TWI687407B - Nr2b之n-烷基芳基-5-氧基芳基-八氫-環戊并[c]吡咯負向異位調節劑 - Google Patents

Nr2b之n-烷基芳基-5-氧基芳基-八氫-環戊并[c]吡咯負向異位調節劑 Download PDF

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TWI687407B
TWI687407B TW104131936A TW104131936A TWI687407B TW I687407 B TWI687407 B TW I687407B TW 104131936 A TW104131936 A TW 104131936A TW 104131936 A TW104131936 A TW 104131936A TW I687407 B TWI687407 B TW I687407B
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alkyl
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pharmaceutically acceptable
acceptable salt
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TW201625528A (zh
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大衛R 安德森
羅伯特A 沃克曼
法蘭克S 曼奈迪
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美商凱登製藥公司
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
TW104131936A 2014-09-26 2015-09-25 Nr2b之n-烷基芳基-5-氧基芳基-八氫-環戊并[c]吡咯負向異位調節劑 TWI687407B (zh)

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US201462056284P 2014-09-26 2014-09-26
US62/056,284 2014-09-26

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TW201625528A TW201625528A (zh) 2016-07-16
TWI687407B true TWI687407B (zh) 2020-03-11

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US12600726B2 (en) 2017-07-12 2026-04-14 Vanderbilt University Antagonists of the muscarinic acetylcholine receptor M4
IL310346A (en) 2017-10-20 2024-03-01 Univ Vanderbilt Muscarinic acetylcholine M4 receptor antagonists
AU2018360581A1 (en) 2017-10-31 2020-06-11 Vanderbilt University Antagonists of the muscarinic acetylcholine receptor M4
CN111788182B (zh) 2018-02-02 2023-09-26 范德堡大学 毒蕈碱性乙酰胆碱受体m4的拮抗剂
CN111818928A (zh) 2018-03-05 2020-10-23 艾库斯生物科学有限公司 精氨酸酶抑制剂
TW202112378A (zh) * 2019-06-04 2021-04-01 德商百靈佳殷格翰國際股份有限公司 嘌呤衍生物及其作為藥物之用途
CN113906033B (zh) 2019-06-04 2024-04-02 勃林格殷格翰国际有限公司 咪唑并吡嗪衍生物及其作为药剂的用途
CN111481543A (zh) * 2020-05-21 2020-08-04 苏州健雄职业技术学院 Nr2b负变构调节剂联合gaba受体调节剂在制备治疗阿尔兹海默症的药物中的用途
CN116744922A (zh) * 2020-12-04 2023-09-12 诺华股份有限公司 Nr2b-nmda受体nam在治疗抑郁症中的剂量方案
MX2023006567A (es) * 2020-12-04 2023-06-16 Novartis Ag Regimen de dosificacion para un nam del receptor nr2b-nmda para el tratamiento de la depresion.
JP2021058765A (ja) * 2021-01-19 2021-04-15 株式会社藤商事 遊技機
CN117120053A (zh) * 2021-03-26 2023-11-24 诺华股份有限公司 新的环戊二烯并[c]吡咯NR2B负变构调节剂
EP4313041A4 (en) * 2021-03-26 2025-01-15 Novartis AG NEW CYCLOPENTAL[C PYRROL NEGATIVE ALLOSTERIC MODULATORS OF NR2B
AU2023278502A1 (en) 2022-06-02 2025-01-02 Novartis Ag Subcutaneous administration of onfasprodil and dosing methods for use in the treatment of depression disorders
IL322082A (en) 2023-01-12 2025-09-01 Novartis Ag Engineered ketoreductase polypeptides
TW202539663A (zh) 2023-12-06 2025-10-16 瑞士商諾華公司 用於治療抑鬱障礙之組成物和方法

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ES2956546T3 (es) 2023-12-22
GT201700062A (es) 2019-09-30
ECSP17025302A (es) 2018-11-30
US20180111902A1 (en) 2018-04-26
BR112017006093B1 (pt) 2023-03-21
UY36326A (es) 2016-04-29
JP2017528502A (ja) 2017-09-28
EP3197868A1 (en) 2017-08-02
SI3197868T1 (sl) 2020-10-30
PH12017500513A1 (en) 2017-08-07
EP4282412A2 (en) 2023-11-29
RS60497B1 (sr) 2020-08-31
JP6772307B2 (ja) 2020-10-21
DK3197868T3 (da) 2020-06-22
ES2791327T3 (es) 2020-11-03
EP3683207B1 (en) 2021-12-29
JO3579B1 (ar) 2020-07-05
US20190152912A1 (en) 2019-05-23
CR20170114A (es) 2017-08-21
NZ729569A (en) 2019-06-28
EA034937B1 (ru) 2020-04-08
CA2962569C (en) 2023-09-19
LT3197868T (lt) 2020-09-10
JP2023052515A (ja) 2023-04-11
TN2017000076A1 (en) 2018-07-04
HRP20200959T1 (hr) 2020-10-02
WO2016049165A1 (en) 2016-03-31
CA2962569A1 (en) 2016-03-31
IL250909A0 (en) 2017-04-30
KR102479356B1 (ko) 2022-12-19
JP7216060B2 (ja) 2023-01-31
EP3197868B1 (en) 2020-04-15
CL2017000474A1 (es) 2017-08-18
AR103199A1 (es) 2017-04-26
US10781174B2 (en) 2020-09-22
CO2017002494A2 (es) 2017-08-31
PE20170893A1 (es) 2017-07-12
AP2017009832A0 (en) 2017-03-31
MX374657B (es) 2025-03-06
SG11201702023QA (en) 2017-04-27
US20220274925A1 (en) 2022-09-01
MY182342A (en) 2021-01-20
EP3974420A1 (en) 2022-03-30
EP4282412A3 (en) 2024-01-17
US12145909B2 (en) 2024-11-19
EP3974420B1 (en) 2023-08-16
IL250909B (en) 2019-06-30
CN106795111A (zh) 2017-05-31
MX2017003940A (es) 2018-03-01
TW201625528A (zh) 2016-07-16
ES2911004T3 (es) 2022-05-17
CU20170037A7 (es) 2017-08-08
ZA201701061B (en) 2019-07-31
AU2015320721A1 (en) 2017-03-30
US10239835B2 (en) 2019-03-26
HUE049698T2 (hu) 2020-10-28
JP2019077713A (ja) 2019-05-23
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