CN102596198B - 包含吲哚化合物的药物组合物 - Google Patents

包含吲哚化合物的药物组合物 Download PDF

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CN102596198B
CN102596198B CN201080048324.2A CN201080048324A CN102596198B CN 102596198 B CN102596198 B CN 102596198B CN 201080048324 A CN201080048324 A CN 201080048324A CN 102596198 B CN102596198 B CN 102596198B
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alkyl
formula
compound
represents hydrogen
halogen
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CN102596198A (zh
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金淳河
金亨秦
朴喜戌
具善领
郭孝信
朴斗喜
金孝洙
赵显宰
金志炫
金珠英
朴光敏
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LG Chem Ltd
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LG Life Sciences Ltd
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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CN201080048324.2A 2009-10-26 2010-10-25 包含吲哚化合物的药物组合物 Active CN102596198B (zh)

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Application Number Priority Date Filing Date Title
KR20090101978 2009-10-26
KR10-2009-0101978 2009-10-26
KR10-2010-0098511 2010-10-08
KR20100098511 2010-10-08
PCT/KR2010/007344 WO2011052950A2 (en) 2009-10-26 2010-10-25 Pharmaceutical composition comprising indole compound

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CN102596198A CN102596198A (zh) 2012-07-18
CN102596198B true CN102596198B (zh) 2016-01-27

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US (2) US20120214804A1 (https=)
EP (1) EP2493469A4 (https=)
JP (1) JP5820813B2 (https=)
KR (1) KR101325272B1 (https=)
CN (1) CN102596198B (https=)
AR (1) AR078775A1 (https=)
BR (1) BR112012009894A2 (https=)
MX (1) MX338807B (https=)
RU (1) RU2557243C2 (https=)
TR (1) TR201204895T1 (https=)
TW (2) TWI535440B (https=)
WO (1) WO2011052950A2 (https=)

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KR101304772B1 (ko) * 2011-04-11 2013-09-05 인제대학교 산학협력단 ＮｅｃｒｏＸ―５를 유효성분으로 포함하는 미토콘드리아 기능 조절용 조성물
WO2013115457A1 (ko) * 2012-01-31 2013-08-08 인제대학교 산학협력단 ＮｅｃｒｏＸ를 함유하는 암 전이 억제용 조성물
KR101400346B1 (ko) * 2012-01-31 2014-05-30 인제대학교 산학협력단 ＮｅｃｒｏＸ를 함유하는 암 전이 억제용 조성물
RU2664696C2 (ru) * 2014-04-18 2018-08-21 ЭлДжи КЕМ, ЛТД. Композиция для предотвращения или лечения жировых болезней печени
CA2953387C (en) 2014-06-30 2023-11-28 The Regents Of The University Of California Ketobutyrate compounds and compositions for treating age-related symptoms and diseases
KR101633703B1 (ko) * 2014-12-30 2016-06-27 한국원자력의학원 necro X-5를 유효성분으로 포함하는 방사선 조사에 의한 세포손상 예방 또는 치료용 조성물
CN107434819B (zh) * 2017-02-15 2020-03-17 河北医科大学第二医院 吲哚-tempo缀合物及其在保护远隔器官对抗缺血再灌注损伤中的用途
CN115109116A (zh) * 2017-08-17 2022-09-27 凯瑞康宁生物工程（武汉）有限公司 活性氧清除剂衍生物的制备及用途
WO2019041361A1 (en) 2017-09-04 2019-03-07 Xw Laboratories, Inc. PREPARATION AND USE OF A REACTIVE OXYGEN SPECIES TRAPPER
CN113692443B (zh) 2018-12-06 2024-08-06 国立癌症中心 包含nc886的用于增强溶瘤病毒活性或用于促进溶瘤病毒生产的组合物
US11795147B2 (en) 2019-08-26 2023-10-24 Boehringer Ingelheim International Gmbh Modulators of complex I
WO2022039506A1 (ko) 2020-08-19 2022-02-24 주식회사 미토이뮨테라퓨틱스 Ｍabc-r 감염에 의한 병적 염증 치료제로서의 미토콘드리아 표적 항산화제
EP4324830A4 (en) 2021-04-12 2025-04-16 MitoImmune Therapeutics Inc. NEW CRYSTAL FORM OF 5-[(1,1-DIOXIDO-4-THIOMORPHOLINYL)METHYL)-2-PHENYL-N-(TETRAHYDRO-2H-PYRAN-4-YL)-1H-INDOLE-7-AMINE
EP4324829A4 (en) 2021-04-12 2025-04-23 MitoImmune Therapeutics Inc. 5-[(1,1-DIOXIDO-4-THIOMORPHOLINYL)METHYL]-2-PHENYL-N-(TETRAHYDRO-2H-PYRAN-4-YL)-1H-INDOL-7-AMINE SULFATE AND A NEW CRYSTALLINE FORM THEREOF
KR20230140401A (ko) * 2022-03-25 2023-10-06 주식회사 미토이뮨테라퓨틱스 항바이러스용 약학적 조성물 및 이의 용도
DE102023204801A1 (de) * 2023-05-23 2024-11-28 Continental Reifen Deutschland Gmbh Verbindung als Alterungsschutzmittel in Kautschukmischungen und Fahrzeugreifen

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009025478A1 (en) * 2007-08-17 2009-02-26 Lg Life Sciences Ltd. Indole and indazole compounds as an inhibitor of cellular necrosis
WO2009088192A2 (ko) * 2008-01-04 2009-07-16 Lg Life Sciences Ltd. 세포, 조직 및 장기 보존 효과를 갖는 인돌 및 인다졸 유도체

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6420429B1 (en) * 1997-12-23 2002-07-16 Yissum Research Development Company Of The Hebrew University Of Jerusalem Brain targeted low molecular weight hydrophobic antioxidant compounds
US6348484B1 (en) * 1997-09-05 2002-02-19 Lead Chemical Co., Ltd. Stereoisomeric indole compounds, process for the preparation of the same, and use thereof
ATE276241T1 (de) * 1998-11-25 2004-10-15 Yissum Res Dev Co Antioxidationsmittel
IL130169A (en) * 1999-05-27 2006-08-20 Neurim Pharma 1991 Indole derivatives, and pharmaceutical preparations, skin protection preparations, and cosmetics containing them
PE20040079A1 (es) * 2002-04-03 2004-04-19 Novartis Ag Derivados de indolilmaleimida
DE10217006A1 (de) * 2002-04-16 2003-11-06 Merck Patent Gmbh Substituierte Indole
EP2308839B1 (en) 2005-04-20 2017-03-01 Takeda Pharmaceutical Company Limited Fused heterocyclic compounds
US20090234011A1 (en) * 2005-04-21 2009-09-17 Goldstein Glenn A N-acetylcysteine amide (nac amide) for the treatment of diseases and conditions associated with oxidative stress
US20070161609A1 (en) * 2006-01-10 2007-07-12 Charles Buck Use of mitochondrially targeted antioxidant in treatment and prevention of drug-induced liver disease
RU2450001C2 (ru) * 2007-12-20 2012-05-10 Эл Джи Лайф Сайенсиз Лтд. Активаторы глюкокиназы и фармацевтические композиции, содержащие их в качестве активного ингредиента

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009025478A1 (en) * 2007-08-17 2009-02-26 Lg Life Sciences Ltd. Indole and indazole compounds as an inhibitor of cellular necrosis
WO2009088192A2 (ko) * 2008-01-04 2009-07-16 Lg Life Sciences Ltd. 세포, 조직 및 장기 보존 효과를 갖는 인돌 및 인다졸 유도체

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