KR102795351B1 - 메틸락탐환 화합물 및 그의 의약 용도 - Google Patents

메틸락탐환 화합물 및 그의 의약 용도 Download PDF

Info

Publication number
KR102795351B1
KR102795351B1 KR1020207025856A KR20207025856A KR102795351B1 KR 102795351 B1 KR102795351 B1 KR 102795351B1 KR 1020207025856 A KR1020207025856 A KR 1020207025856A KR 20207025856 A KR20207025856 A KR 20207025856A KR 102795351 B1 KR102795351 B1 KR 102795351B1
Authority
KR
South Korea
Prior art keywords
compound
acid
formula
reaction mixture
added
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020207025856A
Other languages
English (en)
Korean (ko)
Other versions
KR20200128033A (ko
Inventor
도모야 미우라
요시노리 다마타니
Original Assignee
니뽄 다바코 산교 가부시키가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 니뽄 다바코 산교 가부시키가이샤 filed Critical 니뽄 다바코 산교 가부시키가이샤
Publication of KR20200128033A publication Critical patent/KR20200128033A/ko
Application granted granted Critical
Publication of KR102795351B1 publication Critical patent/KR102795351B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020207025856A 2018-03-01 2019-02-28 메틸락탐환 화합물 및 그의 의약 용도 Active KR102795351B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JPJP-P-2018-036307 2018-03-01
JP2018036307 2018-03-01
PCT/JP2019/007799 WO2019168096A1 (ja) 2018-03-01 2019-02-28 メチルラクタム環化合物及びその医薬用途

Publications (2)

Publication Number Publication Date
KR20200128033A KR20200128033A (ko) 2020-11-11
KR102795351B1 true KR102795351B1 (ko) 2025-04-16

Family

ID=67806229

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020207025856A Active KR102795351B1 (ko) 2018-03-01 2019-02-28 메틸락탐환 화합물 및 그의 의약 용도

Country Status (21)

Country Link
US (3) US11014910B2 (enExample)
EP (1) EP3760624A4 (enExample)
JP (3) JP7206132B2 (enExample)
KR (1) KR102795351B1 (enExample)
CN (1) CN111757877B (enExample)
AR (1) AR114418A1 (enExample)
AU (1) AU2019227770B2 (enExample)
BR (1) BR112020016788A2 (enExample)
CA (1) CA3087859A1 (enExample)
CL (1) CL2020002199A1 (enExample)
IL (1) IL276311B2 (enExample)
MA (1) MA52427A (enExample)
MX (1) MX2020009070A (enExample)
MY (1) MY205197A (enExample)
PE (1) PE20210123A1 (enExample)
PH (1) PH12020551340A1 (enExample)
SA (1) SA520420037B1 (enExample)
SG (1) SG11202007120UA (enExample)
TW (1) TWI805699B (enExample)
WO (1) WO2019168096A1 (enExample)
ZA (1) ZA202004600B (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI805699B (zh) * 2018-03-01 2023-06-21 日商日本煙草產業股份有限公司 甲基內醯胺環化合物及其用途
CN111902408B (zh) 2018-04-04 2023-11-14 日本烟草产业株式会社 杂芳基取代的吡唑化合物及其药物用途
CA3151909A1 (en) * 2019-09-04 2021-03-11 Japan Tobacco Inc. Therapeutic or prophylactic method for diabetes using combination medicine
JPWO2021187548A1 (enExample) * 2020-03-19 2021-09-23

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007034279A2 (en) 2005-09-19 2007-03-29 Pfizer Products Inc. C3a antagonists and pharmaceutical compositions thereof
JP2007332034A (ja) 2005-06-08 2007-12-27 Japan Tobacco Inc 複素環化合物
JP2009534439A (ja) 2006-04-27 2009-09-24 ゾルファイ ファーマスーティカルズ ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｂｘカンナビノイド受容体モジュレータ及びカリウムチャンネルモジュレータを含む医薬組成物
JP2010523583A (ja) 2007-04-02 2010-07-15 セラコス・インコーポレイテッド ベンジルグルコシド誘導体およびその用途
WO2013031922A1 (ja) 2011-08-31 2013-03-07 日本たばこ産業株式会社 ピラゾール化合物及びその医薬用途

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3657282A (en) * 1969-01-23 1972-04-18 Merck & Co Inc Carboxyepoxyethyl-1-phosphonic acid and derivatives
FR2665898B1 (fr) 1990-08-20 1994-03-11 Sanofi Derives d'amido-3 pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
JPH04247081A (ja) 1991-02-01 1992-09-03 Takeda Chem Ind Ltd ５員複素環酸アミド類
FR2692575B1 (fr) 1992-06-23 1995-06-30 Sanofi Elf Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
CA2515119A1 (en) 2003-02-07 2004-08-19 Daiichi Pharmaceutical Co., Ltd. Pyrazole derivative
AU2004200420A1 (en) 2003-03-11 2004-09-30 Astellas Pharma Inc. Inhibitor of cyclooxygenase
JP2006182648A (ja) 2003-04-08 2006-07-13 Dai Ichi Seiyaku Co Ltd ７員複素環誘導体
US20050075375A1 (en) 2003-05-14 2005-04-07 Anadys Pharmaceuticals, Inc. Heterocyclic compounds for treating hepatitis C virus
TW200526588A (en) 2003-11-17 2005-08-16 Smithkline Beecham Corp Chemical compounds
TW200526641A (en) 2003-12-26 2005-08-16 Daiichi Seiyaku Co Amidopyrazole derivatives
CN1980665A (zh) 2004-07-07 2007-06-13 默克公司 吡唑酰胺衍生物，包含这些化合物的组合物和使用方法
EP1811983B1 (en) 2004-11-16 2020-10-07 GW Pharma Limited New use for cannabinoid
JP2008007405A (ja) 2004-12-07 2008-01-17 Takeda Chem Ind Ltd カルボキサミド誘導体
CN101243074A (zh) * 2005-06-08 2008-08-13 日本烟草产业株式会社 杂环化合物
WO2006132436A1 (ja) 2005-06-08 2006-12-14 Japan Tobacco Inc. 複素環化合物
JP2009523748A (ja) 2006-01-18 2009-06-25 シエナ ビオテク ソシエタ ペル アチオニ α７ニコチン性アセチルコリン受容体の調節物質およびそれらの治療への使用
US20080027014A1 (en) 2006-07-28 2008-01-31 Tanabe Seiyaku Co., Ltd. Novel SGLT inhibitors
KR101450356B1 (ko) 2006-11-24 2014-10-15 에이씨 이뮨 에스.에이. 알츠하이머와 같은 아밀로이드 또는 아밀로이드-유사 단백질과 관련된 질환의 치료를 위한 ｎ-(메틸)-1ｈ-피라졸-3-아민, ｎ-(메틸)-피리딘-2-아민 및 ｎ-(메틸)-티아졸-2-아민 유도체
WO2008061796A2 (en) 2006-11-24 2008-05-29 Ac Immune Sa Compounds for the treatment of diseases associated with amyloid or amyloid-like proteins
CL2008000119A1 (es) 2007-01-16 2008-05-16 Wyeth Corp Compuestos derivados de pirazol, antagonistas del receptor nicotinico de acetilcolina; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como demencia senil, alzheimer y esquizofrenia.
US20090181952A1 (en) 2008-01-14 2009-07-16 Wyeth Compounds useful as alpha7 nicotinic acetylcholine receptor agonists
TW201006832A (en) 2008-07-15 2010-02-16 Novartis Ag Organic compounds
RU2017144535A (ru) 2010-03-30 2019-02-18 Версеон Корпорейшн Мультизамещенные ароматические соединения в качестве ингибиторов тромбина
TWI805699B (zh) * 2018-03-01 2023-06-21 日商日本煙草產業股份有限公司 甲基內醯胺環化合物及其用途
CN111902408B (zh) 2018-04-04 2023-11-14 日本烟草产业株式会社 杂芳基取代的吡唑化合物及其药物用途

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007332034A (ja) 2005-06-08 2007-12-27 Japan Tobacco Inc 複素環化合物
WO2007034279A2 (en) 2005-09-19 2007-03-29 Pfizer Products Inc. C3a antagonists and pharmaceutical compositions thereof
JP2009534439A (ja) 2006-04-27 2009-09-24 ゾルファイ ファーマスーティカルズ ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｂｘカンナビノイド受容体モジュレータ及びカリウムチャンネルモジュレータを含む医薬組成物
JP2010523583A (ja) 2007-04-02 2010-07-15 セラコス・インコーポレイテッド ベンジルグルコシド誘導体およびその用途
WO2013031922A1 (ja) 2011-08-31 2013-03-07 日本たばこ産業株式会社 ピラゾール化合物及びその医薬用途

Also Published As

Publication number Publication date
AU2019227770A1 (en) 2020-07-09
US20190352284A1 (en) 2019-11-21
TWI805699B (zh) 2023-06-21
SG11202007120UA (en) 2020-08-28
ZA202004600B (en) 2022-03-30
CN111757877B (zh) 2023-10-27
MX2020009070A (es) 2020-10-08
AU2019227770B2 (en) 2023-10-05
JP2023026566A (ja) 2023-02-24
US20240174646A1 (en) 2024-05-30
MY205197A (en) 2024-10-07
IL276311A (en) 2020-09-30
SA520420037B1 (ar) 2024-07-28
MA52427A (fr) 2021-01-06
IL276311B1 (en) 2023-06-01
US20220064148A1 (en) 2022-03-03
KR20200128033A (ko) 2020-11-11
PE20210123A1 (es) 2021-01-19
EP3760624A4 (en) 2021-11-03
CA3087859A1 (en) 2019-09-06
CN111757877A (zh) 2020-10-09
WO2019168096A1 (ja) 2019-09-06
PH12020551340A1 (en) 2021-05-31
BR112020016788A2 (pt) 2021-01-12
CL2020002199A1 (es) 2020-12-18
RU2020131756A (ru) 2022-03-28
IL276311B2 (en) 2023-10-01
EP3760624A1 (en) 2021-01-06
AR114418A1 (es) 2020-09-02
US11014910B2 (en) 2021-05-25
JP2019151627A (ja) 2019-09-12
TW202000660A (zh) 2020-01-01
JP7206132B2 (ja) 2023-01-17
JP2025026615A (ja) 2025-02-21

Similar Documents

Publication Publication Date Title
KR102795351B1 (ko) 메틸락탐환 화합물 및 그의 의약 용도
KR102806676B1 (ko) 헤테로아릴로 치환된 피라졸 화합물 및 그의 의약 용도
KR101989203B1 (ko) 피라졸 화합물 및 그의 의약 용도
TW200922588A (en) Pyrimidyl indoline compounds
JP2025094217A (ja) 併用医薬による糖尿病の治療又は予防方法
JP2025138791A (ja) 慢性腎臓病の治療又は予防方法
RU2809634C2 (ru) Соединение с метиллактамным кольцом и его применение в фармацевтике
HK40044833A (en) Methyllactam ring compound and medicinal use thereof

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

R18-X000 Changes to party contact information recorded

St.27 status event code: A-3-3-R10-R18-oth-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601