EA015605B1 - Производные пирониндола, фармацевтическая композиция и способы лечения - Google Patents

Производные пирониндола, фармацевтическая композиция и способы лечения Download PDF

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Publication number
EA015605B1
EA015605B1 EA200801580A EA200801580A EA015605B1 EA 015605 B1 EA015605 B1 EA 015605B1 EA 200801580 A EA200801580 A EA 200801580A EA 200801580 A EA200801580 A EA 200801580A EA 015605 B1 EA015605 B1 EA 015605B1
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EA
Eurasian Patent Office
Prior art keywords
compound
stereoisomer
salt
disorder
dosage form
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Application number
EA200801580A
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English (en)
Russian (ru)
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EA200801580A1 (ru
Inventor
Моше Лаудон
Таль Пелег-Шульман
Original Assignee
Ньюрим Фармасьютикалз (1991) Лтд.
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Application filed by Ньюрим Фармасьютикалз (1991) Лтд. filed Critical Ньюрим Фармасьютикалз (1991) Лтд.
Publication of EA200801580A1 publication Critical patent/EA200801580A1/ru
Publication of EA015605B1 publication Critical patent/EA015605B1/ru

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • A61K31/4045Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • AHUMAN NECESSITIES
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    • A61P13/00Drugs for disorders of the urinary system
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    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
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  • General Health & Medical Sciences (AREA)
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  • Obesity (AREA)
  • Addiction (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pregnancy & Childbirth (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Psychology (AREA)
  • Emergency Medicine (AREA)
EA200801580A 2006-02-15 2007-02-13 Производные пирониндола, фармацевтическая композиция и способы лечения EA015605B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77332206P 2006-02-15 2006-02-15
PCT/IB2007/000330 WO2007093880A2 (en) 2006-02-15 2007-02-13 Novel pyrone-indole derivatives and process for their preparation

Publications (2)

Publication Number Publication Date
EA200801580A1 EA200801580A1 (ru) 2009-02-27
EA015605B1 true EA015605B1 (ru) 2011-10-31

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EA200801580A EA015605B1 (ru) 2006-02-15 2007-02-13 Производные пирониндола, фармацевтическая композиция и способы лечения

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US (3) US7635710B2 (enExample)
EP (1) EP1991541B1 (enExample)
JP (1) JP5248332B2 (enExample)
KR (1) KR101207736B1 (enExample)
CN (1) CN101374833B (enExample)
AU (1) AU2007216226B2 (enExample)
BR (1) BRPI0706992C8 (enExample)
CA (1) CA2642465C (enExample)
DK (1) DK1991541T3 (enExample)
EA (1) EA015605B1 (enExample)
ES (1) ES2428873T3 (enExample)
IL (1) IL193236A (enExample)
NO (1) NO339826B1 (enExample)
NZ (1) NZ569797A (enExample)
PL (1) PL1991541T3 (enExample)
PT (1) PT1991541E (enExample)
SI (1) SI1991541T1 (enExample)
TW (1) TWI501960B (enExample)
UA (1) UA104988C2 (enExample)
WO (1) WO2007093880A2 (enExample)
ZA (1) ZA200806799B (enExample)

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US6262118B1 (en) * 1999-06-04 2001-07-17 Metabolex, Inc. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes and hyperlipidemia
US7576131B2 (en) 1999-06-04 2009-08-18 Metabolex, Inc. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidemia and hyperuricemia
CN103319467B (zh) * 2013-06-15 2015-10-14 湖南科技大学 一种4-[5-羟基-4-吡喃酮-2-基亚甲氨基]-3-巯基-1,2,4-三唑化合物及用途
ES2694049T3 (es) * 2014-01-14 2018-12-17 Astellas Pharma Inc. Compuesto de indol
RU2561045C1 (ru) * 2014-07-15 2015-08-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Кубанский государственный университет" (ФГБОУ ВПО "КубГУ") Нейропротекторное фармакологическое средство
US9567510B2 (en) 2014-09-11 2017-02-14 Halliburton Energy Services, Inc. Cyanamide-based carbon dioxide and/or hydrogen sulfide scavengers and methods of use in subterranean operations
AU2016222804C1 (en) 2015-02-25 2021-10-14 The Regents Of The University Of California 5HT agonists for treating disorders
MX381311B (es) * 2016-08-23 2025-03-12 Neurim Pharma 1991 Método para el tratamiento de prurito y/o comezón.
CN111201022A (zh) 2017-08-04 2020-05-26 奥维德医疗公司 加波沙朵在治疗糖尿病及相关状况中的用途
CN111683976B (zh) 2018-02-05 2022-11-18 生物辐射实验室股份有限公司 具有阴离子交换-疏水混合模式配体的色谱树脂
JP2022501384A (ja) 2018-09-20 2022-01-06 オービッド・セラピューティクス・インコーポレイテッドOvid Therapeutics Inc. トゥレット症候群、チックおよび吃音の処置のためのガボキサドールの使用
AU2019405489A1 (en) 2018-12-17 2021-06-10 Ovid Therapeutics Inc. Use of gaboxadol for the treatment of non-24 hour sleep-wake disorder
WO2021229566A1 (en) * 2020-05-11 2021-11-18 B. G. Negev Technologies And Applications Ltd., At Ben-Gurion University Compositions of tryptophol derivatives and 4-ethyl-phenol derivatives, and methods of using same
KR20240006657A (ko) 2021-05-11 2024-01-15 뉴림 파머슈티칼스(1991) 리미티드 염색체 2, 2:107,510,000-107,540,000 유전자좌에서 단일 뉴클레오티드 다형성을 갖는 대상체를 진단 및 치료하는 방법
IL321429A (en) 2023-01-13 2025-08-01 Neurim Pharmaceuticals 1991 Ltd Piromelatine for treating parasomnias associated with loss of rem sleep atonia

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EP0272228A2 (en) * 1986-02-16 1988-06-22 Rotta Research Laboratorium S.P.A. New Derivatives of 5-pentylamino-5-oxopentanoic and 4-pentylamino-4-oxo-butanoic acids with antagonistic activity towards cholecystokinin and a method for their preparation
WO1992007829A1 (en) * 1990-11-02 1992-05-14 The Upjohn Company Indole-3-methanamines useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents
WO2000072815A1 (en) * 1999-05-27 2000-12-07 Neurim Pharmaceuticals (1991) Ltd. Indole derivatives
WO2006002125A1 (en) * 2004-06-23 2006-01-05 Wyeth Indolylalkylamine metabolites as 5-hydroxytrytamine-6 ligands

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WO1992007829A1 (en) * 1990-11-02 1992-05-14 The Upjohn Company Indole-3-methanamines useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents
WO2000072815A1 (en) * 1999-05-27 2000-12-07 Neurim Pharmaceuticals (1991) Ltd. Indole derivatives
WO2006002125A1 (en) * 2004-06-23 2006-01-05 Wyeth Indolylalkylamine metabolites as 5-hydroxytrytamine-6 ligands

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KR101207736B1 (ko) 2012-12-03
AU2007216226B2 (en) 2011-02-24
CA2642465A1 (en) 2007-08-23
HK1126760A1 (en) 2009-09-11
CN101374833A (zh) 2009-02-25
BRPI0706992B1 (pt) 2021-05-04
EP1991541A2 (en) 2008-11-19
DK1991541T3 (da) 2013-10-28
CN101374833B (zh) 2012-06-27
JP2009526831A (ja) 2009-07-23
BRPI0706992C8 (pt) 2021-05-25
PL1991541T3 (pl) 2013-12-31
ES2428873T3 (es) 2013-11-12
TW200835690A (en) 2008-09-01
WO2007093880A2 (en) 2007-08-23
US20080027121A1 (en) 2008-01-31
JP5248332B2 (ja) 2013-07-31
WO2007093880A3 (en) 2007-11-01
EA200801580A1 (ru) 2009-02-27
NZ569797A (en) 2010-06-25
KR20080094945A (ko) 2008-10-27
TWI501960B (zh) 2015-10-01
US7635710B2 (en) 2009-12-22
IL193236A0 (en) 2009-02-11
NO20083905L (no) 2008-09-12
PT1991541E (pt) 2013-10-02
US8242163B2 (en) 2012-08-14
AU2007216226A2 (en) 2009-05-14
US20100048662A1 (en) 2010-02-25
SI1991541T1 (sl) 2014-02-28
UA104988C2 (uk) 2014-04-10
US8569355B2 (en) 2013-10-29
IL193236A (en) 2012-08-30
AU2007216226A1 (en) 2007-08-23
US20120302620A1 (en) 2012-11-29
CA2642465C (en) 2012-08-07
ZA200806799B (en) 2009-10-28
BRPI0706992A2 (pt) 2011-04-12
NO339826B1 (no) 2017-02-06
EP1991541B1 (en) 2013-07-24
BRPI0706992C1 (pt) 2021-05-18

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