TWI668214B - 具有sstr5拮抗作用之雜環化合物 - Google Patents
具有sstr5拮抗作用之雜環化合物 Download PDFInfo
- Publication number
- TWI668214B TWI668214B TW103137143A TW103137143A TWI668214B TW I668214 B TWI668214 B TW I668214B TW 103137143 A TW103137143 A TW 103137143A TW 103137143 A TW103137143 A TW 103137143A TW I668214 B TWI668214 B TW I668214B
- Authority
- TW
- Taiwan
- Prior art keywords
- group
- compound
- mixture
- added
- ethyl acetate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/86—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013-224093 | 2013-10-29 | ||
| JP2013224093 | 2013-10-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201542539A TW201542539A (zh) | 2015-11-16 |
| TWI668214B true TWI668214B (zh) | 2019-08-11 |
Family
ID=51932560
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW103137143A TWI668214B (zh) | 2013-10-29 | 2014-10-28 | 具有sstr5拮抗作用之雜環化合物 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US9120777B2 (enExample) |
| EP (1) | EP3063139B1 (enExample) |
| JP (1) | JP6450755B2 (enExample) |
| AR (2) | AR098215A1 (enExample) |
| CY (1) | CY1121279T1 (enExample) |
| DK (1) | DK3063139T3 (enExample) |
| ES (1) | ES2710657T3 (enExample) |
| HR (1) | HRP20190133T1 (enExample) |
| HU (1) | HUE041792T2 (enExample) |
| LT (1) | LT3063139T (enExample) |
| PL (1) | PL3063139T3 (enExample) |
| PT (1) | PT3063139T (enExample) |
| RS (1) | RS58321B1 (enExample) |
| SI (1) | SI3063139T1 (enExample) |
| SM (1) | SMT201900101T1 (enExample) |
| TR (1) | TR201901986T4 (enExample) |
| TW (1) | TWI668214B (enExample) |
| UY (1) | UY35801A (enExample) |
| WO (1) | WO2015064083A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013122029A1 (ja) * | 2012-02-13 | 2013-08-22 | 武田薬品工業株式会社 | 芳香環化合物 |
| US9605000B2 (en) | 2013-03-14 | 2017-03-28 | Takeda Pharmaceutical Company Limited | Spiro azetidine isoxazole derivatives and their use as SSTR antagonists |
| JO3442B1 (ar) | 2013-10-07 | 2019-10-20 | Takeda Pharmaceuticals Co | مضادات ذات نوع فرعي من مستقبل سوماتوستاتين 5 (sstr5) |
| US20230049619A1 (en) * | 2019-12-19 | 2023-02-16 | Universite De Strasbourg | Sigma-1 receptor ligands and uses thereof |
| WO2022052958A1 (en) | 2020-09-10 | 2022-03-17 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
| CN116354961B (zh) * | 2021-12-27 | 2025-07-25 | 中国科学院上海药物研究所 | 生长抑素受体5拮抗剂及其药物组合物及用途 |
| WO2024204277A1 (ja) | 2023-03-27 | 2024-10-03 | 株式会社スコヒアファーマ | 成長ホルモン分泌促進剤 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008019967A2 (en) * | 2006-08-15 | 2008-02-21 | F. Hoffmann-La Roche Ag | Phenyl, pyridine and quinoline derivatives |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5356906A (en) | 1989-10-27 | 1994-10-18 | The Du Pont Merck Pharmaceutical Company | (N-phthalimidoalkyl) piperidines useful as treatments for psychosis |
| WO2001096308A1 (en) | 2000-06-12 | 2001-12-20 | Eisai Co., Ltd. | 1,2-dihydropyridine compounds, process for preparation of the same and use thereof |
| GB0129260D0 (en) | 2001-12-06 | 2002-01-23 | Eisai London Res Lab Ltd | Pharmaceutical compositions and their uses |
| JP4736043B2 (ja) | 2003-03-14 | 2011-07-27 | 小野薬品工業株式会社 | 含窒素複素環誘導体およびそれらを有効成分とする薬剤 |
| CN1902171A (zh) | 2003-11-10 | 2007-01-24 | 舍林股份公司 | 用作ccr－5拮抗剂的苄醚胺化合物 |
| US7862825B2 (en) | 2007-02-21 | 2011-01-04 | Mladen Vranic | Method of controlling tight blood glucose by somatostatin receptor antagonists |
| US7799806B2 (en) | 2007-04-04 | 2010-09-21 | Hoffmann-La Roche Inc. | Substituted n-benzyl piperidines as somatostatin receptor modulators |
| US20080306116A1 (en) | 2007-06-08 | 2008-12-11 | Christ Andreas D | Aryloxazole, aryloxadiazole and benzimidazole derivatives |
| TW200918062A (en) | 2007-09-12 | 2009-05-01 | Wyeth Corp | Azacyclylisoquinolinone and-isoindolinone derivatives as histamine-3 antagonists |
| WO2010129729A1 (en) | 2009-05-07 | 2010-11-11 | Merck Sharp & Dohme Corp. | Substituted spirocyclic amines useful as antidiabetic compounds |
| US8742110B2 (en) | 2010-08-18 | 2014-06-03 | Merck Sharp & Dohme Corp. | Spiroxazolidinone compounds |
| US9000175B2 (en) | 2010-11-26 | 2015-04-07 | Lupin Limited | Bicyclic GPR119 modulators |
| US9605000B2 (en) | 2013-03-14 | 2017-03-28 | Takeda Pharmaceutical Company Limited | Spiro azetidine isoxazole derivatives and their use as SSTR antagonists |
-
2014
- 2014-10-28 PL PL14800152T patent/PL3063139T3/pl unknown
- 2014-10-28 ES ES14800152T patent/ES2710657T3/es active Active
- 2014-10-28 PT PT14800152T patent/PT3063139T/pt unknown
- 2014-10-28 DK DK14800152.2T patent/DK3063139T3/en active
- 2014-10-28 TR TR2019/01986T patent/TR201901986T4/tr unknown
- 2014-10-28 UY UY0001035801A patent/UY35801A/es not_active Application Discontinuation
- 2014-10-28 JP JP2016526960A patent/JP6450755B2/ja active Active
- 2014-10-28 RS RS20190190A patent/RS58321B1/sr unknown
- 2014-10-28 LT LTEP14800152.2T patent/LT3063139T/lt unknown
- 2014-10-28 SM SM20190101T patent/SMT201900101T1/it unknown
- 2014-10-28 HR HRP20190133TT patent/HRP20190133T1/hr unknown
- 2014-10-28 US US14/525,593 patent/US9120777B2/en active Active
- 2014-10-28 WO PCT/JP2014/005438 patent/WO2015064083A1/en not_active Ceased
- 2014-10-28 AR ARP140104043A patent/AR098215A1/es active IP Right Grant
- 2014-10-28 TW TW103137143A patent/TWI668214B/zh active
- 2014-10-28 EP EP14800152.2A patent/EP3063139B1/en active Active
- 2014-10-28 HU HUE14800152A patent/HUE041792T2/hu unknown
- 2014-10-28 SI SI201431055T patent/SI3063139T1/sl unknown
-
2019
- 2019-02-14 CY CY20191100202T patent/CY1121279T1/el unknown
-
2022
- 2022-12-29 AR ARP220103645A patent/AR128158A2/es unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008019967A2 (en) * | 2006-08-15 | 2008-02-21 | F. Hoffmann-La Roche Ag | Phenyl, pyridine and quinoline derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| LT3063139T (lt) | 2019-02-25 |
| CY1121279T1 (el) | 2020-05-29 |
| EP3063139A1 (en) | 2016-09-07 |
| WO2015064083A1 (en) | 2015-05-07 |
| PL3063139T3 (pl) | 2019-05-31 |
| AR128158A2 (es) | 2024-03-27 |
| UY35801A (es) | 2015-06-30 |
| US20150119412A1 (en) | 2015-04-30 |
| EP3063139B1 (en) | 2018-11-21 |
| JP2016535040A (ja) | 2016-11-10 |
| PT3063139T (pt) | 2019-02-22 |
| ES2710657T3 (es) | 2019-04-26 |
| TR201901986T4 (tr) | 2019-03-21 |
| HUE041792T2 (hu) | 2019-05-28 |
| TW201542539A (zh) | 2015-11-16 |
| DK3063139T3 (en) | 2019-03-11 |
| SI3063139T1 (sl) | 2019-03-29 |
| US9120777B2 (en) | 2015-09-01 |
| RS58321B1 (sr) | 2019-03-29 |
| SMT201900101T1 (it) | 2019-02-28 |
| AR098215A1 (es) | 2016-05-18 |
| JP6450755B2 (ja) | 2019-01-09 |
| HRP20190133T1 (hr) | 2019-03-22 |
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