TWI789644B - 抗－N3pGlu類澱粉β肽抗體及其用途 - Google Patents

抗－N3pGlu類澱粉β肽抗體及其用途 Download PDF

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TWI789644B
TWI789644B TW109140166A TW109140166A TWI789644B TW I789644 B TWI789644 B TW I789644B TW 109140166 A TW109140166 A TW 109140166A TW 109140166 A TW109140166 A TW 109140166A TW I789644 B TWI789644 B TW I789644B
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seq
antibody
amino acid
acid sequence
mammalian cell
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TW202120541A (zh
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拉諾 布萊德理 德瑪托斯
吉讓 盧
唐鷹
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美商美國禮來大藥廠
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
    • C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0684—Cells of the urinary tract or kidneys
    • C12N5/0686—Kidney cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/106—Plasmid DNA for vertebrates
    • C12N2800/107—Plasmid DNA for vertebrates for mammalian

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  • Health & Medical Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
TW109140166A 2017-04-20 2018-04-09 抗－N3pGlu類澱粉β肽抗體及其用途 TWI789644B (zh)

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US201762487550P 2017-04-20 2017-04-20
US62/487,550 2017-04-20

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TWI789644B true TWI789644B (zh) 2023-01-11

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US (3) US10647759B2 (https=)
EP (1) EP3612559A1 (https=)
JP (3) JP6900500B2 (https=)
KR (2) KR102567295B1 (https=)
CN (2) CN117024583A (https=)
AR (1) AR111208A1 (https=)
AU (2) AU2018255221B2 (https=)
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CA (1) CA3058482C (https=)
CL (1) CL2019002922A1 (https=)
CO (1) CO2019011349A2 (https=)
CR (1) CR20190445A (https=)
DO (1) DOP2019000241A (https=)
EA (1) EA201992163A1 (https=)
EC (1) ECSP19075146A (https=)
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JO (1) JOP20190247A1 (https=)
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PE (1) PE20200011A1 (https=)
PH (1) PH12019502361A1 (https=)
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TW (2) TWI789644B (https=)
UA (1) UA126806C2 (https=)
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JOP20210265A1 (ar) 2019-03-26 2023-01-30 Janssen Pharmaceutica Nv الأجسام المضادة لبيروغلوتامات أميلويد بيتا واستخداماتها
WO2021151011A2 (en) * 2020-01-24 2021-07-29 The Board Of Trustees Of Western Michigan University Treatment of neurodegenerative proteinopathies using fas apoptosis inhibitory molecule (faim) or a fragment and/or a mimetic thereof
KR20230078748A (ko) * 2020-10-02 2023-06-02 일라이 릴리 앤드 캄파니 항체 정제 공정에서의 숙주 세포 단백질 함량을 감소시키는 방법 및 감소된 숙주 세포 단백질 함량을 가지는 항체 조성물
TWI843040B (zh) 2021-01-11 2024-05-21 美商美國禮來大藥廠 抗N3pGlu類澱粉β抗體及其用途
TW202300517A (zh) 2021-03-12 2023-01-01 美商美國禮來大藥廠 抗類澱粉β抗體及其用途
TW202300518A (zh) 2021-03-12 2023-01-01 美商美國禮來大藥廠 抗N3pGlu類澱粉β抗體及其用途
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JP7306746B2 (ja) * 2021-09-16 2023-07-11 株式会社ユニバーサルエンターテインメント 遊技機
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CN117327168A (zh) * 2022-06-24 2024-01-02 厦门大学 B2M-GluN1封闭肽、其药物组合物及用途
KR20250107906A (ko) * 2022-11-17 2025-07-14 일라이 릴리 앤드 캄파니 항-N3pGlu 아밀로이드 베타 항체, 그의 용량 및 용도
PE20252307A1 (es) 2022-12-22 2025-09-22 Bioarctic Ab Anticuerpo que se une a abetape3
WO2025106313A1 (en) 2023-11-14 2025-05-22 Eli Lilly And Company Fc RECEPTOR BASED ASSAYS FOR ANALYZING IgG ANTIBODIES
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IL269003A (en) 2019-10-31
ECSP19075146A (es) 2019-10-31
JOP20190247A1 (ar) 2019-10-20
US20210371509A1 (en) 2021-12-02
CL2019002922A1 (es) 2020-03-13
JP6900500B2 (ja) 2021-07-07
DOP2019000241A (es) 2019-10-15
US10647759B2 (en) 2020-05-12
CA3058482C (en) 2023-05-09
SG11201909022PA (en) 2019-11-28
IL269003B1 (en) 2025-06-01
US20200262902A1 (en) 2020-08-20
AR111208A1 (es) 2019-06-12
TW201902924A (zh) 2019-01-16
KR20190129100A (ko) 2019-11-19
CA3058482A1 (en) 2018-10-25
WO2018194951A1 (en) 2018-10-25
MX2019012445A (es) 2020-01-13
JP2020510081A (ja) 2020-04-02
CN117024583A (zh) 2023-11-10
BR112019018810A2 (pt) 2020-05-05
KR20220011800A (ko) 2022-01-28
PH12019502361A1 (en) 2020-07-13
SA519410311B1 (ar) 2022-03-20
CO2019011349A2 (es) 2019-10-31
US20180305444A1 (en) 2018-10-25
ZA201906159B (en) 2026-03-25
KR102567295B1 (ko) 2023-08-16
KR102352670B1 (ko) 2022-01-19
AU2018255221A1 (en) 2019-09-19
JP2023058623A (ja) 2023-04-25
PE20200011A1 (es) 2020-01-06
TW202120541A (zh) 2021-06-01
CR20190445A (es) 2019-11-06
US11078261B2 (en) 2021-08-03
EA201992163A1 (ru) 2020-03-02
CN110582511B (zh) 2023-08-08
EP3612559A1 (en) 2020-02-26
JP2021151253A (ja) 2021-09-30
MA50144A (fr) 2020-07-29
UA126806C2 (uk) 2023-02-08
AU2021203927A1 (en) 2021-07-08
IL269003B2 (en) 2025-10-01
JP7227312B2 (ja) 2023-02-21
JP7532571B2 (ja) 2024-08-13
TWI705975B (zh) 2020-10-01
ZA202007868B (en) 2023-06-28
AU2021203927B2 (en) 2024-03-21
CN110582511A (zh) 2019-12-17
AU2018255221B2 (en) 2021-07-01
MX2022011817A (es) 2022-10-10
NZ758066A (en) 2022-10-28

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