TWI805699B - 甲基內醯胺環化合物及其用途 - Google Patents

甲基內醯胺環化合物及其用途 Download PDF

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Publication number
TWI805699B
TWI805699B TW108106807A TW108106807A TWI805699B TW I805699 B TWI805699 B TW I805699B TW 108106807 A TW108106807 A TW 108106807A TW 108106807 A TW108106807 A TW 108106807A TW I805699 B TWI805699 B TW I805699B
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Taiwan
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compound
acid
formula
minutes
reaction mixture
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TW108106807A
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English (en)
Chinese (zh)
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TW202000660A (zh
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三浦智也
玉谷義憲
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日商日本煙草產業股份有限公司
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
TW108106807A 2018-03-01 2019-02-27 甲基內醯胺環化合物及其用途 TWI805699B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2018-036307 2018-03-01
JP2018036307 2018-03-01

Publications (2)

Publication Number Publication Date
TW202000660A TW202000660A (zh) 2020-01-01
TWI805699B true TWI805699B (zh) 2023-06-21

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TW108106807A TWI805699B (zh) 2018-03-01 2019-02-27 甲基內醯胺環化合物及其用途

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US (3) US11014910B2 (enExample)
EP (1) EP3760624A4 (enExample)
JP (3) JP7206132B2 (enExample)
KR (1) KR102795351B1 (enExample)
CN (1) CN111757877B (enExample)
AR (1) AR114418A1 (enExample)
AU (1) AU2019227770B2 (enExample)
BR (1) BR112020016788A2 (enExample)
CA (1) CA3087859A1 (enExample)
CL (1) CL2020002199A1 (enExample)
IL (1) IL276311B2 (enExample)
MA (1) MA52427A (enExample)
MX (1) MX2020009070A (enExample)
MY (1) MY205197A (enExample)
PE (1) PE20210123A1 (enExample)
PH (1) PH12020551340A1 (enExample)
SA (1) SA520420037B1 (enExample)
SG (1) SG11202007120UA (enExample)
TW (1) TWI805699B (enExample)
WO (1) WO2019168096A1 (enExample)
ZA (1) ZA202004600B (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI805699B (zh) * 2018-03-01 2023-06-21 日商日本煙草產業股份有限公司 甲基內醯胺環化合物及其用途
SG11202009179TA (en) 2018-04-04 2020-10-29 Japan Tobacco Inc Pyrazole compounds substituted with heteroaryl and pharmaceutical use thereof
CN114585387B (zh) * 2019-09-04 2024-10-29 日本烟草产业株式会社 利用联用药物的糖尿病的治疗或预防方法
KR20220156574A (ko) 2020-03-19 2022-11-25 니뽄 다바코 산교 가부시키가이샤 만성 심부전의 치료 또는 예방 방법

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI549949B (zh) * 2011-08-31 2016-09-21 日本煙草產業股份有限公司 吡唑化合物及其醫藥用途

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FR2665898B1 (fr) 1990-08-20 1994-03-11 Sanofi Derives d'amido-3 pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
JPH04247081A (ja) 1991-02-01 1992-09-03 Takeda Chem Ind Ltd ５員複素環酸アミド類
FR2692575B1 (fr) 1992-06-23 1995-06-30 Sanofi Elf Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
WO2004069824A1 (ja) 2003-02-07 2004-08-19 Daiichi Pharmaceutical Co., Ltd. ピラゾール誘導体
AU2004200420A1 (en) 2003-03-11 2004-09-30 Astellas Pharma Inc. Inhibitor of cyclooxygenase
JP2006182648A (ja) 2003-04-08 2006-07-13 Dai Ichi Seiyaku Co Ltd ７員複素環誘導体
WO2004110351A2 (en) 2003-05-14 2004-12-23 Anadys Pharmaceuticals, Inc. Heterocyclic compounds for treating hepatitis c virus
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KR20070089151A (ko) 2004-11-16 2007-08-30 지더블유 파마 리미티드 카나비노이드의 새로운 용도
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TWI805699B (zh) * 2018-03-01 2023-06-21 日商日本煙草產業股份有限公司 甲基內醯胺環化合物及其用途
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Also Published As

Publication number Publication date
IL276311A (en) 2020-09-30
PE20210123A1 (es) 2021-01-19
KR20200128033A (ko) 2020-11-11
JP7206132B2 (ja) 2023-01-17
WO2019168096A1 (ja) 2019-09-06
AU2019227770B2 (en) 2023-10-05
MX2020009070A (es) 2020-10-08
US20190352284A1 (en) 2019-11-21
CL2020002199A1 (es) 2020-12-18
IL276311B1 (en) 2023-06-01
PH12020551340A1 (en) 2021-05-31
JP2019151627A (ja) 2019-09-12
JP2023026566A (ja) 2023-02-24
MY205197A (en) 2024-10-07
SA520420037B1 (ar) 2024-07-28
JP2025026615A (ja) 2025-02-21
TW202000660A (zh) 2020-01-01
BR112020016788A2 (pt) 2021-01-12
CN111757877A (zh) 2020-10-09
US20220064148A1 (en) 2022-03-03
AR114418A1 (es) 2020-09-02
SG11202007120UA (en) 2020-08-28
US11014910B2 (en) 2021-05-25
ZA202004600B (en) 2022-03-30
KR102795351B1 (ko) 2025-04-16
RU2020131756A (ru) 2022-03-28
MA52427A (fr) 2021-01-06
US20240174646A1 (en) 2024-05-30
EP3760624A1 (en) 2021-01-06
EP3760624A4 (en) 2021-11-03
IL276311B2 (en) 2023-10-01
CN111757877B (zh) 2023-10-27
CA3087859A1 (en) 2019-09-06
AU2019227770A1 (en) 2020-07-09

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