TWI563091B - Large scale enzymatic synthesis of oligosaccharides - Google Patents

Large scale enzymatic synthesis of oligosaccharides

Info

Publication number
TWI563091B
TWI563091B TW104133599A TW104133599A TWI563091B TW I563091 B TWI563091 B TW I563091B TW 104133599 A TW104133599 A TW 104133599A TW 104133599 A TW104133599 A TW 104133599A TW I563091 B TWI563091 B TW I563091B
Authority
TW
Taiwan
Prior art keywords
oligosaccharides
large scale
enzymatic synthesis
scale enzymatic
synthesis
Prior art date
Application number
TW104133599A
Other languages
English (en)
Other versions
TW201602353A (zh
Inventor
Chi-Huey Wong
Chung Ti Wu
Tsung I Tsai
Original Assignee
Academia Sinica
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Academia Sinica filed Critical Academia Sinica
Publication of TW201602353A publication Critical patent/TW201602353A/zh
Application granted granted Critical
Publication of TWI563091B publication Critical patent/TWI563091B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/01006—Galactokinase (2.7.1.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/0104—Pyruvate kinase (2.7.1.40)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07—Nucleotidyltransferases (2.7.7)
    • C12Y207/07009—UTP-glucose-1-phosphate uridylyltransferase (2.7.7.9), i.e. UDP-glucose-pyrophosphorylase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07—Nucleotidyltransferases (2.7.7)
    • C12Y207/0701—UTP--hexose-1-phosphate uridylyltransferase (2.7.7.10)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
TW104133599A 2012-08-20 2013-08-19 Large scale enzymatic synthesis of oligosaccharides TWI563091B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261684974P 2012-08-20 2012-08-20

Publications (2)

Publication Number Publication Date
TW201602353A TW201602353A (zh) 2016-01-16
TWI563091B true TWI563091B (en) 2016-12-21

Family

ID=50100297

Family Applications (5)

Application Number Title Priority Date Filing Date
TW102129714A TWI510627B (zh) 2012-08-20 2013-08-19 寡醣之大規模酵素合成
TW104133598A TWI567200B (zh) 2012-08-20 2013-08-19 寡醣之大規模酵素合成
TW104133600A TWI563092B (en) 2012-08-20 2013-08-19 Large scale enzymatic synthesis of oligosaccharides
TW104133252A TWI573876B (zh) 2012-08-20 2013-08-19 寡醣之大規模酵素合成
TW104133599A TWI563091B (en) 2012-08-20 2013-08-19 Large scale enzymatic synthesis of oligosaccharides

Family Applications Before (4)

Application Number Title Priority Date Filing Date
TW102129714A TWI510627B (zh) 2012-08-20 2013-08-19 寡醣之大規模酵素合成
TW104133598A TWI567200B (zh) 2012-08-20 2013-08-19 寡醣之大規模酵素合成
TW104133600A TWI563092B (en) 2012-08-20 2013-08-19 Large scale enzymatic synthesis of oligosaccharides
TW104133252A TWI573876B (zh) 2012-08-20 2013-08-19 寡醣之大規模酵素合成

Country Status (11)

Country Link
US (2) US9340812B2 (zh)
EP (1) EP2885416B8 (zh)
JP (5) JP6125637B2 (zh)
KR (1) KR101685628B1 (zh)
CN (6) CN104822837B (zh)
AU (3) AU2016206315B2 (zh)
CA (4) CA3129035C (zh)
ES (1) ES2974096T3 (zh)
HK (6) HK1207668A1 (zh)
TW (5) TWI510627B (zh)
WO (1) WO2014031602A1 (zh)

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WO2010009271A2 (en) 2008-07-15 2010-01-21 Academia Sinica Glycan arrays on ptfe-like aluminum coated glass slides and related methods
US10087236B2 (en) 2009-12-02 2018-10-02 Academia Sinica Methods for modifying human antibodies by glycan engineering
US11377485B2 (en) 2009-12-02 2022-07-05 Academia Sinica Methods for modifying human antibodies by glycan engineering
WO2011130332A1 (en) 2010-04-12 2011-10-20 Academia Sinica Glycan arrays for high throughput screening of viruses
US10130714B2 (en) 2012-04-14 2018-11-20 Academia Sinica Enhanced anti-influenza agents conjugated with anti-inflammatory activity
WO2014031498A1 (en) 2012-08-18 2014-02-27 Academia Sinica Cell-permeable probes for identification and imaging of sialidases
EP3013365B1 (en) 2013-06-26 2019-06-05 Academia Sinica Rm2 antigens and use thereof
EP3013347B1 (en) 2013-06-27 2019-12-11 Academia Sinica Glycan conjugates and use thereof
CN105682666B (zh) 2013-09-06 2021-06-01 中央研究院 使用醣脂激活人类iNKT细胞
US10150818B2 (en) 2014-01-16 2018-12-11 Academia Sinica Compositions and methods for treatment and detection of cancers
WO2015109180A2 (en) 2014-01-16 2015-07-23 Academia Sinica Compositions and methods for treatment and detection of cancers
TWI797430B (zh) 2014-03-27 2023-04-01 中央研究院 反應性標記化合物及其用途
KR102576850B1 (ko) 2014-05-27 2023-09-11 아카데미아 시니카 박테로이드 기원의 푸코시다제 및 이의 사용 방법
US10118969B2 (en) 2014-05-27 2018-11-06 Academia Sinica Compositions and methods relating to universal glycoforms for enhanced antibody efficacy
JP7062361B2 (ja) 2014-05-27 2022-05-06 アカデミア シニカ 抗ｈｅｒ２糖操作抗体群およびその使用
CA2950415A1 (en) 2014-05-27 2015-12-03 Academia Sinica Anti-cd20 glycoantibodies and uses thereof
KR102494193B1 (ko) 2014-05-28 2023-01-31 아카데미아 시니카 항-ｔｎｆ-알파 글리코항체 및 이의 용도
TWI587871B (zh) 2014-08-22 2017-06-21 中央研究院 新穎之聚醣共軛物及其用途
JP6899321B2 (ja) 2014-09-08 2021-07-07 アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ 糖脂質を使用するヒトｉＮＫＴ細胞活性化
US10495645B2 (en) 2015-01-16 2019-12-03 Academia Sinica Cancer markers and methods of use thereof
US9975965B2 (en) 2015-01-16 2018-05-22 Academia Sinica Compositions and methods for treatment and detection of cancers
TWI736523B (zh) 2015-01-24 2021-08-21 中央研究院 新穎聚醣結合物及其使用方法
KR102630294B1 (ko) 2015-01-24 2024-01-26 아카데미아 시니카 암 마커 및 이를 사용하는 방법
KR102620346B1 (ko) 2015-01-30 2024-01-02 아카데미아 시니카 증진된 항체 효능을 위한 범용 당형태에 관한 조성물 및 방법
JP2019515876A (ja) 2016-03-08 2019-06-13 アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ Ｎ−グリカンおよびそのアレイのモジュール合成のための方法
EP3500594A4 (en) 2016-08-22 2020-03-11 Cho Pharma Inc. ANTIBODIES, BINDING FRAGMENTS AND METHOD FOR USE
US11739283B2 (en) 2019-03-14 2023-08-29 Nof Corporation Lubricant additive, lubricant additive composition, and lubricating oil composition containing the same
CN110195043A (zh) * 2019-05-15 2019-09-03 武汉格莱利生物科技有限公司 一种高水溶性的cgta酶及其制备方法和应用
AU2019400151B2 (en) * 2019-11-15 2022-06-23 Cofco (Jilin) Bio-Chemical Technology Co., Ltd Recombinant Escherichia coli system, construction method thereof, and usage in synthesis of α-1,2-fucosylated oligosaccharide
WO2022256920A1 (en) * 2021-06-07 2022-12-15 The University Of British Columbia Acholetin biopolymers and methods for enzymatic synthesis
CN115710594B (zh) * 2021-08-23 2024-06-28 中国科学院上海药物研究所 一种合成尿苷二磷酸-6-叠氮-d-半乳糖的方法
TWI828311B (zh) * 2021-09-11 2024-01-01 中央研究院 合成化合物、包含該合成化合物的套組及其用途

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Also Published As

Publication number Publication date
TWI567200B (zh) 2017-01-21
KR101685628B1 (ko) 2016-12-12
CN108546643B (zh) 2022-02-25
CA2882294C (en) 2019-10-22
AU2019203313B2 (en) 2020-04-30
HK1254776A1 (zh) 2019-07-26
CA3187148A1 (en) 2014-02-27
HK1254774A1 (zh) 2019-07-26
HK1254775A1 (zh) 2019-07-26
CN108546643A (zh) 2018-09-18
JP2021168693A (ja) 2021-10-28
HK1254772A1 (zh) 2019-07-26
CA3052909A1 (en) 2014-02-27
CA2882294A1 (en) 2014-02-27
JP6647382B2 (ja) 2020-02-14
EP2885416B1 (en) 2024-01-03
TWI573876B (zh) 2017-03-11
JP6925658B2 (ja) 2021-08-25
HK1207668A1 (zh) 2016-02-05
EP2885416A1 (en) 2015-06-24
CN108588151B (zh) 2022-05-13
EP2885416B8 (en) 2024-02-14
JP6462756B2 (ja) 2019-01-30
US20160230201A1 (en) 2016-08-11
CA3129035A1 (en) 2014-02-27
JP2019047822A (ja) 2019-03-28
EP2885416A4 (en) 2016-05-18
CN108504702B (zh) 2021-05-04
CN104822837A (zh) 2015-08-05
CN104822837B (zh) 2018-06-05
CN108611384A (zh) 2018-10-02
CA3052909C (en) 2021-10-19
JP7376136B2 (ja) 2023-11-08
CN108504702A (zh) 2018-09-07
CN108504703B (zh) 2021-06-29
AU2016206315B2 (en) 2017-12-14
KR20150042859A (ko) 2015-04-21
WO2014031602A1 (en) 2014-02-27
CN108504703A (zh) 2018-09-07
TW201602351A (zh) 2016-01-16
JP2015529461A (ja) 2015-10-08
AU2016206315A1 (en) 2016-08-11
CN108611384B (zh) 2022-02-25
TW201418467A (zh) 2014-05-16
HK1254773A1 (zh) 2019-07-26
AU2018200094A1 (en) 2018-01-25
JP2017118883A (ja) 2017-07-06
TW201602352A (zh) 2016-01-16
JP2020054389A (ja) 2020-04-09
TW201602354A (zh) 2016-01-16
AU2013305937A1 (en) 2015-02-19
ES2974096T3 (es) 2024-06-25
CA3129035C (en) 2023-03-07
US20140051127A1 (en) 2014-02-20
CN108588151A (zh) 2018-09-28
JP6125637B2 (ja) 2017-05-10
TWI510627B (zh) 2015-12-01
TW201602353A (zh) 2016-01-16
US9340812B2 (en) 2016-05-17
TWI563092B (en) 2016-12-21
AU2019203313A1 (en) 2019-05-30
AU2018200094B2 (en) 2019-02-14

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