TWI501960B - 新穎吡喃酮-吲哚衍生物及其製備方法 - Google Patents

新穎吡喃酮-吲哚衍生物及其製備方法 Download PDF

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Publication number
TWI501960B
TWI501960B TW096106545A TW96106545A TWI501960B TW I501960 B TWI501960 B TW I501960B TW 096106545 A TW096106545 A TW 096106545A TW 96106545 A TW96106545 A TW 96106545A TW I501960 B TWI501960 B TW I501960B
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Taiwan
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group
alkyl
aryl
ring
oxygen
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TW096106545A
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English (en)
Chinese (zh)
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TW200835690A (en
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Moshe Laudon
Tal Peleg-Shulman
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Neurim Pharma 1991
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Publication of TW200835690A publication Critical patent/TW200835690A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
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    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
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    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/36—Opioid-abuse
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    • A61P27/02—Ophthalmic agents
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P5/00—Drugs for disorders of the endocrine system
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    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Addiction (AREA)
  • Cardiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Pregnancy & Childbirth (AREA)
TW096106545A 2006-02-15 2007-02-26 新穎吡喃酮-吲哚衍生物及其製備方法 TWI501960B (zh)

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US77332206P 2006-02-15 2006-02-15

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TW200835690A TW200835690A (en) 2008-09-01
TWI501960B true TWI501960B (zh) 2015-10-01

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US (3) US7635710B2 (enExample)
EP (1) EP1991541B1 (enExample)
JP (1) JP5248332B2 (enExample)
KR (1) KR101207736B1 (enExample)
CN (1) CN101374833B (enExample)
AU (1) AU2007216226B2 (enExample)
BR (1) BRPI0706992C8 (enExample)
CA (1) CA2642465C (enExample)
DK (1) DK1991541T3 (enExample)
EA (1) EA015605B1 (enExample)
ES (1) ES2428873T3 (enExample)
IL (1) IL193236A (enExample)
NO (1) NO339826B1 (enExample)
NZ (1) NZ569797A (enExample)
PL (1) PL1991541T3 (enExample)
PT (1) PT1991541E (enExample)
SI (1) SI1991541T1 (enExample)
TW (1) TWI501960B (enExample)
UA (1) UA104988C2 (enExample)
WO (1) WO2007093880A2 (enExample)
ZA (1) ZA200806799B (enExample)

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US7576131B2 (en) 1999-06-04 2009-08-18 Metabolex, Inc. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidemia and hyperuricemia
US6262118B1 (en) * 1999-06-04 2001-07-17 Metabolex, Inc. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes and hyperlipidemia
CN103319467B (zh) * 2013-06-15 2015-10-14 湖南科技大学 一种4-[5-羟基-4-吡喃酮-2-基亚甲氨基]-3-巯基-1,2,4-三唑化合物及用途
JP6428645B2 (ja) * 2014-01-14 2018-11-28 アステラス製薬株式会社 インドール化合物
RU2561045C1 (ru) * 2014-07-15 2015-08-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Кубанский государственный университет" (ФГБОУ ВПО "КубГУ") Нейропротекторное фармакологическое средство
US9567510B2 (en) 2014-09-11 2017-02-14 Halliburton Energy Services, Inc. Cyanamide-based carbon dioxide and/or hydrogen sulfide scavengers and methods of use in subterranean operations
DK3261640T3 (da) 2015-02-25 2022-07-11 Univ California 5ht-agonister til behandling af epilepsilidelser
EP3503884B1 (en) * 2016-08-23 2021-07-21 Neurim Pharmaceuticals Ltd. Pharmaceutical composition for use in treating pruritus and/or itch
CA3071939A1 (en) 2017-08-04 2019-02-07 Ovid Therapeutics Inc. Use of gaboxadol in the treatment of diabetes and related conditions
CN111683976B (zh) 2018-02-05 2022-11-18 生物辐射实验室股份有限公司 具有阴离子交换-疏水混合模式配体的色谱树脂
EP3833351A4 (en) 2018-09-20 2021-10-13 Ovid Therapeutics Inc. USE OF GABOXADOL TO TREAT TOURETTE SYNDROME, TICKS, AND STUTTERS
MX2021007224A (es) 2018-12-17 2021-09-23 Ovid Therapeutics Inc Uso de gaboxadol para el tratamiento del trastorno del sue?o vigilia que no es de 24 horas.
WO2021229566A1 (en) * 2020-05-11 2021-11-18 B. G. Negev Technologies And Applications Ltd., At Ben-Gurion University Compositions of tryptophol derivatives and 4-ethyl-phenol derivatives, and methods of using same
WO2022238905A1 (en) * 2021-05-11 2022-11-17 Neurim Pharmaceuticals (1991) Ltd. Method for diagnosing and treating subjects having single nucleotide polymorphisms in chromosome 2, 2:107,510,000-107,540,000 locus
US12674575B1 (en) * 2023-01-13 2026-07-07 Cliffie L. Fitts Candle holder structure

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US6858642B1 (en) * 1999-05-27 2005-02-22 Neurim Pharmaceuticals (1991) Ltd. Indole derivatives

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CA222247A (en) 1922-08-15 Hubert Rogers Reginald Pocket container for confections
IT1196849B (it) 1986-02-16 1988-11-25 Rotta Research Lab Nuovi derivati degli acidi 5 pentilammino 5 oxo pentaoico e 4 pentilammino 4 oxo butanoico ad attivita antagonista della colecistochinina e procedimento per la loro preparazione
AU8876591A (en) 1990-11-02 1992-05-26 Upjohn Company, The Indole-3-methanamines useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents
US5840751A (en) * 1993-11-19 1998-11-24 Warner-Lambert Company 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents
EP0841063A1 (en) * 1996-03-27 1998-05-13 Toray Industries, Inc. Ketone derivatives and medicinal use thereof
EP1324993A2 (en) * 2000-04-18 2003-07-09 Cytovia, Inc. Substituted 1,4-thiazepine and analogs as activators of caspases and inducers of apoptosis and the use thereof
PE20060303A1 (es) 2004-06-23 2006-05-19 Wyeth Corp Metabolitos de indolilalquilamina como ligandos de 5-hidroxitriptamina-6
US7834050B2 (en) * 2006-03-29 2010-11-16 Duke University Small molecule insulin mimetics absent quinones

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Publication number Publication date
WO2007093880A3 (en) 2007-11-01
KR101207736B1 (ko) 2012-12-03
PT1991541E (pt) 2013-10-02
US8569355B2 (en) 2013-10-29
DK1991541T3 (da) 2013-10-28
KR20080094945A (ko) 2008-10-27
EP1991541B1 (en) 2013-07-24
BRPI0706992C1 (pt) 2021-05-18
ZA200806799B (en) 2009-10-28
AU2007216226B2 (en) 2011-02-24
EA015605B1 (ru) 2011-10-31
US20120302620A1 (en) 2012-11-29
EA200801580A1 (ru) 2009-02-27
US7635710B2 (en) 2009-12-22
US20080027121A1 (en) 2008-01-31
IL193236A (en) 2012-08-30
NZ569797A (en) 2010-06-25
NO20083905L (no) 2008-09-12
BRPI0706992A2 (pt) 2011-04-12
JP2009526831A (ja) 2009-07-23
CA2642465C (en) 2012-08-07
ES2428873T3 (es) 2013-11-12
US20100048662A1 (en) 2010-02-25
CA2642465A1 (en) 2007-08-23
AU2007216226A1 (en) 2007-08-23
SI1991541T1 (sl) 2014-02-28
UA104988C2 (uk) 2014-04-10
JP5248332B2 (ja) 2013-07-31
TW200835690A (en) 2008-09-01
CN101374833A (zh) 2009-02-25
HK1126760A1 (en) 2009-09-11
US8242163B2 (en) 2012-08-14
CN101374833B (zh) 2012-06-27
EP1991541A2 (en) 2008-11-19
BRPI0706992C8 (pt) 2021-05-25
NO339826B1 (no) 2017-02-06
BRPI0706992B1 (pt) 2021-05-04
AU2007216226A2 (en) 2009-05-14
WO2007093880A2 (en) 2007-08-23
IL193236A0 (en) 2009-02-11
PL1991541T3 (pl) 2013-12-31

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