TWI775874B - Ｇ蛋白偶合受體６（ｇｐｒ６）之四氫吡啶並吡調節劑 - Google Patents

Ｇ蛋白偶合受體６（ｇｐｒ６）之四氫吡啶並吡調節劑 Download PDF

Info

Publication number
TWI775874B
TWI775874B TW107120685A TW107120685A TWI775874B TW I775874 B TWI775874 B TW I775874B TW 107120685 A TW107120685 A TW 107120685A TW 107120685 A TW107120685 A TW 107120685A TW I775874 B TWI775874 B TW I775874B
Authority
TW
Taiwan
Prior art keywords
pharmaceutically acceptable
compound
acceptable salt
disease
dose
Prior art date
Application number
TW107120685A
Other languages
English (en)
Chinese (zh)
Other versions
TW201906844A (zh
Inventor
傑森 布朗
史帝芬 希區考克
瑪莉亞 霍金斯
菊地正太
霍格 寞內辛
荷莉 理查
克莉斯汀 史雷雀
孫會凱
陶德 麥克林
Original Assignee
日商武田藥品工業股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 日商武田藥品工業股份有限公司 filed Critical 日商武田藥品工業股份有限公司
Publication of TW201906844A publication Critical patent/TW201906844A/zh
Application granted granted Critical
Publication of TWI775874B publication Critical patent/TWI775874B/zh

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW107120685A 2017-06-15 2018-06-15 Ｇ蛋白偶合受體６（ｇｐｒ６）之四氫吡啶並吡調節劑 TWI775874B (zh)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201762520430P 2017-06-15 2017-06-15
US62/520,430 2017-06-15
US201762591247P 2017-11-28 2017-11-28
US62/591,247 2017-11-28
US201862649856P 2018-03-29 2018-03-29
US62/649,856 2018-03-29
US201862672261P 2018-05-16 2018-05-16
US62/672,261 2018-05-16

Publications (2)

Publication Number Publication Date
TW201906844A TW201906844A (zh) 2019-02-16
TWI775874B true TWI775874B (zh) 2022-09-01

Family

ID=64656005

Family Applications (1)

Application Number Title Priority Date Filing Date
TW107120685A TWI775874B (zh) 2017-06-15 2018-06-15 Ｇ蛋白偶合受體６（ｇｐｒ６）之四氫吡啶並吡調節劑

Country Status (25)

Country Link
US (1) US10406157B2 (https=)
EP (1) EP3638673B9 (https=)
JP (2) JP7460369B2 (https=)
KR (1) KR102802861B1 (https=)
CN (1) CN110730781B (https=)
AU (1) AU2018285677B2 (https=)
CA (1) CA3067032A1 (https=)
CO (1) CO2019015086A2 (https=)
DK (1) DK3638673T3 (https=)
ES (1) ES2988680T3 (https=)
FI (1) FI3638673T3 (https=)
HR (1) HRP20241231T1 (https=)
HU (1) HUE068346T2 (https=)
IL (1) IL271332B2 (https=)
JO (1) JOP20180057A1 (https=)
LT (1) LT3638673T (https=)
MX (1) MX2019014940A (https=)
PH (1) PH12019502792A1 (https=)
PL (1) PL3638673T3 (https=)
PT (1) PT3638673T (https=)
RS (1) RS66018B1 (https=)
SG (1) SG11201912149WA (https=)
SI (1) SI3638673T1 (https=)
TW (1) TWI775874B (https=)
WO (1) WO2018232202A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2026067262A1 (zh) * 2024-09-26 2026-04-02 四川科伦药物研究院有限公司 并环化合物、包含其的药物组合物及其用途和方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201605854A (zh) * 2013-12-20 2016-02-16 武田藥品工業有限公司 Ｇｐｒ６ 的四氫吡啶並吡調節劑

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
GB9518953D0 (en) 1995-09-15 1995-11-15 Pfizer Ltd Pharmaceutical formulations
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
US7229557B2 (en) 2004-02-04 2007-06-12 Konec, Inc. Method to separate stereoisomers
US20120101106A1 (en) 2009-07-09 2012-04-26 Mercer Swati P Tetrahydronapthyridine Orexin Receptor Antagonists
JP6526034B2 (ja) 2014-02-14 2019-06-05 武田薬品工業株式会社 Ｇｐｒ６のピリドピラジンモジュレーター
KR20160122215A (ko) * 2014-02-14 2016-10-21 다케다 야쿠힌 고교 가부시키가이샤 Gpr6의 피라진 조절제

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201605854A (zh) * 2013-12-20 2016-02-16 武田藥品工業有限公司 Ｇｐｒ６ 的四氫吡啶並吡調節劑

Also Published As

Publication number Publication date
EP3638673A4 (en) 2021-03-24
PT3638673T (pt) 2024-10-07
IL271332A (en) 2020-01-30
RS66018B1 (sr) 2024-11-29
EP3638673A1 (en) 2020-04-22
MX2019014940A (es) 2020-02-19
JOP20180057A1 (ar) 2019-01-30
KR102802861B1 (ko) 2025-04-30
JP2022188199A (ja) 2022-12-20
FI3638673T3 (fi) 2024-09-13
LT3638673T (lt) 2024-09-10
HUE068346T2 (hu) 2024-12-28
CA3067032A1 (en) 2018-12-20
KR20200014796A (ko) 2020-02-11
IL271332B (en) 2022-10-01
ES2988680T3 (es) 2024-11-21
US20180360831A1 (en) 2018-12-20
SI3638673T1 (sl) 2025-01-31
WO2018232202A1 (en) 2018-12-20
AU2018285677A1 (en) 2019-12-19
BR112019026430A2 (pt) 2020-07-14
EP3638673B9 (en) 2024-11-20
EP3638673B1 (en) 2024-07-17
CO2019015086A2 (es) 2020-04-13
AU2018285677B2 (en) 2022-07-14
TW201906844A (zh) 2019-02-16
JP7497400B2 (ja) 2024-06-10
SG11201912149WA (en) 2020-01-30
JP7460369B2 (ja) 2024-04-02
NZ759708A (en) 2024-04-26
HRP20241231T1 (hr) 2024-12-20
JP2020523287A (ja) 2020-08-06
CN110730781B (zh) 2023-05-05
PL3638673T3 (pl) 2024-11-18
IL271332B2 (en) 2023-02-01
RU2019144408A (ru) 2021-07-15
US10406157B2 (en) 2019-09-10
CN110730781A (zh) 2020-01-24
DK3638673T3 (da) 2024-09-16
PH12019502792A1 (en) 2020-09-14
RU2019144408A3 (https=) 2021-09-07

Similar Documents

Publication Publication Date Title
US10435389B2 (en) Octahydrocyclopenta[c]pyrrole allosteric inhibitors of SHP2
JP6002785B2 (ja) ナトリウムチャネルモジュレーターとしてのベンゾイミダゾールおよびイミダゾピリジン誘導体
AU2004299456B2 (en) (3,4-disubstituted)propanoic carboxylates as S1P (Edg) receptor agonists
TWI873185B (zh) 唑稠合之嗒-3(2h)-酮衍生物
CN102119047B (zh) 作为dgat1抑制剂的杂芳基衍生物
AU2014236719B2 (en) Compounds and methods for inducing chondrogenesis
CN107108671B (zh) 作为raf激酶抑制剂的化合物和组合物
CN104302638A (zh) 用于抑制abl1、abl2和bcr-abl1的活性的苯甲酰胺衍生物
TW200413331A (en) Small molecule PI 3-kinase inhibitors and methods of their use
CN105254557A (zh) 作为钙或钠通道阻滞剂的芳基取代羧酰胺衍生物
TW202000659A (zh) 六氫吡啶基-3-(芳氧基)丙醯胺及丙酸酯
CA3064484A1 (fr) Composes inhibiteurs des canaux ioniques pour le traitement du cancer
TW202402735A (zh) Ｎ－（吡咯啶－３－基或哌啶－４－基）乙醯胺衍生物
TW202204341A (zh) Ｎ－雜芳基烷基－２－（雜環基及雜環基甲基）乙醯胺衍生物
JP7497400B2 (ja) Ｇｐｒ６のテトラヒドロピリドピラジンモジュレーター
RU2818783C2 (ru) Тетрагидропиридопиразиновые модуляторы gpr6
HK40022760A (en) Tetrahydropyridopyrazine modulators of gpr6
HK40022760B (en) Tetrahydropyridopyrazine modulators of gpr6
BR112019026430B1 (pt) Composto de tetrahidropiridopirazina ou seus sais aceitáveis, composição comprendendo o mesmo, combinação, e seu uso no tratamento de doença relacionada ao gpr6
NL1026828C2 (nl) Derivaten van azachinazoline.
TW202530182A (zh) Ｎ—（１—（胺基甲基）環丙基）（芳基或雜芳基）甲醯胺衍生物

Legal Events

Date Code Title Description
GD4A Issue of patent certificate for granted invention patent