TWI276631B - Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation - Google Patents
Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation Download PDFInfo
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- TWI276631B TWI276631B TW092124975A TW92124975A TWI276631B TW I276631 B TWI276631 B TW I276631B TW 092124975 A TW092124975 A TW 092124975A TW 92124975 A TW92124975 A TW 92124975A TW I276631 B TWI276631 B TW I276631B
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- phenyl
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- 230000004663 cell proliferation Effects 0.000 title claims abstract description 26
- 230000002401 inhibitory effect Effects 0.000 title claims description 29
- BVNWQSXXRMNYKH-UHFFFAOYSA-N 4-phenyl-2h-benzotriazole Chemical class C1=CC=CC=C1C1=CC=CC2=C1NN=N2 BVNWQSXXRMNYKH-UHFFFAOYSA-N 0.000 title abstract 2
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 185
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D515/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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US41076102P | 2002-09-12 | 2002-09-12 |
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TW200404784A TW200404784A (en) | 2004-04-01 |
TWI276631B true TWI276631B (en) | 2007-03-21 |
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TW092124975A TWI276631B (en) | 2002-09-12 | 2003-09-10 | Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation |
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US (1) | US7256287B2 (pt) |
EP (1) | EP1546157A4 (pt) |
JP (1) | JP2006503048A (pt) |
KR (1) | KR20050050102A (pt) |
CN (1) | CN1694889A (pt) |
AR (1) | AR041252A1 (pt) |
AU (1) | AU2003279729A1 (pt) |
BR (1) | BR0314235A (pt) |
CA (1) | CA2498495A1 (pt) |
MX (1) | MXJL05000010A (pt) |
NZ (1) | NZ538547A (pt) |
PE (1) | PE20050036A1 (pt) |
PL (1) | PL375811A1 (pt) |
RU (1) | RU2005109911A (pt) |
TW (1) | TWI276631B (pt) |
WO (1) | WO2004024897A2 (pt) |
ZA (1) | ZA200502738B (pt) |
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WO2002072090A1 (en) * | 2001-03-12 | 2002-09-19 | Avanir Pharmaceuticals | Benzimidazole compounds for modulating ige and inhibiting cellular proliferation |
TW200304820A (en) * | 2002-03-25 | 2003-10-16 | Avanir Pharmaceuticals | Use of benzimidazole analogs in the treatment of cell proliferation |
AU2003270426A1 (en) | 2002-09-12 | 2004-04-30 | Avanir Pharmaceuticals | PHENYL-INDOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION |
JP2007501618A (ja) * | 2003-08-08 | 2007-02-01 | アバニール・ファーマシューティカルズ | タンパク質輸送の選択的薬理学的阻害、および関連した、ヒト疾患を治療する方法 |
JP2007513184A (ja) | 2003-12-04 | 2007-05-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | プロテインキナーゼのインヒビターとして有用なキノキサリン |
CA2584179C (en) * | 2004-10-13 | 2013-01-29 | Wolfgang Staehle | N,n'-diphenylurea derivatives which are suitable as kinase inhibitors |
JP2008521768A (ja) * | 2004-12-23 | 2008-06-26 | エフ.ホフマン−ラ ロシュ アーゲー | ヘテロ環式カルバミン酸誘導体、それらの製造及び医薬品としての使用 |
WO2006066913A2 (en) * | 2004-12-23 | 2006-06-29 | F. Hoffmann-La Roche Ag | Benzamide substituted imidazo- and pyrolo-pyridines as protein kinase inhibitors |
KR20060087386A (ko) | 2005-01-28 | 2006-08-02 | 주식회사 대웅제약 | 신규 벤조이미다졸 유도체 및 이를 함유하는 약제학적조성물 |
CN101208339B (zh) | 2005-08-01 | 2010-12-29 | 霍夫曼-拉罗奇有限公司 | 杂环苄基氨基衍生物,它们的制备以及作为药剂的应用 |
CA2662031A1 (en) | 2006-09-06 | 2008-03-13 | F. Hoffmann-La Roche Ag | Heteroaryl derivatives as protein kinase inhibitors |
PE20091561A1 (es) | 2008-02-29 | 2009-10-30 | Array Biopharma Inc | Compuestos inhibidores de raf y metodos para su uso |
CN105073744B (zh) | 2012-12-21 | 2019-11-08 | 齐尼思表观遗传学有限公司 | 作为溴结构域抑制剂的新型杂环化合物 |
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US9296754B2 (en) | 2013-03-15 | 2016-03-29 | Novartis Ag | Compounds and compositions for the treatment of parasitic diseases |
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WO2015002754A2 (en) | 2013-06-21 | 2015-01-08 | Zenith Epigenetics Corp. | Novel bicyclic bromodomain inhibitors |
CN105593224B (zh) | 2013-07-31 | 2021-05-25 | 恒元生物医药科技(苏州)有限公司 | 作为溴结构域抑制剂的新型喹唑啉酮类化合物 |
PE20160865A1 (es) | 2013-12-19 | 2016-09-03 | Novartis Ag | Derivados de [1,2,4] triazolo [1,5-a]pirimidina como inhibidores de proteasoma para el tratamiento de enfermedades parasitarias tales como leishmaniasis |
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-
2003
- 2003-09-10 TW TW092124975A patent/TWI276631B/zh not_active IP Right Cessation
- 2003-09-12 CN CNA038250934A patent/CN1694889A/zh active Pending
- 2003-09-12 CA CA002498495A patent/CA2498495A1/en not_active Abandoned
- 2003-09-12 RU RU2005109911/04A patent/RU2005109911A/ru not_active Application Discontinuation
- 2003-09-12 AR ARP030103321A patent/AR041252A1/es not_active Application Discontinuation
- 2003-09-12 PL PL03375811A patent/PL375811A1/xx not_active Application Discontinuation
- 2003-09-12 AU AU2003279729A patent/AU2003279729A1/en not_active Abandoned
- 2003-09-12 BR BR0314235-3A patent/BR0314235A/pt not_active IP Right Cessation
- 2003-09-12 WO PCT/US2003/030962 patent/WO2004024897A2/en active Application Filing
- 2003-09-12 PE PE2003000933A patent/PE20050036A1/es not_active Application Discontinuation
- 2003-09-12 JP JP2004536644A patent/JP2006503048A/ja not_active Withdrawn
- 2003-09-12 NZ NZ538547A patent/NZ538547A/en unknown
- 2003-09-12 EP EP03773067A patent/EP1546157A4/en not_active Withdrawn
- 2003-09-12 MX MXJL05000010A patent/MXJL05000010A/es not_active Application Discontinuation
- 2003-09-12 KR KR1020057004331A patent/KR20050050102A/ko not_active Application Discontinuation
- 2003-09-12 US US10/661,296 patent/US7256287B2/en not_active Expired - Fee Related
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- 2005-04-05 ZA ZA200502738A patent/ZA200502738B/en unknown
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TW200404784A (en) | 2004-04-01 |
EP1546157A2 (en) | 2005-06-29 |
PL375811A1 (en) | 2005-12-12 |
MXJL05000010A (es) | 2005-06-07 |
RU2005109911A (ru) | 2006-04-27 |
WO2004024897A3 (en) | 2004-08-26 |
US20040116466A1 (en) | 2004-06-17 |
PE20050036A1 (es) | 2005-01-24 |
NZ538547A (en) | 2007-05-31 |
CN1694889A (zh) | 2005-11-09 |
KR20050050102A (ko) | 2005-05-27 |
US7256287B2 (en) | 2007-08-14 |
BR0314235A (pt) | 2005-08-09 |
AR041252A1 (es) | 2005-05-11 |
CA2498495A1 (en) | 2004-03-25 |
EP1546157A4 (en) | 2007-02-28 |
AU2003279729A1 (en) | 2004-04-30 |
ZA200502738B (en) | 2007-04-25 |
JP2006503048A (ja) | 2006-01-26 |
WO2004024897A2 (en) | 2004-03-25 |
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