TWI532495B - 藥學製劑 - Google Patents
藥學製劑Info
- Publication number
- TWI532495B TWI532495B TW099132570A TW99132570A TWI532495B TW I532495 B TWI532495 B TW I532495B TW 099132570 A TW099132570 A TW 099132570A TW 99132570 A TW99132570 A TW 99132570A TW I532495 B TWI532495 B TW I532495B
- Authority
- TW
- Taiwan
- Prior art keywords
- sialic acid
- hcg
- sialylation
- glycosidation
- rhcg
- Prior art date
Links
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1081—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Reproductive Health (AREA)
- Wood Science & Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Diabetes (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09252360 | 2009-10-05 |
Publications (2)
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| TW201113030A TW201113030A (en) | 2011-04-16 |
| TWI532495B true TWI532495B (zh) | 2016-05-11 |
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| TW099132570A TWI532495B (zh) | 2009-10-05 | 2010-09-27 | 藥學製劑 |
| TW104140348A TWI604850B (zh) | 2009-10-05 | 2010-09-27 | 藥學製劑 |
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| Application Number | Title | Priority Date | Filing Date |
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| TW104140348A TWI604850B (zh) | 2009-10-05 | 2010-09-27 | 藥學製劑 |
Country Status (25)
| Country | Link |
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| US (5) | US8975226B2 (enEXAMPLES) |
| EP (2) | EP2486051B1 (enEXAMPLES) |
| JP (6) | JP6176924B2 (enEXAMPLES) |
| KR (7) | KR102213154B1 (enEXAMPLES) |
| CN (1) | CN107050434B (enEXAMPLES) |
| AR (2) | AR079876A1 (enEXAMPLES) |
| AU (1) | AU2010304922B2 (enEXAMPLES) |
| BR (1) | BR112012007990A2 (enEXAMPLES) |
| CA (1) | CA2776790A1 (enEXAMPLES) |
| DK (1) | DK2486051T3 (enEXAMPLES) |
| ES (2) | ES3036152T3 (enEXAMPLES) |
| HR (1) | HRP20200941T1 (enEXAMPLES) |
| HU (1) | HUE050793T2 (enEXAMPLES) |
| IL (3) | IL218548A (enEXAMPLES) |
| IN (1) | IN2012DN02073A (enEXAMPLES) |
| JO (1) | JOP20200039A1 (enEXAMPLES) |
| LT (1) | LT2486051T (enEXAMPLES) |
| MX (1) | MX2012003951A (enEXAMPLES) |
| PL (1) | PL2486051T3 (enEXAMPLES) |
| PT (1) | PT2486051T (enEXAMPLES) |
| RS (1) | RS60413B1 (enEXAMPLES) |
| RU (2) | RU2724528C2 (enEXAMPLES) |
| SI (1) | SI2486051T1 (enEXAMPLES) |
| TW (2) | TWI532495B (enEXAMPLES) |
| WO (1) | WO2011042688A1 (enEXAMPLES) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| TWI488640B (zh) | 2008-04-16 | 2015-06-21 | Ferring Int Ct Sa | 藥學製劑 |
| TWI532495B (zh) * | 2009-10-05 | 2016-05-11 | 菲瑞茵國際中心股份有限公司 | 藥學製劑 |
| CA3163525A1 (en) * | 2011-03-31 | 2012-10-04 | Ferring Bv. | Pharmaceutical preparation |
| WO2012168680A1 (en) * | 2011-06-06 | 2012-12-13 | Ferring B.V. | Pharmaceutical preparation comprising recombinant fsh |
| JO3092B1 (ar) * | 2011-08-08 | 2017-03-15 | Ferring Bv | مركب لتحفيز مسيطر عليه للمبيض |
| WO2013093760A2 (en) * | 2011-12-19 | 2013-06-27 | Grifols, S.A. | Compositions, methods, and kits for preparing sialylated recombinant proteins |
| CN108646019B (zh) | 2012-12-10 | 2021-06-25 | 生化学工业株式会社 | 新重组因子c、其制造方法、及内毒素的测定法 |
| EP3237608B1 (en) * | 2014-12-22 | 2019-10-09 | F. Hoffmann-La Roche AG | Cmp-dependent sialidase activity |
| WO2016170113A1 (en) * | 2015-04-24 | 2016-10-27 | Ferring B.V. | Method of production of gonadotrophin |
| JP6845813B2 (ja) * | 2015-06-26 | 2021-03-24 | フェリング ベスローテン フェンノートシャップ | 精製および／またはウイルス不活性化の方法 |
| HRP20250452T1 (hr) | 2018-04-30 | 2025-06-06 | Ferring B.V. | Pripravak za kontroliranu stimulaciju jajnika |
| CN115023436A (zh) * | 2020-02-05 | 2022-09-06 | 诺华股份有限公司 | 表达il-15异二聚体的cho细胞 |
| CN116199742B (zh) * | 2022-07-06 | 2025-01-24 | 华兰基因工程有限公司 | 一种重组人绒毛膜促性腺激素Fc融合蛋白制备方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US4840896A (en) * | 1983-11-02 | 1989-06-20 | Integrated Genetics, Inc. | Heteropolymeric protein |
| DK49987A (da) * | 1987-01-30 | 1988-07-31 | Nordisk Gentofte | Fremgangsmaade til behandling af infertilitet og middel til anvendelse ved fremgangsmaaden |
| IT1206302B (it) | 1987-06-26 | 1989-04-14 | Serono Cesare Ist Ricerca | Ormone follicolo-stimolante urinario |
| JP4165718B2 (ja) * | 1995-03-21 | 2008-10-15 | ラボラトワール セローノ ソシエテ アノニム | ｈＣＧ液体製剤 |
| TW518235B (en) * | 1997-01-15 | 2003-01-21 | Akzo Nobel Nv | A gonadotropin-containing pharmaceutical composition with improved stability on prolong storage |
| ZA985545B (en) | 1997-06-25 | 1999-04-01 | Applied Research Systems | Disulfide crosslinking glycoprotein hormone analogs and their preparation and use |
| US6500627B1 (en) | 1998-02-03 | 2002-12-31 | The Trustees Of Columbia University In The City Of New York | Methods for predicting pregnancy outcome in a subject by HCG assay |
| WO2003050286A1 (en) * | 2001-10-29 | 2003-06-19 | Crucell Holland B.V. | Methods and means for producing proteins with predetermined post-translational modifications |
| ES2267531T5 (es) | 1999-05-07 | 2015-11-24 | Merck Serono Sa | Uso de LH administrada en la fase folicular media o tardía para el tratamiento de mujeres anovulatorias |
| UA86938C2 (uk) * | 2000-02-22 | 2009-06-10 | Эплайд Рисьорч Системз ЭРС Холдинг Н.В. | РЕКОМБІНАНТНИЙ hCG ТА ЙОГО ЗАСТОСУВАННЯ ДЛЯ ВИГОТОВЛЕННЯ ЛІКАРСЬКОГО ЗАСОБУ ДЛЯ ЛІКУВАННЯ РОЗЛАДІВ, ПОВ'ЯЗАНИХ З БЕЗПЛІДНІСТЮ |
| CN100536912C (zh) | 2001-09-12 | 2009-09-09 | 雪兰诺实验室有限公司 | 人绒毛膜促性腺激素在控制性超排卵中的应用 |
| ATE329930T1 (de) | 2001-10-22 | 2006-07-15 | Applied Research Systems | Fsh-zusammensetzungen mit hohem sialylierungsgrad und deren verwendung zur herstellung von arzneimitteln |
| CA2465007C (en) | 2001-10-29 | 2012-01-17 | Crucell Holland B.V. | Methods and means for producing proteins with predetermined post-translational modifications |
| CN1374525A (zh) * | 2001-12-31 | 2002-10-16 | 陕西超英生物医学研究开发有限公司 | 一种抗体芯片、其制备技术及其检测方法 |
| CA2517487A1 (en) | 2003-04-01 | 2004-10-14 | Applied Research Systems Ars Holding N.V. | Inhibitors of phosphodiesterases in infertility |
| EP2338333B1 (en) * | 2003-04-09 | 2017-09-06 | ratiopharm GmbH | Glycopegylation methods and proteins/peptides produced by the methods |
| US20040248784A1 (en) * | 2003-06-03 | 2004-12-09 | Marco Filicori | Unitary combinations of FSH and hCG |
| JP4518464B2 (ja) | 2003-06-30 | 2010-08-04 | ミヨシ油脂株式会社 | 紙類処理剤及び紙類 |
| PL1654353T3 (pl) * | 2003-08-18 | 2013-11-29 | Glycotope Gmbh | Nowotworowe linie komórkowe NM-F9 (DSM ACC2606) i NM-D4 (DSM ACC2605) oraz ich zastosowanie |
| CA2554968C (en) | 2004-02-04 | 2012-03-27 | Centre National De La Recherche Scientifique | Process for screening glycoform-specific antibodies |
| WO2005080585A1 (en) * | 2004-02-13 | 2005-09-01 | Glycotope Gmbh | Highly active glycoproteins-process conditions and an efficient method for their production |
| AU2006222187A1 (en) * | 2005-03-11 | 2006-09-14 | Fresenius Kabi Deutschland Gmbh | Production of bioactive glycoproteins from inactive starting material by conjugation with hydroxyalkylstarch |
| JP2009504985A (ja) * | 2005-08-15 | 2009-02-05 | シーメンス ヴィディーオー オートモーティヴ コーポレイション | ディーゼル車排気への炭化水素計量弁 |
| RU2309411C2 (ru) * | 2005-11-24 | 2007-10-27 | Ростовский НИИ акушерства и педиатрии МЗ РФ | Способ отбора пациенток с синдромом "пустых" фолликулов для проведения программы эко и пэ донорскими ооцитами |
| KR100809945B1 (ko) * | 2006-02-01 | 2008-03-05 | 대한민국 | 인체장내정상세균총 특이반응 ｄｎａ칩 및 이를 이용한인체장내정상세균총의 변화에 의한 인체 위해성의 평가방법 |
| US20080242607A1 (en) * | 2006-07-21 | 2008-10-02 | Neose Technologies, Inc. | Glycosylation of peptides via o-linked glycosylation sequences |
| JP2010505874A (ja) * | 2006-10-03 | 2010-02-25 | ノヴォ ノルディスク アー／エス | ポリペプチドコンジュゲートの精製方法 |
| TWI488640B (zh) * | 2008-04-16 | 2015-06-21 | Ferring Int Ct Sa | 藥學製劑 |
| TWI532495B (zh) | 2009-10-05 | 2016-05-11 | 菲瑞茵國際中心股份有限公司 | 藥學製劑 |
| CA3163525A1 (en) * | 2011-03-31 | 2012-10-04 | Ferring Bv. | Pharmaceutical preparation |
| JO3092B1 (ar) * | 2011-08-08 | 2017-03-15 | Ferring Bv | مركب لتحفيز مسيطر عليه للمبيض |
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2010
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