CA3060573A1 - Oncolytic virotherapy and immunotherapy - Google Patents

Oncolytic virotherapy and immunotherapy Download PDF

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Publication number
CA3060573A1
CA3060573A1 CA3060573A CA3060573A CA3060573A1 CA 3060573 A1 CA3060573 A1 CA 3060573A1 CA 3060573 A CA3060573 A CA 3060573A CA 3060573 A CA3060573 A CA 3060573A CA 3060573 A1 CA3060573 A1 CA 3060573A1
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Prior art keywords
seq
cell
cancer
virus
car
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CA3060573A
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English (en)
French (fr)
Inventor
Masataka Suzuki
Amanda ROSEWELL SHAW
Caroline Elaine PORTER
Norihiro Watanabe
Malcolm K. Brenner
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Baylor College of Medicine
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Baylor College of Medicine
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/761—Adenovirus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/861—Adenoviral vectors
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    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5434—IL-12
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C—CHEMISTRY; METALLURGY
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    • C07K2319/00—Fusion polypeptide
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    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Health & Medical Sciences (AREA)
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  • Immunology (AREA)
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  • Biotechnology (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
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  • Oncology (AREA)
  • Endocrinology (AREA)
  • Physics & Mathematics (AREA)
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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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CA3060573A 2017-04-21 2018-04-20 Oncolytic virotherapy and immunotherapy Pending CA3060573A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762488181P 2017-04-21 2017-04-21
US62/488,181 2017-04-21
PCT/US2018/028577 WO2018195427A2 (en) 2017-04-21 2018-04-20 Oncolytic virotherapy and immunotherapy

Publications (1)

Publication Number Publication Date
CA3060573A1 true CA3060573A1 (en) 2018-10-25

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Application Number Title Priority Date Filing Date
CA3060573A Pending CA3060573A1 (en) 2017-04-21 2018-04-20 Oncolytic virotherapy and immunotherapy

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US (2) US11896634B2 (enExample)
EP (1) EP3612202A2 (enExample)
JP (2) JP7260173B2 (enExample)
KR (2) KR20240093758A (enExample)
CN (1) CN110785180B (enExample)
AU (2) AU2018254566B2 (enExample)
CA (1) CA3060573A1 (enExample)
NZ (1) NZ758626A (enExample)
SG (1) SG11201909749PA (enExample)
TW (1) TWI799411B (enExample)
WO (1) WO2018195427A2 (enExample)

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SG11201507393TA (en) 2013-03-14 2015-10-29 Salk Inst For Biological Studi Oncolytic adenovirus compositions
ES2899913T3 (es) 2014-09-24 2022-03-15 Salk Inst For Biological Studi Virus tumorales oncolíticos y métodos de uso
GB201500319D0 (en) * 2015-01-09 2015-02-25 Agency Science Tech & Res Anti-PD-L1 antibodies
EP3390645B1 (en) 2016-02-23 2022-09-14 Salk Institute for Biological Studies Exogenous gene expression in therapeutic adenovirus for minimal impact on viral kinetics
WO2017147265A1 (en) 2016-02-23 2017-08-31 Salk Institute For Biological Studies High throughput assay for measuring adenovirus replication kinetics
AU2017375633C1 (en) 2016-12-12 2023-04-27 Salk Institute For Biological Studies Tumor-targeting synthetic adenoviruses and uses thereof
KR20240093758A (ko) * 2017-04-21 2024-06-24 베이롤 칼리지 오브 메드신 종양용해성 바이러스요법 및 면역요법
SG10201801219VA (en) * 2018-02-13 2019-09-27 Agency Science Tech & Res Anti-HER2 Antibodies
BR112020019942A2 (pt) 2018-04-09 2021-01-26 Salk Institute For Biological Studies composições de adenovírus oncolítico com propriedades de replicação aprimoradas
WO2019202118A1 (en) * 2018-04-20 2019-10-24 Baylor College Of Medicine Oncolytic virotherapy and immunotherapy
US11413315B2 (en) * 2018-04-29 2022-08-16 City Of Hope Neural stem cell-mediated cancer treatment
EP3870297B1 (en) * 2018-10-25 2023-08-30 Baylor College of Medicine Oncolytic virotherapy and immunotherapy
JP7840511B2 (ja) 2019-02-01 2026-04-06 石▲薬▼集▲団▼巨石生物制▲薬▼有限公司 抗クローディン１８抗体及びそれらの使用の方法
CN111743923B (zh) * 2019-03-27 2024-11-08 北京康万达医药科技有限公司 包含分离的重组溶瘤腺病毒和免疫细胞的治疗剂及其应用
MX2021010577A (es) * 2019-04-29 2021-10-13 Mayo Found Medical Education & Res Compuestos de union a pd-l1 multivalentes para tratar cancer.
WO2021091560A1 (en) * 2019-11-07 2021-05-14 Baylor College Of Medicine Oncolytic virotherapy and immunotherapy
CN111632146B (zh) * 2020-05-29 2021-09-28 中山大学 Oat抑制剂和溶瘤病毒在制备抗肿瘤药物中的应用
CN111676245B (zh) * 2020-06-24 2022-09-13 武汉波睿达生物科技有限公司 一种含有HSV-1型溶瘤病毒的NFAT-Cre-CAR-T细胞及其应用
CN113913379B (zh) * 2020-07-07 2024-02-06 深圳市菲鹏生物治疗股份有限公司 T淋巴细胞及其应用
CN113425856B (zh) * 2021-07-07 2022-01-04 浙江康佰裕生物科技有限公司 一种含有基因修饰的溶瘤病毒的药物组合物及其在治疗癌症的用途
US20250121017A1 (en) * 2021-10-29 2025-04-17 Unm Rainforest Innovations Oncolytic virotherapy compositions and methods
CN114032323B (zh) * 2021-11-17 2023-08-08 云南省烟草农业科学研究院 一种与雪茄烟抗黑胫病基因紧密连锁的共显性ssr标记及其应用
WO2024042231A1 (en) * 2022-08-26 2024-02-29 Universite De Namur Adenovirus-based adjuvants for cancer treatment
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