TWI774758B - C5-苯胺喹唑啉化合物及其治療癌症之用途 - Google Patents
C5-苯胺喹唑啉化合物及其治療癌症之用途 Download PDFInfo
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- TWI774758B TWI774758B TW107114297A TW107114297A TWI774758B TW I774758 B TWI774758 B TW I774758B TW 107114297 A TW107114297 A TW 107114297A TW 107114297 A TW107114297 A TW 107114297A TW I774758 B TWI774758 B TW I774758B
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- Prior art keywords
- triazol
- compound
- amino
- phenyl
- acetamide
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- 206010028980 Neoplasm Diseases 0.000 title claims description 50
- 201000011510 cancer Diseases 0.000 title claims description 42
- LKOVMZOJAULFNX-UHFFFAOYSA-N n-phenylquinazolin-5-amine Chemical class C=1C=CC2=NC=NC=C2C=1NC1=CC=CC=C1 LKOVMZOJAULFNX-UHFFFAOYSA-N 0.000 title description 2
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 19
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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| TWI377944B (en) * | 2007-06-05 | 2012-12-01 | Hanmi Holdings Co Ltd | Novel amide derivative for inhibiting the growth of cancer cells |
| TWI555745B (zh) * | 2011-05-17 | 2016-11-01 | 江蘇康緣藥業股份有限公司 | 喹唑啉－７－醚化合物及其使用方法 |
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| AU2009246263B2 (en) | 2008-05-14 | 2014-08-21 | Amgen Inc. | Combinations VEGF(R) inhibitors and hepatocyte growth factor (c-Met) inhibitors for the treatment of cancer |
| WO2011153553A2 (en) | 2010-06-04 | 2011-12-08 | The Regents Of The University Of California | Methods and compositions for kinase inhibition |
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| CN103254142B (zh) | 2013-04-26 | 2015-10-28 | 浙江工业大学 | 4-[4-(2-取代氨基乙酰氨基)苯胺基]喹唑啉类衍生物及制备和应用 |
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| ES2888298T3 (es) * | 2017-04-27 | 2022-01-03 | Astrazeneca Ab | Compuestos de C5-anilinoquinazolina y su uso en el tratamiento de cáncer |
| JP7117323B2 (ja) | 2017-04-27 | 2022-08-12 | アストラゼネカ・アクチエボラーグ | フェノキシキナゾリン化合物及び癌の処置におけるそれらの使用 |
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| US7709479B1 (en) * | 1999-09-21 | 2010-05-04 | Astrazeneca | Quinazoline derivatives and their use as pharmaceuticals |
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| BR112019022229A2 (pt) | 2020-05-12 |
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| MX389244B (es) | 2025-03-20 |
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| US20180312490A1 (en) | 2018-11-01 |
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| AU2018259078B2 (en) | 2021-10-07 |
| KR102603153B1 (ko) | 2023-11-15 |
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| US20190263787A1 (en) | 2019-08-29 |
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| RU2019136279A (ru) | 2021-05-27 |
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| EP3615522B1 (en) | 2021-08-04 |
| RU2769694C2 (ru) | 2022-04-05 |
| AU2018259078A1 (en) | 2019-10-17 |
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