TWI535440B - 包括吲哚化合物之醫藥組成物 - Google Patents
包括吲哚化合物之醫藥組成物 Download PDFInfo
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- TWI535440B TWI535440B TW102147720A TW102147720A TWI535440B TW I535440 B TWI535440 B TW I535440B TW 102147720 A TW102147720 A TW 102147720A TW 102147720 A TW102147720 A TW 102147720A TW I535440 B TWI535440 B TW I535440B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
- A61K8/492—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid having condensed rings, e.g. indol
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Birds (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Biotechnology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20090101978 | 2009-10-26 | ||
| KR20100098511 | 2010-10-08 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201414473A TW201414473A (zh) | 2014-04-16 |
| TWI535440B true TWI535440B (zh) | 2016-06-01 |
Family
ID=43922791
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW102147720A TWI535440B (zh) | 2009-10-26 | 2010-10-22 | 包括吲哚化合物之醫藥組成物 |
| TW099136045A TW201119651A (en) | 2009-10-26 | 2010-10-22 | Pharmaceutical composition comprising indole compound |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW099136045A TW201119651A (en) | 2009-10-26 | 2010-10-22 | Pharmaceutical composition comprising indole compound |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20120214804A1 (https=) |
| EP (1) | EP2493469A4 (https=) |
| JP (1) | JP5820813B2 (https=) |
| KR (1) | KR101325272B1 (https=) |
| CN (1) | CN102596198B (https=) |
| AR (1) | AR078775A1 (https=) |
| BR (1) | BR112012009894A2 (https=) |
| MX (1) | MX338807B (https=) |
| RU (1) | RU2557243C2 (https=) |
| TR (1) | TR201204895T1 (https=) |
| TW (2) | TWI535440B (https=) |
| WO (1) | WO2011052950A2 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101304772B1 (ko) * | 2011-04-11 | 2013-09-05 | 인제대학교 산학협력단 | NecroX―5를 유효성분으로 포함하는 미토콘드리아 기능 조절용 조성물 |
| WO2013115457A1 (ko) * | 2012-01-31 | 2013-08-08 | 인제대학교 산학협력단 | NecroX를 함유하는 암 전이 억제용 조성물 |
| KR101400346B1 (ko) * | 2012-01-31 | 2014-05-30 | 인제대학교 산학협력단 | NecroX를 함유하는 암 전이 억제용 조성물 |
| RU2664696C2 (ru) * | 2014-04-18 | 2018-08-21 | ЭлДжи КЕМ, ЛТД. | Композиция для предотвращения или лечения жировых болезней печени |
| CA2953387C (en) | 2014-06-30 | 2023-11-28 | The Regents Of The University Of California | Ketobutyrate compounds and compositions for treating age-related symptoms and diseases |
| KR101633703B1 (ko) * | 2014-12-30 | 2016-06-27 | 한국원자력의학원 | necro X-5를 유효성분으로 포함하는 방사선 조사에 의한 세포손상 예방 또는 치료용 조성물 |
| CN107434819B (zh) * | 2017-02-15 | 2020-03-17 | 河北医科大学第二医院 | 吲哚-tempo缀合物及其在保护远隔器官对抗缺血再灌注损伤中的用途 |
| CN115109116A (zh) * | 2017-08-17 | 2022-09-27 | 凯瑞康宁生物工程(武汉)有限公司 | 活性氧清除剂衍生物的制备及用途 |
| WO2019041361A1 (en) | 2017-09-04 | 2019-03-07 | Xw Laboratories, Inc. | PREPARATION AND USE OF A REACTIVE OXYGEN SPECIES TRAPPER |
| CN113692443B (zh) | 2018-12-06 | 2024-08-06 | 国立癌症中心 | 包含nc886的用于增强溶瘤病毒活性或用于促进溶瘤病毒生产的组合物 |
| US11795147B2 (en) | 2019-08-26 | 2023-10-24 | Boehringer Ingelheim International Gmbh | Modulators of complex I |
| WO2022039506A1 (ko) | 2020-08-19 | 2022-02-24 | 주식회사 미토이뮨테라퓨틱스 | Mabc-r 감염에 의한 병적 염증 치료제로서의 미토콘드리아 표적 항산화제 |
| EP4324830A4 (en) | 2021-04-12 | 2025-04-16 | MitoImmune Therapeutics Inc. | NEW CRYSTAL FORM OF 5-[(1,1-DIOXIDO-4-THIOMORPHOLINYL)METHYL)-2-PHENYL-N-(TETRAHYDRO-2H-PYRAN-4-YL)-1H-INDOLE-7-AMINE |
| EP4324829A4 (en) | 2021-04-12 | 2025-04-23 | MitoImmune Therapeutics Inc. | 5-[(1,1-DIOXIDO-4-THIOMORPHOLINYL)METHYL]-2-PHENYL-N-(TETRAHYDRO-2H-PYRAN-4-YL)-1H-INDOL-7-AMINE SULFATE AND A NEW CRYSTALLINE FORM THEREOF |
| KR20230140401A (ko) * | 2022-03-25 | 2023-10-06 | 주식회사 미토이뮨테라퓨틱스 | 항바이러스용 약학적 조성물 및 이의 용도 |
| DE102023204801A1 (de) * | 2023-05-23 | 2024-11-28 | Continental Reifen Deutschland Gmbh | Verbindung als Alterungsschutzmittel in Kautschukmischungen und Fahrzeugreifen |
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| US6420429B1 (en) * | 1997-12-23 | 2002-07-16 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Brain targeted low molecular weight hydrophobic antioxidant compounds |
| US6348484B1 (en) * | 1997-09-05 | 2002-02-19 | Lead Chemical Co., Ltd. | Stereoisomeric indole compounds, process for the preparation of the same, and use thereof |
| ATE276241T1 (de) * | 1998-11-25 | 2004-10-15 | Yissum Res Dev Co | Antioxidationsmittel |
| IL130169A (en) * | 1999-05-27 | 2006-08-20 | Neurim Pharma 1991 | Indole derivatives, and pharmaceutical preparations, skin protection preparations, and cosmetics containing them |
| PE20040079A1 (es) * | 2002-04-03 | 2004-04-19 | Novartis Ag | Derivados de indolilmaleimida |
| DE10217006A1 (de) * | 2002-04-16 | 2003-11-06 | Merck Patent Gmbh | Substituierte Indole |
| EP2308839B1 (en) | 2005-04-20 | 2017-03-01 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compounds |
| US20090234011A1 (en) * | 2005-04-21 | 2009-09-17 | Goldstein Glenn A | N-acetylcysteine amide (nac amide) for the treatment of diseases and conditions associated with oxidative stress |
| US20070161609A1 (en) * | 2006-01-10 | 2007-07-12 | Charles Buck | Use of mitochondrially targeted antioxidant in treatment and prevention of drug-induced liver disease |
| CN101801965B (zh) * | 2007-08-17 | 2014-07-30 | 株式会社Lg生命科学 | 作为细胞坏死抑制剂的吲哚化合物 |
| RU2450001C2 (ru) * | 2007-12-20 | 2012-05-10 | Эл Джи Лайф Сайенсиз Лтд. | Активаторы глюкокиназы и фармацевтические композиции, содержащие их в качестве активного ингредиента |
| EP2230238B1 (en) | 2008-01-04 | 2013-12-11 | LG Life Sciences Ltd. | Indole and indazole derivatives having a cell-, tissue- and organ-preserving effect |
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- 2010-10-25 WO PCT/KR2010/007344 patent/WO2011052950A2/en not_active Ceased
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- 2010-10-25 JP JP2012536664A patent/JP5820813B2/ja active Active
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| EP2493469A2 (en) | 2012-09-05 |
| RU2012121815A (ru) | 2013-12-10 |
| JP2013508452A (ja) | 2013-03-07 |
| WO2011052950A2 (en) | 2011-05-05 |
| KR20110046321A (ko) | 2011-05-04 |
| TR201204895T1 (tr) | 2013-01-21 |
| TW201414473A (zh) | 2014-04-16 |
| CN102596198B (zh) | 2016-01-27 |
| TW201119651A (en) | 2011-06-16 |
| JP5820813B2 (ja) | 2015-11-24 |
| MX338807B (es) | 2016-05-02 |
| US20120214804A1 (en) | 2012-08-23 |
| US20170165272A1 (en) | 2017-06-15 |
| BR112012009894A2 (pt) | 2016-11-29 |
| AR078775A1 (es) | 2011-11-30 |
| EP2493469A4 (en) | 2013-05-29 |
| CN102596198A (zh) | 2012-07-18 |
| US10322135B2 (en) | 2019-06-18 |
| MX2012004504A (es) | 2012-09-07 |
| KR101325272B1 (ko) | 2013-11-05 |
| WO2011052950A3 (en) | 2011-11-24 |
| RU2557243C2 (ru) | 2015-07-20 |
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