TWI426905B - 用於乳癌、大腸直腸癌、胰臟癌、卵巢癌及肺癌之治療的７-乙基-１０羥喜樹鹼之多臂聚合性共軛物 - Google Patents
用於乳癌、大腸直腸癌、胰臟癌、卵巢癌及肺癌之治療的７-乙基-１０羥喜樹鹼之多臂聚合性共軛物 Download PDFInfo
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- TWI426905B TWI426905B TW096104772A TW96104772A TWI426905B TW I426905 B TWI426905 B TW I426905B TW 096104772 A TW096104772 A TW 096104772A TW 96104772 A TW96104772 A TW 96104772A TW I426905 B TWI426905 B TW I426905B
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- compound
- cycloalkyl
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- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 claims description 38
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- 238000000034 method Methods 0.000 claims description 24
- KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 claims description 22
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 13
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- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims description 8
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- HAWJUUUDZFZUKG-UHFFFAOYSA-N 2,2-diaminoheptanedioic acid Chemical compound OC(=O)C(N)(N)CCCCC(O)=O HAWJUUUDZFZUKG-UHFFFAOYSA-N 0.000 claims description 3
- FUOOLUPWFVMBKG-UHFFFAOYSA-N 2-Aminoisobutyric acid Chemical compound CC(C)(N)C(O)=O FUOOLUPWFVMBKG-UHFFFAOYSA-N 0.000 claims description 3
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- XABCFXXGZPWJQP-UHFFFAOYSA-N 3-aminoadipic acid Chemical compound OC(=O)CC(N)CCC(O)=O XABCFXXGZPWJQP-UHFFFAOYSA-N 0.000 claims description 3
- SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 claims description 3
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 claims description 3
- JUQLUIFNNFIIKC-YFKPBYRVSA-N L-2-aminopimelic acid Chemical compound OC(=O)[C@@H](N)CCCCC(O)=O JUQLUIFNNFIIKC-YFKPBYRVSA-N 0.000 claims description 3
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- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims description 3
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- CWLQUGTUXBXTLF-UHFFFAOYSA-N N-methyl-L-proline monohydrate Natural products CN1CCCC1C(O)=O CWLQUGTUXBXTLF-UHFFFAOYSA-N 0.000 claims description 3
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Classifications
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- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
- C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
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- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
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- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77246406P | 2006-02-09 | 2006-02-09 | |
| US80439106P | 2006-06-09 | 2006-06-09 | |
| US84493806P | 2006-09-15 | 2006-09-15 | |
| US86451606P | 2006-11-06 | 2006-11-06 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW200810757A TW200810757A (en) | 2008-03-01 |
| TWI426905B true TWI426905B (zh) | 2014-02-21 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| TW096104772A TWI426905B (zh) | 2006-02-09 | 2007-02-09 | 用於乳癌、大腸直腸癌、胰臟癌、卵巢癌及肺癌之治療的７-乙基-１０羥喜樹鹼之多臂聚合性共軛物 |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1996208B1 (enExample) |
| JP (1) | JP5265384B2 (enExample) |
| KR (1) | KR20080091829A (enExample) |
| CN (1) | CN101420963B (enExample) |
| AU (1) | AU2007212201B2 (enExample) |
| CA (1) | CA2640013A1 (enExample) |
| ES (1) | ES2436109T3 (enExample) |
| IL (1) | IL193164A0 (enExample) |
| MX (1) | MX2008010303A (enExample) |
| TW (1) | TWI426905B (enExample) |
| WO (1) | WO2007092646A2 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7462627B2 (en) * | 2006-02-09 | 2008-12-09 | Enzon Pharmaceuticals, Inc. | Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers |
| US7671067B2 (en) | 2006-02-09 | 2010-03-02 | Enzon Pharmaceuticals, Inc. | Treatment of non-hodgkin's lymphomas with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamtothecin |
| EP2109448B1 (en) | 2007-02-09 | 2013-09-11 | Enzon Pharmaceuticals, Inc. | Treatment of resistant or refractory cancers with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin |
| WO2010025337A1 (en) * | 2008-08-29 | 2010-03-04 | Enzon Pharmaceuticals, Inc. | Method of treating ras associated cancer |
| JP2012506380A (ja) * | 2008-10-21 | 2012-03-15 | エンゾン ファーマシューティカルズ，インコーポレーテッド | ７−エチル−１０−ヒドロキシカンプトテシンのマルチアーム型ポリマーコンジュゲートによる神経芽腫の治療 |
| CA2758263A1 (en) * | 2009-04-17 | 2010-10-21 | Enzon Pharmaceuticals, Inc. | Methods for inhibiting angiogenesis with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin |
| US20140378404A1 (en) | 2011-10-25 | 2014-12-25 | Nektar Therapeutics | Treatment of Patients Suffering from Cancer |
| WO2014085571A1 (en) * | 2012-11-28 | 2014-06-05 | Nektar Therapeutics | Method for assessing and predicting efficacy of breast cancer treatment with a long-acting topoisomerase i inhibitor |
| EP3004888A1 (en) | 2013-05-31 | 2016-04-13 | Nektar Therapeutics | Method for predicting and evaluating responsiveness to cancer treatment with dna-damaging chemotherapeutic agents |
| CN104650342B (zh) * | 2013-11-18 | 2018-07-10 | 江苏豪森药业集团有限公司 | 多支链聚合药物前体及其应用 |
| JP6758195B2 (ja) | 2014-01-14 | 2020-09-23 | ネクター セラピューティクス | 併用ベースの治療方法 |
| CN110448533B (zh) * | 2014-12-05 | 2022-03-29 | 天津键凯科技有限公司 | 一种聚乙二醇修饰的喜树碱类衍生物的药物组合物及其制备方法 |
| CN106831853B (zh) * | 2017-02-15 | 2019-02-22 | 浙江海正药业股份有限公司 | 7-乙基-10-o-叔丁基二苯基硅基喜树碱-20-o-甘氨酸盐酸盐的制备工艺 |
| CN108727584B (zh) * | 2017-04-21 | 2021-01-05 | 博瑞生物医药（苏州）股份有限公司 | 抗癌偶联物 |
| CN108727583B (zh) * | 2017-04-21 | 2022-03-22 | 高瑞耀业(北京)科技有限公司 | 多臂靶向抗癌偶联物 |
| CN108164419B (zh) * | 2017-12-25 | 2021-03-16 | 武汉大学 | 单分散聚乙二醇单甲醚修饰的丙泊酚前药的制备与应用 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050112088A1 (en) * | 2003-09-17 | 2005-05-26 | Xuan Zhao | Multi-arm polymer prodrugs |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5880131A (en) * | 1993-10-20 | 1999-03-09 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
| YU10899A (sh) * | 1996-08-30 | 2002-03-18 | Eli Lilli And Company | Farmaceutska jedinjenja |
| US20040009229A1 (en) * | 2000-01-05 | 2004-01-15 | Unger Evan Charles | Stabilized nanoparticle formulations of camptotheca derivatives |
| US6548488B2 (en) * | 2000-03-17 | 2003-04-15 | Aventis Pharma S.A. | Composition comprising camptothecin or a camptothecin derivative and an alkylating agent for the treatment of cancer |
| US7132423B2 (en) * | 2001-09-21 | 2006-11-07 | Reddy Us Therapeutics, Inc. | Methods and compositions of novel triazine compounds |
| JP2006514064A (ja) * | 2003-01-16 | 2006-04-27 | テクノ マート シーオー．，エルティーディー． | ポルフィリン誘導体 |
| DE10307787A1 (de) * | 2003-02-24 | 2004-09-02 | Ktb Tumorforschungsgesellschaft Mbh | Protein-bindende Camptothecin-Derivate |
| KR20070087266A (ko) * | 2003-04-03 | 2007-08-28 | 세마포르 파머슈티컬즈, 아이엔씨. | 피아이-3 키나아제 억제제 프로드러그 |
| DK3549936T3 (da) * | 2003-04-11 | 2021-07-12 | Ptc Therapeutics Inc | 1,2,4-oxadiazol-benzoesyreforbindelse og dens anvendelse til nonsense-undertrykkelse og behandlingen af sygdom |
| TWI334868B (en) * | 2003-06-03 | 2010-12-21 | Nippon Kayaku Kk | [1,2,4] triazoro [1,5-a] pyrimidine-2-ylurea derivative and use thereof |
| US20040247624A1 (en) * | 2003-06-05 | 2004-12-09 | Unger Evan Charles | Methods of making pharmaceutical formulations for the delivery of drugs having low aqueous solubility |
| WO2005068424A1 (en) * | 2004-01-20 | 2005-07-28 | Cell Therapeutics Europe S.R.L. | Indolinone derivatives as receptor tyrosine kinase ihibitors |
| TW200530236A (en) * | 2004-02-23 | 2005-09-16 | Chugai Pharmaceutical Co Ltd | Heteroaryl phenylurea |
| ITRM20040239A1 (it) * | 2004-05-13 | 2004-08-13 | Sigma Tau Ind Farmaceuti | Derivati ciclopeptidici ad attivita' antintegrine. |
-
2007
- 2007-02-09 CA CA002640013A patent/CA2640013A1/en not_active Abandoned
- 2007-02-09 EP EP07763709.8A patent/EP1996208B1/en not_active Not-in-force
- 2007-02-09 TW TW096104772A patent/TWI426905B/zh not_active IP Right Cessation
- 2007-02-09 ES ES07763709T patent/ES2436109T3/es active Active
- 2007-02-09 KR KR1020087021163A patent/KR20080091829A/ko not_active Withdrawn
- 2007-02-09 CN CN2007800127903A patent/CN101420963B/zh not_active Expired - Fee Related
- 2007-02-09 WO PCT/US2007/003808 patent/WO2007092646A2/en not_active Ceased
- 2007-02-09 AU AU2007212201A patent/AU2007212201B2/en not_active Ceased
- 2007-02-09 JP JP2008554430A patent/JP5265384B2/ja not_active Expired - Fee Related
- 2007-02-09 MX MX2008010303A patent/MX2008010303A/es unknown
-
2008
- 2008-07-31 IL IL193164A patent/IL193164A0/en unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050112088A1 (en) * | 2003-09-17 | 2005-05-26 | Xuan Zhao | Multi-arm polymer prodrugs |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2640013A1 (en) | 2007-08-16 |
| CN101420963A (zh) | 2009-04-29 |
| TW200810757A (en) | 2008-03-01 |
| EP1996208A2 (en) | 2008-12-03 |
| ES2436109T3 (es) | 2013-12-27 |
| JP5265384B2 (ja) | 2013-08-14 |
| AU2007212201A1 (en) | 2007-08-16 |
| JP2009526076A (ja) | 2009-07-16 |
| WO2007092646A3 (en) | 2008-10-16 |
| EP1996208B1 (en) | 2013-09-25 |
| CN101420963B (zh) | 2012-09-05 |
| AU2007212201B2 (en) | 2012-09-13 |
| MX2008010303A (es) | 2009-03-05 |
| IL193164A0 (en) | 2009-08-03 |
| KR20080091829A (ko) | 2008-10-14 |
| WO2007092646A2 (en) | 2007-08-16 |
| EP1996208A4 (en) | 2011-04-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Annulment or lapse of patent due to non-payment of fees |