TWI623528B - 金屬酶抑制劑化合物、抑制金屬酶活性之方法、組合物、治療或預防植物疾病或病症之方法及其用途 - Google Patents

金屬酶抑制劑化合物、抑制金屬酶活性之方法、組合物、治療或預防植物疾病或病症之方法及其用途 Download PDF

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Publication number
TWI623528B
TWI623528B TW105144241A TW105144241A TWI623528B TW I623528 B TWI623528 B TW I623528B TW 105144241 A TW105144241 A TW 105144241A TW 105144241 A TW105144241 A TW 105144241A TW I623528 B TWI623528 B TW I623528B
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Taiwan
Prior art keywords
phenyl
pyridin
difluoro
piperazin
hydroxy
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TW105144241A
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English (en)
Chinese (zh)
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TW201734000A (zh
Inventor
克里斯多夫Ｍ 耶茨
聖米Ｒ 雪佛
威廉Ｊ 荷科斯特
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維愛美製藥公司
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pyridine Compounds (AREA)
TW105144241A 2015-12-30 2016-12-30 金屬酶抑制劑化合物、抑制金屬酶活性之方法、組合物、治療或預防植物疾病或病症之方法及其用途 TWI623528B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562273167P 2015-12-30 2015-12-30
US62/273,167 2015-12-30

Publications (2)

Publication Number Publication Date
TW201734000A TW201734000A (zh) 2017-10-01
TWI623528B true TWI623528B (zh) 2018-05-11

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TW105144241A TWI623528B (zh) 2015-12-30 2016-12-30 金屬酶抑制劑化合物、抑制金屬酶活性之方法、組合物、治療或預防植物疾病或病症之方法及其用途

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US (1) US10464922B2 (enExample)
EP (1) EP3397629B1 (enExample)
JP (1) JP6803923B2 (enExample)
KR (1) KR102240920B1 (enExample)
CN (1) CN108779094B (enExample)
AU (1) AU2016380349B2 (enExample)
BR (1) BR112018013522A2 (enExample)
CA (1) CA3006469C (enExample)
EA (1) EA038421B1 (enExample)
MX (1) MX376201B (enExample)
TW (1) TWI623528B (enExample)
WO (1) WO2017117393A1 (enExample)

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JP2017514790A (ja) 2014-03-19 2017-06-08 ヴィアメット ファーマスーティカルズ，インコーポレイテッド 抗真菌化合物の調製方法
JP6606508B2 (ja) 2014-03-19 2019-11-13 マイコヴィア ファーマシューティカルズ，インコーポレイテッド 抗真菌化合物の調製方法
MX371291B (es) 2014-03-19 2020-01-24 Viamet Pharmaceuticals Nc Inc 2-(2,4-difluorofenil)-1,1-difluoro-1-(5-sustituido-piridin-2-il)- 3-(1h-tetrazol-1-il)propan-2-oles y procedimientos para su preparacion.
AU2015231220B2 (en) 2014-03-19 2019-04-04 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Antifungal compound process
JP6572234B2 (ja) 2014-03-19 2019-09-04 ヴィアメット ファーマスーティカルズ（エヌシー），インコーポレイテッド 抗真菌化合物の調製方法
AU2015231234B2 (en) 2014-03-19 2019-04-04 Mycovia Pharmaceuticals, Inc. Antifungal compound process
EA037587B1 (ru) 2014-03-19 2021-04-19 Майковиа Фармасьютикалс, Инк. Способ получения противогрибковых соединений
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US12357615B2 (en) 2018-10-11 2025-07-15 Kembi Therapeutics Pty Ltd Compositions for the treatment of brain tumors
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CN113444131B (zh) * 2021-06-24 2022-10-21 鲁东大学 N-乙酰氨基葡萄糖类化合物及其制备方法和应用
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CN115466227B (zh) * 2022-06-30 2024-07-19 杭州国瑞生物科技有限公司 一种3-(氯甲基)-1-甲基-1h-1,2,4-三唑盐酸盐的制备方法

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MX2018008105A (es) 2018-11-12
BR112018013522A2 (pt) 2018-12-11
CA3006469C (en) 2023-01-10
JP2019502755A (ja) 2019-01-31
JP6803923B2 (ja) 2020-12-23
CN108779094A (zh) 2018-11-09
KR102240920B1 (ko) 2021-04-16
US20190016700A1 (en) 2019-01-17
EP3397629A4 (en) 2019-06-05
EP3397629A1 (en) 2018-11-07
AU2016380349A1 (en) 2018-06-14
AU2016380349B2 (en) 2020-10-29
EA201891539A1 (ru) 2018-12-28
KR20180099845A (ko) 2018-09-05
WO2017117393A1 (en) 2017-07-06
US10464922B2 (en) 2019-11-05
EP3397629B1 (en) 2023-04-19
CA3006469A1 (en) 2017-07-06
TW201734000A (zh) 2017-10-01
EA038421B1 (ru) 2021-08-26
MX376201B (es) 2025-03-07
CN108779094B (zh) 2021-11-16

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