CN115515652A - 一种医用水凝胶及其制备方法和用途 - Google Patents
一种医用水凝胶及其制备方法和用途 Download PDFInfo
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- CN115515652A CN115515652A CN202180001722.7A CN202180001722A CN115515652A CN 115515652 A CN115515652 A CN 115515652A CN 202180001722 A CN202180001722 A CN 202180001722A CN 115515652 A CN115515652 A CN 115515652A
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- Materials For Medical Uses (AREA)
Abstract
本公开属于生物医用材料领域，具体涉及一种医用水凝胶及其制备方法、用途和制备医用水凝胶的试剂盒。本公开的医用水凝胶包括水凝胶骨架，和与所述水凝胶骨架相螯合的螯合剂；其中水凝胶骨架包含由式(I)所示结构的聚乙二醇衍生物I，和式(II)所示结构的聚乙二醇衍生物II键合形成的具有多条“长臂”的聚合物。以单宁酸和/或柠檬酸为螯合剂与水凝胶骨架螯合后，能够得到具有良好的抑菌性能、力学性能、粘附性能，低溶胀，以及凝胶速率和降解速率可控的医用水凝胶。此外，该水凝胶能够在湿润状态下保持粘性，不受体液影响，在组织有运动或搏动状态下仍能保证有效粘附和创面封闭，具有巨大的临床应用前景。
Description
PCT国内申请，说明书已公开。
Claims (11)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2021104024931 | 2021-04-14 | ||
| CN202110402493 | 2021-04-14 | ||
| PCT/CN2021/099446 WO2022217733A1 (zh) | 2021-04-14 | 2021-06-10 | 一种医用水凝胶及其制备方法和用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115515652A true CN115515652A (zh) | 2022-12-23 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202180001722.7A Pending CN115515652A (zh) | 2021-04-14 | 2021-06-10 | 一种医用水凝胶及其制备方法和用途 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20230256134A1 (zh) |
| EP (1) | EP4252787A4 (zh) |
| CN (1) | CN115515652A (zh) |
| WO (1) | WO2022217733A1 (zh) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115634308B (zh) * | 2022-12-13 | 2023-03-28 | 北京大学第三医院（北京大学第三临床医学院） | 聚乙二醇生物粘合剂及其制备方法和应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104174071A (zh) * | 2004-04-28 | 2014-12-03 | 安希奥设备国际有限责任公司 | 用于形成交联生物材料的组合物和系统及关联的制备方法与用途 |
| JPWO2012035598A1 (ja) * | 2010-09-13 | 2014-01-20 | 株式会社グツドマン | 医療用材料、乾燥体及びそれらの製造方法 |
| KR101307367B1 (ko) * | 2010-09-14 | 2013-09-25 | 주식회사 이노테라피 | 탄닌, 폴리에틸렌글리콜 및 물, 저급 알코올 또는 이들의 혼합물을 포함하는 접착제 조성물 |
| CN102911493A (zh) * | 2012-09-28 | 2013-02-06 | 山东赛克赛斯药业科技有限公司 | 可生物降解的医用水凝胶及其制备方法与应用 |
| CN104399109B (zh) * | 2014-11-26 | 2018-02-02 | 沈伟 | 一种凝胶止血材料组合物及其制备方法 |
| CN106519264B (zh) | 2016-11-10 | 2019-02-26 | 中国科学院化学研究所 | 基于peg和多糖的双网络水凝胶及其制备方法与应用 |
| CN108525016B (zh) | 2017-03-01 | 2020-09-22 | 中国科学院化学研究所 | 基于可快速降解化学键的peg水凝胶及其制备方法与应用 |
| CN108525002B (zh) | 2017-03-01 | 2020-09-29 | 中国科学院化学研究所 | 一种具有高强粘附性能的可注射生物胶水及其制备方法与应用 |
| CN110025821A (zh) * | 2018-01-12 | 2019-07-19 | 北京环球利康科技有限公司 | 使用生物相容性止血剂和组织封闭剂的组合物处理活动性出血的方法 |
-
2021
- 2021-06-10 CN CN202180001722.7A patent/CN115515652A/zh active Pending
- 2021-06-10 WO PCT/CN2021/099446 patent/WO2022217733A1/zh unknown
- 2021-06-10 EP EP21936605.1A patent/EP4252787A4/en active Pending
- 2021-06-10 US US18/014,385 patent/US20230256134A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP4252787A1 (en) | 2023-10-04 |
| US20230256134A1 (en) | 2023-08-17 |
| EP4252787A4 (en) | 2024-06-12 |
| WO2022217733A1 (zh) | 2022-10-20 |
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