CN117024583A - 抗N3pGlu淀粉状蛋白β肽抗体及其用途 - Google Patents

抗N3pGlu淀粉状蛋白β肽抗体及其用途 Download PDF

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Publication number
CN117024583A
CN117024583A CN202310757235.4A CN202310757235A CN117024583A CN 117024583 A CN117024583 A CN 117024583A CN 202310757235 A CN202310757235 A CN 202310757235A CN 117024583 A CN117024583 A CN 117024583A
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antibody
seq
amino acid
present
acid sequence
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Chinese (zh)
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R·B·德马托斯
J·卢
唐鹰
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Eli Lilly and Co
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
    • C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0684—Cells of the urinary tract or kidneys
    • C12N5/0686—Kidney cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/106—Plasmid DNA for vertebrates
    • C12N2800/107—Plasmid DNA for vertebrates for mammalian

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  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
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  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN202310757235.4A 2017-04-20 2018-04-16 抗N3pGlu淀粉状蛋白β肽抗体及其用途 Pending CN117024583A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762487550P 2017-04-20 2017-04-20
US62/487,550 2017-04-20
PCT/US2018/027718 WO2018194951A1 (en) 2017-04-20 2018-04-16 ANTI-N3pGlu AMYLOID BETA PEPTIDE ANTIBODIES AND USES THEREOF
CN201880025982.6A CN110582511B (zh) 2017-04-20 2018-04-16 抗N3pGlu淀粉状蛋白β肽抗体及其用途

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CN117024583A true CN117024583A (zh) 2023-11-10

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CN201880025982.6A Active CN110582511B (zh) 2017-04-20 2018-04-16 抗N3pGlu淀粉状蛋白β肽抗体及其用途

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EP (1) EP3612559A1 (https=)
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KR (2) KR102352670B1 (https=)
CN (2) CN117024583A (https=)
AR (1) AR111208A1 (https=)
AU (2) AU2018255221B2 (https=)
BR (1) BR112019018810A2 (https=)
CA (1) CA3058482C (https=)
CL (1) CL2019002922A1 (https=)
CO (1) CO2019011349A2 (https=)
CR (1) CR20190445A (https=)
DO (1) DOP2019000241A (https=)
EA (1) EA201992163A1 (https=)
EC (1) ECSP19075146A (https=)
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TW (2) TWI705975B (https=)
UA (1) UA126806C2 (https=)
WO (1) WO2018194951A1 (https=)
ZA (2) ZA201906159B (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118459583A (zh) * 2024-07-11 2024-08-09 齐鲁制药有限公司 抗N3pGlu淀粉样蛋白β抗体及其用途
CN118459583B (zh) * 2024-07-11 2024-09-10 齐鲁制药有限公司 抗N3pGlu淀粉样蛋白β抗体及其用途

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CN110582511A (zh) 2019-12-17
TWI705975B (zh) 2020-10-01
KR102352670B1 (ko) 2022-01-19
US20200262902A1 (en) 2020-08-20
US20180305444A1 (en) 2018-10-25
AU2021203927A1 (en) 2021-07-08
KR102567295B1 (ko) 2023-08-16
JP7227312B2 (ja) 2023-02-21
JP7532571B2 (ja) 2024-08-13
AU2018255221B2 (en) 2021-07-01
TW201902924A (zh) 2019-01-16
PH12019502361A1 (en) 2020-07-13
ZA201906159B (en) 2026-03-25
JOP20190247A1 (ar) 2019-10-20
KR20220011800A (ko) 2022-01-28
MX2019012445A (es) 2020-01-13
US10647759B2 (en) 2020-05-12
WO2018194951A1 (en) 2018-10-25
ZA202007868B (en) 2023-06-28
UA126806C2 (uk) 2023-02-08
CN110582511B (zh) 2023-08-08
CR20190445A (es) 2019-11-06
IL269003A (en) 2019-10-31
AR111208A1 (es) 2019-06-12
SA519410311B1 (ar) 2022-03-20
MX2022011817A (es) 2022-10-10
NZ758066A (en) 2022-10-28
SG11201909022PA (en) 2019-11-28
IL269003B2 (en) 2025-10-01
ECSP19075146A (es) 2019-10-31
DOP2019000241A (es) 2019-10-15
CA3058482A1 (en) 2018-10-25
KR20190129100A (ko) 2019-11-19
US11078261B2 (en) 2021-08-03
MA50144A (fr) 2020-07-29
TWI789644B (zh) 2023-01-11
CA3058482C (en) 2023-05-09
BR112019018810A2 (pt) 2020-05-05
JP2023058623A (ja) 2023-04-25
EA201992163A1 (ru) 2020-03-02
CO2019011349A2 (es) 2019-10-31
AU2021203927B2 (en) 2024-03-21
PE20200011A1 (es) 2020-01-06
US20210371509A1 (en) 2021-12-02
JP6900500B2 (ja) 2021-07-07
TW202120541A (zh) 2021-06-01
IL269003B1 (en) 2025-06-01
AU2018255221A1 (en) 2019-09-19
CL2019002922A1 (es) 2020-03-13
JP2020510081A (ja) 2020-04-02
EP3612559A1 (en) 2020-02-26
JP2021151253A (ja) 2021-09-30

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