TW593336B - Low-toxicity human interferon-alpha analog - Google Patents
Low-toxicity human interferon-alpha analog Download PDFInfo
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- TW593336B TW593336B TW087117293A TW87117293A TW593336B TW 593336 B TW593336 B TW 593336B TW 087117293 A TW087117293 A TW 087117293A TW 87117293 A TW87117293 A TW 87117293A TW 593336 B TW593336 B TW 593336B
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- Prior art keywords
- amino acid
- leu
- interferon
- sequence
- glu
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Applications Claiming Priority (1)
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| US08/954,395 US6204022B1 (en) | 1996-04-12 | 1997-10-20 | Low-toxicity human interferon-alpha analogs |
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| TW593336B true TW593336B (en) | 2004-06-21 |
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| TW087117293A TW593336B (en) | 1997-10-20 | 1998-12-29 | Low-toxicity human interferon-alpha analog |
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| US (1) | US6204022B1 (enExample) |
| EP (1) | EP1025124B1 (enExample) |
| JP (2) | JP2001520238A (enExample) |
| KR (2) | KR100861007B1 (enExample) |
| CN (1) | CN1240717C (enExample) |
| AT (1) | ATE402957T1 (enExample) |
| AU (1) | AU744774B2 (enExample) |
| CA (1) | CA2308116C (enExample) |
| DE (1) | DE69839812D1 (enExample) |
| DK (1) | DK1025124T3 (enExample) |
| ES (1) | ES2310931T3 (enExample) |
| TW (1) | TW593336B (enExample) |
| WO (1) | WO1999020653A1 (enExample) |
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| US6833256B1 (en) * | 1999-06-22 | 2004-12-21 | University Of Maryland | Interferon tau mutants and methods for making them |
| WO2001016178A1 (en) * | 1999-08-27 | 2001-03-08 | University Of Florida | MATERIALS AND METHODS FOR INHIBITION OF IgE PRODUCTION |
| EP1803730A1 (en) * | 2000-04-12 | 2007-07-04 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| AU2587002A (en) * | 2000-11-03 | 2002-05-15 | Biomedicines Inc | Method for short-term and long-term drug dosimetry |
| EP1404359A2 (en) * | 2000-12-07 | 2004-04-07 | Board Of Regents, The University Of Texas System | Methods of treatment involving human mda-7 |
| CN1568369A (zh) * | 2001-08-12 | 2005-01-19 | 派普根公司 | 杂合的干扰素/干扰素Tau蛋白、组合物和使用方法 |
| JP2005516041A (ja) * | 2001-11-09 | 2005-06-02 | インターシア・セラピューティクス・インコーポレイテッド | オメガインターフェロンを用いる疾患の治療方法 |
| EP1490101A4 (en) * | 2002-03-05 | 2006-09-20 | Univ Texas | PROCESS FOR IMPROVING IMMUNE INDUCTION WITH MDA-7 |
| EP1539960B1 (en) * | 2002-09-09 | 2010-04-28 | Hanall Pharmaceutical Co., Ltd. | Protease-resistant modified interferon alpha polypeptides |
| US20040126360A1 (en) * | 2002-10-09 | 2004-07-01 | Manning Mark C. | Oral formulations for proteins and polypeptides |
| US7731947B2 (en) | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
| KR20060002793A (ko) * | 2003-03-03 | 2006-01-09 | 더 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 | Ｍｄａ-7을 포함하는 방법 및 조성물 |
| US20050003533A1 (en) * | 2003-05-08 | 2005-01-06 | Pawel Kalinski | Mature type-1 polarized dendritic cells with enhanced IL-12 production and methods of serum-free production and use |
| CA2548220A1 (en) * | 2003-12-01 | 2005-09-09 | Introgen Therapeutics, Inc. | Use of mda-7 to inhibit infection by pathogenic organisms |
| BRPI0507169A (pt) * | 2004-02-02 | 2007-06-26 | Ambrx Inc | polipeptìdeos do hormÈnio de crescimento humano modificados e seu usos |
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| JP2008531481A (ja) * | 2005-02-08 | 2008-08-14 | ボード オブ リージェンツ， ザ ユニバーシティ オブ テキサス システム | 癌の治療のための、ｍｄａ−７を含む組成物および方法 |
| AU2006262151A1 (en) * | 2005-06-20 | 2007-01-04 | Pepgen Corporation | Low-toxicity, long-circulating chimeras of human interferon- alpha analogs and interferon tau |
| US7695710B2 (en) * | 2005-06-20 | 2010-04-13 | Pepgen Corporation | Antitumor and antiviral combination therapies using low-toxicity, long-circulating human interferon-alpha analogs |
| RU2288474C1 (ru) * | 2005-12-28 | 2006-11-27 | Федеральное государственное учреждение науки "Московский научно-исследовательский институт эпидемиологии и микробиологии имени Г.Н. Габричевского Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека" (ФГУН МНИИЭМ им. Г.Н. Габричевского Роспотребнадзора) | Способ определения токсического действия оральной мукозальной интерферонотерапии |
| US20070243163A1 (en) * | 2006-02-17 | 2007-10-18 | Chih-Ping Liu | Respiratory tract delivery of interferon-tau |
| NZ572003A (en) | 2006-05-30 | 2010-07-30 | Intarcia Therapeutics Inc | Two-piece, internal-channel osmotic delivery system flow modulator with spiral fluid channel |
| DK2049081T3 (da) | 2006-08-09 | 2013-02-25 | Intarcia Therapeutics Inc | Osmotiske leveringssystemer og stempelarrangementer |
| WO2008121461A2 (en) * | 2007-02-26 | 2008-10-09 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Vaccine for activating helper function of cd8+ tcells |
| US20080260820A1 (en) * | 2007-04-19 | 2008-10-23 | Gilles Borrelly | Oral dosage formulations of protease-resistant polypeptides |
| PL2157967T3 (pl) | 2007-04-23 | 2013-06-28 | Intarcia Therapeutics Inc | Formulacje zawiesinowe peptydów insulinotropowych i ich zastosowania |
| CA2726861C (en) | 2008-02-13 | 2014-05-27 | Intarcia Therapeutics, Inc. | Devices, formulations, and methods for delivery of multiple beneficial agents |
| JP5908397B2 (ja) | 2009-06-09 | 2016-04-26 | デフィルス、インコーポレイテッドＤｅｆｙｒｕｓ， Ｉｎｃ． | 病原体感染を予防又は治療するためのインターフェロン投与 |
| NZ598686A (en) | 2009-09-28 | 2014-05-30 | Intarcia Therapeutics Inc | Rapid establishment and/or termination of substantial steady-state drug delivery |
| US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
| WO2012177892A2 (en) * | 2011-06-21 | 2012-12-27 | University Of Florida Research Foundation, Inc. | Type i interferon mimetics as therapeutics for cancer, viral infections, and multiple sclerosis |
| US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
| AU2016270984B2 (en) | 2015-06-03 | 2021-02-25 | Intarcia Therapeutics, Inc. | Implant placement and removal systems |
| MA53353A (fr) | 2016-05-16 | 2021-06-09 | Intarcia Therapeutics Inc | Polypeptides sélectifs pour le récepteur du glucagon et méthodes pour leur utilisation |
| USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
| USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
| CN110225762A (zh) | 2017-01-03 | 2019-09-10 | 因塔西亚制药公司 | 包括glp-1受体激动剂的连续施用和药物的共同施用的方法 |
| CN112043685A (zh) * | 2020-09-18 | 2020-12-08 | 深圳科兴药业有限公司 | 重组人干扰素α1b突变体吸入溶液及其制备方法 |
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| GB2016015B (en) | 1978-01-22 | 1982-05-06 | Hayashibara Co | Method of preparing interferon and preparations containing interferon |
| US4460574A (en) | 1980-06-16 | 1984-07-17 | Yabrov Alexander A | Prophylaxis or treatment of interferon-sensitive diseases |
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| US4414150A (en) | 1980-11-10 | 1983-11-08 | Genentech, Inc. | Hybrid human leukocyte interferons |
| US4507281A (en) | 1981-10-13 | 1985-03-26 | Exovir, Inc. | Interferon-containing compositions |
| WO1983002461A1 (en) | 1982-01-19 | 1983-07-21 | Cetus Corp | Multiclass hybrid interferons |
| US6936694B1 (en) | 1982-05-06 | 2005-08-30 | Intermune, Inc. | Manufacture and expression of large structural genes |
| US4892743A (en) | 1983-12-21 | 1990-01-09 | Schering Corporation | Novel hybrid interferon species |
| EP0146903A3 (en) | 1983-12-19 | 1987-07-22 | Schering Corporation | Production of a vector encoding a novel hybrid interferon species |
| US4636383A (en) | 1984-08-29 | 1987-01-13 | Schering Corporation | Interferon-cyclaradine combination |
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| DE3607835A1 (de) | 1986-03-10 | 1987-09-24 | Boehringer Ingelheim Int | Hybridinterferone, deren verwendung als arzneimittel und als zwischenprodukte zur herstellung von antikoerpern und deren verwendung sowie verfahren zu ihrer herstellung |
| US4846782A (en) | 1986-03-14 | 1989-07-11 | Schering Corporation | Treatment of cancer with interferon and radiotherapy |
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| ZA878295B (en) | 1986-11-06 | 1988-05-03 | Amarillo Cell Culture Co. Inc. | Treatment of immuno-resistant disease |
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| TW391983B (en) | 1992-10-30 | 2000-06-01 | Univ Florida | Human interferon TAU, processes thereof and pharmaceutical uses thereof |
| US5939286A (en) * | 1995-05-10 | 1999-08-17 | University Of Florida | Hybrid interferon tau/alpha polypeptides, their recombinant production, and methods using them |
-
1997
- 1997-10-20 US US08/954,395 patent/US6204022B1/en not_active Expired - Fee Related
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1998
- 1998-10-20 ES ES98952350T patent/ES2310931T3/es not_active Expired - Lifetime
- 1998-10-20 DE DE69839812T patent/DE69839812D1/de not_active Expired - Lifetime
- 1998-10-20 KR KR1020067002021A patent/KR100861007B1/ko not_active Expired - Fee Related
- 1998-10-20 WO PCT/US1998/021936 patent/WO1999020653A1/en not_active Ceased
- 1998-10-20 CN CNB988103680A patent/CN1240717C/zh not_active Expired - Fee Related
- 1998-10-20 DK DK98952350T patent/DK1025124T3/da active
- 1998-10-20 EP EP98952350A patent/EP1025124B1/en not_active Expired - Lifetime
- 1998-10-20 AT AT98952350T patent/ATE402957T1/de not_active IP Right Cessation
- 1998-10-20 KR KR1020007004158A patent/KR100586625B1/ko not_active Expired - Fee Related
- 1998-10-20 CA CA2308116A patent/CA2308116C/en not_active Expired - Fee Related
- 1998-10-20 AU AU98072/98A patent/AU744774B2/en not_active Ceased
- 1998-10-20 JP JP2000516991A patent/JP2001520238A/ja active Pending
- 1998-12-29 TW TW087117293A patent/TW593336B/zh not_active IP Right Cessation
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Also Published As
| Publication number | Publication date |
|---|---|
| ES2310931T3 (es) | 2009-01-16 |
| US6204022B1 (en) | 2001-03-20 |
| CA2308116C (en) | 2010-12-14 |
| ATE402957T1 (de) | 2008-08-15 |
| CA2308116A1 (en) | 1999-04-29 |
| EP1025124B1 (en) | 2008-07-30 |
| CN1240717C (zh) | 2006-02-08 |
| CN1276797A (zh) | 2000-12-13 |
| DE69839812D1 (de) | 2008-09-11 |
| DK1025124T3 (da) | 2008-10-06 |
| JP2001520238A (ja) | 2001-10-30 |
| WO1999020653A1 (en) | 1999-04-29 |
| AU744774B2 (en) | 2002-03-07 |
| AU9807298A (en) | 1999-05-10 |
| EP1025124A1 (en) | 2000-08-09 |
| KR100586625B1 (ko) | 2006-06-07 |
| JP2008247926A (ja) | 2008-10-16 |
| KR20010031206A (ko) | 2001-04-16 |
| KR100861007B1 (ko) | 2008-09-30 |
| KR20060015701A (ko) | 2006-02-17 |
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