EP2555616A4 - Process for the preparation of memantine hydrochloride - Google Patents

Process for the preparation of memantine hydrochloride

Info

Publication number
EP2555616A4
EP2555616A4 EP10849334.7A EP10849334A EP2555616A4 EP 2555616 A4 EP2555616 A4 EP 2555616A4 EP 10849334 A EP10849334 A EP 10849334A EP 2555616 A4 EP2555616 A4 EP 2555616A4
Authority
EP
European Patent Office
Prior art keywords
preparation
memantine hydrochloride
memantine
hydrochloride
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP10849334.7A
Other languages
German (de)
French (fr)
Other versions
EP2555616A1 (en
Inventor
Reddy Bandi Parthasaradhi
Reddy Kura Rathnakar
Reddy Dasari Muralidhara
Reddy Rapolu Raji
Reddy Matta Ramakrishna
Krishna Bandi Vamsi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hetero Research Foundation
Original Assignee
Hetero Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hetero Research Foundation filed Critical Hetero Research Foundation
Publication of EP2555616A1 publication Critical patent/EP2555616A1/en
Publication of EP2555616A4 publication Critical patent/EP2555616A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/013—Preparation of halogenated hydrocarbons by addition of halogens
    • C07C17/06—Preparation of halogenated hydrocarbons by addition of halogens combined with replacement of hydrogen atoms by halogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/62—Preparation of compounds containing amino groups bound to a carbon skeleton by cleaving carbon-to-nitrogen, sulfur-to-nitrogen, or phosphorus-to-nitrogen bonds, e.g. hydrolysis of amides, N-dealkylation of amines or quaternary ammonium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/82—Purification; Separation; Stabilisation; Use of additives
    • C07C209/84—Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/10—Preparation of carboxylic acid amides from compounds not provided for in groups C07C231/02 - C07C231/08
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EP10849334.7A 2010-04-08 2010-04-08 Process for the preparation of memantine hydrochloride Withdrawn EP2555616A4 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IN2010/000230 WO2011125062A1 (en) 2010-04-08 2010-04-08 Process for the preparation of memantine hydrochloride

Publications (2)

Publication Number Publication Date
EP2555616A1 EP2555616A1 (en) 2013-02-13
EP2555616A4 true EP2555616A4 (en) 2014-04-02

Family

ID=44762075

Family Applications (1)

Application Number Title Priority Date Filing Date
EP10849334.7A Withdrawn EP2555616A4 (en) 2010-04-08 2010-04-08 Process for the preparation of memantine hydrochloride

Country Status (2)

Country Link
EP (1) EP2555616A4 (en)
WO (1) WO2011125062A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106966909B (en) * 2016-09-06 2019-04-12 南京优科制药有限公司 A kind of purification process of memantine
CN110845339A (en) * 2019-11-08 2020-02-28 湖南洞庭药业股份有限公司 Synthetic method of memantine hydrochloride

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3391142A (en) * 1966-02-09 1968-07-02 Lilly Co Eli Adamantyl secondary amines
WO2006076560A1 (en) * 2005-01-11 2006-07-20 Teva Pharmaceutical Fine Chemicals S.R.L. Polymorphs of memantine hydrochloride
WO2006122238A1 (en) * 2005-05-11 2006-11-16 Dr. Reddy's Laboratories Ltd. Process for preparing memantine
US20080033054A1 (en) * 2006-03-27 2008-02-07 Valeriano Merli Process for preparing memantine hydrochloride substantially free of impurities
WO2008040560A1 (en) * 2006-10-05 2008-04-10 Krka, D.D., Novo Mesto Process for the preparation of memantine and its hydrochloric acid salt form
WO2008062472A2 (en) * 2006-10-24 2008-05-29 Cadila Healthcare Limited Process for the preparation of memantine

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3391142A (en) * 1966-02-09 1968-07-02 Lilly Co Eli Adamantyl secondary amines
WO2006076560A1 (en) * 2005-01-11 2006-07-20 Teva Pharmaceutical Fine Chemicals S.R.L. Polymorphs of memantine hydrochloride
WO2006122238A1 (en) * 2005-05-11 2006-11-16 Dr. Reddy's Laboratories Ltd. Process for preparing memantine
US20080033054A1 (en) * 2006-03-27 2008-02-07 Valeriano Merli Process for preparing memantine hydrochloride substantially free of impurities
WO2008040560A1 (en) * 2006-10-05 2008-04-10 Krka, D.D., Novo Mesto Process for the preparation of memantine and its hydrochloric acid salt form
WO2008062472A2 (en) * 2006-10-24 2008-05-29 Cadila Healthcare Limited Process for the preparation of memantine

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2011125062A1 *

Also Published As

Publication number Publication date
WO2011125062A1 (en) 2011-10-13
EP2555616A1 (en) 2013-02-13

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 20120926

AK Designated contracting states

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Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20140228

RIC1 Information provided on ipc code assigned before grant

Ipc: C07C 231/10 20060101ALI20140224BHEP

Ipc: C07C 17/06 20060101ALI20140224BHEP

Ipc: A01N 33/02 20060101AFI20140224BHEP

Ipc: C07C 231/22 20060101ALI20140224BHEP

Ipc: C07C 209/84 20060101ALI20140224BHEP

Ipc: C07C 209/62 20060101ALI20140224BHEP

Ipc: A61K 31/13 20060101ALI20140224BHEP

STAA Information on the status of an ep patent application or granted ep patent

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18D Application deemed to be withdrawn

Effective date: 20140930