TW585771B - A pharmaceutical composition for treatment of bronchoconstrictor or airway hyperreactivity or related lung diseases caused by late phase allergic reactions - Google Patents
A pharmaceutical composition for treatment of bronchoconstrictor or airway hyperreactivity or related lung diseases caused by late phase allergic reactions Download PDFInfo
- Publication number
- TW585771B TW585771B TW087112755A TW87112755A TW585771B TW 585771 B TW585771 B TW 585771B TW 087112755 A TW087112755 A TW 087112755A TW 87112755 A TW87112755 A TW 87112755A TW 585771 B TW585771 B TW 585771B
- Authority
- TW
- Taiwan
- Prior art keywords
- composition
- scope
- antigen
- ulmwh
- item
- Prior art date
Links
- 238000011282 treatment Methods 0.000 title claims abstract description 58
- 206010020751 Hypersensitivity Diseases 0.000 title claims abstract description 23
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 13
- 208000019693 Lung disease Diseases 0.000 title claims 3
- 230000003435 bronchoconstrictive effect Effects 0.000 title description 2
- 230000036428 airway hyperreactivity Effects 0.000 title 1
- 239000004044 bronchoconstricting agent Substances 0.000 title 1
- 208000010668 atopic eczema Diseases 0.000 claims abstract description 46
- 208000006673 asthma Diseases 0.000 claims abstract description 40
- 238000000034 method Methods 0.000 claims abstract description 34
- 229940127215 low-molecular weight heparin Drugs 0.000 claims abstract description 17
- 206010061218 Inflammation Diseases 0.000 claims abstract description 12
- 230000004054 inflammatory process Effects 0.000 claims abstract description 12
- 150000004676 glycans Chemical class 0.000 claims abstract description 11
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 9
- 239000005017 polysaccharide Substances 0.000 claims abstract description 9
- 230000000699 topical effect Effects 0.000 claims abstract description 5
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims abstract description 4
- 206010039073 rheumatoid arthritis Diseases 0.000 claims abstract description 4
- 206010012434 Dermatitis allergic Diseases 0.000 claims abstract description 3
- 206010039085 Rhinitis allergic Diseases 0.000 claims abstract description 3
- 201000010105 allergic rhinitis Diseases 0.000 claims abstract description 3
- 201000008937 atopic dermatitis Diseases 0.000 claims abstract description 3
- 206010010744 Conjunctivitis allergic Diseases 0.000 claims abstract 2
- 208000002205 allergic conjunctivitis Diseases 0.000 claims abstract 2
- 208000024998 atopic conjunctivitis Diseases 0.000 claims abstract 2
- 239000000203 mixture Substances 0.000 claims description 78
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical group OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 42
- 229920000669 heparin Polymers 0.000 claims description 39
- 229960002897 heparin Drugs 0.000 claims description 38
- 206010006482 Bronchospasm Diseases 0.000 claims description 37
- 230000007885 bronchoconstriction Effects 0.000 claims description 31
- 238000006243 chemical reaction Methods 0.000 claims description 25
- 239000003055 low molecular weight heparin Substances 0.000 claims description 15
- 239000000843 powder Substances 0.000 claims description 12
- 210000004072 lung Anatomy 0.000 claims description 11
- 239000000443 aerosol Substances 0.000 claims description 10
- 150000004044 tetrasaccharides Chemical class 0.000 claims description 10
- ZEPAXLPHESYSJU-UHFFFAOYSA-N 2,3,4,5,6,7,8-heptahydroxyoctanal Chemical compound OCC(O)C(O)C(O)C(O)C(O)C(O)C=O ZEPAXLPHESYSJU-UHFFFAOYSA-N 0.000 claims description 8
- 208000030961 allergic reaction Diseases 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 8
- 230000000890 antigenic effect Effects 0.000 claims description 7
- 239000000243 solution Substances 0.000 claims description 7
- 201000010099 disease Diseases 0.000 claims description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 6
- 230000002685 pulmonary effect Effects 0.000 claims description 6
- 239000003146 anticoagulant agent Substances 0.000 claims description 5
- 239000002775 capsule Substances 0.000 claims description 5
- 230000002757 inflammatory effect Effects 0.000 claims description 5
- 238000001990 intravenous administration Methods 0.000 claims description 5
- 229940071648 metered dose inhaler Drugs 0.000 claims description 5
- 235000000346 sugar Nutrition 0.000 claims description 5
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims description 4
- 229920001287 Chondroitin sulfate Polymers 0.000 claims description 4
- 230000007815 allergy Effects 0.000 claims description 4
- 229940059329 chondroitin sulfate Drugs 0.000 claims description 4
- 239000003380 propellant Substances 0.000 claims description 4
- 206010018364 Glomerulonephritis Diseases 0.000 claims description 3
- 229920002683 Glycosaminoglycan Polymers 0.000 claims description 3
- 210000000621 bronchi Anatomy 0.000 claims description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N lactose group Chemical group OC1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](O2)CO)[C@H](O1)CO GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 3
- 150000003839 salts Chemical class 0.000 claims description 3
- 230000001568 sexual effect Effects 0.000 claims description 3
- 230000009885 systemic effect Effects 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 206010006458 Bronchitis chronic Diseases 0.000 claims description 2
- 201000004624 Dermatitis Diseases 0.000 claims description 2
- 206010014561 Emphysema Diseases 0.000 claims description 2
- 102000004190 Enzymes Human genes 0.000 claims description 2
- 108090000790 Enzymes Proteins 0.000 claims description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 2
- 206010006451 bronchitis Diseases 0.000 claims description 2
- 208000007451 chronic bronchitis Diseases 0.000 claims description 2
- 150000002386 heptoses Chemical class 0.000 claims description 2
- 239000008101 lactose Substances 0.000 claims description 2
- 201000000306 sarcoidosis Diseases 0.000 claims description 2
- 239000007921 spray Substances 0.000 claims description 2
- 230000001960 triggered effect Effects 0.000 claims description 2
- 102000008186 Collagen Human genes 0.000 claims 1
- 108010035532 Collagen Proteins 0.000 claims 1
- 206010040914 Skin reaction Diseases 0.000 claims 1
- 229940127090 anticoagulant agent Drugs 0.000 claims 1
- 229920001436 collagen Polymers 0.000 claims 1
- 239000000428 dust Substances 0.000 claims 1
- 208000031169 hemorrhagic disease Diseases 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 239000002504 physiological saline solution Substances 0.000 claims 1
- 229920002401 polyacrylamide Polymers 0.000 claims 1
- 230000036647 reaction Effects 0.000 claims 1
- 231100000430 skin reaction Toxicity 0.000 claims 1
- 230000035483 skin reaction Effects 0.000 claims 1
- 150000008163 sugars Chemical class 0.000 claims 1
- 239000013589 supplement Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 208000002200 Respiratory Hypersensitivity Diseases 0.000 abstract description 41
- 230000010085 airway hyperresponsiveness Effects 0.000 abstract description 41
- 230000037396 body weight Effects 0.000 abstract description 3
- 239000000427 antigen Substances 0.000 description 174
- 102000036639 antigens Human genes 0.000 description 173
- 108091007433 antigens Proteins 0.000 description 173
- 241001494479 Pecora Species 0.000 description 47
- 229940079593 drug Drugs 0.000 description 45
- 239000003814 drug Substances 0.000 description 45
- 230000000172 allergic effect Effects 0.000 description 43
- 230000009977 dual effect Effects 0.000 description 42
- 230000000694 effects Effects 0.000 description 37
- 238000012360 testing method Methods 0.000 description 32
- 241001465754 Metazoa Species 0.000 description 29
- 230000004044 response Effects 0.000 description 29
- 230000001154 acute effect Effects 0.000 description 20
- 230000008859 change Effects 0.000 description 17
- 208000024891 symptom Diseases 0.000 description 14
- 238000002474 experimental method Methods 0.000 description 8
- 210000003630 histaminocyte Anatomy 0.000 description 8
- 208000009079 Bronchial Spasm Diseases 0.000 description 6
- 208000014181 Bronchial disease Diseases 0.000 description 6
- 241000699670 Mus sp. Species 0.000 description 6
- 230000003110 anti-inflammatory effect Effects 0.000 description 6
- 239000003246 corticosteroid Substances 0.000 description 6
- 229960001334 corticosteroids Drugs 0.000 description 6
- 239000002552 dosage form Substances 0.000 description 6
- 210000003979 eosinophil Anatomy 0.000 description 6
- 230000007246 mechanism Effects 0.000 description 6
- UCTWMZQNUQWSLP-UHFFFAOYSA-N Adrenaline Natural products CNCC(O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-UHFFFAOYSA-N 0.000 description 5
- 208000037883 airway inflammation Diseases 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 5
- 150000002016 disaccharides Chemical class 0.000 description 5
- 230000008030 elimination Effects 0.000 description 5
- 238000003379 elimination reaction Methods 0.000 description 5
- 230000007774 longterm Effects 0.000 description 5
- 230000014508 negative regulation of coagulation Effects 0.000 description 5
- 238000011176 pooling Methods 0.000 description 5
- 238000007639 printing Methods 0.000 description 5
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 229940127219 anticoagulant drug Drugs 0.000 description 4
- AIXAANGOTKPUOY-UHFFFAOYSA-N carbachol Chemical compound [Cl-].C[N+](C)(C)CCOC(N)=O AIXAANGOTKPUOY-UHFFFAOYSA-N 0.000 description 4
- 229960004484 carbachol Drugs 0.000 description 4
- 230000008602 contraction Effects 0.000 description 4
- 229940087051 fragmin Drugs 0.000 description 4
- 239000002565 heparin fraction Substances 0.000 description 4
- 150000002402 hexoses Chemical class 0.000 description 4
- 230000037361 pathway Effects 0.000 description 4
- 102000005962 receptors Human genes 0.000 description 4
- 108020003175 receptors Proteins 0.000 description 4
- 210000003491 skin Anatomy 0.000 description 4
- 102000004411 Antithrombin III Human genes 0.000 description 3
- 108090000935 Antithrombin III Proteins 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 239000000556 agonist Substances 0.000 description 3
- 201000009961 allergic asthma Diseases 0.000 description 3
- 208000026935 allergic disease Diseases 0.000 description 3
- 229960005348 antithrombin iii Drugs 0.000 description 3
- 239000000969 carrier Substances 0.000 description 3
- IMZMKUWMOSJXDT-UHFFFAOYSA-N cromoglycic acid Chemical compound O1C(C(O)=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C(O)=O)O2 IMZMKUWMOSJXDT-UHFFFAOYSA-N 0.000 description 3
- 230000002327 eosinophilic effect Effects 0.000 description 3
- 230000005284 excitation Effects 0.000 description 3
- 210000001508 eye Anatomy 0.000 description 3
- 239000012634 fragment Substances 0.000 description 3
- 239000005556 hormone Substances 0.000 description 3
- 229940088597 hormone Drugs 0.000 description 3
- 208000027866 inflammatory disease Diseases 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 3
- 238000002203 pretreatment Methods 0.000 description 3
- 230000000750 progressive effect Effects 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 238000010898 silica gel chromatography Methods 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 241000244188 Ascaris suum Species 0.000 description 2
- 108010039209 Blood Coagulation Factors Proteins 0.000 description 2
- 102000015081 Blood Coagulation Factors Human genes 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- 108090000190 Thrombin Proteins 0.000 description 2
- 230000008369 airway response Effects 0.000 description 2
- 230000003266 anti-allergic effect Effects 0.000 description 2
- 229940124599 anti-inflammatory drug Drugs 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 239000003114 blood coagulation factor Substances 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 229960000265 cromoglicic acid Drugs 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000002651 drug therapy Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 238000007429 general method Methods 0.000 description 2
- 229960001340 histamine Drugs 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 150000002617 leukotrienes Chemical class 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 210000004877 mucosa Anatomy 0.000 description 2
- 210000005036 nerve Anatomy 0.000 description 2
- 210000001331 nose Anatomy 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 150000004804 polysaccharides Polymers 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000004043 responsiveness Effects 0.000 description 2
- 230000008054 signal transmission Effects 0.000 description 2
- 150000003431 steroids Chemical class 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 230000002889 sympathetic effect Effects 0.000 description 2
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 description 2
- 229960004072 thrombin Drugs 0.000 description 2
- RAEOEMDZDMCHJA-UHFFFAOYSA-N 2-[2-[bis(carboxymethyl)amino]ethyl-[2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]ethyl]amino]acetic acid Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CCN(CC(O)=O)CC(O)=O)CC(O)=O RAEOEMDZDMCHJA-UHFFFAOYSA-N 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 206010061430 Arthritis allergic Diseases 0.000 description 1
- 241000244186 Ascaris Species 0.000 description 1
- 206010003557 Asthma exercise induced Diseases 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- 206010053567 Coagulopathies Diseases 0.000 description 1
- 208000029147 Collagen-vascular disease Diseases 0.000 description 1
- 201000003883 Cystic fibrosis Diseases 0.000 description 1
- 241000508725 Elymus repens Species 0.000 description 1
- 102000057955 Eosinophil Cationic Human genes 0.000 description 1
- 101710191360 Eosinophil cationic protein Proteins 0.000 description 1
- 208000004657 Exercise-Induced Asthma Diseases 0.000 description 1
- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- 108010049003 Fibrinogen Proteins 0.000 description 1
- 102000008946 Fibrinogen Human genes 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 108010033040 Histones Proteins 0.000 description 1
- 108091008585 IP3 receptors Proteins 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 102000007640 Inositol 1,4,5-Trisphosphate Receptors Human genes 0.000 description 1
- 102000015696 Interleukins Human genes 0.000 description 1
- 108010063738 Interleukins Proteins 0.000 description 1
- 108090001060 Lipase Proteins 0.000 description 1
- 102000004882 Lipase Human genes 0.000 description 1
- 239000004367 Lipase Substances 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 206010030111 Oedema mucosal Diseases 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 102000016611 Proteoglycans Human genes 0.000 description 1
- 108010067787 Proteoglycans Proteins 0.000 description 1
- 108010094028 Prothrombin Proteins 0.000 description 1
- 102100027378 Prothrombin Human genes 0.000 description 1
- 108010023197 Streptokinase Proteins 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 240000008866 Ziziphus nummularia Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000001919 adrenal effect Effects 0.000 description 1
- 210000004100 adrenal gland Anatomy 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 239000013566 allergen Substances 0.000 description 1
- 230000009285 allergic inflammation Effects 0.000 description 1
- AEMOLEFTQBMNLQ-WAXACMCWSA-N alpha-D-glucuronic acid Chemical group O[C@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-WAXACMCWSA-N 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 239000000043 antiallergic agent Substances 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 229940125715 antihistaminic agent Drugs 0.000 description 1
- 239000004019 antithrombin Substances 0.000 description 1
- OZQJTTOWXPKJFG-UHFFFAOYSA-N azane;propane-1,2,3-triol Chemical compound N.N.OCC(O)CO OZQJTTOWXPKJFG-UHFFFAOYSA-N 0.000 description 1
- 210000003651 basophil Anatomy 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 1
- MSWZFWKMSRAUBD-QZABAPFNSA-N beta-D-glucosamine Chemical compound N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-QZABAPFNSA-N 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 238000005842 biochemical reaction Methods 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 230000037182 bone density Effects 0.000 description 1
- 230000008468 bone growth Effects 0.000 description 1
- 229940124630 bronchodilator Drugs 0.000 description 1
- 239000000168 bronchodilator agent Substances 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000007975 buffered saline Substances 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000036755 cellular response Effects 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 208000023819 chronic asthma Diseases 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000002079 cooperative effect Effects 0.000 description 1
- 239000006184 cosolvent Substances 0.000 description 1
- 229940109248 cromoglycate Drugs 0.000 description 1
- 239000000824 cytostatic agent Substances 0.000 description 1
- 230000003112 degranulating effect Effects 0.000 description 1
- 238000011033 desalting Methods 0.000 description 1
- AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 208000024695 exercise-induced bronchoconstriction Diseases 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 229940012952 fibrinogen Drugs 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 238000002309 gasification Methods 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000005414 inactive ingredient Substances 0.000 description 1
- 229940060367 inert ingredients Drugs 0.000 description 1
- 210000004969 inflammatory cell Anatomy 0.000 description 1
- 230000028709 inflammatory response Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229940125369 inhaled corticosteroids Drugs 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 210000004347 intestinal mucosa Anatomy 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- AEMOLEFTQBMNLQ-CLQWQSTFSA-N l-iduronic acid Chemical compound O[C@H]1O[C@H](C(O)=O)[C@H](O)[C@@H](O)[C@@H]1O AEMOLEFTQBMNLQ-CLQWQSTFSA-N 0.000 description 1
- 235000019421 lipase Nutrition 0.000 description 1
- 239000006193 liquid solution Substances 0.000 description 1
- 239000006194 liquid suspension Substances 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 210000004379 membrane Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- -1 methods Substances 0.000 description 1
- 239000011859 microparticle Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 239000006199 nebulizer Substances 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 210000000440 neutrophil Anatomy 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 229940043138 pentosan polysulfate Drugs 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229940045627 porcine heparin Drugs 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000000770 proinflammatory effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 229940039716 prothrombin Drugs 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 150000003212 purines Chemical class 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
- 230000012369 regulation of mast cell degranulation Effects 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 235000015067 sauces Nutrition 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008227 sterile water for injection Substances 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 239000006190 sub-lingual tablet Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 229960000278 theophylline Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- 230000009772 tissue formation Effects 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
- 230000003827 upregulation Effects 0.000 description 1
- 231100000925 very toxic Toxicity 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Otolaryngology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/904,565 US5980865A (en) | 1995-08-18 | 1997-08-04 | Method for treating late phase allergic reactions and inflammatory diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW585771B true TW585771B (en) | 2004-05-01 |
Family
ID=25419368
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW087112755A TW585771B (en) | 1997-08-04 | 1998-08-05 | A pharmaceutical composition for treatment of bronchoconstrictor or airway hyperreactivity or related lung diseases caused by late phase allergic reactions |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US5980865A (https=) |
| EP (1) | EP1003479B1 (https=) |
| JP (1) | JP2001511439A (https=) |
| KR (1) | KR100551773B1 (https=) |
| CN (1) | CN1092049C (https=) |
| AR (1) | AR005221A1 (https=) |
| AT (1) | ATE323500T1 (https=) |
| AU (1) | AU8684698A (https=) |
| BR (1) | BR9811823A (https=) |
| CA (1) | CA2298445C (https=) |
| DE (1) | DE69834256T2 (https=) |
| DK (1) | DK1003479T3 (https=) |
| ES (1) | ES2260843T3 (https=) |
| HU (1) | HUP0003013A3 (https=) |
| IL (1) | IL134230A0 (https=) |
| NO (1) | NO20000558L (https=) |
| NZ (1) | NZ502498A (https=) |
| PL (1) | PL191796B1 (https=) |
| PT (1) | PT1003479E (https=) |
| RU (1) | RU2209624C2 (https=) |
| SK (1) | SK1172000A3 (https=) |
| TW (1) | TW585771B (https=) |
| UA (1) | UA75022C2 (https=) |
| WO (1) | WO1999006025A1 (https=) |
| ZA (1) | ZA986890B (https=) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050220909A1 (en) * | 2004-03-30 | 2005-10-06 | Theoharides Theoharis C | Composition for protection against superficial vasodilator flush syndrome |
| US7906153B2 (en) * | 1998-04-08 | 2011-03-15 | Theta Biomedical Consulting & Development Co., Inc. | Anti-inflammatory compositions for treating multiple sclerosis |
| US20080153761A1 (en) * | 1998-04-08 | 2008-06-26 | Theoharides Theoharis C | Compositions for protection against superficial vasodilator flush syndrome, and methods of use |
| US6689748B1 (en) * | 1998-04-08 | 2004-02-10 | Theoharis C. Theoharides | Method of treating mast cell activation-induced diseases with a proteoglycan |
| US6984667B2 (en) * | 1998-04-08 | 2006-01-10 | Theta Biomedical Consulting And Development Co. | Synergistic proteoglycan compositions for inflammatory conditions |
| US7799766B2 (en) * | 1998-04-08 | 2010-09-21 | Theta Biomedical Consulting & Development Co., Inc. | Composition for treating hormonally-dependent cancers |
| US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
| GB9917092D0 (en) | 1999-07-22 | 1999-09-22 | Ml Lab Plc | Treatment of angiogenesis-dependent conditions |
| US20040230559A1 (en) * | 1999-08-09 | 2004-11-18 | Mark Newman | Information processing device and information processing method |
| US20040224922A1 (en) * | 1999-08-26 | 2004-11-11 | Malcolm King | Use of charged dextran as a mucoactive agent and methods and pharmaceutical compositions relating thereto |
| GB0003048D0 (en) * | 2000-02-11 | 2000-03-29 | Dealler Stephen F | The therapeutic use of polysulphonated polyglycosides or other polyanionic compounds in autism |
| SE0001631D0 (sv) * | 2000-05-04 | 2000-05-04 | Sahltech Ab | New use |
| AU2001264817A1 (en) * | 2000-05-23 | 2001-12-17 | Exhale Therapeutics, Inc. | Method for treating respiratory disorders associated with pulmonary elastic fiber injury comprising the use of clycosaminoglycans |
| PT1511466E (pt) | 2002-02-18 | 2009-01-16 | Ockham Biotech Ltd | Utilização de glicosaminoglicanos tais como heparina para o tratamento de desordens respiratórias tais como dpoc |
| WO2003080149A2 (en) | 2002-03-20 | 2003-10-02 | Mannkind Corporation | Inhalation apparatus |
| CN1627948A (zh) * | 2002-04-24 | 2005-06-15 | 麦迪卡博公司 | 治疗炎症性肠病的组合物和试剂盒 |
| US20040152694A1 (en) * | 2003-02-04 | 2004-08-05 | Istvan Kurucz | Methods and compositions for treating inflammatory disorders of the airways |
| WO2004084918A1 (ja) * | 2003-03-25 | 2004-10-07 | Sekisui Chemical Co., Ltd. | 皮膚止痒外用組成物 |
| GB0327723D0 (en) * | 2003-09-15 | 2003-12-31 | Vectura Ltd | Pharmaceutical compositions |
| RU2240801C1 (ru) * | 2003-10-02 | 2004-11-27 | Государственное учреждение Научно-исследовательский институт фармакологии Томского научного центра СО РАМН | Средство, обладающее противоаллергическим действием |
| US7923043B2 (en) * | 2004-03-30 | 2011-04-12 | Theta Biomedical Consulting & Development Co., Inc. | Method for protecting humans against superficial vasodilator flush syndrome |
| PL1786784T3 (pl) | 2004-08-20 | 2011-04-29 | Mannkind Corp | Kataliza syntezy diketopiperazyn |
| KR101644250B1 (ko) | 2004-08-23 | 2016-07-29 | 맨카인드 코포레이션 | 약물 전달용 디케토피페라진염, 디케토모르포린염 또는 디케토디옥산염 |
| EP1791555B1 (en) * | 2004-09-10 | 2013-03-13 | Pharmaorigin ApS | Methods for treating local tracheal, bronchial or alveolar bleeding or hemoptysis |
| TW200621794A (en) * | 2004-10-06 | 2006-07-01 | Akzo Nobel Nv | Pulmonary administration of an antithrombotic compound |
| US8569367B2 (en) | 2004-11-16 | 2013-10-29 | Allergan, Inc. | Ophthalmic compositions and methods for treating eyes |
| CN104324362B (zh) | 2005-09-14 | 2018-04-24 | 曼金德公司 | 以提高活性试剂对结晶微粒表面的亲和力为基础的药物配制方法 |
| US8057840B2 (en) * | 2006-01-25 | 2011-11-15 | Tate & Lyle Ingredients Americas Llc | Food products comprising a slowly digestible or digestion resistant carbohydrate composition |
| IN2015DN00888A (https=) | 2006-02-22 | 2015-07-10 | Mannkind Corp | |
| RU2322987C2 (ru) * | 2006-05-23 | 2008-04-27 | Ольга Александровна Субботина | Средство для лечения иммунных заболеваний кожи |
| CN101095693B (zh) * | 2006-06-29 | 2010-10-13 | 重庆华邦制药股份有限公司 | 治疗皮炎的复方药物 |
| NZ601148A (en) * | 2007-05-31 | 2012-08-31 | Glycan Biosciences | Use of pentosan polysulfate for treatment or prophylaxis of allergic rhinitis |
| ES2929343T3 (es) | 2008-06-13 | 2022-11-28 | Mannkind Corp | Inhalador de polvo seco accionado por aspiración para la administración de fármacos |
| US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
| KR101628410B1 (ko) | 2008-06-20 | 2016-06-08 | 맨카인드 코포레이션 | 흡입 활동에 관한 실시간 프로파일링을 위한 대화형 장치 및 방법 |
| TWI614024B (zh) | 2008-08-11 | 2018-02-11 | 曼凱公司 | 超快起作用胰島素之用途 |
| US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
| DK2405963T3 (da) | 2009-03-11 | 2013-12-16 | Mannkind Corp | Apparat, system og fremgangsmåde til at måle modstand i en inhalator |
| CN104721825B (zh) | 2009-06-12 | 2019-04-12 | 曼金德公司 | 具有确定比表面积的二酮哌嗪颗粒 |
| US9050275B2 (en) * | 2009-08-03 | 2015-06-09 | Theta Biomedical Consulting & Development Co., Inc. | Methods of screening for and treating autism spectrum disorders and compositions for same |
| US9176146B2 (en) * | 2009-08-03 | 2015-11-03 | Theta Biomedical Consulting & Development Co., Inc. | Methods of treating autism spectrum disorders and compositions for same |
| WO2011056889A1 (en) | 2009-11-03 | 2011-05-12 | Mannkind Corporation | An apparatus and method for simulating inhalation efforts |
| RU2576033C2 (ru) * | 2009-12-03 | 2016-02-27 | Опко Хелс, Инк. | Составы на основе гиперсулфатированных дисахаридов |
| US20110212181A1 (en) * | 2010-02-26 | 2011-09-01 | The University Of Hong Kong | Compositions and methods for treating chronic respiratory inflammation |
| IL223742A (en) | 2010-06-21 | 2016-06-30 | Mannkind Corp | A dry powder inhaler and preparation for it |
| US20130203695A1 (en) * | 2010-10-29 | 2013-08-08 | Opko Health, Inc. | Hypersulfated disaccharides to treat elastase related disorders |
| AU2012236150B2 (en) | 2011-04-01 | 2016-03-31 | Mannkind Corporation | Blister package for pharmaceutical cartridges |
| EP2706990A1 (en) * | 2011-05-12 | 2014-03-19 | Aventis Pharma S.A. | Semuloparin for the prevention of venous thromboembolism in cancer patients receiving chemotherapy |
| WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
| US8957048B2 (en) | 2011-10-06 | 2015-02-17 | Allergan, Inc. | Compositions for the treatment of dry eye |
| BR112014009686A2 (pt) | 2011-10-24 | 2018-08-07 | Mannkind Corp | composição analgésica inalável, pó seco e método para tratar dor |
| US9907826B2 (en) | 2011-12-07 | 2018-03-06 | Allergan, Inc. | Efficient lipid delivery to human tear film using a salt-sensitive emulsion system |
| ES2797650T3 (es) | 2011-12-07 | 2020-12-03 | Allergan Inc | Administración de lípido eficiente a película lagrimal humana usando un sistema de emulsión sensible a sal |
| CN104619369B (zh) | 2012-07-12 | 2018-01-30 | 曼金德公司 | 干粉药物输送系统和方法 |
| US10159644B2 (en) | 2012-10-26 | 2018-12-25 | Mannkind Corporation | Inhalable vaccine compositions and methods |
| AU2014228415B2 (en) | 2013-03-15 | 2018-08-09 | Mannkind Corporation | Microcrystalline diketopiperazine compositions and methods |
| MX375448B (es) | 2013-07-18 | 2025-03-06 | Mannkind Corp | Composiciones farmacéuticas en polvo seco estables al calor y métodos. |
| US11446127B2 (en) | 2013-08-05 | 2022-09-20 | Mannkind Corporation | Insufflation apparatus and methods |
| US10307464B2 (en) | 2014-03-28 | 2019-06-04 | Mannkind Corporation | Use of ultrarapid acting insulin |
| WO2016040570A2 (en) | 2014-09-12 | 2016-03-17 | Children's Medical Center Corporation | Dietary emulsion formulations and methods for using the same |
| US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
| JP6768653B2 (ja) | 2014-11-25 | 2020-10-14 | アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ | 安定したオメガ−３眼科用組成物 |
| EP3500583A1 (en) | 2016-08-16 | 2019-06-26 | OPKO Pharmaceuticals, LLC | Pure heptasulfated disaccharides having improved oral bioavailability |
| WO2018107200A1 (en) | 2016-12-13 | 2018-06-21 | Beta Therapeutics Pty Ltd | Heparanase inhibitors and use thereof |
| US11787783B2 (en) | 2016-12-13 | 2023-10-17 | Beta Therapeutics Pty Ltd | Heparanase inhibitors and use thereof |
| CN114053251A (zh) * | 2020-07-29 | 2022-02-18 | 苏州融析生物科技有限公司 | 硫酸化多糖吸入制剂及其在防治新冠病毒相关疾病中的应用 |
| US20220211746A1 (en) * | 2021-01-07 | 2022-07-07 | Bionovax Corp. | Special heparinoid composition, with repair, prophylactic and anti-inflammatory effects, applied to the lungs |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3405120A (en) * | 1966-01-27 | 1968-10-08 | Green Cross Corp | Low molecular chondroitin sulfate and method for manufacturing the same |
| IT1195497B (it) | 1983-03-08 | 1988-10-19 | Opocrin Spa | Procedimento per la preparazione di frazioni oligosaccaridiche dotate di proprieta' farmacologiche per degradazione chimica di eparina |
| US4847338A (en) * | 1985-03-28 | 1989-07-11 | University Of Iowa Research Foundation | Low molecular weight heparin fragments as inhibitors of complement activation |
| FR2584606A1 (fr) * | 1985-07-12 | 1987-01-16 | Dropic | Utilisation de poly- et oligosaccharides pour l'obtention de medicaments actifs dans les pathologies du tissu conjonctif |
| FR2584728B1 (fr) * | 1985-07-12 | 1987-11-20 | Choay Sa | Procede de sulfatation de glycosaminoglycanes et de leurs fragments |
| IT1230582B (it) * | 1988-10-21 | 1991-10-28 | Opocrin S P A Lab Farmabiologi | Oliogosaccaridi di dermatan solfato ed eparina aventi attivita' antiaterosclerotica |
| US5032679A (en) | 1988-12-15 | 1991-07-16 | Glycomed, Inc. | Heparin fragments as inhibitors of smooth muscle cell proliferation |
| US5380716A (en) | 1988-12-15 | 1995-01-10 | Glycomed, Inc. | Sulfated polysaccharides as inhibitors of smooth muscle cell proliferation |
| JPH06507635A (ja) * | 1991-05-02 | 1994-09-01 | イエダ リサーチ アンド ディベロップメント カンパニー リミテッド | 病理学的過程の予防および／または治療用組成物 |
| CA2156735A1 (en) * | 1993-02-22 | 1994-09-01 | Ulrich-Christoph Von Arnim | Pharmaceutical compositions for the treatment of inflammatory or immunological diseases and a method for the treatment of said diseases |
| FR2704861B1 (fr) * | 1993-05-07 | 1995-07-28 | Sanofi Elf | Fractions d'héparine purifiées, procédé d'obtention et compositions pharmaceutiques les contenant. |
| US5527785A (en) * | 1993-05-14 | 1996-06-18 | The Regents Of The University Of California | Selectin receptor modulating compositions |
| SE9303612D0 (sv) * | 1993-11-02 | 1993-11-02 | Kabi Pharmacia Ab | New use |
| US5690910A (en) * | 1995-08-18 | 1997-11-25 | Baker Norton Pharmaceuticals, Inc. | Method for treating asthma |
-
1997
- 1997-08-04 US US08/904,565 patent/US5980865A/en not_active Expired - Lifetime
-
1998
- 1998-04-08 UA UA2000020607A patent/UA75022C2/uk unknown
- 1998-07-31 ZA ZA986890A patent/ZA986890B/xx unknown
- 1998-08-03 AR ARP980103829A patent/AR005221A1/es not_active Application Discontinuation
- 1998-08-04 HU HU0003013A patent/HUP0003013A3/hu unknown
- 1998-08-04 ES ES98938290T patent/ES2260843T3/es not_active Expired - Lifetime
- 1998-08-04 SK SK117-2000A patent/SK1172000A3/sk unknown
- 1998-08-04 CA CA002298445A patent/CA2298445C/en not_active Expired - Fee Related
- 1998-08-04 DE DE69834256T patent/DE69834256T2/de not_active Expired - Lifetime
- 1998-08-04 PL PL338551A patent/PL191796B1/pl unknown
- 1998-08-04 RU RU2000105383/14A patent/RU2209624C2/ru not_active IP Right Cessation
- 1998-08-04 EP EP98938290A patent/EP1003479B1/en not_active Expired - Lifetime
- 1998-08-04 DK DK98938290T patent/DK1003479T3/da active
- 1998-08-04 AT AT98938290T patent/ATE323500T1/de active
- 1998-08-04 BR BR9811823-4A patent/BR9811823A/pt not_active Application Discontinuation
- 1998-08-04 AU AU86846/98A patent/AU8684698A/en not_active Abandoned
- 1998-08-04 IL IL13423098A patent/IL134230A0/xx unknown
- 1998-08-04 KR KR1020007001123A patent/KR100551773B1/ko not_active Expired - Fee Related
- 1998-08-04 JP JP2000504840A patent/JP2001511439A/ja not_active Withdrawn
- 1998-08-04 CN CN98808919A patent/CN1092049C/zh not_active Expired - Fee Related
- 1998-08-04 WO PCT/US1998/016111 patent/WO1999006025A1/en not_active Ceased
- 1998-08-04 PT PT98938290T patent/PT1003479E/pt unknown
- 1998-08-04 NZ NZ502498A patent/NZ502498A/en not_active IP Right Cessation
- 1998-08-05 TW TW087112755A patent/TW585771B/zh not_active IP Right Cessation
-
1999
- 1999-05-04 US US09/304,814 patent/US6193957B1/en not_active Expired - Lifetime
-
2000
- 2000-02-03 NO NO20000558A patent/NO20000558L/no not_active Application Discontinuation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TW585771B (en) | A pharmaceutical composition for treatment of bronchoconstrictor or airway hyperreactivity or related lung diseases caused by late phase allergic reactions | |
| JP3263723B2 (ja) | 喘息を治療するための組成物、及び喘息にかかった患者を治療するための気管支内薬物の製造における超低分子量ヘパリンの使用 | |
| JP6543467B2 (ja) | 二糖繰り返し単位を含んでいる非抗凝固グリコサミノグリカンおよびそれらの医療用途 | |
| JP2006501815A (ja) | 粘膜送達のための方法および製品 | |
| JP2004531460A (ja) | 炎症性関節炎の抑制のためのヒアルロン酸誘導体の使用 | |
| US20150057226A1 (en) | Method for treatment of labor arrest | |
| EP2830635A1 (en) | Combination treatment comprising sulphated glycosaminoglycans for inducing labor | |
| WO1993019734A1 (en) | Method and composition for treating antigen-induced and exercise-induced asthma | |
| EP1731131A1 (en) | Hgf production accelerator containing heparin-like oligosaccharide | |
| JP2005510453A (ja) | 高硫酸化二糖類及び炎症治療のためのそれらの使用方法 | |
| AU775161B2 (en) | Method and compositions for treating late phase allergic reactions and inflammatory diseases | |
| RU2179445C2 (ru) | Способ и композиция для лечения астмы | |
| MXPA00000992A (en) | Method and compositions for treating late phase allergic reactions and inflammatory diseases | |
| MXPA98001165A (en) | Method and composition for the treatment of the | |
| HK1030370B (en) | Compositions for treating late phase allergic reactions and inflammatory diseases, and use thereof | |
| CZ2000426A3 (cs) | Farmaceutický přípravek k léčení pozdní fáze alergické reakce a zánětlivé nemoci | |
| HK1062524B (en) | Use of hyaluronic acid derivatives for the prevention of inflammatory arthritis | |
| CA2779838A1 (en) | Treatment of cytokine mediated conditions |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Annulment or lapse of patent due to non-payment of fees |