EA015605B1 - Производные пирониндола, фармацевтическая композиция и способы лечения - Google Patents

Производные пирониндола, фармацевтическая композиция и способы лечения Download PDF

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Publication number
EA015605B1
EA015605B1 EA200801580A EA200801580A EA015605B1 EA 015605 B1 EA015605 B1 EA 015605B1 EA 200801580 A EA200801580 A EA 200801580A EA 200801580 A EA200801580 A EA 200801580A EA 015605 B1 EA015605 B1 EA 015605B1
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EA
Eurasian Patent Office
Prior art keywords
compound
stereoisomer
salt
disorder
dosage form
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Application number
EA200801580A
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English (en)
Russian (ru)
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EA200801580A1 (ru
Inventor
Моше Лаудон
Таль Пелег-Шульман
Original Assignee
Ньюрим Фармасьютикалз (1991) Лтд.
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Application filed by Ньюрим Фармасьютикалз (1991) Лтд. filed Critical Ньюрим Фармасьютикалз (1991) Лтд.
Publication of EA200801580A1 publication Critical patent/EA200801580A1/ru
Publication of EA015605B1 publication Critical patent/EA015605B1/ru

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • A61K31/4045Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • AHUMAN NECESSITIES
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    • A61P13/00Drugs for disorders of the urinary system
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    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
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  • Hematology (AREA)
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  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Addiction (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Rheumatology (AREA)
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  • Child & Adolescent Psychology (AREA)
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EA200801580A 2006-02-15 2007-02-13 Производные пирониндола, фармацевтическая композиция и способы лечения EA015605B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77332206P 2006-02-15 2006-02-15
PCT/IB2007/000330 WO2007093880A2 (en) 2006-02-15 2007-02-13 Novel pyrone-indole derivatives and process for their preparation

Publications (2)

Publication Number Publication Date
EA200801580A1 EA200801580A1 (ru) 2009-02-27
EA015605B1 true EA015605B1 (ru) 2011-10-31

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EA200801580A EA015605B1 (ru) 2006-02-15 2007-02-13 Производные пирониндола, фармацевтическая композиция и способы лечения

Country Status (21)

Country Link
US (3) US7635710B2 (enExample)
EP (1) EP1991541B1 (enExample)
JP (1) JP5248332B2 (enExample)
KR (1) KR101207736B1 (enExample)
CN (1) CN101374833B (enExample)
AU (1) AU2007216226B2 (enExample)
BR (1) BRPI0706992C8 (enExample)
CA (1) CA2642465C (enExample)
DK (1) DK1991541T3 (enExample)
EA (1) EA015605B1 (enExample)
ES (1) ES2428873T3 (enExample)
IL (1) IL193236A (enExample)
NO (1) NO339826B1 (enExample)
NZ (1) NZ569797A (enExample)
PL (1) PL1991541T3 (enExample)
PT (1) PT1991541E (enExample)
SI (1) SI1991541T1 (enExample)
TW (1) TWI501960B (enExample)
UA (1) UA104988C2 (enExample)
WO (1) WO2007093880A2 (enExample)
ZA (1) ZA200806799B (enExample)

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US7576131B2 (en) * 1999-06-04 2009-08-18 Metabolex, Inc. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidemia and hyperuricemia
US6262118B1 (en) * 1999-06-04 2001-07-17 Metabolex, Inc. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes and hyperlipidemia
CN103319467B (zh) * 2013-06-15 2015-10-14 湖南科技大学 一种4-[5-羟基-4-吡喃酮-2-基亚甲氨基]-3-巯基-1,2,4-三唑化合物及用途
US9637451B2 (en) 2014-01-14 2017-05-02 Astellas Pharma Inc. Indole compound
RU2561045C1 (ru) * 2014-07-15 2015-08-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Кубанский государственный университет" (ФГБОУ ВПО "КубГУ") Нейропротекторное фармакологическое средство
US9567510B2 (en) 2014-09-11 2017-02-14 Halliburton Energy Services, Inc. Cyanamide-based carbon dioxide and/or hydrogen sulfide scavengers and methods of use in subterranean operations
KR102385665B1 (ko) * 2015-02-25 2022-04-14 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 질환을 치료하기 위한 5ht 작용제
SG11201901449XA (en) * 2016-08-23 2019-03-28 Neurim Pharmaceuticals 1991 Ltd Method for treating pruritus and/or itch
MX2020001342A (es) 2017-08-04 2020-08-31 Ovid Therapeutics Inc Uso de gaboxadol en el tratamiento contra diabetes y afecciones relacionadas.
CN111683976B (zh) 2018-02-05 2022-11-18 生物辐射实验室股份有限公司 具有阴离子交换-疏水混合模式配体的色谱树脂
MX2021003302A (es) 2018-09-20 2021-05-13 Ovid Therapeutics Inc Uso de gaboxadol para el tratamiento del sindrome de tourette, los tics y la tartamudez.
MX2021007224A (es) 2018-12-17 2021-09-23 Ovid Therapeutics Inc Uso de gaboxadol para el tratamiento del trastorno del sue?o vigilia que no es de 24 horas.
EP4149458A4 (en) 2020-05-11 2024-06-05 B.G. Negev Technologies and Applications Ltd., at Ben-Gurion University COMPOSITIONS OF TRYPTOPHOL DERIVATIVES AND 4-ETHYL-PHENOL DERIVATIVES, AND METHODS OF USE THEREOF
CN117377777A (zh) 2021-05-11 2024-01-09 纽瑞姆制药(1991)有限公司 诊断和治疗具有2号染色体2:107,510,000-107,540,000基因座单核苷酸多态性受试者的方法
IL321429A (en) 2023-01-13 2025-08-01 Neurim Pharmaceuticals 1991 Ltd Piromelatine for treating parasomnias associated with loss of rem sleep atonia

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EP0272228A2 (en) * 1986-02-16 1988-06-22 Rotta Research Laboratorium S.P.A. New Derivatives of 5-pentylamino-5-oxopentanoic and 4-pentylamino-4-oxo-butanoic acids with antagonistic activity towards cholecystokinin and a method for their preparation
WO1992007829A1 (en) * 1990-11-02 1992-05-14 The Upjohn Company Indole-3-methanamines useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents
WO2000072815A1 (en) * 1999-05-27 2000-12-07 Neurim Pharmaceuticals (1991) Ltd. Indole derivatives
WO2006002125A1 (en) * 2004-06-23 2006-01-05 Wyeth Indolylalkylamine metabolites as 5-hydroxytrytamine-6 ligands

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WO1992007829A1 (en) * 1990-11-02 1992-05-14 The Upjohn Company Indole-3-methanamines useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents
WO2000072815A1 (en) * 1999-05-27 2000-12-07 Neurim Pharmaceuticals (1991) Ltd. Indole derivatives
WO2006002125A1 (en) * 2004-06-23 2006-01-05 Wyeth Indolylalkylamine metabolites as 5-hydroxytrytamine-6 ligands

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JP5248332B2 (ja) 2013-07-31
US20120302620A1 (en) 2012-11-29
BRPI0706992A2 (pt) 2011-04-12
TW200835690A (en) 2008-09-01
EP1991541A2 (en) 2008-11-19
JP2009526831A (ja) 2009-07-23
KR101207736B1 (ko) 2012-12-03
IL193236A0 (en) 2009-02-11
WO2007093880A3 (en) 2007-11-01
AU2007216226A2 (en) 2009-05-14
CA2642465A1 (en) 2007-08-23
NO339826B1 (no) 2017-02-06
WO2007093880A2 (en) 2007-08-23
TWI501960B (zh) 2015-10-01
CN101374833A (zh) 2009-02-25
BRPI0706992B1 (pt) 2021-05-04
SI1991541T1 (sl) 2014-02-28
US7635710B2 (en) 2009-12-22
US8242163B2 (en) 2012-08-14
US20080027121A1 (en) 2008-01-31
PL1991541T3 (pl) 2013-12-31
KR20080094945A (ko) 2008-10-27
NZ569797A (en) 2010-06-25
NO20083905L (no) 2008-09-12
BRPI0706992C8 (pt) 2021-05-25
IL193236A (en) 2012-08-30
US8569355B2 (en) 2013-10-29
UA104988C2 (uk) 2014-04-10
US20100048662A1 (en) 2010-02-25
EA200801580A1 (ru) 2009-02-27
CA2642465C (en) 2012-08-07
HK1126760A1 (en) 2009-09-11
AU2007216226A1 (en) 2007-08-23
ZA200806799B (en) 2009-10-28
AU2007216226B2 (en) 2011-02-24
BRPI0706992C1 (pt) 2021-05-18
CN101374833B (zh) 2012-06-27
DK1991541T3 (da) 2013-10-28
PT1991541E (pt) 2013-10-02
ES2428873T3 (es) 2013-11-12
EP1991541B1 (en) 2013-07-24

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