CN107080831A - 短抗微生物脂肽 - Google Patents

短抗微生物脂肽 Download PDF

Info

Publication number
CN107080831A
CN107080831A CN201710009878.5A CN201710009878A CN107080831A CN 107080831 A CN107080831 A CN 107080831A CN 201710009878 A CN201710009878 A CN 201710009878A CN 107080831 A CN107080831 A CN 107080831A
Authority
CN
China
Prior art keywords
peptide
skin
acid
lipid
antimicrobial
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201710009878.5A
Other languages
English (en)
Chinese (zh)
Inventor
L.张
R.卡迈克尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Helix Biomedix Inc
Original Assignee
Helix Biomedix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Helix Biomedix Inc filed Critical Helix Biomedix Inc
Publication of CN107080831A publication Critical patent/CN107080831A/zh
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0815Tripeptides with the first amino acid being basic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06086Dipeptides with the first amino acid being basic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05Dipeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06Tripeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/33Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • A61K38/34Melanocyte stimulating hormone [MSH], e.g. alpha- or beta-melanotropin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542Carboxylic acids, e.g. a fatty acid or an amino acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/10Anti-acne agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02Local antiseptics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Birds (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
CN201710009878.5A 2012-03-20 2013-03-07 短抗微生物脂肽 Pending CN107080831A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261613212P 2012-03-20 2012-03-20
US61/613212 2012-03-20
CN201380014970.0A CN104379177B (zh) 2012-03-20 2013-03-07 短抗微生物脂肽

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201380014970.0A Division CN104379177B (zh) 2012-03-20 2013-03-07 短抗微生物脂肽

Publications (1)

Publication Number Publication Date
CN107080831A true CN107080831A (zh) 2017-08-22

Family

ID=47901428

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201380014970.0A Active CN104379177B (zh) 2012-03-20 2013-03-07 短抗微生物脂肽
CN201710009878.5A Pending CN107080831A (zh) 2012-03-20 2013-03-07 短抗微生物脂肽

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN201380014970.0A Active CN104379177B (zh) 2012-03-20 2013-03-07 短抗微生物脂肽

Country Status (18)

Country Link
US (1) US9278994B2 (enExample)
EP (1) EP2827907B1 (enExample)
JP (1) JP6261560B2 (enExample)
KR (1) KR20140136494A (enExample)
CN (2) CN104379177B (enExample)
AR (1) AR090439A1 (enExample)
AU (1) AU2013235692B2 (enExample)
CA (1) CA2864179A1 (enExample)
DK (1) DK2827907T3 (enExample)
ES (1) ES2729237T3 (enExample)
MX (1) MX2014011290A (enExample)
MY (1) MY163100A (enExample)
PL (1) PL2827907T3 (enExample)
RU (2) RU2627648C2 (enExample)
SG (2) SG10201607784VA (enExample)
TW (1) TWI541254B (enExample)
WO (1) WO2013142088A1 (enExample)
ZA (1) ZA201405950B (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10835572B2 (en) 2014-06-30 2020-11-17 Rohto Pharmaceutical Co., Ltd. Composition for external application
JP6906274B2 (ja) * 2014-06-30 2021-07-21 ロート製薬株式会社 外用組成物、眼科用組成物、抗菌剤、及び抗菌方法
US10660979B2 (en) * 2015-08-26 2020-05-26 The General Hospital Corporation System and method for electrical control of bacteria
KR101855170B1 (ko) 2015-11-18 2018-05-08 (주)노바셀테크놀로지 신규 항균 펩타이드 및 그의 용도
CN109320585B (zh) * 2018-09-06 2021-10-26 南方医科大学 一种具有专一性抗痤疮丙酸杆菌作用及抗炎作用的短脂肽
CA3112268A1 (en) * 2018-09-12 2020-03-19 The Governing Council Of The University Of Toronto Indole-oxadiazole compounds and their therapeutic use
CN111035764B (zh) * 2018-10-14 2021-09-07 深圳市健元医药科技有限公司 一种治疗类风湿性关节炎的组合物及其制备方法
CN110279844A (zh) * 2019-01-31 2019-09-27 浙江星杭泰乐生物医药有限公司 人工合成抗菌肽在制备抑菌消炎祛痘化妆品或外用药物制剂中的应用及抑菌消炎祛痘组合物
CN111303242B (zh) * 2020-02-27 2022-04-26 广州领晟医疗科技有限公司 一种KdPT的修饰肽
KR102163568B1 (ko) * 2020-08-21 2020-10-07 주식회사 비드테크 지방산 항균펩타이드 및 이를 함유하는 항균 조성물
JP2023545899A (ja) * 2020-09-29 2023-11-01 ユニリーバー・アイピー・ホールディングス・ベー・フェー アミノ酸を含むパーソナルケア組成物
US11793746B2 (en) * 2020-10-01 2023-10-24 Chanda Zaveri Intense skin hydration systems and methods
CN112679576B (zh) * 2020-11-06 2022-09-20 黄石瀚海新材料科技有限公司 抗菌脂肽、抗菌脂肽水凝胶制备方法及其应用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0979831A2 (en) * 1998-08-12 2000-02-16 JAPAN as repr. by DIR. GENERAL of NATIONAL INST. OF SERICULTURAL & ENTOMOLOGICAL SCIENCE MINISTRY OF AGR, FORESTRY & FISHERIES Antibacterial peptides and antibacterial agents containing such peptides as an effective ingredient
CN1744913A (zh) * 2003-01-29 2006-03-08 利波佩普泰德公司 Cathelicidin ll-37及其衍生物在伤口愈合中的用途
CN1893911A (zh) * 2003-11-17 2007-01-10 赛德玛公司 含有四肽和三肽混合物的配方
US20070231284A1 (en) * 2004-05-11 2007-10-04 Centre National De La Recherche Scentifique (Cnrs) Alpha-Msh-Antagonist Dipeptide Conjugates
US20100160213A1 (en) * 2003-06-19 2010-06-24 Yeda Research & Development Co. Ltd. Antimicrobial and anticancer lipopeptides
CN102329375A (zh) * 2011-09-30 2012-01-25 中国药科大学 一组末端酰胺化的抗菌肽

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993008815A1 (en) * 1991-10-28 1993-05-13 Cytoven Pharmaceutical dipeptide compositions and methods of use thereof
US6492326B1 (en) 1999-04-19 2002-12-10 The Procter & Gamble Company Skin care compositions containing combination of skin care actives
DE10106852A1 (de) 2001-02-14 2002-09-05 T Luger Entzündungshemmende Verbindungen
DE102004055541A1 (de) * 2004-11-17 2006-05-18 Henkel Kgaa Kosmetische und dermatologische Zusammensetzungen zur Behandlung reifer Haut
US20100215726A1 (en) * 2009-02-25 2010-08-26 Peter Thomas Roth Compositions for Diminishing the Appearance of Wrinkles

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0979831A2 (en) * 1998-08-12 2000-02-16 JAPAN as repr. by DIR. GENERAL of NATIONAL INST. OF SERICULTURAL & ENTOMOLOGICAL SCIENCE MINISTRY OF AGR, FORESTRY & FISHERIES Antibacterial peptides and antibacterial agents containing such peptides as an effective ingredient
CN1744913A (zh) * 2003-01-29 2006-03-08 利波佩普泰德公司 Cathelicidin ll-37及其衍生物在伤口愈合中的用途
US20100160213A1 (en) * 2003-06-19 2010-06-24 Yeda Research & Development Co. Ltd. Antimicrobial and anticancer lipopeptides
CN1893911A (zh) * 2003-11-17 2007-01-10 赛德玛公司 含有四肽和三肽混合物的配方
US20070231284A1 (en) * 2004-05-11 2007-10-04 Centre National De La Recherche Scentifique (Cnrs) Alpha-Msh-Antagonist Dipeptide Conjugates
CN102329375A (zh) * 2011-09-30 2012-01-25 中国药科大学 一组末端酰胺化的抗菌肽

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
JEAN-HUBERT CAUCHARD等: "activation of latent transforming growth factor beta 1 and inhibition of matrix metalloprotease activity by a thrombospondin-like tripeptide linked to elaidic acid", 《BIOCHEMICAL PHARMCOLOGY》 *
MARIAGRAZIA CUTULI等: "antimicrobial effects of α-MSH petides", 《JOURNAL OF LEUKOCYTE BIOLOGY》 *
李洁思等: "明胶酶与皮肤伤口愈合", 《中国麻风皮肤病杂志》 *
石冰等: "基质金属蛋白酶及其组织抑制剂与慢性创面的形成", 《中国美容医学》 *

Also Published As

Publication number Publication date
AU2013235692A1 (en) 2014-09-25
MX2014011290A (es) 2014-10-13
WO2013142088A1 (en) 2013-09-26
TWI541254B (zh) 2016-07-11
RU2017127273A (ru) 2019-02-04
ZA201405950B (en) 2017-08-30
HK1204453A1 (en) 2015-11-20
JP2015512386A (ja) 2015-04-27
AR090439A1 (es) 2014-11-12
JP6261560B2 (ja) 2018-01-17
EP2827907A1 (en) 2015-01-28
ES2729237T3 (es) 2019-10-31
TW201339176A (zh) 2013-10-01
MY163100A (en) 2017-08-04
RU2627648C2 (ru) 2017-08-09
US9278994B2 (en) 2016-03-08
US20150080291A1 (en) 2015-03-19
AU2013235692B2 (en) 2016-12-08
KR20140136494A (ko) 2014-11-28
EP2827907B1 (en) 2019-03-06
DK2827907T3 (da) 2019-06-11
SG10201607784VA (en) 2016-11-29
RU2014142038A (ru) 2016-05-10
PL2827907T3 (pl) 2019-08-30
CN104379177A (zh) 2015-02-25
CA2864179A1 (en) 2013-09-26
CN104379177B (zh) 2017-07-04
SG11201405244RA (en) 2014-10-30

Similar Documents

Publication Publication Date Title
CN107080831A (zh) 短抗微生物脂肽
US8871716B2 (en) Use of antimicrobial peptides in regeneration of skin cells
JP2011521970A (ja) 皮膚化粧用組成物におけるオリゴマーバイオサーファクタント
JP2024075684A (ja) 皮膚症状を改善するためのポリペプチドおよび方法
CN105120884B (zh) 用于促进伤口愈合的短生物活性肽
US20110269695A1 (en) Novel anti-aging peptides and cosmetic and/or pharmaceutical composition containing same
KR20130032788A (ko) 발모 촉진용 펩타이드 및 이의 용도
KR20210075098A (ko) 피부 노화 및 광 노화 치료 및 예방에 사용하기 위한 펩타이드
US8450456B2 (en) Activating peptide of the synthesis of aquaporins and cosmetic and/or pharmaceutical composition containing it
CN104428036A (zh) 多肽及其用途
EP4380599A1 (en) Composition for the prevention and/or treatment of acne
EP3329905A1 (en) Topical cosmetic compositions comprising an oligopeptide against anti-aging of the skin
JP7016886B2 (ja) イソトレチノインとペプチドの結合体
US8304392B2 (en) Pharmaceutical and/or cosmetic composition containing an active principle activator of cytochrome C
KR20150072144A (ko) 항균펩타이드 베타-디펜신 3 및 3h의 라우릭산 융합을 통한 장기지속형 유도체, 세포투과성 펩타이드 융합을 통한 피부투과형 유도체 개발과 이를 함유하는 화장료 조성물
JP7503503B2 (ja) 炎症性成分を有する皮膚または粘膜の罹患を予防および処置するための化合物
EP3831358A1 (en) Peptides and compositions for use in cosmetics and medicine
HK1204453B (en) Short antimicrobial lipopeptides
KR20180125419A (ko) 이소트레티노인과 펩타이드의 결합체

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20170822