TWI351926B - Iron sulfate based phosphate adsorbent - Google Patents
Iron sulfate based phosphate adsorbent Download PDFInfo
- Publication number
- TWI351926B TWI351926B TW094121167A TW94121167A TWI351926B TW I351926 B TWI351926 B TW I351926B TW 094121167 A TW094121167 A TW 094121167A TW 94121167 A TW94121167 A TW 94121167A TW I351926 B TWI351926 B TW I351926B
- Authority
- TW
- Taiwan
- Prior art keywords
- iron
- composition
- hydroxide
- solution
- suspension
- Prior art date
Links
- 229910019142 PO4 Inorganic materials 0.000 title claims description 13
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 title claims description 13
- 239000010452 phosphate Substances 0.000 title claims description 13
- 239000003463 adsorbent Substances 0.000 title claims description 9
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 title description 3
- 229910000358 iron sulfate Inorganic materials 0.000 title description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 77
- 239000000203 mixture Substances 0.000 claims description 39
- 229910052742 iron Inorganic materials 0.000 claims description 33
- 238000000034 method Methods 0.000 claims description 29
- 239000000243 solution Substances 0.000 claims description 18
- NCNCGGDMXMBVIA-UHFFFAOYSA-L iron(ii) hydroxide Chemical compound [OH-].[OH-].[Fe+2] NCNCGGDMXMBVIA-UHFFFAOYSA-L 0.000 claims description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 230000032683 aging Effects 0.000 claims description 14
- 235000014413 iron hydroxide Nutrition 0.000 claims description 14
- 150000001720 carbohydrates Chemical class 0.000 claims description 9
- 235000014633 carbohydrates Nutrition 0.000 claims description 9
- 150000003839 salts Chemical class 0.000 claims description 9
- QJZYHAIUNVAGQP-UHFFFAOYSA-N 3-nitrobicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid Chemical compound C1C2C=CC1C(C(=O)O)C2(C(O)=O)[N+]([O-])=O QJZYHAIUNVAGQP-UHFFFAOYSA-N 0.000 claims description 8
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 8
- 229930006000 Sucrose Natural products 0.000 claims description 8
- 239000004021 humic acid Substances 0.000 claims description 8
- 239000005720 sucrose Substances 0.000 claims description 8
- 229920002472 Starch Polymers 0.000 claims description 7
- 239000007864 aqueous solution Substances 0.000 claims description 7
- 238000001035 drying Methods 0.000 claims description 7
- 239000008107 starch Substances 0.000 claims description 7
- 235000019698 starch Nutrition 0.000 claims description 7
- VCJMYUPGQJHHFU-UHFFFAOYSA-N iron(3+);trinitrate Chemical compound [Fe+3].[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O VCJMYUPGQJHHFU-UHFFFAOYSA-N 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 6
- 239000004375 Dextrin Substances 0.000 claims description 5
- 229920001353 Dextrin Polymers 0.000 claims description 5
- 235000019425 dextrin Nutrition 0.000 claims description 5
- 230000002401 inhibitory effect Effects 0.000 claims description 5
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 4
- 239000007900 aqueous suspension Substances 0.000 claims description 4
- 235000013305 food Nutrition 0.000 claims description 4
- 239000002244 precipitate Substances 0.000 claims description 4
- 230000000069 prophylactic effect Effects 0.000 claims description 4
- 230000001225 therapeutic effect Effects 0.000 claims description 4
- 159000000007 calcium salts Chemical class 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 claims description 3
- 238000000502 dialysis Methods 0.000 claims description 3
- RUTXIHLAWFEWGM-UHFFFAOYSA-H iron(3+) sulfate Chemical compound [Fe+3].[Fe+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O RUTXIHLAWFEWGM-UHFFFAOYSA-H 0.000 claims description 3
- 229910000360 iron(III) sulfate Inorganic materials 0.000 claims description 3
- 238000005406 washing Methods 0.000 claims description 3
- -1 alkali metal hydrogencarbonate Chemical class 0.000 claims description 2
- 150000001450 anions Chemical class 0.000 claims description 2
- 239000008280 blood Substances 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 claims description 2
- 239000002552 dosage form Substances 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 238000001556 precipitation Methods 0.000 claims description 2
- 229910021653 sulphate ion Inorganic materials 0.000 claims description 2
- 239000002585 base Substances 0.000 claims 3
- 239000012266 salt solution Substances 0.000 claims 3
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims 2
- 229910052751 metal Inorganic materials 0.000 claims 2
- 239000002184 metal Substances 0.000 claims 2
- 150000002736 metal compounds Chemical class 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 238000011282 treatment Methods 0.000 claims 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 1
- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical class [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 claims 1
- 229910002651 NO3 Inorganic materials 0.000 claims 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims 1
- 239000003513 alkali Substances 0.000 claims 1
- 229910052783 alkali metal Inorganic materials 0.000 claims 1
- 229910000288 alkali metal carbonate Inorganic materials 0.000 claims 1
- 150000008041 alkali metal carbonates Chemical class 0.000 claims 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 claims 1
- 150000001719 carbohydrate derivatives Chemical class 0.000 claims 1
- MSNWSDPPULHLDL-UHFFFAOYSA-K ferric hydroxide Chemical compound [OH-].[OH-].[OH-].[Fe+3] MSNWSDPPULHLDL-UHFFFAOYSA-K 0.000 claims 1
- 201000005991 hyperphosphatemia Diseases 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims 1
- 235000017557 sodium bicarbonate Nutrition 0.000 claims 1
- KKCBUQHMOMHUOY-UHFFFAOYSA-N sodium oxide Chemical compound [O-2].[Na+].[Na+] KKCBUQHMOMHUOY-UHFFFAOYSA-N 0.000 claims 1
- 229910001948 sodium oxide Inorganic materials 0.000 claims 1
- FIWQZURFGYXCEO-UHFFFAOYSA-M sodium;decanoate Chemical compound [Na+].CCCCCCCCCC([O-])=O FIWQZURFGYXCEO-UHFFFAOYSA-M 0.000 claims 1
- 239000002689 soil Substances 0.000 claims 1
- 239000002594 sorbent Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 description 32
- 239000000463 material Substances 0.000 description 15
- 238000001179 sorption measurement Methods 0.000 description 13
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 9
- 239000011574 phosphorus Substances 0.000 description 9
- 229910052698 phosphorus Inorganic materials 0.000 description 9
- 238000010908 decantation Methods 0.000 description 7
- 239000000843 powder Substances 0.000 description 6
- 239000006228 supernatant Substances 0.000 description 6
- 238000004255 ion exchange chromatography Methods 0.000 description 5
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 4
- 239000001913 cellulose Substances 0.000 description 4
- 229920002678 cellulose Polymers 0.000 description 4
- 235000010980 cellulose Nutrition 0.000 description 4
- 239000001488 sodium phosphate Substances 0.000 description 4
- 229910000162 sodium phosphate Inorganic materials 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 2
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 2
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 229960004887 ferric hydroxide Drugs 0.000 description 2
- 238000002309 gasification Methods 0.000 description 2
- 239000007903 gelatin capsule Substances 0.000 description 2
- IEECXTSVVFWGSE-UHFFFAOYSA-M iron(3+);oxygen(2-);hydroxide Chemical compound [OH-].[O-2].[Fe+3] IEECXTSVVFWGSE-UHFFFAOYSA-M 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000010025 steaming Methods 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 239000005569 Iron sulphate Substances 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 229920002774 Maltodextrin Polymers 0.000 description 1
- 239000005913 Maltodextrin Substances 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 102000006335 Phosphate-Binding Proteins Human genes 0.000 description 1
- 108010058514 Phosphate-Binding Proteins Proteins 0.000 description 1
- 206010041349 Somnolence Diseases 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical group OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- VBHASXCYHVJBIN-UHFFFAOYSA-J [Sr+2].[OH-].[Fe+2].[OH-].[OH-].[OH-] Chemical compound [Sr+2].[OH-].[Fe+2].[OH-].[OH-].[OH-] VBHASXCYHVJBIN-UHFFFAOYSA-J 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- WDIHJSXYQDMJHN-UHFFFAOYSA-L barium chloride Chemical compound [Cl-].[Cl-].[Ba+2] WDIHJSXYQDMJHN-UHFFFAOYSA-L 0.000 description 1
- 229910001626 barium chloride Inorganic materials 0.000 description 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 description 1
- 239000001639 calcium acetate Substances 0.000 description 1
- 229960005147 calcium acetate Drugs 0.000 description 1
- 235000011092 calcium acetate Nutrition 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 229910000420 cerium oxide Inorganic materials 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000009918 complex formation Effects 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000012050 conventional carrier Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000008393 encapsulating agent Substances 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 229940035034 maltodextrin Drugs 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000005374 membrane filtration Methods 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- BMMGVYCKOGBVEV-UHFFFAOYSA-N oxo(oxoceriooxy)cerium Chemical compound [Ce]=O.O=[Ce]=O BMMGVYCKOGBVEV-UHFFFAOYSA-N 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000006069 physical mixture Substances 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 230000005070 ripening Effects 0.000 description 1
- 238000009991 scouring Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000010865 sewage Substances 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000021147 sweet food Nutrition 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 229910000406 trisodium phosphate Inorganic materials 0.000 description 1
- 238000009834 vaporization Methods 0.000 description 1
- 230000008016 vaporization Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/30—Oligoelements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
- B01J20/0203—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising compounds of metals not provided for in B01J20/04
- B01J20/0225—Compounds of Fe, Ru, Os, Co, Rh, Ir, Ni, Pd, Pt
- B01J20/0229—Compounds of Fe
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
- B01J20/06—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising oxides or hydroxides of metals not provided for in group B01J20/04
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
- C01G49/00—Compounds of iron
- C01G49/02—Oxides; Hydroxides
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
- C01G49/00—Compounds of iron
- C01G49/02—Oxides; Hydroxides
- C01G49/06—Ferric oxide [Fe2O3]
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/28—Treatment of water, waste water, or sewage by sorption
- C02F1/288—Treatment of water, waste water, or sewage by sorption using composite sorbents, e.g. coated, impregnated, multi-layered
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09C—TREATMENT OF INORGANIC MATERIALS, OTHER THAN FIBROUS FILLERS, TO ENHANCE THEIR PIGMENTING OR FILLING PROPERTIES ; PREPARATION OF CARBON BLACK ; PREPARATION OF INORGANIC MATERIALS WHICH ARE NO SINGLE CHEMICAL COMPOUNDS AND WHICH ARE MAINLY USED AS PIGMENTS OR FILLERS
- C09C1/00—Treatment of specific inorganic materials other than fibrous fillers; Preparation of carbon black
- C09C1/22—Compounds of iron
- C09C1/24—Oxides of iron
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2220/00—Aspects relating to sorbent materials
- B01J2220/40—Aspects relating to the composition of sorbent or filter aid materials
- B01J2220/46—Materials comprising a mixture of inorganic and organic materials
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F2101/00—Nature of the contaminant
- C02F2101/10—Inorganic compounds
- C02F2101/105—Phosphorus compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Analytical Chemistry (AREA)
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Description
Λ W浮液可於室溫或室溫以下溫度例如靜置1至5小時 時間。於該段期間，懸浮液可經攪掉。 然後所得沉抑佳财洗—次，更佳洗數次 ，於各種 清况下，於絲/懸浮操作後，水較佳係藉傾析、過渡、離 、及/或逆參透程序例如膜過濾去除^所得濕產物未經乾 燥。濕產物懸浮於水中”jc含量並無特殊限制；但該程序 較佳為所得懸浮液之鐵含量（以Fe計算）至多為i〇 wt%，特 佳由2至8 wt.%。 於添加其它成分之前，所得氫氧化鐵水性懸浮液較佳 具有於約6.5至7_5範圍之約略中性pH值。較低pH值將導致 氫氧化鐵再度部分溶解於溶液。較高pH值不合所需，較高 PH值可能導致步驟c)生成錯合物。 根據本發明方法特佳係以於步驟c)添加額外成分之 刖，貫質上未出現氫氧化鐵之老化之方式進行。於沉澱老 化期間，最初隨機定位之分子再度集結成群，經常形成或 多或少規則晶格。大部分情況下，沉澱老化不僅涉及結晶， 同時由於澳斯沃熟成結果也造成粒子放大。 於步驟c)，於如上所得懸浮液添加又另一種成分，其 具有前文說明之步驟C)所得氫氧化鐵沉澱的老化。此種抑 制氫氧化鐵老化之成分較佳係選自於由碳水化合物類、碳 水化合物衍生物及腐植酸組成之組群。該成分較佳係以固 體形式添加，但原則上也可能以水溶液形式添加。 根據本發明，特佳使用下列作為其它抑制老化成分： 碳水化合物，諸如各種碳水化合物類及糠類，例如瓊脂、 葡萄聚糖、糊精、麥芽糖糊精、糊精衍生物、葡萄聚糖衍 生物、澱粉、纖維素諸如微晶纖維素及纖維素衍生物、蔗 糖、麥芽糖、乳糖或甘露糖醇， 特佳為澱粉、蔗糖、糊精及/或其混合物。以澱粉、蔗 糖或其混合物為最佳H與特別係選自殺粉、麥芽糖、 糊精及纖維素尤其微晶纖維素之至少另—種成分之混合物 為極佳。額外成分之功能不欲受理論所限，推㈣2 安定化新鮮製備之氫氧化鐵，藉祕止聽化軌殿的老 化。 較佳碳水化合物類或腐植酸之用量係選定為相對於每 克鐵（以Fe計算）’添加至少05克且較佳至少i克額外之抑 氛氧化鐵老化成分，諸如碳水化合物及/或腐植酸。較佳所 得組成物之鐵含量不大㈣wt%，較佳不Μ約4Q 7 所得組成物之鐵含量較佳為至少2Gwt%e可抑化 老化成分諸如碳水化合物類及/或腐植酸之最大含=: 特殊限制，主要係由經濟gj f # -+- ^ θ ± …、 仙心，及更佳約由心。料含^隹約由5至 於步=可抑制氲氧化鐵老化成分 懸浮液以已知方式乾燥。乾 侍水性 乾進行。 可㈣真线縮或藉噴 於根據本發明方法之 得組成物之乾燥前或乾燥後，二丨、例中’於根據本發明所 發例如為無機酸鹽或有機_ =添加—賴鹽。適當詞 4增加鱗酸鹽結合能力Z ·別為乙酸.添加辦鹽 寺別於較高pH值之結合能力。特 1351926 佳係使用被提供ρ Η值大於5之鈣鹽之吸附劑，原因在於即便 如此仍然保有完整磷酸鹽結合能力。業已顯示相對於每克 鐵，添加400毫克至2克例如約1克鈣鹽特別為乙酸鈣為特 優0 5
10 15
20 根據本發明所得材料實質上為氫氧化鐵與可抑制氫氧 化鐵老化成分諸如碳水化合物類或腐植酸之物理混合物。 如前文說明，假設後者係與新鮮沉澱之氫氧化鐵接觸，結 果導致氫氧化鐵之安定化，因而未出現材料的老化，材料 老化可能降低磷酸鹽吸附能力。於根據本發明選用之添加 水性懸浮液之條件下，不會發生如DE 42 39 442所述之錯合 物生成，原因在於錯合物生成要求例如於碳水化合物添加 至氫氧化鐵期間，有強鹼條件。 經由根據本發明方法所得之組成物較佳用來由水溶液 製造磷酸鹽吸附劑。較佳於人體或動物體經口及/或經注射 投藥之製劑係藉根據本發明方法所得之組成物製造。特 別，根據本發明所得組成物用於製備預防及/或治療血中磷 酸鹽過高狀態。特佳，根據本發明所得組成物用於製造透 析病人之預防及/或治療製劑。 為了達成該項目的，根據本發明所得組成物係以已知 方式調配成藥學劑型例如供口服投藥劑型。該組成物可就 此調配，或連同習知藥學添加劑如習知載劑或輔劑物質調 配。舉例言之，可進行包囊，可使用習知用於製藥之材料 如硬明膠膠囊或軟明膠膠囊作為包囊劑。根據本發明所得 組成物之微包囊亦屬可能。可提供吸附劑，選擇性連同輔 10 助物質及添加劑，呈粒劑、錠劑、糖衣錠、填充於囊袋、 呈凝膠形式或棒形而提供。根據本發明所得組成物之每日 劑量例如以鐵為基準為1至3克，且較佳約1.5克。 根據本發明所得組成物也適合用來吸附結合於食物之 填酸鹽；例如用於此項目的，根據此目的可混入食物。為 了達成該項目的，可製備例如前述配方供藥用。 根據本發明所得組成物特別適合用作為由體液、由乳 糜、及食物吸附無機與食物結合之填酸鹽之吸附劑。其具 有類似根據EP 0868125所得吸附劑之磷酸鹽吸附能力，且 製造上簡單而價廉。 本發明進一步係有關經由根據本發明所得之吸附劑。 經由使用硫酸鐵及/或硝酸鐵作為起始物料，根據本發 明可獲得一種具有特低氣化物之組成物，氯化物只微量存 在於組成物。氣化物含量特別係低於習知阿卡加石之氣化 物含量。如此本發明亦係關於一種組成物含有氫氧化鐵(ΠΙ) 及至少一種選自於由碳水化合物類及腐植酸組成之組群之 成分，該組成物含有低於0.05 wt.°/〇，較佳低於0.03 wt.Q/0及 更佳低於0.01 wt.Q/o氣陰離子。 將藉下列實施例說明本發明之進一步細節： 實施例1 444克硫酸鐵(III)溶液（11.3 % w/w Fe)以20-30分鐘時 間以攪拌（葉片型攪拌器）逐滴添加至116 0克蘇打溶液 (d20=1.185克/毫升）。懸浮液又攪拌1小時。隨後以授拌添 加2升水至懸浮液；混合物經靜置’然後傾析去除上清液。 1351926 此程序重複5次。藉此方式，獲得1238克具有鐵含量4.0 %(w/w)(藉錯合計量術測定）之懸浮液》各73·9克蔗糖及澱粉 添加至1238克前述懸浮液。然後懸浮液於60°C旋轉蒸發器 濃縮，及於50°C於高度真空乾燥。獲得223克具有鐵含量 5 21.5 %(w/w)之粉末。 磷酸鹽吸附能力之測定： 1〇毫升磷酸鈉溶液（13.68克/升Ν々Ρ〇4 X 12 h2〇)添加
至233宅克根據前述貫施例製備之材料（相當於〇·9毫莫耳 鐵X莫耳比Fe:P=l:0.4)。調整pH值後，讓懸浮液於37〇c反應 1〇 2小時。然後懸浮液經離心；上清液經傾析去除，以蒸餾水 凋整至25毫升’測定其碟含量。根據實施例製備之材料之 磷酸鹽吸附能力，藉離子層析術測得為於阳3〇為〇戰克 磷/毫克鐵及於pH5·5為0.16毫克碟/毫克鐵。 實施例2 15 20 /克硫酸鐵(ΠΙ)溶液阳w/w Fe)以2〇·30分淘 間以攪拌（葉片型攪拌态-夭丄 ⑽6。/ /、 逐滴添加至刪毫升氫氧化# 液（9.6 /〇 w/v)。懸浮液 水良縣、〜，人 馳小時。隨後以攪拌添加: 拎至心汙液，混合物經靜 序重福…“ 後傾析去除上清液。 ㈣二Sr:清=硫酸鹽為止- Λ 獲得丨606克具有鐵含吾 %(w/w)(藉錯合計量 量 + 』疋）之懸洋液。各66.0克蔗糖及 添加至1606克前述懸浮 夂 濃縮，及於机於高度真”，_6°C旋轉蒸 之粉末。 ^。獲得190克具有鐵 12 磷酸鹽吸附能力之測定： 10毫升鱗酸鈉溶液（13 68克/升叫⑽4 X 12 H2〇)添加 至226毫克根據前述實施例製備之材料（相當於〇 9毫莫耳 鐵)(莫耳比Fe:P=l:〇.4)«>調整pH值後，讓懸浮液於37七反應 5 2小時。然後懸浮液經離心；上清液經傾析去除，以蒸餾水 s周整至25毫升，測定其碟含量。 根據實施例2製備之材料之磷酸鹽吸附能力，藉離子層 析術測得為於pH 3.0為〇.丨9毫克磷/毫克鐵及於pH 5.5為 〇·15毫克磷/毫克鐵。 10 實施例3 535克硝酸鐵(in)溶液(9 7 % w/w Fe)以20-30分鐘時間 以攪拌（葉片型攪拌器）逐滴添加至12〇〇克蘇打溶液 (d20=U85克/毫升）。懸浮液又攪拌卜】、時。隨後懸浮液移 至過濾袋内，經由以水連續清洗洗滌3小時時間（3小時後之 15洗條水之導電係數約為300 pS/cm)。藉此方式，獲得923克 具有鐵含量4.3 %(w/w)(藉錯合計量術測定）之懸浮液。各 6(U克蔗糖及澱粉添加至923克前述懸浮液。然後懸浮液於 60 C旋轉蒸發器濃縮，及於50°C於高度真空乾燥。獲得172 克具有鐵含量22.3 %〇^)之粉末。 20磷酸鹽吸附能力之測定： 10毫升磷酸鈉溶液（13.68克/升他3?〇4乂12%〇)添加 至225毫克根據前述實施例製備之材料（相當於0.9毫莫耳 鐵X莫耳比Fe:P=l:0.4)。調整pH值後’讓懸浮液於37。(：反應 2小時。然後懸浮液經離心；上清液經傾析去除，以蒸德水 升，測定其碟含量。根據實施例製備之材料之 ㈣鹽吸附能力，藉離子層析術測得為於ΡΗ3.0為021毫克 4/¾克鐵及於ΡΗ5·5為0.17毫克磷/毫克鐵。 ·克 實施例4 ^硫酸鐵㈣溶液⑴4 % ·吻㈣分鐘時 二型授掉器)逐滴添加至615克蘇打溶液 至迅廣代85克/②升）。料液又攪拌1小時。然後懸浮液移 過慮衣’經由财連續清洗而洗_3小時日㈣（以氣化 鎖f則試轉在有额鹽）。祕方式，獲得47〇克具有鐵 含量6.0 %(w/w)(藉錯合計量術測定）之懸浮液mi克蔗 糖及殿粉添加至47〇克前㈣浮液1後料液於6代旋轉 蒸發器濃縮，及於5(TC於高度真空乾^獲得2()3克具有 鐵含量20.3 %(w/w)之粉末。 磷酸鹽吸附能力之測定： 10毫升磷酸鈉溶液（13.68克/#Na3P〇4 χ 12 H2〇)添加 至247毫克根據前述實施例製備之材料（相當於〇 9毫莫耳 鐵)(莫耳比Fe:P=l :0.4)。調整pH值後，讓懸浮液於3rt反應 2小時。然後懸浮液經離心；上清液經傾析去除，以蒸餾水 調整至25毫升，測定其磷含量。根據實施例製備之材料之 磷酸鹽吸附能力，藉離子層析術測得為於pH 3 〇為〇 21毫克 碟/毫克鐵及於pH 5.5為0.17毫克磷/毫克鐵。 實施例5 223克硫酸鐵(III)溶液⑴4 % w/w Fe)以20-30分鐘時 間以搜拌（葉片型攪拌器）逐滴添加至585克蘇打溶液 1351926 (£120=1.185克/毫升）。懸浮液又攪拌1小時。然後懸浮液移 至過瀘、袋，經由以水連續清洗而洗務約3小時時間（以氯化 鋇來測試不存在有硫酸鹽）。藉此方式，獲得447克具有鐵 含量6.0 %(w/w)(藉錯合計量術測定)之懸浮液。各20.6克蔗 5 糖及澱粉添加至447克前述懸浮液。然後懸浮液於60°C旋轉 蒸發器濃縮，及於5〇它於高度真空乾燥。獲得65克具有鐵 含量20.6%(w/w)之粉末。 磷酸鹽吸附能力之測定：
15
毫升磷酸鈉溶液（13.68克/升^^31>〇4 X 12 H2〇)添加 至244毫克根據前述實施例製備之材料（相當於0.9毫莫耳 鐵)(莫耳比Fe:P=l:〇_4)。調整pH值後，讓懸浮液於37〇c反應 2小時。然㈣浮液經離d清液經傾析去除，以蒸館水 調整至25毫升，測定其齡量。根據實_製備之材料之 :鹽吸附能力，藉離子層析術測得為於PH3,0為〇.20毫克 克鐵及於pH5·5為〇.Π毫克磷/毫克鐵。 【睏式簡單說明】 (無） 【主要元件符號說明】 (無） 15
Claims (1)
1351926 第94121167號專利申請索說明書暨申請 十、申請專利範圍 -種製備組成物之方法，該方法包含下列步驟：
a) 添加至少—種鹼至水性含硫酸鹽及/或硝酸鹽之鐵 (ΠΙ)鹽溶液來形成氫氧化鐵沉澱， b) 選擇性地以水洗滌所得沉澱-次或多次，獲得氫 氧化鐵水性懸浮液，
c) 於所得水性懸浮液添加至少又一成分，該成分可 抑制步驟b)所得之氫氧化鐵沉澱之老化， d) 乾燥步驟c)所得之組成物， "中該額外抑制氫氧化鐵之沉澱老化之成分係選自於 由奴水化合物類、碳水化合物衍生物及腐植酸組成之組 群。 2·如申請專利範圍第丨項之方法，其特徵在於含硫酸鹽之 鐵(III)鹽溶液係被使用。 •如申吻專利範圍第丨或2項之方法，其特徵在於該鐵(ΙΠ) 鹽溶液為水性硫酸鐵(III)溶液。 如申％專利範圍第丨或2項之方法，其特徵在於該鐵(ΠΙ) 鹽溶液為水性硝酸鐵(III)溶液。 5·如申4專利範15第1或2項之方法’其特徵在於於步驟a) 建立之pH值至少為3。 6. 如申睛專利範圍第1或2項之方法，其特徵在於所得組成 物含有不多於50 wt·%鐵。 7. 如申凊專利範圍第1或2項之方法，其特徵在於該鹼係選 自驗金屬化合物及驗土金屬化合物。 16 1351926 第州21167號專利申請案說明書暨申請專利範圍修正本修正日期：100年08月〇9日 8.如申請專利範圍第丨或2項之方法，其特徵在於該鹼係選 自驗金屬氫氧化物及驗金屬碳酸鹽。 9·如申請專利範圍第丨或2項之方法，其特徵在於鹼金屬碳 酸鹽水溶液、鹼金屬碳酸氫鹽水溶液、或鹼金屬氫氧化 物水溶液於步驟a)用作為鹼。 10. 如申請專利範圍第1或2項之方法，其特徵在於於步驟a) 建立之pH值至少為6。 11. 如申請專利範圍第丨或2項之方法，其特徵在於於步驟幻 使用IL氧化鈉、ί炭酸納及/或碳酸氫鈉作為驗。 12. 如申請專利範圍第丨或2項之方法，其特徵在於該額外抑 制氫氧化鐵老化之成分係選自於由澱粉、蔗糖及糊精組 成之組群。 13·如申請專利範圍第丨或2項之方法，其特徵在於於該組成 物乾燥前或乾燥後，添加至少一種鈣鹽。 14. 如申請專利範圍第丨或2項之方法，其特徵在於於步驟c) 添加額外成分之前，實質上未出現氫氧化鐵之老化。 15. 如申請專利範圍第丨或2項之方法，其特徵在於所得組成 物係於額外步驟e)被配方成為藥學劑型。 16. —種可由如申請專利範圍第丨至15項中任一項方法所獲 得之組成物之用途，其係用於製造由水溶液吸附磷酸鹽 之吸附劑。 π_—種可由如申請專利範圍第丨至15項中任一項之方法所 獲得之組成物之用途，其係用於製造於人體或動物體經 口投藥及/或經腸道外投藥用之製劑。 17 1351926 第94121167號專利申請案說明書暨申請專利範圍修正本 修正日期：100年08月09曰 18. —種可由如申請專利範圍第1至15項中任一項之方法所 獲得之組成物之用途，其係用於製備血中磷酸鹽濃度過 高狀態之預防及/或治療用之製劑。 19. 如申請專利範圍第16至18項中任一項之用途，其係用於 製造透析病人之預防性處理及/或治療性處理用之製 劑。 20. —種吸附劑，其可經由如申請專利範圍第1至15中任一 項之方法獲得。
21. —種如申請專利範圍第1至15項中任一項之方法所獲得 之組成物之用途，其係用於製造與食品混合用之吸附 劑。 22. —種組成物，該組成物含有氫氧化鐵(III)以及選自於由 碳水化合物類及腐植酸組成之組群之至少一種成分，其 特徵在於該組成物含有低於0.05 wt.%氣陰離子。
23. —種用於預防及/或治療高磷酸鹽血症狀態之藥學組成 物，包含如申請專利範圍第1至15項中任一項之方法所 獲得之組成物。 24. —種用於透析病人之預防性處理及/或治療性處理之藥 學組成物，包含如申請專利範圍第1至15項中任一項之 方法所獲得之組成物。 18
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| DE102004031181A DE102004031181A1 (de) | 2004-06-28 | 2004-06-28 | Phosphatadsorbens |
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| PT2319804E (pt) * | 2006-12-14 | 2014-11-24 | Novartis Ag | Adsorvente de fosfato à base de ferro (iii)-carboidrato |
| EP1932807A1 (en) * | 2006-12-14 | 2008-06-18 | Novartis AG | Inorganic compounds |
| EP2319804B1 (en) * | 2006-12-14 | 2014-10-22 | Novartis AG | Iron(III)-Carbohydrate based phosphate adsorbent |
| TWI468167B (zh) | 2007-11-16 | 2015-01-11 | 威佛（國際）股份有限公司 | 藥學組成物 |
| US20110086097A1 (en) * | 2008-06-13 | 2011-04-14 | Daniel Kaufmann | Manufacture process for the preparation of an iron containing phosphate adsorbent |
| CN101318122B (zh) * | 2008-07-21 | 2013-03-20 | 郜洪文 | 阴离子表面活性剂-硫酸钡复合吸附材料及其制备方法 |
| SG173887A1 (en) * | 2009-03-02 | 2011-10-28 | Vifor Int Ag | Phosphate adsorbent |
| JP2012192326A (ja) * | 2011-03-15 | 2012-10-11 | Kyoto Univ | 硫黄含有ガス除去材、その製造方法および硫黄含有ガス除去方法 |
| DE102011112898A1 (de) | 2011-09-08 | 2013-03-14 | Charité - Universitätsmedizin Berlin | Nanopartikuläres Phosphatadsorbens basierend auf Maghämit oder Maghämit/Magnetit, dessen Herstellung und Verwendungen |
| RU2496722C1 (ru) * | 2012-04-10 | 2013-10-27 | Леонид Асхатович Мазитов | Способ очистки сточной воды от фосфатов |
| ES2820737T3 (es) * | 2013-11-27 | 2021-04-22 | Vifor Fresenius Medical Care Renal Pharma Ltd | Composición farmacéutica que comprende partículas de quelante de fosfato |
| US11583846B2 (en) | 2014-11-25 | 2023-02-21 | Graver Technologies Llc | High capacity adsorbent for oxyanions and cations and method for making the same |
| US10343154B2 (en) | 2014-11-25 | 2019-07-09 | Graver Technologies Llc | High capacity adsorbent for fluoride ion and oxyanions of phosphorous and arsenic and method for making the same |
| CN107397810B (zh) * | 2016-05-19 | 2021-08-24 | 欣凯医药化工中间体（上海）有限公司 | 基于铁的氢氧化物－桃胶的磷结合剂、其制备方法及其应用 |
| CN107397760B (zh) * | 2016-05-19 | 2021-07-30 | 欣凯医药化工中间体（上海）有限公司 | 基于铁的氢氧化物－低分子量糖的磷结合剂、其制备方法及其应用 |
| CN107397758A (zh) * | 2016-05-19 | 2017-11-28 | 欣凯医药化工中间体（上海）有限公司 | 一种磷结合剂及其制备方法 |
| CN107397759A (zh) * | 2016-05-19 | 2017-11-28 | 欣凯医药化工中间体（上海）有限公司 | 基于铁的氢氧化物－降解的碳水化合物的磷结合剂、其制备方法及其应用 |
| CN108773889A (zh) * | 2018-09-10 | 2018-11-09 | 芜湖新达园林绿化集团有限公司 | 一种去污絮凝剂用复合微球及去污絮凝剂的制备、应用 |
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Also Published As
| Publication number | Publication date |
|---|---|
| ES2718458T3 (es) | 2019-07-02 |
| KR20070031420A (ko) | 2007-03-19 |
| CN1997596A (zh) | 2007-07-11 |
| AR049522A1 (es) | 2006-08-09 |
| NO20070391L (no) | 2007-03-20 |
| TW200603746A (en) | 2006-02-01 |
| HK1108422A1 (en) | 2008-05-09 |
| RU2007103154A (ru) | 2008-08-10 |
| CA2571364C (en) | 2013-05-14 |
| CA2571364A1 (en) | 2006-01-05 |
| RU2344083C2 (ru) | 2009-01-20 |
| ZA200700767B (en) | 2008-09-25 |
| WO2006000547A3 (de) | 2006-06-22 |
| BRPI0512636A (pt) | 2008-03-25 |
| EP1899270B1 (de) | 2019-02-27 |
| DE102004031181A1 (de) | 2006-01-19 |
| WO2006000547A2 (de) | 2006-01-05 |
| NZ552247A (en) | 2010-06-25 |
| CN1997596B (zh) | 2011-03-30 |
| EP1899270A2 (de) | 2008-03-19 |
| JP4997107B2 (ja) | 2012-08-08 |
| JP2008504344A (ja) | 2008-02-14 |
| UA92894C2 (ru) | 2010-12-27 |
| AU2005256617B2 (en) | 2010-08-26 |
| MX2007000335A (es) | 2007-03-12 |
| AU2005256617A1 (en) | 2006-01-05 |
| KR101122752B1 (ko) | 2012-03-23 |
| US20090169645A1 (en) | 2009-07-02 |
| US20140335202A1 (en) | 2014-11-13 |
| AU2005256617C1 (en) | 2011-03-10 |
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