RU2627648C2 - Короткие антимикробные липопептиды - Google Patents

Короткие антимикробные липопептиды Download PDF

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Publication number
RU2627648C2
RU2627648C2 RU2014142038A RU2014142038A RU2627648C2 RU 2627648 C2 RU2627648 C2 RU 2627648C2 RU 2014142038 A RU2014142038 A RU 2014142038A RU 2014142038 A RU2014142038 A RU 2014142038A RU 2627648 C2 RU2627648 C2 RU 2627648C2
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RU
Russia
Prior art keywords
skin
proline
lysine
peptides
lipid
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Application number
RU2014142038A
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English (en)
Russian (ru)
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RU2014142038A (ru
Inventor
Лицзюань ЧЖАН
Робин КАРМАЙКЛ
Original Assignee
Хеликс Байомедикс, Инк.
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Publication of RU2014142038A publication Critical patent/RU2014142038A/ru
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • A61K38/34—Melanocyte stimulating hormone [MSH], e.g. alpha- or beta-melanotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pulmonology (AREA)
  • Birds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
RU2014142038A 2012-03-20 2013-03-07 Короткие антимикробные липопептиды RU2627648C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261613212P 2012-03-20 2012-03-20
US61/613,212 2012-03-20
PCT/US2013/029696 WO2013142088A1 (en) 2012-03-20 2013-03-07 Short antimicrobial lipopeptides

Related Child Applications (1)

Application Number Title Priority Date Filing Date
RU2017127273A Division RU2017127273A (ru) 2012-03-20 2013-03-07 Короткие антимикробные липопептиды

Publications (2)

Publication Number Publication Date
RU2014142038A RU2014142038A (ru) 2016-05-10
RU2627648C2 true RU2627648C2 (ru) 2017-08-09

Family

ID=47901428

Family Applications (2)

Application Number Title Priority Date Filing Date
RU2014142038A RU2627648C2 (ru) 2012-03-20 2013-03-07 Короткие антимикробные липопептиды
RU2017127273A RU2017127273A (ru) 2012-03-20 2013-03-07 Короткие антимикробные липопептиды

Family Applications After (1)

Application Number Title Priority Date Filing Date
RU2017127273A RU2017127273A (ru) 2012-03-20 2013-03-07 Короткие антимикробные липопептиды

Country Status (18)

Country Link
US (1) US9278994B2 (enExample)
EP (1) EP2827907B1 (enExample)
JP (1) JP6261560B2 (enExample)
KR (1) KR20140136494A (enExample)
CN (2) CN107080831A (enExample)
AR (1) AR090439A1 (enExample)
AU (1) AU2013235692B2 (enExample)
CA (1) CA2864179A1 (enExample)
DK (1) DK2827907T3 (enExample)
ES (1) ES2729237T3 (enExample)
MX (1) MX2014011290A (enExample)
MY (1) MY163100A (enExample)
PL (1) PL2827907T3 (enExample)
RU (2) RU2627648C2 (enExample)
SG (2) SG10201607784VA (enExample)
TW (1) TWI541254B (enExample)
WO (1) WO2013142088A1 (enExample)
ZA (1) ZA201405950B (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6906274B2 (ja) * 2014-06-30 2021-07-21 ロート製薬株式会社 外用組成物、眼科用組成物、抗菌剤、及び抗菌方法
WO2016002767A1 (ja) * 2014-06-30 2016-01-07 ロート製薬株式会社 外用組成物
US10660979B2 (en) * 2015-08-26 2020-05-26 The General Hospital Corporation System and method for electrical control of bacteria
KR101855170B1 (ko) * 2015-11-18 2018-05-08 (주)노바셀테크놀로지 신규 항균 펩타이드 및 그의 용도
CN109320585B (zh) * 2018-09-06 2021-10-26 南方医科大学 一种具有专一性抗痤疮丙酸杆菌作用及抗炎作用的短脂肽
CA3112268A1 (en) * 2018-09-12 2020-03-19 The Governing Council Of The University Of Toronto Indole-oxadiazole compounds and their therapeutic use
CN111035764B (zh) * 2018-10-14 2021-09-07 深圳市健元医药科技有限公司 一种治疗类风湿性关节炎的组合物及其制备方法
CN110279844A (zh) * 2019-01-31 2019-09-27 浙江星杭泰乐生物医药有限公司 人工合成抗菌肽在制备抑菌消炎祛痘化妆品或外用药物制剂中的应用及抑菌消炎祛痘组合物
CN111303242B (zh) * 2020-02-27 2022-04-26 广州领晟医疗科技有限公司 一种KdPT的修饰肽
KR102163568B1 (ko) * 2020-08-21 2020-10-07 주식회사 비드테크 지방산 항균펩타이드 및 이를 함유하는 항균 조성물
MX2023003595A (es) * 2020-09-29 2023-04-05 Unilever Ip Holdings B V Una composicion para el cuidado personal que comprende aminoacidos.
US11793746B2 (en) * 2020-10-01 2023-10-24 Chanda Zaveri Intense skin hydration systems and methods
CN112679576B (zh) * 2020-11-06 2022-09-20 黄石瀚海新材料科技有限公司 抗菌脂肽、抗菌脂肽水凝胶制备方法及其应用
CN121471309B (zh) * 2026-01-05 2026-07-07 中国科学院理化技术研究所 一种菌群友好型选择性抗真菌肽hri及其应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993008815A1 (en) * 1991-10-28 1993-05-13 Cytoven Pharmaceutical dipeptide compositions and methods of use thereof
RU2007122285A (ru) * 2004-11-17 2008-12-27 Хенкель Коммандитгезелльшафт Ауф Акциен (DE) Косметические и дерматологические композиции для лечения зрелой кожи
US20100215726A1 (en) * 2009-02-25 2010-08-26 Peter Thomas Roth Compositions for Diminishing the Appearance of Wrinkles

Family Cites Families (8)

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JP3273314B2 (ja) * 1998-08-12 2002-04-08 独立行政法人農業生物資源研究所 抗菌ペプチド及びこれを有効成分とする抗菌剤
US6492326B1 (en) 1999-04-19 2002-12-10 The Procter & Gamble Company Skin care compositions containing combination of skin care actives
DE10106852A1 (de) 2001-02-14 2002-09-05 T Luger Entzündungshemmende Verbindungen
SE0300207D0 (sv) * 2003-01-29 2003-01-29 Karolinska Innovations Ab New use and composition
US7671011B2 (en) * 2003-06-19 2010-03-02 Yeda Research & Development Co. Ltd. Antimicrobial and anticancer lipopeptides
KR101045658B1 (ko) * 2003-11-17 2011-07-01 쎄데르마 테트라펩티드 및 트리펩티드 혼합물을 포함하는 조성물
FR2870244B1 (fr) * 2004-05-11 2011-01-07 Centre Nat Rech Scient Conjugues dipeptidiques antagonistes de l'alpha-msh
CN102329375A (zh) * 2011-09-30 2012-01-25 中国药科大学 一组末端酰胺化的抗菌肽

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993008815A1 (en) * 1991-10-28 1993-05-13 Cytoven Pharmaceutical dipeptide compositions and methods of use thereof
RU2007122285A (ru) * 2004-11-17 2008-12-27 Хенкель Коммандитгезелльшафт Ауф Акциен (DE) Косметические и дерматологические композиции для лечения зрелой кожи
US20100215726A1 (en) * 2009-02-25 2010-08-26 Peter Thomas Roth Compositions for Diminishing the Appearance of Wrinkles

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CUTULI M., et al., Antimicrobial effects of alpha-MSH peptides.J Leukoc Biol. 2000 Feb;67(2):233-9. БЕЛИКОВ В.Г., Фармацевтическая химия, М., Высшая школа, 1993, с. 43-47. *

Also Published As

Publication number Publication date
AU2013235692B2 (en) 2016-12-08
AR090439A1 (es) 2014-11-12
PL2827907T3 (pl) 2019-08-30
JP2015512386A (ja) 2015-04-27
ES2729237T3 (es) 2019-10-31
TWI541254B (zh) 2016-07-11
TW201339176A (zh) 2013-10-01
CN107080831A (zh) 2017-08-22
CA2864179A1 (en) 2013-09-26
CN104379177B (zh) 2017-07-04
SG11201405244RA (en) 2014-10-30
KR20140136494A (ko) 2014-11-28
MY163100A (en) 2017-08-04
JP6261560B2 (ja) 2018-01-17
US20150080291A1 (en) 2015-03-19
SG10201607784VA (en) 2016-11-29
CN104379177A (zh) 2015-02-25
DK2827907T3 (da) 2019-06-11
AU2013235692A1 (en) 2014-09-25
EP2827907A1 (en) 2015-01-28
RU2014142038A (ru) 2016-05-10
EP2827907B1 (en) 2019-03-06
ZA201405950B (en) 2017-08-30
RU2017127273A (ru) 2019-02-04
WO2013142088A1 (en) 2013-09-26
HK1204453A1 (en) 2015-11-20
US9278994B2 (en) 2016-03-08
MX2014011290A (es) 2014-10-13

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Effective date: 20200308