TWI799411B - 溶瘤病毒療法及免疫療法 - Google Patents

溶瘤病毒療法及免疫療法 Download PDF

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TWI799411B
TWI799411B TW107113504A TW107113504A TWI799411B TW I799411 B TWI799411 B TW I799411B TW 107113504 A TW107113504 A TW 107113504A TW 107113504 A TW107113504 A TW 107113504A TW I799411 B TWI799411 B TW I799411B
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Taiwan
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immunotherapy
oncolytic virotherapy
virotherapy
oncolytic
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TW107113504A
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Chinese (zh)
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TW201903154A (zh
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鈴木正崇
蕭 亞曼達 羅斯威
卡洛琳 波特
渡部紀宏
馬康 K 布萊納
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美國貝勒醫學院
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TW107113504A 2017-04-21 2018-04-20 溶瘤病毒療法及免疫療法 TWI799411B (zh)

Applications Claiming Priority (2)

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US201762488181P 2017-04-21 2017-04-21
US62/488,181 2017-04-21

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TW201903154A TW201903154A (zh) 2019-01-16
TWI799411B true TWI799411B (zh) 2023-04-21

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US (2) US11896634B2 (enExample)
EP (1) EP3612202A2 (enExample)
JP (2) JP7260173B2 (enExample)
KR (2) KR20240093758A (enExample)
CN (1) CN110785180B (enExample)
AU (2) AU2018254566B2 (enExample)
CA (1) CA3060573A1 (enExample)
NZ (1) NZ758626A (enExample)
SG (1) SG11201909749PA (enExample)
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WO (1) WO2018195427A2 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6576326B2 (ja) 2013-03-14 2019-09-18 ソーク インスティテュート フォー バイオロジカル スタディーズ 腫瘍溶解性アデノウイルス組成物
GB201500319D0 (en) 2015-01-09 2015-02-25 Agency Science Tech & Res Anti-PD-L1 antibodies
KR20220163505A (ko) 2016-02-23 2022-12-09 솔크 인스티튜트 포 바이올로지칼 스터디즈 바이러스 동역학에 미치는 영향 최소화를 위한 치료용 아데노바이러스의 외인성 유전자 발현
AU2017222568B2 (en) 2016-02-23 2020-09-10 Salk Institute For Biological Studies High throughput assay for measuring adenovirus replication kinetics
AU2017375633C1 (en) 2016-12-12 2023-04-27 Salk Institute For Biological Studies Tumor-targeting synthetic adenoviruses and uses thereof
AU2018254566B2 (en) * 2017-04-21 2025-02-13 Baylor College Of Medicine Oncolytic virotherapy and immunotherapy
SG10201801219VA (en) * 2018-02-13 2019-09-27 Agency Science Tech & Res Anti-HER2 Antibodies
CN112292449A (zh) 2018-04-09 2021-01-29 萨克生物研究学院 具有增强的复制特性的溶瘤腺病毒组合物
WO2019202118A1 (en) * 2018-04-20 2019-10-24 Baylor College Of Medicine Oncolytic virotherapy and immunotherapy
US11413315B2 (en) * 2018-04-29 2022-08-16 City Of Hope Neural stem cell-mediated cancer treatment
EP4285914A3 (en) * 2018-10-25 2024-02-28 Baylor College of Medicine Oncolytic virotherapy and immunotherapy
EP3917564A4 (en) * 2019-02-01 2022-12-21 NovaRock Biotherapeutics, Ltd. ANTI-CLAUDINE 18 ANTIBODIES AND THEIR METHODS OF USE
CN111743923B (zh) * 2019-03-27 2024-11-08 北京康万达医药科技有限公司 包含分离的重组溶瘤腺病毒和免疫细胞的治疗剂及其应用
MX2021010577A (es) * 2019-04-29 2021-10-13 Mayo Found Medical Education & Res Compuestos de union a pd-l1 multivalentes para tratar cancer.
WO2021091560A1 (en) * 2019-11-07 2021-05-14 Baylor College Of Medicine Oncolytic virotherapy and immunotherapy
CN111632146B (zh) * 2020-05-29 2021-09-28 中山大学 Oat抑制剂和溶瘤病毒在制备抗肿瘤药物中的应用
CN111676245B (zh) * 2020-06-24 2022-09-13 武汉波睿达生物科技有限公司 一种含有HSV-1型溶瘤病毒的NFAT-Cre-CAR-T细胞及其应用
CN113913379B (zh) * 2020-07-07 2024-02-06 深圳市菲鹏生物治疗股份有限公司 T淋巴细胞及其应用
CN113425856B (zh) * 2021-07-07 2022-01-04 浙江康佰裕生物科技有限公司 一种含有基因修饰的溶瘤病毒的药物组合物及其在治疗癌症的用途
WO2023076469A1 (en) * 2021-10-29 2023-05-04 Unm Rainforest Innovations Oncolytic virotherapy compositions and methods
CN114032323B (zh) * 2021-11-17 2023-08-08 云南省烟草农业科学研究院 一种与雪茄烟抗黑胫病基因紧密连锁的共显性ssr标记及其应用
WO2024042231A1 (en) * 2022-08-26 2024-02-29 Universite De Namur Adenovirus-based adjuvants for cancer treatment
WO2024229083A1 (en) * 2023-05-03 2024-11-07 Mayo Foundation For Medical Education And Research Methods and materials for treating cancer
CN118930652B (zh) * 2024-07-29 2025-03-11 北京肿瘤医院(北京大学肿瘤医院) 一种免疫检查点pd-l2靶向单链抗体及放射性核素标记物与应用

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69426841T2 (de) 1993-02-16 2001-09-06 Onyx Pharma Inc Cytopatische Viren zur Therapie und Prophylaxe der Neoplasie
AU687829B2 (en) 1993-06-24 1998-03-05 Advec, Inc. Adenovirus vectors for gene therapy
US6080569A (en) 1993-06-24 2000-06-27 Merck & Co., Inc. Adenovirus vectors generated from helper viruses and helper-dependent vectors
US6730507B1 (en) 1993-06-24 2004-05-04 Merck & Co., Inc. Use of helper-dependent adenoviral vectors of alternative serotypes permits repeat vector administration
US7045347B2 (en) 1993-06-24 2006-05-16 Advec, Inc. Helper dependent adenovirus vectors based on integrase family site-specific recombinases
US5919676A (en) 1993-06-24 1999-07-06 Advec, Inc. Adenoviral vector system comprising Cre-loxP recombination
WO1998013508A1 (en) 1996-09-24 1998-04-02 Dana-Farber Cancer Institute Method of targeting malignant cells using an e2f responsive promoter
US20030017138A1 (en) 1998-07-08 2003-01-23 Menzo Havenga Chimeric adenoviruses
US20060275262A1 (en) 2001-07-26 2006-12-07 Mathis James M Conditionally replicating viruses and methods for cancer virotherapy
KR100523028B1 (ko) 2003-02-27 2005-10-20 윤채옥 개선된 암세포 특이성과 활성을 가지는 사람 텔로미어역전사효소 프로모터 및 이를 포함하는 재조합 벡터
WO2005086922A2 (en) * 2004-03-10 2005-09-22 Board Of Regents, University Of Texas System Oncolytic adenovirus armed with therapeutic genes
HUE031689T2 (en) 2008-12-22 2017-07-28 Targovax Oy Oncolytic adenoviral vectors and related procedures and applications
US20130243731A1 (en) 2010-09-24 2013-09-19 Oncos Therapeutics Oy Oncolytic adenoviral vectors coding for monoclonal anti-ctla-4 antibodies
AU2011306846B2 (en) 2010-09-24 2015-05-14 Oncos Therapeutics Oy Oncolytic adenoviral vectors and methods and uses related thereto
FI123955B (en) 2011-11-25 2014-01-15 Oncos Therapeutics Ltd Oncolytic adenovirus
ES2534782T3 (es) 2012-02-02 2015-04-28 Baylor College Of Medicine Sistema biológico de administración y expresión basado en adenovirus para uso en el tratamiento de la osteoartritis
ES2802878T3 (es) 2013-01-25 2021-01-21 Baylor College Medicine Un sistema de administración y expresión de terapia génica adenoviral dependiente de linfocitos T colaboradores
JP6576326B2 (ja) 2013-03-14 2019-09-18 ソーク インスティテュート フォー バイオロジカル スタディーズ 腫瘍溶解性アデノウイルス組成物
GB201500319D0 (en) 2015-01-09 2015-02-25 Agency Science Tech & Res Anti-PD-L1 antibodies
CN106831987B (zh) * 2015-12-04 2020-01-21 浙江大学 一种抗人her2抗体及其编码基因和应用
CN106831986B (zh) * 2015-12-04 2020-01-21 浙江大学 一种抗人her2抗体及其编码基因和应用
AU2018254566B2 (en) * 2017-04-21 2025-02-13 Baylor College Of Medicine Oncolytic virotherapy and immunotherapy

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
期刊 Konerua et al., "IL-12 secreting tumor-targeted chimeric antigen receptor T cells eradicate ovarian tumors in vivo", Oncoimmunology, Vol. 4, No. 3, 2015 Jan 23, Pages e994446-1至5.

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