AU2018259078B2 - C5-anilinoquinazoline compounds and their use in treating cancer - Google Patents

C5-anilinoquinazoline compounds and their use in treating cancer Download PDF

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Publication number
AU2018259078B2
AU2018259078B2 AU2018259078A AU2018259078A AU2018259078B2 AU 2018259078 B2 AU2018259078 B2 AU 2018259078B2 AU 2018259078 A AU2018259078 A AU 2018259078A AU 2018259078 A AU2018259078 A AU 2018259078A AU 2018259078 B2 AU2018259078 B2 AU 2018259078B2
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Australia
Prior art keywords
compound
triazol
acetamide
formula
amino
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AU2018259078A
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English (en)
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AU2018259078A1 (en
Inventor
Tudor GRECU
Jason Grant Kettle
Martin John Packer
Stuart Eric Pearson
James Michael Smith
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AstraZeneca AB
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AstraZeneca AB
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2018259078A 2017-04-27 2018-04-26 C5-anilinoquinazoline compounds and their use in treating cancer Active AU2018259078B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762490859P 2017-04-27 2017-04-27
US62/490,859 2017-04-27
PCT/EP2018/060798 WO2018197642A1 (en) 2017-04-27 2018-04-26 C5-anilinoquinazoline compounds and their use in treating cancer

Publications (2)

Publication Number Publication Date
AU2018259078A1 AU2018259078A1 (en) 2019-10-17
AU2018259078B2 true AU2018259078B2 (en) 2021-10-07

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AU2018259078A Active AU2018259078B2 (en) 2017-04-27 2018-04-26 C5-anilinoquinazoline compounds and their use in treating cancer

Country Status (13)

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US (2) US10273227B2 (enExample)
EP (1) EP3615522B1 (enExample)
JP (1) JP7128204B2 (enExample)
KR (1) KR102603153B1 (enExample)
CN (1) CN110573505B (enExample)
AR (1) AR111494A1 (enExample)
AU (1) AU2018259078B2 (enExample)
CA (1) CA3059283A1 (enExample)
ES (1) ES2888298T3 (enExample)
MX (1) MX389244B (enExample)
RU (1) RU2769694C2 (enExample)
TW (1) TWI774758B (enExample)
WO (1) WO2018197642A1 (enExample)

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ES2888298T3 (es) * 2017-04-27 2022-01-03 Astrazeneca Ab Compuestos de C5-anilinoquinazolina y su uso en el tratamiento de cáncer
WO2020078453A1 (en) * 2018-10-18 2020-04-23 Sinomab Bioscience Limited Methods of treating rheumatoid arthritis
UY38540A (es) * 2019-01-14 2020-08-31 Pi Industries Ltd Compuestos de fenilamidina 3-sustituida, preparación y uso
IL297986A (en) 2020-05-08 2023-01-01 Genmab As Bispecific antibodies against cd3 and cd20
US20240034788A1 (en) * 2020-08-20 2024-02-01 The Board Of Trustees Of The Leland Stanford Junior University Abscopal therapy for cancer
MX2023002545A (es) 2020-09-10 2023-03-14 Genmab As Anticuerpo biespecifico contra cumulo de diferenciacion 3 (cd3) y cumulo de diferenciacion 20 (cd20) en terapia de combinacion para el tratamiento de linfoma difuso de celulas b grandes.
CN116406293A (zh) 2020-09-10 2023-07-07 健玛保 用于治疗滤泡性淋巴瘤的联合疗法中的针对cd3和cd20的双特异性抗体
CN116437956A (zh) 2020-09-10 2023-07-14 健玛保 用于治疗慢性淋巴细胞白血病的针对cd3和cd20的双特异性抗体
CN116507363A (zh) 2020-09-10 2023-07-28 健玛保 用于治疗滤泡性淋巴瘤的联合疗法中的针对cd3和cd20的双特异性抗体
CA3192255A1 (en) 2020-09-10 2022-03-17 Brian Elliott Bispecific antibody against cd3 and cd20 in combination therapy for treating diffuse large b-cell lymphoma
KR20240117094A (ko) * 2021-12-09 2024-07-31 데시페라 파마슈티칼스, 엘엘씨. Kit 키나아제 억제제로서의 헤테로시클릭 화합물
WO2025188669A1 (en) * 2024-03-04 2025-09-12 Cardiff Oncology, Inc. Use of plk1 inhibitor as monotherapy and in combination with cetuximab in treating ras wild-type colorectal cancer

Citations (2)

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US20060178382A1 (en) * 2003-06-17 2006-08-10 Astrazeneca Ab Chinazoline derivatives as aurora kinase inhibitors
US7709479B1 (en) * 1999-09-21 2010-05-04 Astrazeneca Quinazoline derivatives and their use as pharmaceuticals

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GB9510757D0 (en) 1994-09-19 1995-07-19 Wellcome Found Therapeuticaly active compounds
GB9514265D0 (en) 1995-07-13 1995-09-13 Wellcome Found Hetrocyclic compounds
BRPI0209216B8 (pt) 2001-04-27 2021-05-25 Kyowa Hakko Kirin Co Ltd derivados de quinolina e de quinazolina, composições farmacêuticas compreendendo os mesmos e seus usos
US20050267182A1 (en) * 2003-11-13 2005-12-01 Ambit Biosciences Corporation Urea derivatives as FLT-3 modulators
WO2006040520A1 (en) 2004-10-12 2006-04-20 Astrazeneca Ab Quinazoline derivatives
JO2787B1 (en) 2005-04-27 2014-03-15 امجين إنك, Alternative amide derivatives and methods of use
US20070106549A1 (en) 2005-11-04 2007-05-10 Stocking Christine A Turnkey aviation budget management
UY30183A1 (es) 2006-03-02 2007-10-31 Astrazeneca Ab Derivados de quinolina
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CN102918029B (zh) * 2011-05-17 2015-06-17 江苏康缘药业股份有限公司 4-苯胺-6-丁烯酰胺-7-烷醚喹唑啉衍生物及其制备方法和用途
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US20060178382A1 (en) * 2003-06-17 2006-08-10 Astrazeneca Ab Chinazoline derivatives as aurora kinase inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEMMEDCHEM, 2013, vol. 8, no. 6, pages 928 - 933 *

Also Published As

Publication number Publication date
WO2018197642A1 (en) 2018-11-01
BR112019022229A2 (pt) 2020-05-12
AR111494A1 (es) 2019-07-17
CN110573505B (zh) 2023-04-11
MX389244B (es) 2025-03-20
US10273227B2 (en) 2019-04-30
RU2019136279A3 (enExample) 2021-05-31
US10829479B2 (en) 2020-11-10
TW201904960A (zh) 2019-02-01
CN110573505A (zh) 2019-12-13
US20180312490A1 (en) 2018-11-01
KR20190141203A (ko) 2019-12-23
ES2888298T3 (es) 2022-01-03
KR102603153B1 (ko) 2023-11-15
JP7128204B2 (ja) 2022-08-30
US20190263787A1 (en) 2019-08-29
CA3059283A1 (en) 2018-11-01
TWI774758B (zh) 2022-08-21
RU2019136279A (ru) 2021-05-27
EP3615522A1 (en) 2020-03-04
MX2019012847A (es) 2022-01-07
JP2020517677A (ja) 2020-06-18
EP3615522B1 (en) 2021-08-04
RU2769694C2 (ru) 2022-04-05
AU2018259078A1 (en) 2019-10-17

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