TW226375B - - Google Patents

Info

Publication number
TW226375B
TW226375B TW081106755A TW81106755A TW226375B TW 226375 B TW226375 B TW 226375B TW 081106755 A TW081106755 A TW 081106755A TW 81106755 A TW81106755 A TW 81106755A TW 226375 B TW226375 B TW 226375B
Authority
TW
Taiwan
Prior art keywords
treating
azocinopyrimidines
azepino
pyrido
pyrrolo
Prior art date
Application number
TW081106755A
Other languages
English (en)
Chinese (zh)
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/782,025 external-priority patent/US5149699A/en
Priority claimed from GB9207560A external-priority patent/GB2265899A/en
Priority claimed from US07/901,485 external-priority patent/US5256654A/en
Application filed by American Home Prod filed Critical American Home Prod
Application granted granted Critical
Publication of TW226375B publication Critical patent/TW226375B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW081106755A 1991-10-24 1992-08-27 TW226375B (Direct)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/782,025 US5149699A (en) 1991-10-24 1991-10-24 Substituted pyridopyrimidines useful as antgiotensin II antagonists
GB9207560A GB2265899A (en) 1992-04-07 1992-04-07 Substituted pyrimidines
US07/901,485 US5256654A (en) 1991-10-24 1992-06-25 Substituted pyrrolopyrimidines, azepinopyrimidines and pyridopyrimidines useful as angiotensin II antagonists

Publications (1)

Publication Number Publication Date
TW226375B true TW226375B (Direct) 1994-07-11

Family

ID=27266132

Family Applications (1)

Application Number Title Priority Date Filing Date
TW081106755A TW226375B (Direct) 1991-10-24 1992-08-27

Country Status (21)

Country Link
EP (1) EP0539086B1 (Direct)
JP (1) JP3240192B2 (Direct)
KR (1) KR100286624B1 (Direct)
CN (2) CN1039324C (Direct)
AT (1) ATE161537T1 (Direct)
AU (1) AU653635B2 (Direct)
CA (1) CA2080705C (Direct)
DE (1) DE69223734T2 (Direct)
DK (1) DK0539086T3 (Direct)
ES (1) ES2111617T3 (Direct)
FI (1) FI103971B1 (Direct)
GR (1) GR3025926T3 (Direct)
HK (1) HK1003031A1 (Direct)
HU (2) HU218786B (Direct)
IL (1) IL103436A (Direct)
LV (1) LV12047B (Direct)
NO (1) NO301275B1 (Direct)
SG (1) SG47626A1 (Direct)
SK (1) SK280292B6 (Direct)
TW (1) TW226375B (Direct)
UA (1) UA27748C2 (Direct)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0643704T3 (da) * 1991-11-18 2004-01-19 Merck & Co Inc Tetrazolylphenylboronsyremellemprodukter til syntese af All-receptor antagonister
DE69415706T2 (de) * 1993-03-24 1999-05-20 American Home Products Corp., Madison, N.J. Substituierte Pyridopyrimidine als Antihypertensiva
WO1996009301A1 (en) * 1994-09-20 1996-03-28 Wakunaga Seiyaku Kabushiki Kaisha Process for producing n-biphenylmethylthiadiazoline derivative or salt thereof and intermediate for producing the same
IT1292437B1 (it) * 1997-06-30 1999-02-08 Zambon Spa Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti
US6638937B2 (en) 1998-07-06 2003-10-28 Bristol-Myers Squibb Co. Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
AR033390A1 (es) 2000-08-22 2003-12-17 Novartis Ag Una composicion farmaceutica que comprende un antagonista del receptor at1 y un potenciador de la secrecion de insulina, el uso de dicha composicion para la fabricacion de un medicamento y un kit de partes
US8168616B1 (en) 2000-11-17 2012-05-01 Novartis Ag Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension
US7732162B2 (en) 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
GB0327839D0 (en) 2003-12-01 2003-12-31 Novartis Ag Organic compounds
GB0402262D0 (en) 2004-02-02 2004-03-10 Novartis Ag Process for the manufacture of organic compounds
CA2558020A1 (en) 2004-03-17 2005-09-29 Novartis Ag Use of renin inhibitors in therapy
PT1799199E (pt) 2004-10-08 2012-07-03 Novartis Ag Uso de inibidores da renina para a prevenção ou tratamento da disfunção diastólica ou insuficiência cardíaca diastólica
EP1749828A1 (en) 2005-08-04 2007-02-07 Farmaprojects S.L. Process for preparing an angiotensin II receptor antagonist
WO2008104580A1 (en) 2007-03-01 2008-09-04 Probiodrug Ag New use of glutaminyl cyclase inhibitors
DK2142514T3 (da) 2007-04-18 2015-03-23 Probiodrug Ag Thioureaderivater som glutaminylcyclase-inhibitorer
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
AU2008261102B2 (en) 2007-06-04 2013-11-28 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
MX2009012917A (es) * 2007-06-07 2010-01-14 Sigma Tau Ind Farmaceuti Derivados de 5beta, 14-beta-androestano utiles para el tratamiento de restenosis despues de angioplastia o endoarterectomia y enfermedades debido a la fibrosis de organos.
CA2930674A1 (en) 2008-06-04 2009-12-10 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP3241839B1 (en) 2008-07-16 2019-09-04 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US8486940B2 (en) 2009-09-11 2013-07-16 Probiodrug Ag Inhibitors
US9181233B2 (en) 2010-03-03 2015-11-10 Probiodrug Ag Inhibitors of glutaminyl cyclase
EP2545047B9 (en) 2010-03-10 2015-06-10 Probiodrug AG Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5)
EP2560953B1 (en) 2010-04-21 2016-01-06 Probiodrug AG Inhibitors of glutaminyl cyclase
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
EP2686313B1 (en) 2011-03-16 2016-02-03 Probiodrug AG Benzimidazole derivatives as inhibitors of glutaminyl cyclase
BR112014014527A2 (pt) 2011-12-15 2017-06-13 Takeda Pharmaceuticals Usa Inc combinações de azilsartan e clorotalidona para tratar hipertensão em pacientes negros
HK1220611A1 (zh) 2013-03-15 2017-05-12 Bausch Health Ireland Limited 用於治疗胃肠道病症的组成物
EP2970384A1 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
SI3004138T1 (sl) 2013-06-05 2024-07-31 Bausch Health Ireland Limited Ultra čisti agonisti gvanilat ciklaze C, postopek za njihovo pripravo in uporabo
PL3461819T3 (pl) 2017-09-29 2020-11-30 Probiodrug Ag Inhibitory cyklazy glutaminylowej

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0407342A3 (en) * 1989-07-06 1991-07-10 Ciba-Geigy Ag Pyrimidine derivatives
US5100897A (en) * 1989-08-28 1992-03-31 Merck & Co., Inc. Substituted pyrimidinones as angiotensin ii antagonists
EP0415886A3 (en) * 1989-08-30 1991-10-23 Ciba-Geigy Ag Aza compounds
WO1991011999A1 (en) * 1990-02-13 1991-08-22 Merck & Co., Inc. Angiotensin ii antagonists incorporating a substituted benzyl element
IL100917A0 (en) 1991-02-16 1992-11-15 Fisons Plc Pyridinone and pyrimidinone derivatives,their preparation and pharmaceutical compositions containing them
US5149699A (en) * 1991-10-24 1992-09-22 American Home Products Corporation Substituted pyridopyrimidines useful as antgiotensin II antagonists

Also Published As

Publication number Publication date
NO924121L (no) 1993-04-26
SK322192A3 (en) 1999-11-08
CA2080705A1 (en) 1993-04-25
EP0539086B1 (en) 1997-12-29
CN1175414A (zh) 1998-03-11
HU218786B (hu) 2000-12-28
FI924397A0 (fi) 1992-09-30
SG47626A1 (en) 1998-04-17
AU2607992A (en) 1993-04-29
NO301275B1 (no) 1997-10-06
IL103436A (en) 1996-03-31
UA27748C2 (uk) 2000-10-16
HU9203161D0 (en) 1992-12-28
NO924121D0 (no) 1992-10-23
FI103971B (fi) 1999-10-29
FI924397L (fi) 1993-04-25
LV12047B (en) 1998-08-20
DE69223734T2 (de) 1998-04-16
GR3025926T3 (en) 1998-04-30
SK280292B6 (sk) 1999-11-08
JP3240192B2 (ja) 2001-12-17
DE69223734D1 (de) 1998-02-05
IL103436A0 (en) 1993-03-15
EP0539086A2 (en) 1993-04-28
AU653635B2 (en) 1994-10-06
DK0539086T3 (da) 1998-02-02
LV12047A (lv) 1998-05-20
CN1039324C (zh) 1998-07-29
CN1072682A (zh) 1993-06-02
CA2080705C (en) 2002-12-03
ES2111617T3 (es) 1998-03-16
EP0539086A3 (en) 1993-06-16
JPH05222039A (ja) 1993-08-31
ATE161537T1 (de) 1998-01-15
KR930007949A (ko) 1993-05-20
HUT62893A (en) 1993-06-28
HU211915A9 (en) 1996-01-29
HK1003031A1 (en) 1998-09-30
KR100286624B1 (ko) 2001-05-02
FI103971B1 (fi) 1999-10-29

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