TWI453022B - 造血系腫瘤之化學治療 - Google Patents

造血系腫瘤之化學治療 Download PDF

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Publication number
TWI453022B
TWI453022B TW099111650A TW99111650A TWI453022B TW I453022 B TWI453022 B TW I453022B TW 099111650 A TW099111650 A TW 099111650A TW 99111650 A TW99111650 A TW 99111650A TW I453022 B TWI453022 B TW I453022B
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TW
Taiwan
Prior art keywords
leukemia
mll
translocation
fluoro
mixed lineage
Prior art date
Application number
TW099111650A
Other languages
English (en)
Chinese (zh)
Other versions
TW201105328A (en
Inventor
Marcio Chedid
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42174602&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TWI453022(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of TW201105328A publication Critical patent/TW201105328A/zh
Application granted granted Critical
Publication of TWI453022B publication Critical patent/TWI453022B/zh

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
TW099111650A 2009-04-14 2010-04-14 造血系腫瘤之化學治療 TWI453022B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16909409P 2009-04-14 2009-04-14

Publications (2)

Publication Number Publication Date
TW201105328A TW201105328A (en) 2011-02-16
TWI453022B true TWI453022B (zh) 2014-09-21

Family

ID=42174602

Family Applications (1)

Application Number Title Priority Date Filing Date
TW099111650A TWI453022B (zh) 2009-04-14 2010-04-14 造血系腫瘤之化學治療

Country Status (23)

Country Link
US (2) US8802668B2 (enExample)
EP (1) EP2419106A1 (enExample)
JP (1) JP5699129B2 (enExample)
KR (1) KR101290509B1 (enExample)
CN (1) CN102395372B (enExample)
AU (1) AU2010236747B2 (enExample)
BR (1) BRPI1013774A2 (enExample)
CA (1) CA2758473C (enExample)
CL (1) CL2011002531A1 (enExample)
DO (1) DOP2011000312A (enExample)
EA (1) EA018933B1 (enExample)
EC (1) ECSP11011403A (enExample)
IL (1) IL215107A0 (enExample)
MA (1) MA33184B1 (enExample)
MX (1) MX2011010937A (enExample)
MY (1) MY157218A (enExample)
NZ (1) NZ595413A (enExample)
PE (1) PE20120772A1 (enExample)
SG (1) SG175207A1 (enExample)
TN (1) TN2011000500A1 (enExample)
TW (1) TWI453022B (enExample)
UA (1) UA103792C2 (enExample)
WO (1) WO2010120614A1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5699129B2 (ja) * 2009-04-14 2015-04-08 イーライ リリー アンド カンパニー 造血器新生物および白血病の治療のためのベンゾジアゼピン誘導体
US9446048B2 (en) 2011-03-17 2016-09-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods for treating leukemia and disorders mediated by CBFβ and RUNX1 proteins
US10905652B2 (en) 2011-03-23 2021-02-02 Ironshore Pharmaceuticals & Development, Inc. Compositions for treatment of attention deficit hyperactivity disorder
US10292937B2 (en) 2011-03-23 2019-05-21 Ironshore Pharmaceuticals & Development, Inc. Methods of treatment of attention deficit hyperactivity disorder
US9119809B2 (en) 2011-03-23 2015-09-01 Ironshore Pharmaceuticals & Development, Inc. Compositions for treatment of attention deficit hyperactivity disorder
US9498447B2 (en) 2011-03-23 2016-11-22 Ironshore Pharmaceuticals & Development, Inc. Compositions for treatment of attention deficit hyperactivity disorder
US11241391B2 (en) 2011-03-23 2022-02-08 Ironshore Pharmaceuticals & Development, Inc. Compositions for treatment of attention deficit hyperactivity disorder
US9603809B2 (en) 2011-03-23 2017-03-28 Ironshore Pharmaceuticals & Development, Inc. Methods of treatment of attention deficit hyperactivity disorder
WO2014050779A1 (ja) * 2012-09-25 2014-04-03 第一三共株式会社 Gsk3阻害剤と抗dr5抗体の組み合わせ
CN102887896B (zh) * 2012-10-26 2015-11-18 南京工业大学 一种2-(咪唑并[1,2-a]吡啶-3-基)乙腈的制备方法
US9724331B2 (en) 2012-12-10 2017-08-08 Centogene Ag Use of maleimide derivatives for preventing and treating leukemia
JP6534098B2 (ja) * 2014-09-12 2019-06-26 国立大学法人 鹿児島大学 成人t細胞白血病治療薬
CN104945436B (zh) * 2015-07-09 2017-02-08 山东罗欣药业集团股份有限公司 一种米诺膦酸的制备方法
KR101694063B1 (ko) 2015-10-12 2017-01-17 전남대학교병원 Bio 화합물을 함유하는 심혈관질환의 치료용 조성물
US11071720B2 (en) 2016-11-03 2021-07-27 Ucl Business Ltd Cancer therapy
WO2020163812A1 (en) 2019-02-08 2020-08-13 Frequency Therapeutics, Inc. Valproic acid compounds and wnt agonists for treating ear disorders

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200911272A (en) * 2007-07-02 2009-03-16 Lilly Co Eli Potentiation of cancer chemotherapy

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
ES2276048T3 (es) * 2002-03-05 2007-06-16 Eli Lilly And Company Derivados de purina como inhibidores de cinasa.
EP2217231B1 (en) 2007-12-05 2011-11-30 Johannes Gutenberg-Universität Mainz Use of 3-(indolyl)- or 3-(azaindolyl)-4-arylmaleimide derivatives in leukemia management
JP5699129B2 (ja) * 2009-04-14 2015-04-08 イーライ リリー アンド カンパニー 造血器新生物および白血病の治療のためのベンゾジアゼピン誘導体

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200911272A (en) * 2007-07-02 2009-03-16 Lilly Co Eli Potentiation of cancer chemotherapy

Also Published As

Publication number Publication date
CN102395372A (zh) 2012-03-28
CA2758473C (en) 2013-12-17
AU2010236747A1 (en) 2011-10-06
EP2419106A1 (en) 2012-02-22
CA2758473A1 (en) 2010-10-21
IL215107A0 (en) 2011-12-29
EA018933B1 (ru) 2013-11-29
JP2012524089A (ja) 2012-10-11
SG175207A1 (en) 2011-11-28
PE20120772A1 (es) 2012-06-27
US20100261712A1 (en) 2010-10-14
TW201105328A (en) 2011-02-16
US20140235621A1 (en) 2014-08-21
WO2010120614A1 (en) 2010-10-21
CL2011002531A1 (es) 2012-06-01
AU2010236747B2 (en) 2012-11-08
NZ595413A (en) 2013-05-31
US8802668B2 (en) 2014-08-12
MY157218A (en) 2016-05-13
TN2011000500A1 (en) 2013-05-24
JP5699129B2 (ja) 2015-04-08
ECSP11011403A (es) 2011-11-30
DOP2011000312A (es) 2011-10-31
MX2011010937A (es) 2011-11-02
UA103792C2 (uk) 2013-11-25
CN102395372B (zh) 2014-07-02
KR20120004447A (ko) 2012-01-12
EA201171243A1 (ru) 2012-03-30
BRPI1013774A2 (pt) 2016-04-05
US9044487B2 (en) 2015-06-02
KR101290509B1 (ko) 2013-07-26
MA33184B1 (fr) 2012-04-02

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