CN101374833B - 新型吡喃酮-吲哚衍生物及其制备方法 - Google Patents

新型吡喃酮-吲哚衍生物及其制备方法 Download PDF

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CN101374833B
CN101374833B CN2007800039654A CN200780003965A CN101374833B CN 101374833 B CN101374833 B CN 101374833B CN 2007800039654 A CN2007800039654 A CN 2007800039654A CN 200780003965 A CN200780003965 A CN 200780003965A CN 101374833 B CN101374833 B CN 101374833B
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ring
preparation
pyrone
salt
disease
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CN101374833A (zh
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莫什·劳顿
塔尔·派莱格舒尔曼
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Neurim Pharmaceuticals 1991 Ltd
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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CN2007800039654A 2006-02-15 2007-02-13 新型吡喃酮-吲哚衍生物及其制备方法 Active CN101374833B (zh)

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US77332206P 2006-02-15 2006-02-15
US60/773,322 2006-02-15
PCT/IB2007/000330 WO2007093880A2 (en) 2006-02-15 2007-02-13 Novel pyrone-indole derivatives and process for their preparation

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Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6262118B1 (en) * 1999-06-04 2001-07-17 Metabolex, Inc. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes and hyperlipidemia
US7576131B2 (en) 1999-06-04 2009-08-18 Metabolex, Inc. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidemia and hyperuricemia
CN103319467B (zh) * 2013-06-15 2015-10-14 湖南科技大学 一种4-[5-羟基-4-吡喃酮-2-基亚甲氨基]-3-巯基-1,2,4-三唑化合物及用途
ES2694049T3 (es) * 2014-01-14 2018-12-17 Astellas Pharma Inc. Compuesto de indol
RU2561045C1 (ru) * 2014-07-15 2015-08-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Кубанский государственный университет" (ФГБОУ ВПО "КубГУ") Нейропротекторное фармакологическое средство
US9567510B2 (en) 2014-09-11 2017-02-14 Halliburton Energy Services, Inc. Cyanamide-based carbon dioxide and/or hydrogen sulfide scavengers and methods of use in subterranean operations
AU2016222804C1 (en) 2015-02-25 2021-10-14 The Regents Of The University Of California 5HT agonists for treating disorders
MX381311B (es) * 2016-08-23 2025-03-12 Neurim Pharma 1991 Método para el tratamiento de prurito y/o comezón.
CN111201022A (zh) 2017-08-04 2020-05-26 奥维德医疗公司 加波沙朵在治疗糖尿病及相关状况中的用途
CN111683976B (zh) 2018-02-05 2022-11-18 生物辐射实验室股份有限公司 具有阴离子交换-疏水混合模式配体的色谱树脂
JP2022501384A (ja) 2018-09-20 2022-01-06 オービッド・セラピューティクス・インコーポレイテッドOvid Therapeutics Inc. トゥレット症候群、チックおよび吃音の処置のためのガボキサドールの使用
AU2019405489A1 (en) 2018-12-17 2021-06-10 Ovid Therapeutics Inc. Use of gaboxadol for the treatment of non-24 hour sleep-wake disorder
WO2021229566A1 (en) * 2020-05-11 2021-11-18 B. G. Negev Technologies And Applications Ltd., At Ben-Gurion University Compositions of tryptophol derivatives and 4-ethyl-phenol derivatives, and methods of using same
KR20240006657A (ko) 2021-05-11 2024-01-15 뉴림 파머슈티칼스(1991) 리미티드 염색체 2, 2:107,510,000-107,540,000 유전자좌에서 단일 뉴클레오티드 다형성을 갖는 대상체를 진단 및 치료하는 방법
IL321429A (en) 2023-01-13 2025-08-01 Neurim Pharmaceuticals 1991 Ltd Piromelatine for treating parasomnias associated with loss of rem sleep atonia

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1352545A (zh) * 1999-05-27 2002-06-05 纽里姆药品(1991)有限公司 吲哚衍生物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA222247A (en) 1922-08-15 Hubert Rogers Reginald Pocket container for confections
IT1196849B (it) 1986-02-16 1988-11-25 Rotta Research Lab Nuovi derivati degli acidi 5 pentilammino 5 oxo pentaoico e 4 pentilammino 4 oxo butanoico ad attivita antagonista della colecistochinina e procedimento per la loro preparazione
AU8876591A (en) 1990-11-02 1992-05-26 Upjohn Company, The Indole-3-methanamines useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents
US5789440A (en) * 1993-11-19 1998-08-04 Warner-Lambert Company 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents
CN1215835C (zh) * 1996-03-27 2005-08-24 东丽株式会社 酮衍生物及其在医学上的应用
AU2001293372A1 (en) * 2000-04-18 2001-10-30 Cytovia, Inc. Substituted 1,4-thiazepine and analogs and their use as activators of caspases
PE20060303A1 (es) 2004-06-23 2006-05-19 Wyeth Corp Metabolitos de indolilalquilamina como ligandos de 5-hidroxitriptamina-6
US7834050B2 (en) * 2006-03-29 2010-11-16 Duke University Small molecule insulin mimetics absent quinones

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1352545A (zh) * 1999-05-27 2002-06-05 纽里姆药品(1991)有限公司 吲哚衍生物

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Bhim C Maiti et al.Reaction of dehydroacetic acid with aliphatic,aromatic and heterocyclic amines.《Indian Journal of Chemistry》.1998,第37B卷710-712. *
BhimCMaitietal.Reactionofdehydroaceticacidwithaliphatic aromatic and heterocyclic amines.《Indian Journal of Chemistry》.1998

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US8242163B2 (en) 2012-08-14
AU2007216226A2 (en) 2009-05-14
US20100048662A1 (en) 2010-02-25
SI1991541T1 (sl) 2014-02-28
UA104988C2 (uk) 2014-04-10
US8569355B2 (en) 2013-10-29
IL193236A (en) 2012-08-30
AU2007216226A1 (en) 2007-08-23
US20120302620A1 (en) 2012-11-29
CA2642465C (en) 2012-08-07
ZA200806799B (en) 2009-10-28
BRPI0706992A2 (pt) 2011-04-12
NO339826B1 (no) 2017-02-06
EP1991541B1 (en) 2013-07-24
BRPI0706992C1 (pt) 2021-05-18

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