TWI541254B - 短抗微生物脂肽 - Google Patents
短抗微生物脂肽 Download PDFInfo
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- TWI541254B TWI541254B TW102109748A TW102109748A TWI541254B TW I541254 B TWI541254 B TW I541254B TW 102109748 A TW102109748 A TW 102109748A TW 102109748 A TW102109748 A TW 102109748A TW I541254 B TWI541254 B TW I541254B
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- skin
- lysine
- proline
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- lipid
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Landscapes
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261613212P | 2012-03-20 | 2012-03-20 | |
| PCT/US2013/029696 WO2013142088A1 (en) | 2012-03-20 | 2013-03-07 | Short antimicrobial lipopeptides |
Publications (2)
| Publication Number | Publication Date |
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| TW201339176A TW201339176A (zh) | 2013-10-01 |
| TWI541254B true TWI541254B (zh) | 2016-07-11 |
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| TW102109748A TWI541254B (zh) | 2012-03-20 | 2013-03-19 | 短抗微生物脂肽 |
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| EP (1) | EP2827907B1 (enExample) |
| JP (1) | JP6261560B2 (enExample) |
| KR (1) | KR20140136494A (enExample) |
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| CA (1) | CA2864179A1 (enExample) |
| DK (1) | DK2827907T3 (enExample) |
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| MX (1) | MX2014011290A (enExample) |
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| PL (1) | PL2827907T3 (enExample) |
| RU (2) | RU2627648C2 (enExample) |
| SG (2) | SG10201607784VA (enExample) |
| TW (1) | TWI541254B (enExample) |
| WO (1) | WO2013142088A1 (enExample) |
| ZA (1) | ZA201405950B (enExample) |
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| US10835572B2 (en) | 2014-06-30 | 2020-11-17 | Rohto Pharmaceutical Co., Ltd. | Composition for external application |
| JP6906274B2 (ja) * | 2014-06-30 | 2021-07-21 | ロート製薬株式会社 | 外用組成物、眼科用組成物、抗菌剤、及び抗菌方法 |
| US10660979B2 (en) * | 2015-08-26 | 2020-05-26 | The General Hospital Corporation | System and method for electrical control of bacteria |
| KR101855170B1 (ko) | 2015-11-18 | 2018-05-08 | (주)노바셀테크놀로지 | 신규 항균 펩타이드 및 그의 용도 |
| CN109320585B (zh) * | 2018-09-06 | 2021-10-26 | 南方医科大学 | 一种具有专一性抗痤疮丙酸杆菌作用及抗炎作用的短脂肽 |
| CA3112268A1 (en) * | 2018-09-12 | 2020-03-19 | The Governing Council Of The University Of Toronto | Indole-oxadiazole compounds and their therapeutic use |
| CN111035764B (zh) * | 2018-10-14 | 2021-09-07 | 深圳市健元医药科技有限公司 | 一种治疗类风湿性关节炎的组合物及其制备方法 |
| CN110279844A (zh) * | 2019-01-31 | 2019-09-27 | 浙江星杭泰乐生物医药有限公司 | 人工合成抗菌肽在制备抑菌消炎祛痘化妆品或外用药物制剂中的应用及抑菌消炎祛痘组合物 |
| CN111303242B (zh) * | 2020-02-27 | 2022-04-26 | 广州领晟医疗科技有限公司 | 一种KdPT的修饰肽 |
| KR102163568B1 (ko) * | 2020-08-21 | 2020-10-07 | 주식회사 비드테크 | 지방산 항균펩타이드 및 이를 함유하는 항균 조성물 |
| JP2023545899A (ja) * | 2020-09-29 | 2023-11-01 | ユニリーバー・アイピー・ホールディングス・ベー・フェー | アミノ酸を含むパーソナルケア組成物 |
| US11793746B2 (en) * | 2020-10-01 | 2023-10-24 | Chanda Zaveri | Intense skin hydration systems and methods |
| CN112679576B (zh) * | 2020-11-06 | 2022-09-20 | 黄石瀚海新材料科技有限公司 | 抗菌脂肽、抗菌脂肽水凝胶制备方法及其应用 |
Family Cites Families (11)
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|---|---|---|---|---|
| WO1993008815A1 (en) * | 1991-10-28 | 1993-05-13 | Cytoven | Pharmaceutical dipeptide compositions and methods of use thereof |
| JP3273314B2 (ja) * | 1998-08-12 | 2002-04-08 | 独立行政法人農業生物資源研究所 | 抗菌ペプチド及びこれを有効成分とする抗菌剤 |
| US6492326B1 (en) | 1999-04-19 | 2002-12-10 | The Procter & Gamble Company | Skin care compositions containing combination of skin care actives |
| DE10106852A1 (de) | 2001-02-14 | 2002-09-05 | T Luger | Entzündungshemmende Verbindungen |
| SE0300207D0 (sv) * | 2003-01-29 | 2003-01-29 | Karolinska Innovations Ab | New use and composition |
| EP1633380A4 (en) * | 2003-06-19 | 2010-08-11 | Yeda Res & Dev | ANTIMICROBIAL AND ANTICANCER LIPOPEPTIDES |
| JP4256389B2 (ja) | 2003-11-17 | 2009-04-22 | セダーマ | テトラペプチドとトリペプチドの混合物を含む組成物 |
| FR2870244B1 (fr) * | 2004-05-11 | 2011-01-07 | Centre Nat Rech Scient | Conjugues dipeptidiques antagonistes de l'alpha-msh |
| DE102004055541A1 (de) * | 2004-11-17 | 2006-05-18 | Henkel Kgaa | Kosmetische und dermatologische Zusammensetzungen zur Behandlung reifer Haut |
| US20100215726A1 (en) * | 2009-02-25 | 2010-08-26 | Peter Thomas Roth | Compositions for Diminishing the Appearance of Wrinkles |
| CN102329375A (zh) * | 2011-09-30 | 2012-01-25 | 中国药科大学 | 一组末端酰胺化的抗菌肽 |
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| ZA201405950B (en) | 2017-08-30 |
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| EP2827907A1 (en) | 2015-01-28 |
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| MY163100A (en) | 2017-08-04 |
| RU2627648C2 (ru) | 2017-08-09 |
| US9278994B2 (en) | 2016-03-08 |
| US20150080291A1 (en) | 2015-03-19 |
| AU2013235692B2 (en) | 2016-12-08 |
| KR20140136494A (ko) | 2014-11-28 |
| EP2827907B1 (en) | 2019-03-06 |
| DK2827907T3 (da) | 2019-06-11 |
| SG10201607784VA (en) | 2016-11-29 |
| RU2014142038A (ru) | 2016-05-10 |
| PL2827907T3 (pl) | 2019-08-30 |
| CN104379177A (zh) | 2015-02-25 |
| CA2864179A1 (en) | 2013-09-26 |
| CN104379177B (zh) | 2017-07-04 |
| SG11201405244RA (en) | 2014-10-30 |
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