TWI506334B - 具有可接受程度之能量損失的聚矽氧水凝膠隱形眼鏡 - Google Patents
具有可接受程度之能量損失的聚矽氧水凝膠隱形眼鏡 Download PDFInfo
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- TWI506334B TWI506334B TW101106102A TW101106102A TWI506334B TW I506334 B TWI506334 B TW I506334B TW 101106102 A TW101106102 A TW 101106102A TW 101106102 A TW101106102 A TW 101106102A TW I506334 B TWI506334 B TW I506334B
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- monomer
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- lens
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- contact lens
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- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- UGCDBQWJXSAYIL-UHFFFAOYSA-N vat blue 6 Chemical compound O=C1C2=CC=CC=C2C(=O)C(C=C2Cl)=C1C1=C2NC2=C(C(=O)C=3C(=CC=CC=3)C3=O)C3=CC(Cl)=C2N1 UGCDBQWJXSAYIL-UHFFFAOYSA-N 0.000 description 1
- 239000003190 viscoelastic substance Substances 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
- C08G77/42—Block-or graft-polymers containing polysiloxane sequences
-
- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C7/00—Optical parts
- G02C7/02—Lenses; Lens systems ; Methods of designing lenses
- G02C7/04—Contact lenses for the eyes
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
- C08G77/04—Polysiloxanes
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
- G02B1/04—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
- G02B1/04—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
- G02B1/041—Lenses
- G02B1/043—Contact lenses
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Optics & Photonics (AREA)
- General Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Eyeglasses (AREA)
- Macromonomer-Based Addition Polymer (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161447197P | 2011-02-28 | 2011-02-28 |
Publications (2)
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| TW201239451A TW201239451A (en) | 2012-10-01 |
| TWI506334B true TWI506334B (zh) | 2015-11-01 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW101106102A TWI506334B (zh) | 2011-02-28 | 2012-02-23 | 具有可接受程度之能量損失的聚矽氧水凝膠隱形眼鏡 |
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| US (2) | US8481662B2 (enExample) |
| EP (1) | EP2681616B1 (enExample) |
| JP (1) | JP5842297B2 (enExample) |
| KR (1) | KR101743801B1 (enExample) |
| CN (1) | CN103620480B (enExample) |
| AU (1) | AU2012223592B2 (enExample) |
| BR (1) | BR112013021871B1 (enExample) |
| CA (1) | CA2828458C (enExample) |
| ES (1) | ES2719850T3 (enExample) |
| GB (1) | GB2502502A (enExample) |
| HU (1) | HUE043683T2 (enExample) |
| MX (1) | MX2013009217A (enExample) |
| MY (1) | MY164188A (enExample) |
| SG (2) | SG192230A1 (enExample) |
| TW (1) | TWI506334B (enExample) |
| WO (1) | WO2012118681A2 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI658922B (zh) * | 2016-09-20 | 2019-05-11 | 瑞士商諾華公司 | 軟性接觸鏡片及生產其之方法 |
| TWI828345B (zh) * | 2022-09-30 | 2024-01-01 | 晶碩光學股份有限公司 | 矽氧烷單體、隱形眼鏡組成物及隱形眼鏡 |
Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3808178A (en) * | 1972-06-16 | 1974-04-30 | Polycon Laboratories | Oxygen-permeable contact lens composition,methods and article of manufacture |
| US4602074A (en) * | 1983-12-20 | 1986-07-22 | Nippon Contact Lens Manufacturing Ltd. | Contact lens material |
| US6031059A (en) * | 1998-09-30 | 2000-02-29 | Johnson & Johnson Vision Products, Inc. | Optically transparent hydrogels and processes for their production |
Family Cites Families (138)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US470533A (en) | 1892-03-08 | Churn | ||
| US2393266A (en) | 1943-12-07 | 1946-01-22 | Donald J Riddell | Contact lens |
| US2989894A (en) | 1959-06-22 | 1961-06-27 | Contact Lens Guild Inc | Corneal contact lens with spiral vent ducts |
| US3246941A (en) | 1962-02-28 | 1966-04-19 | Herbert L Moss | Contact lens with upper crescent shaped scleral flange and having vent channels and apertures |
| US3228741A (en) | 1962-06-29 | 1966-01-11 | Mueller Welt Contact Lenses In | Corneal contact lens fabricated from transparent silicone rubber |
| US3431046A (en) | 1964-02-14 | 1969-03-04 | Studies Inc | Flexible polyethylene corneal contact lens |
| US3594074A (en) | 1969-06-16 | 1971-07-20 | Mencher Alexander | Contact lens with flexible central portion |
| US3907851A (en) | 1971-03-30 | 1975-09-23 | Union Carbide Corp | Novel process for producing organosilicon hydroxy compounds and novel organosilicon adducts |
| CA983230A (en) | 1972-01-03 | 1976-02-10 | Lawrence Stark | Physiologically compatible plastic contact lenses and a method for their production |
| US4099859A (en) | 1974-12-02 | 1978-07-11 | High Voltage Engineering Corporation | Contact lens having a smooth surface layer of a hydrophilic polymer |
| DE2546692C3 (de) | 1975-10-17 | 1978-10-19 | American Optical Corp., Framingham, Mass. (V.St.A.) | Verfahren und Vorrichtung zur Endbearbeitung und Herstellung von rillen- oder nutenartigen Vertiefungen am Randabschnitt einer Silikongummi-Kontaktlinse |
| US4121896A (en) | 1976-03-24 | 1978-10-24 | Shepherd Thomas H | Apparatus for the production of contact lenses |
| US4120570A (en) | 1976-06-22 | 1978-10-17 | Syntex (U.S.A.) Inc. | Method for correcting visual defects, compositions and articles of manufacture useful therein |
| US4182822A (en) | 1976-11-08 | 1980-01-08 | Chang Sing Hsiung | Hydrophilic, soft and oxygen permeable copolymer composition |
| US4136250A (en) | 1977-07-20 | 1979-01-23 | Ciba-Geigy Corporation | Polysiloxane hydrogels |
| US4153641A (en) | 1977-07-25 | 1979-05-08 | Bausch & Lomb Incorporated | Polysiloxane composition and contact lens |
| US4217038A (en) | 1978-06-05 | 1980-08-12 | Bausch & Lomb Incorporated | Glass coated polysiloxane contact lens |
| US4208365A (en) | 1978-12-20 | 1980-06-17 | National Patent Development Corporation | Method and apparatus for molding toric contact lenses |
| JPS55112262A (en) | 1979-02-23 | 1980-08-29 | Shin Etsu Chem Co Ltd | Photosetting organopolysiloxane compostion |
| US4246389A (en) | 1979-06-25 | 1981-01-20 | American Optical Corporation | Contact lens composition having increased oxygen permeability |
| US4401371A (en) | 1979-09-24 | 1983-08-30 | Neefe Charles W | Hydrogel oxygen generator with improved fluid flow |
| US4260725A (en) | 1979-12-10 | 1981-04-07 | Bausch & Lomb Incorporated | Hydrophilic contact lens made from polysiloxanes which are thermally bonded to polymerizable groups and which contain hydrophilic sidechains |
| US4259467A (en) | 1979-12-10 | 1981-03-31 | Bausch & Lomb Incorporated | Hydrophilic contact lens made from polysiloxanes containing hydrophilic sidechains |
| US4353849A (en) | 1981-06-19 | 1982-10-12 | Lawrence Lewison | Manufacture of soft contact lenses having vent passageways |
| EP0080539B1 (en) | 1981-11-27 | 1986-05-07 | Tsuetaki, George F. | Polymers primarily for contact lenses, and contact lenses made from them |
| US4640594A (en) | 1982-01-07 | 1987-02-03 | Richard Berger | Tear pump contact lens |
| US4440918A (en) | 1982-01-18 | 1984-04-03 | Minnesota Mining And Manufacturing Company | Contact lens containing a fluorinated telechelic polyether |
| US4487905A (en) | 1983-03-14 | 1984-12-11 | Dow Corning Corporation | Wettable silicone resin optical devices and curable compositions therefor |
| US4605712A (en) | 1984-09-24 | 1986-08-12 | Ciba-Geigy Corporation | Unsaturated polysiloxanes and polymers thereof |
| JPS61138613A (ja) | 1984-12-10 | 1986-06-26 | Toyo Contact Lens Co Ltd | 酸素透過性軟質コンタクトレンズ用材料 |
| US4711943A (en) | 1985-04-26 | 1987-12-08 | Sola U.S.A. Inc. | Hydrophilic siloxane monomers and dimers for contact lens materials, and contact lenses fabricated therefrom |
| DE3708308A1 (de) | 1986-04-10 | 1987-10-22 | Bayer Ag | Kontaktoptische gegenstaende |
| JP2532406B2 (ja) | 1986-09-30 | 1996-09-11 | ホ−ヤ株式会社 | 耐衝撃性の優れた酸素透過性ハ−ドコンタクトレンズ用材料 |
| US5712327A (en) | 1987-01-07 | 1998-01-27 | Chang; Sing-Hsiung | Soft gas permeable contact lens having improved clinical performance |
| FR2617763B1 (fr) | 1987-07-07 | 1989-12-01 | Essilor Int | Procede de fabrication de lentille de contact en un polymere proteique naturel, par moulage avant reticulation |
| US5009497A (en) | 1987-11-12 | 1991-04-23 | Cohen Allen L | Contact lenses utilizing keel orientation |
| US5258490A (en) | 1987-12-14 | 1993-11-02 | Chang Sing Hsiung | Non-irritating soft gas permeable contact lens and process for producing same |
| EP0330617B1 (en) | 1988-02-26 | 1991-07-03 | Ciba-Geigy Ag | Wettable, flexible, oxygen permeable contact lens containing block copolymer polysiloxane-polyoxyalkylene backbone units |
| ATE64214T1 (de) | 1988-02-26 | 1991-06-15 | Ciba Geigy Ag | Benetzbare, flexible, sauerstoffdurchlaessige kontaktlinse, bestehend aus blockcopolymeren mit polysiloxan-polyoxyalkylen-gliedern in der hauptkette, und verwendung hierfuer. |
| US5070169A (en) | 1988-02-26 | 1991-12-03 | Ciba-Geigy Corporation | Wettable, flexible, oxygen permeable contact lens containing block copolymer polysiloxane-polyoxyalkylene backbone units and use thereof |
| GB2217869A (en) | 1988-04-22 | 1989-11-01 | Ceskoslovenska Akademie Ved | Contact lenses |
| US5104213A (en) | 1989-01-17 | 1992-04-14 | Wolfson Leonard G | Polymer buttons having holes therein and contact lenses manufactured therefrom and method of manufacture |
| US4954586A (en) | 1989-01-17 | 1990-09-04 | Menicon Co., Ltd | Soft ocular lens material |
| US5070215A (en) | 1989-05-02 | 1991-12-03 | Bausch & Lomb Incorporated | Novel vinyl carbonate and vinyl carbamate contact lens material monomers |
| US5034461A (en) | 1989-06-07 | 1991-07-23 | Bausch & Lomb Incorporated | Novel prepolymers useful in biomedical devices |
| JPH04501882A (ja) | 1989-09-14 | 1992-04-02 | チヤン，シン―シウン | 改良された臨床的性能を有する柔軟なガス透過性コンタクトレンズ |
| US5010141A (en) | 1989-10-25 | 1991-04-23 | Ciba-Geigy Corporation | Reactive silicone and/or fluorine containing hydrophilic prepolymers and polymers thereof |
| US5079319A (en) | 1989-10-25 | 1992-01-07 | Ciba-Geigy Corporation | Reactive silicone and/or fluorine containing hydrophilic prepolymers and polymers thereof |
| DE69020509T2 (de) | 1989-12-05 | 1995-11-09 | Shinetsu Chemical Co | Mit selbstklebender Polysiloxankautschukzusammensetzung beschichtete Gewebe. |
| AU629725B2 (en) | 1990-01-24 | 1992-10-08 | Novartis Ag | Contact lens and process for the manufacture thereof |
| US4997897A (en) | 1990-04-03 | 1991-03-05 | Bausch & Lomb Incorporated | Polymerizable dye |
| US5314960A (en) | 1990-04-10 | 1994-05-24 | Permeable Technologies, Inc. | Silicone-containing polymers, oxygen permeable hydrophilic contact lenses and methods for making these lenses and treating patients with visual impairment |
| US5158717A (en) | 1990-11-27 | 1992-10-27 | Bausch & Lomb Incorporated | Method of molding shaped polymeric articles |
| US5274008A (en) | 1990-11-27 | 1993-12-28 | Bausch & Lomb Incorporated | Mold materials for silicone containing lens materials |
| US5483304A (en) | 1991-07-26 | 1996-01-09 | Hanita Lenses | Multifocal contact lens |
| DE69216100T2 (de) | 1991-09-12 | 1997-06-12 | Bausch & Lomb Inc., Rochester, N.Y. | Benetzungsfaehige silikon-hydrogel-zusammensetzungen und verfahren zu deren herstellung |
| US5621083A (en) | 1991-11-04 | 1997-04-15 | Xoma Corporation | Immunotoxins comprising ribosome-inactivating proteins |
| BR9206889A (pt) | 1991-11-05 | 1995-05-02 | Bausch & Lomb | Método para melhorar a molhabilidade de hidrogéis, composição de hidrogel, dispositivo biomédico e lente de contato |
| US5352714A (en) | 1991-11-05 | 1994-10-04 | Bausch & Lomb Incorporated | Wettable silicone hydrogel compositions and methods for their manufacture |
| US5358995A (en) | 1992-05-15 | 1994-10-25 | Bausch & Lomb Incorporated | Surface wettable silicone hydrogels |
| US5260000A (en) | 1992-08-03 | 1993-11-09 | Bausch & Lomb Incorporated | Process for making silicone containing hydrogel lenses |
| US5347326A (en) | 1992-10-05 | 1994-09-13 | Volk Donald A | Diagnostic or therapeutic contact lens |
| US5944853A (en) | 1992-10-26 | 1999-08-31 | Johnson & Johnson Vision Products, Inc. | Method for preparing halotriazine dye- and vinyl sulfone dye-monomer compounds |
| US5321108A (en) | 1993-02-12 | 1994-06-14 | Bausch & Lomb Incorporated | Fluorosilicone hydrogels |
| US5374662A (en) | 1993-03-15 | 1994-12-20 | Bausch & Lomb Incorporated | Fumarate and fumaramide siloxane hydrogel compositions |
| US5598233A (en) | 1994-08-18 | 1997-01-28 | Harold A. Gell | Soft contact lens with contamination indicator |
| US5760100B1 (en) | 1994-09-06 | 2000-11-14 | Ciba Vision Corp | Extended wear ophthalmic lens |
| US7468398B2 (en) | 1994-09-06 | 2008-12-23 | Ciba Vision Corporation | Extended wear ophthalmic lens |
| TW585882B (en) | 1995-04-04 | 2004-05-01 | Novartis Ag | A method of using a contact lens as an extended wear lens and a method of screening an ophthalmic lens for utility as an extended-wear lens |
| DE29624309U1 (de) | 1995-04-04 | 2002-01-03 | Commonwealth Scientific And Industrial Research Organisation, Campbell | Dauertraglinsen |
| TW393498B (en) | 1995-04-04 | 2000-06-11 | Novartis Ag | The preparation and use of Polysiloxane-comprising perfluoroalkyl ethers |
| US5641437A (en) | 1995-09-29 | 1997-06-24 | Johnson & Johnson Vision Products, Inc. | Marking of mold inserts to produce marked contact lenses |
| US5807944A (en) | 1996-06-27 | 1998-09-15 | Ciba Vision Corporation | Amphiphilic, segmented copolymer of controlled morphology and ophthalmic devices including contact lenses made therefrom |
| AR009439A1 (es) | 1996-12-23 | 2000-04-12 | Novartis Ag | Un articulo que comprende un sustrato con un recubrimiento polimerico primario que porta grupos reactivos predominantemente en su superficie, unmetodo para preparar dicho articulo, un articulo que posee un recubrimiento de tipo hibrido y una lente de contacto |
| GB9711818D0 (en) | 1997-06-06 | 1997-08-06 | Bausch & Lomb | Contact lens packing solutions and methods for improving the comfort of disposable contact lenses |
| US6020445A (en) | 1997-10-09 | 2000-02-01 | Johnson & Johnson Vision Products, Inc. | Silicone hydrogel polymers |
| US6310116B1 (en) | 1997-10-09 | 2001-10-30 | Kuraray Co., Ltd. | Molded polymer article having a hydrophilic surface and process for producing the same |
| US5817924A (en) | 1998-01-21 | 1998-10-06 | Modern Controls, Inc. | Method and apparatus for measuring oxygen transmission through contact lenses |
| US5998498A (en) | 1998-03-02 | 1999-12-07 | Johnson & Johnson Vision Products, Inc. | Soft contact lenses |
| US5962548A (en) | 1998-03-02 | 1999-10-05 | Johnson & Johnson Vision Products, Inc. | Silicone hydrogel polymers |
| US7052131B2 (en) | 2001-09-10 | 2006-05-30 | J&J Vision Care, Inc. | Biomedical devices containing internal wetting agents |
| US6849671B2 (en) | 1998-03-02 | 2005-02-01 | Johnson & Johnson Vision Care, Inc. | Contact lenses |
| US6367929B1 (en) | 1998-03-02 | 2002-04-09 | Johnson & Johnson Vision Care, Inc. | Hydrogel with internal wetting agent |
| US6943203B2 (en) | 1998-03-02 | 2005-09-13 | Johnson & Johnson Vision Care, Inc. | Soft contact lenses |
| US6822016B2 (en) | 2001-09-10 | 2004-11-23 | Johnson & Johnson Vision Care, Inc. | Biomedical devices containing internal wetting agents |
| US7461937B2 (en) | 2001-09-10 | 2008-12-09 | Johnson & Johnson Vision Care, Inc. | Soft contact lenses displaying superior on-eye comfort |
| AU740278B2 (en) | 1998-05-05 | 2001-11-01 | Bausch & Lomb Incorporated | Plasma surface treatment of silicone hydrogel contact lenses |
| US6359024B2 (en) | 1998-05-15 | 2002-03-19 | Bausch & Lomb Incorporated | Method for polymerizing contact lenses |
| US5969076A (en) | 1998-05-15 | 1999-10-19 | Bausch & Lomb Incorporated | Thermoplastic silicone-containing hydrogels |
| US5959117A (en) | 1998-08-10 | 1999-09-28 | Bausch & Lomb | Monomers useful for contact lens materials |
| DE19850507C1 (de) * | 1998-11-03 | 2000-05-04 | Goldschmidt Ag Th | Verfahren zur Herstellung von Acrylsäureestern und/oder Methacrylsäureestern von hydroxyfunktionellen Siloxanen und/oder polyoxyalkylenmodifizierten Siloxanen und deren Verwendung |
| US5981675A (en) | 1998-12-07 | 1999-11-09 | Bausch & Lomb Incorporated | Silicone-containing macromonomers and low water materials |
| US6727336B1 (en) | 1999-05-12 | 2004-04-27 | Menicon Co., Ltd. | Ocular lens materials and process for producing the same |
| US6440571B1 (en) | 1999-05-20 | 2002-08-27 | Bausch & Lomb Incorporated | Surface treatment of silicone medical devices with reactive hydrophilic polymers |
| US6630243B2 (en) | 1999-05-20 | 2003-10-07 | Bausch & Lomb Incorporated | Surface treatment of silicone hydrogel contact lenses comprising hydrophilic polymer chains attached to an intermediate carbon coating |
| ES2206270T3 (es) | 1999-07-27 | 2004-05-16 | BAUSCH & LOMB INCORPORATED | Material para lentes de contacto. |
| US6649722B2 (en) | 1999-12-10 | 2003-11-18 | Novartis Ag | Contact lens |
| WO2001044861A1 (en) | 1999-12-16 | 2001-06-21 | Asahikasei Aime Co., Ltd. | Soft contact lens capable of being worn for a long period |
| JP3929014B2 (ja) * | 2000-02-24 | 2007-06-13 | Ｈｏｙａヘルスケア株式会社 | 側鎖にポリシロキサン構造を有するマクロマーからなるコンタクトレンズ材料 |
| WO2001071415A1 (en) | 2000-03-22 | 2001-09-27 | Menicon Co., Ltd. | Material for ocular lens |
| US6372815B1 (en) | 2000-04-18 | 2002-04-16 | Ocular Sciences Inc | Ophthalmic lenses and compositions, and methods for producing same |
| US6689480B2 (en) | 2000-05-10 | 2004-02-10 | Toray Industries, Inc. | Surface-treated plastic article and method of surface treatment |
| US6886936B2 (en) | 2000-07-28 | 2005-05-03 | Ocular Sciences, Inc. | Contact lenses with blended microchannels |
| US6779888B2 (en) | 2000-07-28 | 2004-08-24 | Ocular Sciences, Inc. | Contact lenses with microchannels |
| WO2002015955A2 (en) | 2000-08-23 | 2002-02-28 | Surfarc Aps | Biocompatible materials |
| US6652095B2 (en) | 2000-11-17 | 2003-11-25 | Hsiao-Ching Tung | Orthokeratology and bi-focal contact lens |
| US6861123B2 (en) | 2000-12-01 | 2005-03-01 | Johnson & Johnson Vision Care, Inc. | Silicone hydrogel contact lens |
| US6774178B2 (en) | 2001-01-05 | 2004-08-10 | Novartis Ag | Tinted, high Dk ophthalmic molding and a method for making same |
| US6815074B2 (en) | 2001-05-30 | 2004-11-09 | Novartis Ag | Polymeric materials for making contact lenses |
| US6891010B2 (en) | 2001-10-29 | 2005-05-10 | Bausch & Lomb Incorporated | Silicone hydrogels based on vinyl carbonate endcapped fluorinated side chain polysiloxanes |
| JP3881221B2 (ja) | 2001-11-16 | 2007-02-14 | 石根 三井 | 近視および／または乱視矯正用コンタクトレンズ |
| TWI255224B (en) | 2002-01-09 | 2006-05-21 | Novartis Ag | Polymeric articles having a lubricious coating and method for making the same |
| US7216975B2 (en) | 2003-07-15 | 2007-05-15 | Shinn-Gwo Hong | Method for preparing the reactive tinting compound and the tinted contact lens |
| US8425926B2 (en) * | 2003-07-16 | 2013-04-23 | Yongxing Qiu | Antimicrobial medical devices |
| US8147728B2 (en) * | 2004-04-01 | 2012-04-03 | Novartis Ag | Pad transfer printing of silicone hydrogel lenses using colored ink |
| US9248614B2 (en) | 2004-06-30 | 2016-02-02 | Novartis Ag | Method for lathing silicone hydrogel lenses |
| KR101367538B1 (ko) | 2004-08-27 | 2014-02-26 | 쿠퍼비젼 인터내셔날 홀딩 캄파니, 엘피 | 실리콘 히드로겔 콘택트 렌즈 |
| MY142084A (en) * | 2004-09-01 | 2010-08-30 | Novartis Ag | Method for making colored silicone hydrogel contact lenses |
| US7247692B2 (en) | 2004-09-30 | 2007-07-24 | Johnson & Johnson Vision Care, Inc. | Biomedical devices containing amphiphilic block copolymers |
| US7249848B2 (en) | 2004-09-30 | 2007-07-31 | Johnson & Johnson Vision Care, Inc. | Wettable hydrogels comprising reactive, hydrophilic, polymeric internal wetting agents |
| US7426993B2 (en) | 2005-08-09 | 2008-09-23 | Coopervision International Holding Company, Lp | Contact lens package |
| CN101378894A (zh) | 2005-12-20 | 2009-03-04 | 庄臣及庄臣视力保护公司 | 浸提硅氧烷水凝胶眼镜片的方法和系统 |
| US20070155851A1 (en) * | 2005-12-30 | 2007-07-05 | Azaam Alli | Silicone containing polymers formed from non-reactive silicone containing prepolymers |
| US7572841B2 (en) * | 2006-06-15 | 2009-08-11 | Coopervision International Holding Company, Lp | Wettable silicone hydrogel contact lenses and related compositions and methods |
| US8231218B2 (en) | 2006-06-15 | 2012-07-31 | Coopervision International Holding Company, Lp | Wettable silicone hydrogel contact lenses and related compositions and methods |
| US7540609B2 (en) | 2006-06-15 | 2009-06-02 | Coopervision International Holding Company, Lp | Wettable silicone hydrogel contact lenses and related compositions and methods |
| TWI443116B (zh) * | 2006-06-15 | 2014-07-01 | Coopervision Int Holding Co Lp | 可溼性矽氧水凝膠隱形眼鏡及相關組合物及方法 |
| US8003024B2 (en) | 2006-09-18 | 2011-08-23 | Coopervision International Holding Company, Lp | Polyolefin contact lens molds and uses thereof |
| GB0623299D0 (en) * | 2006-11-22 | 2007-01-03 | Sauflon Cl Ltd | Contact lens |
| EP2167555B1 (en) | 2007-07-10 | 2018-10-10 | Bausch & Lomb Incorporated | Crosslink agents and dual radical cure polymer |
| US7934830B2 (en) | 2007-12-03 | 2011-05-03 | Bausch & Lomb Incorporated | High water content silicone hydrogels |
| CN101932632B (zh) * | 2008-02-08 | 2015-06-24 | 库柏维景国际控股公司 | 亲水性聚硅氧烷大单体、其制造及用途 |
| JP4646152B2 (ja) | 2008-05-27 | 2011-03-09 | 信越化学工業株式会社 | 眼科デバイス製造用モノマー |
| US8470906B2 (en) | 2008-09-30 | 2013-06-25 | Johnson & Johnson Vision Care, Inc. | Ionic silicone hydrogels having improved hydrolytic stability |
| US7915323B2 (en) | 2009-07-09 | 2011-03-29 | Bausch & Lamb Incorporated | Mono ethylenically unsaturated polycarbosiloxane monomers |
| SG173578A1 (en) | 2009-09-22 | 2011-09-29 | Coopervision Int Holding Co Lp | Wettable hydrogel materials for use in ophthalmic applications and methods |
| US8672475B2 (en) | 2009-10-01 | 2014-03-18 | Coopervision International Holding Company, LLC | Silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses |
| AU2012223592B2 (en) | 2011-02-28 | 2014-10-30 | Coopervision International Limited | Silicone hydrogel contact lenses having acceptable levels of energy loss |
-
2012
- 2012-02-23 AU AU2012223592A patent/AU2012223592B2/en active Active
- 2012-02-23 HU HUE12752742A patent/HUE043683T2/hu unknown
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- 2012-02-23 SG SG2013058110A patent/SG192230A1/en unknown
- 2012-02-23 MX MX2013009217A patent/MX2013009217A/es unknown
- 2012-02-23 SG SG10201402884XA patent/SG10201402884XA/en unknown
- 2012-02-23 ES ES12752742T patent/ES2719850T3/es active Active
- 2012-02-24 US US13/404,040 patent/US8481662B2/en active Active
-
2013
- 2013-05-31 US US13/906,369 patent/US8658748B2/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3808178A (en) * | 1972-06-16 | 1974-04-30 | Polycon Laboratories | Oxygen-permeable contact lens composition,methods and article of manufacture |
| US4602074A (en) * | 1983-12-20 | 1986-07-22 | Nippon Contact Lens Manufacturing Ltd. | Contact lens material |
| US6031059A (en) * | 1998-09-30 | 2000-02-29 | Johnson & Johnson Vision Products, Inc. | Optically transparent hydrogels and processes for their production |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI658922B (zh) * | 2016-09-20 | 2019-05-11 | 瑞士商諾華公司 | 軟性接觸鏡片及生產其之方法 |
| TWI828345B (zh) * | 2022-09-30 | 2024-01-01 | 晶碩光學股份有限公司 | 矽氧烷單體、隱形眼鏡組成物及隱形眼鏡 |
| US12441845B2 (en) | 2022-09-30 | 2025-10-14 | Pegavision Corporation | Siloxane monomer, contact lens composition and contact lens |
Also Published As
| Publication number | Publication date |
|---|---|
| US20130261216A1 (en) | 2013-10-03 |
| GB201316967D0 (en) | 2013-11-06 |
| BR112013021871B1 (pt) | 2021-01-05 |
| US20120220690A1 (en) | 2012-08-30 |
| KR20140009399A (ko) | 2014-01-22 |
| SG10201402884XA (en) | 2014-07-30 |
| HK1190795A1 (zh) | 2014-07-11 |
| JP2014513812A (ja) | 2014-06-05 |
| CA2828458C (en) | 2017-04-11 |
| CN103620480A (zh) | 2014-03-05 |
| HUE043683T2 (hu) | 2019-09-30 |
| WO2012118681A2 (en) | 2012-09-07 |
| AU2012223592B2 (en) | 2014-10-30 |
| EP2681616A2 (en) | 2014-01-08 |
| SG192230A1 (en) | 2013-09-30 |
| US8658748B2 (en) | 2014-02-25 |
| CN103620480B (zh) | 2015-12-09 |
| JP5842297B2 (ja) | 2016-01-13 |
| BR112013021871A2 (pt) | 2017-03-28 |
| US8481662B2 (en) | 2013-07-09 |
| MY164188A (en) | 2017-11-30 |
| CA2828458A1 (en) | 2012-09-07 |
| ES2719850T3 (es) | 2019-07-16 |
| KR101743801B1 (ko) | 2017-06-05 |
| EP2681616B1 (en) | 2019-01-23 |
| EP2681616A4 (en) | 2017-12-06 |
| AU2012223592A1 (en) | 2013-09-12 |
| TW201239451A (en) | 2012-10-01 |
| MX2013009217A (es) | 2014-09-08 |
| GB2502502A (en) | 2013-11-27 |
| WO2012118681A3 (en) | 2013-12-12 |
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