 | Alnylam Pharmaceuticals, Inc. | Angiopoietin-like 3 (angptl3) irna compositions and methods of use thereof |
| WO2017059223A2 (en) | 2015-10-01 | 2017-04-06 | Arrowhead Pharmaceuticals, Inc. | Compositions and methods for inhibiting gene expression of lpa |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| NL9201440A (nl) | 1992-08-11 | 1994-03-01 | Univ Leiden | Triantennaire clusterglycosiden, hun bereiding en toepassing. |
| US5998203A (en) | 1996-04-16 | 1999-12-07 | Ribozyme Pharmaceuticals, Inc. | Enzymatic nucleic acids containing 5'-and/or 3'-cap structures |
| AU767195B2 (en) | 1999-03-10 | 2003-11-06 | Phogen Limited | Delivery of substances to cells |
| EP1239050A4 (en) | 1999-12-09 | 2004-07-21 | Sankyo Co | METHOD FOR TESTING CURATIVE OR PREVENTIVE AGENT OF HYPERLIPEMIA |
| KR101012904B1 (ko) | 2001-11-16 | 2011-02-08 | 제넨테크, 인크. | 안지오포이에틴-유사 단백질 3 angptl3을 함유하는조성물 및 이를 사용하는 방법 |
| CA2881743A1 (en) * | 2002-09-25 | 2004-04-08 | University Of Massachusetts | In vivo gene silencing by chemically modified and stable sirna |
| WO2006006948A2 (en) | 2002-11-14 | 2006-01-19 | Dharmacon, Inc. | METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY |
| EP2213738B1 (en) | 2002-11-14 | 2012-10-10 | Dharmacon, Inc. | siRNA molecules targeting Bcl-2 |
| US20040198640A1 (en) | 2003-04-02 | 2004-10-07 | Dharmacon, Inc. | Stabilized polynucleotides for use in RNA interference |
| US20040224405A1 (en) | 2003-05-06 | 2004-11-11 | Dharmacon Inc. | siRNA induced systemic gene silencing in mammalian systems |
| US20070276134A1 (en) * | 2006-05-24 | 2007-11-29 | Nastech Pharmaceutical Company Inc. | Compositions and methods for complexes of nucleic acids and organic cations |
| WO2008022309A2 (en) | 2006-08-18 | 2008-02-21 | F. Hoffmann-La Roche Ag | Polyconjugates for in vivo delivery of polynucleotides |
| WO2009082607A2 (en) | 2007-12-04 | 2009-07-02 | Alnylam Pharmaceuticals, Inc. | Targeting lipids |
| EP2504435B1 (en) * | 2009-11-26 | 2019-11-13 | Quark Pharmaceuticals, Inc. | Sirna compounds comprising terminal substitutions |
| ES2677969T3 (es) | 2010-01-08 | 2018-08-07 | Ionis Pharmaceuticals, Inc. | Modulación de la expresión tipo angiopoyetina 3 |
| RS54578B1 (sr) | 2010-02-24 | 2016-06-30 | Arrowhead Research Corporation | Preparati za ciljano dopremanje sirnk |
| EP2632472B1 (en) | 2010-10-29 | 2017-12-13 | Sirna Therapeutics, Inc. | Rna interference mediated inhibition of gene expression using short interfering nucleic acids (sina) |
| US8501930B2 (en) | 2010-12-17 | 2013-08-06 | Arrowhead Madison Inc. | Peptide-based in vivo siRNA delivery system |
| CN104024328A (zh) | 2011-08-26 | 2014-09-03 | 箭头研究公司 | 用于体内核酸递送的聚(乙烯基酯)聚合物 |
| FI3366775T4 (fi) * | 2011-11-18 | 2025-11-14 | Alnylam Pharmaceuticals Inc | Modifioituja rnai-agensseja |
| BR112014004528A2 (pt) | 2012-04-18 | 2019-09-24 | Arrowhead Res Corp | polímeros de poli(acrilato) para entrega de ácido nucleico in vivo |
| EP3453762B1 (en) * | 2012-05-02 | 2021-04-21 | Sirna Therapeutics, Inc. | Short interfering nucleic acid (sina) compositions |
| WO2015100394A1 (en) | 2013-12-24 | 2015-07-02 | Isis Pharmaceuticals, Inc. | Modulation of angiopoietin-like 3 expression |
| EP3845547A1 (en) | 2014-05-01 | 2021-07-07 | Ionis Pharmaceuticals, Inc. | Galnac3 conjugated modified oligonucleotide for modulating angiopoietin-like 3 expression |
| IL316808A (en) | 2014-08-20 | 2025-01-01 | Alnylam Pharmaceuticals Inc | Modified double-stranded RNA materials and their uses |
| WO2016149331A2 (en) * | 2015-03-17 | 2016-09-22 | Arrowhead Research Corporation | Compositions and methods for inhibiting gene expression of factor xii |
| WO2016154127A2 (en) | 2015-03-20 | 2016-09-29 | Protiva Biotherapeutics, Inc. | Compositions and methods for treating hypertriglyceridemia |
| CN113797348A (zh) | 2016-03-07 | 2021-12-17 | 箭头药业股份有限公司 | 用于治疗性化合物的靶向配体 |
| MA45328A (fr) * | 2016-04-01 | 2019-02-06 | Avidity Biosciences Llc | Compositions acide nucléique-polypeptide et utilisations de celles-ci |
| MA45340A (fr) * | 2016-04-01 | 2019-02-06 | Avidity Biosciences Llc | Acides nucléiques du récepteur des androgènes et leurs utilisations |
| US10294474B2 (en) | 2016-09-02 | 2019-05-21 | Arrowhead Pharmaceuticals, Inc. | Targeting ligands |
-
2018
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014524738A (ja) | 2011-06-21 | 2014-09-25 | アルナイラム ファーマシューティカルズ, インコーポレイテッド | アンジオポエチン様3(ANGPTL3)iRNA組成物及びその使用方法 |
| WO2016168286A1 (en) | 2015-04-13 | 2016-10-20 | Alnylam Pharmaceuticals, Inc. | Angiopoietin-like 3 (angptl3) irna compositions and methods of use thereof |
| WO2017059223A2 (en) | 2015-10-01 | 2017-04-06 | Arrowhead Pharmaceuticals, Inc. | Compositions and methods for inhibiting gene expression of lpa |
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