TWI243816B - Polymorphs of donepezil hydrochloride and process for production - Google Patents

Polymorphs of donepezil hydrochloride and process for production Download PDF

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Publication number
TWI243816B
TWI243816B TW089110397A TW89110397A TWI243816B TW I243816 B TWI243816 B TW I243816B TW 089110397 A TW089110397 A TW 089110397A TW 89110397 A TW89110397 A TW 89110397A TW I243816 B TWI243816 B TW I243816B
Authority
TW
Taiwan
Prior art keywords
polymorph
hydrochloride
dunapal
dunapar
hydrochloric acid
Prior art date
Application number
TW089110397A
Other languages
English (en)
Chinese (zh)
Inventor
Akio Imai
Hideaki Watanabe
Takashi Kajima
Yasushi Ishihama
Akiyo Ohtsuka
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/JP1996/003881 external-priority patent/WO1997046526A1/en
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Application granted granted Critical
Publication of TWI243816B publication Critical patent/TWI243816B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
TW089110397A 1996-06-07 1997-06-05 Polymorphs of donepezil hydrochloride and process for production TWI243816B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP14629396 1996-06-07
PCT/JP1996/003881 WO1997046526A1 (en) 1996-06-07 1996-12-27 Stable polymorphs of donepezil (1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine) hydrochloride and process for production
US08/774,802 US6140321A (en) 1996-06-07 1996-12-30 Polymorphs of donepezil hydrochloride and process for production

Publications (1)

Publication Number Publication Date
TWI243816B true TWI243816B (en) 2005-11-21

Family

ID=26477192

Family Applications (1)

Application Number Title Priority Date Filing Date
TW089110397A TWI243816B (en) 1996-06-07 1997-06-05 Polymorphs of donepezil hydrochloride and process for production

Country Status (10)

Country Link
CN (1) CN1207282C (no)
AT (1) ATE230396T1 (no)
CY (1) CY2316B1 (no)
CZ (1) CZ296619B6 (no)
DE (1) DE69718216T2 (no)
NO (1) NO20060377L (no)
PL (1) PL330362A1 (no)
PT (1) PT1019374E (no)
TR (2) TR200202374T2 (no)
TW (1) TWI243816B (no)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101906066B (zh) * 2010-08-08 2015-03-11 浙江华海药业股份有限公司 一种制备盐酸奈哌齐晶型i的方法
CN102060752B (zh) * 2011-01-24 2013-03-13 上海右手医药科技开发有限公司 高纯度盐酸多奈哌齐无水i晶型的生产方法及其产品
CN103012247B (zh) * 2013-01-18 2014-12-10 浙江东亚药业有限公司 一种盐酸多奈哌齐无水i晶型的制备方法
CN103694164B (zh) * 2014-01-23 2015-08-12 天津大学 一种盐酸多奈哌齐新晶型及制备方法
CN107550884B (zh) * 2017-09-19 2018-06-05 扬子江药业集团上海海尼药业有限公司 一种盐酸多奈哌齐胶囊及其制备方法

Also Published As

Publication number Publication date
PL330362A1 (en) 1999-05-10
TR199802531T2 (xx) 1999-02-22
CN1221404A (zh) 1999-06-30
CY2316B1 (en) 2003-11-14
CZ296619B6 (cs) 2006-05-17
PT1019374E (pt) 2003-03-31
CN1207282C (zh) 2005-06-22
NO20060377L (no) 1999-01-28
CZ396098A3 (cs) 1999-03-17
DE69718216D1 (de) 2003-02-06
TR200202374T2 (tr) 2003-01-21
ATE230396T1 (de) 2003-01-15
DE69718216T2 (de) 2003-10-09

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MM4A Annulment or lapse of patent due to non-payment of fees