TWI562977B - Process for the preparation of substituted n-(benzyl)cyclopropanamines by imine hydrogenation - Google Patents

Process for the preparation of substituted n-(benzyl)cyclopropanamines by imine hydrogenation

Info

Publication number
TWI562977B
TWI562977B TW100137972A TW100137972A TWI562977B TW I562977 B TWI562977 B TW I562977B TW 100137972 A TW100137972 A TW 100137972A TW 100137972 A TW100137972 A TW 100137972A TW I562977 B TWI562977 B TW I562977B
Authority
TW
Taiwan
Prior art keywords
cyclopropanamines
benzyl
substituted
preparation
imine hydrogenation
Prior art date
Application number
TW100137972A
Other languages
English (en)
Other versions
TW201249780A (en
Inventor
Norbert Lui
Wahed Ahmed Moradi
Original Assignee
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh
Publication of TW201249780A publication Critical patent/TW201249780A/zh
Application granted granted Critical
Publication of TWI562977B publication Critical patent/TWI562977B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/44—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers
    • C07C209/52—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers by reduction of imines or imino-ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/34—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton
    • C07C211/35—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton containing only non-condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/58—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
    • C07C251/24—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
TW100137972A 2010-11-05 2011-10-19 Process for the preparation of substituted n-(benzyl)cyclopropanamines by imine hydrogenation TWI562977B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41051710P 2010-11-05 2010-11-05
EP10190077 2010-11-05

Publications (2)

Publication Number Publication Date
TW201249780A TW201249780A (en) 2012-12-16
TWI562977B true TWI562977B (en) 2016-12-21

Family

ID=43805674

Family Applications (2)

Application Number Title Priority Date Filing Date
TW100137972A TWI562977B (en) 2010-11-05 2011-10-19 Process for the preparation of substituted n-(benzyl)cyclopropanamines by imine hydrogenation
TW105128670A TWI622573B (zh) 2010-11-05 2011-10-19 藉由亞胺氫化製備經取代ｎ－（苄基）環丙胺之方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
TW105128670A TWI622573B (zh) 2010-11-05 2011-10-19 藉由亞胺氫化製備經取代ｎ－（苄基）環丙胺之方法

Country Status (12)

Country Link
US (1) US9260378B2 (zh)
EP (1) EP2635551B1 (zh)
JP (1) JP2014503481A (zh)
KR (1) KR101874659B1 (zh)
CN (1) CN103402970B (zh)
BR (1) BR112013010990B1 (zh)
DK (1) DK2635551T3 (zh)
ES (1) ES2680546T3 (zh)
IL (1) IL226132B (zh)
MX (1) MX2013004881A (zh)
TW (2) TWI562977B (zh)
WO (1) WO2012059585A1 (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112014025981B1 (pt) 2012-04-26 2020-10-20 Bayer Cropscience Ag N-(5-cloro-2-isopropilbenzil) ciclopropanamina e seu processo de preparação, 2-bromo-4- cloro-1-isopropilbenzeno e seu processo de preparação e uso de um composto
WO2016143737A1 (ja) * 2015-03-11 2016-09-15 三菱瓦斯化学株式会社 新規ポリアミン化合物及びその製造方法、並びに、及びこれを用いたエポキシ樹脂用硬化剤、エポキシ樹脂組成物及びエポキシ樹脂硬化物
US9958781B2 (en) * 2015-04-24 2018-05-01 Jsr Corporation Method for film formation, and pattern-forming method

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3083226A (en) * 1961-10-18 1963-03-26 Abbott Lab N-benzyl cyclopropylamines and carbamates
US3153093A (en) * 1961-11-22 1964-10-13 Abbott Lab Amino derivatives of nu-cyclopropylbenzylamines

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6252090B1 (en) * 2000-08-29 2001-06-26 Allergan Sales, Inc. Compounds having activity as inhibitors of cytochrome P450RAI
BR0315115A (pt) 2002-10-11 2005-08-16 Actelion Pharmaceuticals Ltd Compostos, composições farmacêuticas, método para tratar ou prevenir doenças ou distúrbios em que se requer um antagonista de receptores de orexina humana, processo para a fabricação de composições farmacêuticas, e, uso de um ou mais compostos em combinação com outros compostos farmacologicamente ativos
GB0428250D0 (en) 2004-12-23 2005-01-26 Novartis Ag Organic compounds
AR056882A1 (es) 2006-02-01 2007-10-31 Bayer Cropscience Sa Derivados del fungicida n- cicloalquil- bencil- amida
EP2061792A2 (en) 2006-09-15 2009-05-27 Schering Corporation Azetidinone derivatives for the treatment of disorders of the lipid metabolism
US7638526B2 (en) 2006-09-15 2009-12-29 Schering Corporation Azetidine derivatives useful in treating pain, diabetes and disorders of lipid metabolism
RU2470918C2 (ru) 2007-01-15 2012-12-27 Сантен Фармасьютикал Ко., Лтд. НОВЫЕ ПРОИЗВОДНЫЕ ИНДОЛА, ОБЛАДАЮЩИЕ ИНГИБИРУЮЩЕЙ АКТИВНОСТЬЮ В ОТНОШЕНИИ IκB КИНАЗЫ β
EP2155643B1 (en) * 2007-06-08 2016-08-10 MannKind Corporation Ire-1a inhibitors
CN102015682B (zh) * 2008-05-05 2014-07-16 埃科特莱茵药品有限公司 作为肾素抑制剂的3,4-取代的哌啶衍生物
BR112014025981B1 (pt) * 2012-04-26 2020-10-20 Bayer Cropscience Ag N-(5-cloro-2-isopropilbenzil) ciclopropanamina e seu processo de preparação, 2-bromo-4- cloro-1-isopropilbenzeno e seu processo de preparação e uso de um composto

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3083226A (en) * 1961-10-18 1963-03-26 Abbott Lab N-benzyl cyclopropylamines and carbamates
US3153093A (en) * 1961-11-22 1964-10-13 Abbott Lab Amino derivatives of nu-cyclopropylbenzylamines

Also Published As

Publication number Publication date
EP2635551B1 (en) 2018-05-02
MX2013004881A (es) 2013-07-02
ES2680546T3 (es) 2018-09-10
BR112013010990B1 (pt) 2019-03-26
TW201700451A (zh) 2017-01-01
JP2014503481A (ja) 2014-02-13
CN103402970A (zh) 2013-11-20
TWI622573B (zh) 2018-05-01
IL226132A0 (en) 2013-06-27
US20130217910A1 (en) 2013-08-22
WO2012059585A1 (en) 2012-05-10
TW201249780A (en) 2012-12-16
KR20130115290A (ko) 2013-10-21
CN103402970B (zh) 2017-02-15
EP2635551A1 (en) 2013-09-11
DK2635551T3 (en) 2018-08-06
US9260378B2 (en) 2016-02-16
KR101874659B1 (ko) 2018-07-04
BR112013010990A2 (pt) 2016-08-30
IL226132B (en) 2018-02-28

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