TW202406531A - 口腔用組成物 - Google Patents
口腔用組成物 Download PDFInfo
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- TW202406531A TW202406531A TW112120269A TW112120269A TW202406531A TW 202406531 A TW202406531 A TW 202406531A TW 112120269 A TW112120269 A TW 112120269A TW 112120269 A TW112120269 A TW 112120269A TW 202406531 A TW202406531 A TW 202406531A
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- oral composition
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Abstract
議題：本發明提供可有效地去除牙菌斑（牙垢）、著色（染色）、蛋白質髒污、口臭、牙結石等之口腔用組成物。解決方式：本發明關於一種口腔用組成物，其含有（A）30～95質量％的液狀油分、（B）一種以上的非離子界面活性劑。
Description
本發明係關於口腔用組成物等，更詳細而言，係關於含有液狀油分之口腔用組成物等。
在口腔內，起因於飲食物與牙齒表面接觸並殘留，而會發生各種的口腔問題。食物殘渣係因口腔內細菌的代謝而成為在牙齒表面上形成牙菌斑（牙垢）之原因，並促進蛀牙、牙周病等口腔內疾病的發生、進行。又，柑橘類、非酒精飲料等酸性飲食物係因與牙齒的接觸而直接地引起脫鈣（酸蝕）。再者，牙齒的染色髒污亦即著色係因累積源自飲食物的多酚等染色成分而形成，會使牙齒的美觀性惡化，而使嘴巴周圍的清潔感甚至臉整體的印象降低。
為了預防此等口腔問題，期望進行披覆牙齒表面等動作，極力減少飲食物與牙齒表面接觸之狀態。作為披覆牙齒表面之技術，提案有由磷酸酯或聚合物所進行之牙齒表面塗層技術（專利文獻1及2）、由茶萃取物所進行之牙本質強化技術（專利文獻3）等。
[先行技術文獻]
[專利文獻]
[專利文獻1] 日本特開平5-320032號公報
[專利文獻2] 日本特開2005-200345號公報
[專利文獻3] 日本特開2005-29496號公報
[發明所欲解決的問題]
然而，由上述專利文獻1～3所提案之技術難以使使用者滿意實際感覺到的所述牙齒表面塗層效果，存在提升使用的實際感覺的問題。在經常被唾液濕潤之口腔內，難以藉由使用以專利文獻1～3為首之以往的水系口腔用組成物而賦予牙齒表面塗層的實際感覺。
[用以解決問題的手段]
本發明人等專心致志地進行探討，結果發現摻合液狀油分及界面活性劑之油系組成物係藉由油狀基劑在口腔內分散並披覆口腔組織而表現高的牙齒表面塗層的實際感覺。
並且，藉由優異的牙齒表面滯留性，可進行由牙齒表面塗層所致之牙菌斑的沉積防止、著色的沉積防止以及鈣離子從牙表面的溶出防止。再者，只要為本發明的口腔用組成物，則因亦具有優異的口腔內（牙齒表面、牙齦、黏膜、舌）滯留性，故可使組成物所含有之有效成分的口腔內滯留量增加。
藉此，能提供提高牙本質強化、殺菌、消炎、感覺過敏抑制、牙結石形成抑制、膠原蛋白分解抑制、收斂作用、血液循環促進、細胞活化、膠原蛋白產生、組織修復、止血保濕作用之口腔用組成物。
再者，只要為本發明的口腔用組成物，則亦具有由經高摻合之液狀油分、界面活性劑所致之高的清洗效果，因此可有效地去除牙菌斑（牙垢）、著色（染色）、蛋白質髒污、口臭、牙結石。
本發明例如包含以下的項所記載之主題。
項1.
一種口腔用組成物，其含有：
（A）30～95質量％的液狀油分；
（B）一種以上的非離子界面活性劑。
項2.
如項1所記載之口腔用組成物，其中，液狀油分為酯化合物。
項3.
如項1或2所記載之口腔用組成物，其中，液狀油分為飽和脂肪酸酯化合物。
項4.
如項1～3中任一項所記載之口腔用組成物，其中，非離子性界面活性劑的一種以上為HLB值5～13。
項5.
如項1～4中任一項所記載之口腔用組成物，其中，進一步含有1～30質量％的熔點為50～120℃的固體油分。
項6.
如項5所記載之口腔用組成物，其中，固體油分為烴。
項7.
如項1～6中任一項所記載之口腔用組成物，其中，進一步含有（C）能適用於口腔內的清涼化劑及／或甜味劑。
項8.
如項1～7中任一項所記載之口腔用組成物，其中，進一步含有縮合磷酸鹽，縮合磷酸鹽為選自由焦磷酸鹽、三聚磷酸鹽及偏磷酸鹽所組成之群組的一種以上。
項9－1.
如項1～8中任一項所記載之口腔用組成物，其中，進一步含有親油性有效成分，親油性有效成分為選自由異丙基甲酚、氯化十六烷基吡啶、甘草酸苷類、甘草次酸、維生素類所組成之群組的一種以上。
項9－2.
如請求項1所記載之口腔用組成物，其中，進一步含有殺菌消毒劑、消炎劑及／或維生素類，殺菌消毒劑為異丙基甲酚或氯化十六烷基吡啶，消炎劑為甘草酸苷類或甘草次酸。
項10.
如項1～9中任一項所記載之口腔用組成物，其中，進一步含有一種以上的具有牙齒硬組織的染色去除效果及／或漂白效果之水溶性高分子。
項11.
一種去除牙齒著色之方法，其係由併用如項1～9中任一項所記載之口腔用組成物與電動牙刷所致。
[發明功效]
本發明的口腔用組成物具有高的牙齒表面塗層的實際感覺，同時亦可提高由牙齒表面塗層所致之牙菌斑的沉積預防、著色的沉積預防、脫鈣抑制效果、高的清洗效果以及所含有之有效成分在口腔內的滯留性。
[用以實施發明的形態]
以下，針對本發明所包含之各實施形態進一步詳細地進行說明。本發明較佳為包含口腔用組成物、該組成物的製造方法等，但並不受限於此等，本發明包含本說明書所公開之全部內容。此外，以下除非另有說明，否則「％」表示「質量％」。
作為液狀油分，只要能適用於口腔內且在室溫（25℃）下為液狀則未被特別限定。可列舉例如：棕櫚酸2－乙基己酯、肉荳蔻酸異丙酯、亞麻油酸乙酯、棕櫚酸異丙酯、油酸油酯、肉豆蔻酸異十三酯、肉豆蔻酸2－乙基己酯、油酸癸酯、肉豆蔻酸異十八酯、肉荳蔻酸十二酯、硬脂酸2－乙基己酯、硬脂酸2－己基癸酯、棕櫚酸異十八酯、油酸2－辛基十二酯、異硬脂酸異丙酯、2－乙基己酸鯨蠟酯、二（辛癸酸）丙二醇、二辛酸丙二醇、二癸酸丙二醇、三辛酸甘油酯、三－2－乙基己酸甘油酯、三異硬脂酸甘油酯、三（辛癸酸）甘油酯、三異棕櫚酸甘油酯、三羥甲丙烷三異硬脂酸、三羥甲丙烷三－2－乙基己酯、異壬酸異壬酯、異壬酸異十三酯、異硬脂酸異十八酯、異硬脂酸2－己基癸酯等酯油；鯊烷、聚丁烯、液態石蠟、凡士林、低比重液態石蠟、輕質液體異構烷烴、重質液體異構烷烴、聚異丁烯等烴油；荷荷芭油、鰐梨油、紅花子油、山茶油、貂油、蓖麻油、乳木果油、澳洲堅果油、醋酸羊毛脂、液狀羊毛脂等油脂類；異硬脂醇、油醇等高級醇類；甲基苯基聚矽氧烷、十二甲基環六矽氧烷、甲基氫聚矽氧烷、十甲基環五矽氧烷、八甲基環四矽氧烷等聚矽氧油；等。
相對於本口腔用組成物，液狀油分的含量需要為30％～95％，較佳為35～90％，更佳為40～85％。相對於本口腔用組成物，液狀油分的含量可為45％以上、50％以上、55％以上、60％以上、65％以上或70％以上，且可為80％以下、75％以下或70％以下。液狀油分的含量過少之情形，與口腔組織接觸之油狀成分量減少，使用時的塗層的實際感覺降低。相反地，液狀油分的含量過多之情形，口腔內的使用感不佳。液狀油分可一種單獨或組合二種以上而使用。
作為非離子界面活性劑，只要能適用於口腔內則未被特別限定。可列舉例如：聚氧乙烯芳烷醚（20E.O.）、聚氧乙烯辛基十二烷基醚、聚氧乙烯油基醚（polyoxyethylene oleyl ether）、聚氧乙烯膽固醚、聚氧乙烯硬脂基醚、聚氧乙烯肉荳蔻基醚、聚氧乙烯月桂基醚、聚氧乙烯鯨蠟基醚、聚氧乙烯二十二烷基醚、聚氧乙烯聚氧基丙二醇、聚氧乙烯聚氧丙烯鯨蠟基醚、聚氧乙烯聚氧丙烯癸基十四烷基醚、聚氧乙烯聚氧丙烯丁基醚等醚型；乙二醇單硬脂酸酯、乙二醇二硬脂酸酯、山梨醇酐單硬脂酸酯、山梨醇酐單異硬脂酸酯、山梨糖醇酐倍半異硬脂酸酯（sorbitan sesquiisostearate）、山梨醇酐倍半硬脂酸酯、山梨醇酐單棕櫚酸酯、山梨醇酐單油酸酯、山梨醇酐三油酸酯、山梨醇酐三硬脂酸酯、親油型單硬脂酸甘油酯、自乳化型單硬脂酸甘油酯等酯型、聚乙二醇單油酸酯、聚乙二醇單硬脂酸酯、聚氧乙烯單硬脂酸甘油酯、聚氧乙烯異硬脂酸甘油酯、聚氧乙烯山梨醇四油酸酯、聚氧乙烯山梨醇單月桂酸酯、聚氧乙烯氫化蓖麻油、聚乙二醇二月桂酸酯、聚甘油二硬脂酸酯、聚甘油二異硬脂酸酯、聚甘油十油酸酯、二甘油三異硬脂酸酯、聚甘油五油酸酯、聚甘油單異硬脂酸酯、聚甘油單油酸酯、聚甘油單硬脂酸酯、十甘油單肉豆蔻酸酯、聚甘油單月桂酸酯等醚酯型；硬脂酸單乙醇醯胺、硬脂酸二乙醇醯胺、肉豆蔻酸二乙醇醯胺、椰子油脂肪酸二乙醇醯胺、月桂酸二乙醇醯胺等脂肪酸鏈烷醇醯胺型；烷基糖苷等。
非離子界面活性劑的HLB（Hydrophilic-Lipophilic Balance，親水親油平衡）只要為不損及本發明的效果之範圍則未被特別限制。一般而言，為3～18左右，較佳為4～16左右，更佳為5～13左右。又，非離子性界面活性劑的HLB值過低之情形，與牙齒表面等親水性口腔組織的親和性變低，有使用感不佳之情形。相反地，在HLB值過高之情形中，因由水沖洗、唾液所致之稀釋而促進製劑脫離，有組成物及組成物成分的口腔內滯留性變得不充分之情形。
非離子界面活性劑的含量只要為不損及本發明的效果之範圍則未被特別限制。一般而言，相對於本口腔用組成物，為3％～40％左右，較佳為4％～35％左右，更佳為5％～30％左右。又，非離子性界面活性劑的含量過少之情形，牙齒表面等親水性口腔組織與油系基劑的親和性變低，有使用感不佳之情形。相反地，在含量過多之情形中，有使用時的刺激性變強之情形。非離子界面活性劑可一種單獨或組合二種以上而使用。
本發明的口腔用組成物可進一步包含清涼化劑及／或甜味劑。藉由包含此等，即使本發明的組成物本質上為油系的組成物，亦能在口腔內獲得良好的使用感，因此非常有效。
作為清涼化劑，只要能適用於口腔內則未被特別限定。可列舉例如薄荷醇類、茴香腦、丁香酚、水楊酸甲酯、檸檬烯、蘿勒萜、正癸醇、香茅醛、α－松油醇、乙酸甲酯、乙酸香茅酯、甲基丁香酚、桉樹腦、沈香醇、乙基沈香醇、香草醛、瑞香酚、薄荷油、綠薄荷油、薄荷油、檸檬油、橙油、鼠尾草油、迷迭香油、桂皮油、紫蘇油、冬青油、丁香油、桉樹油等。此等成分亦可被摻合作為香料成分的一部分。
清涼化劑的含量只要為能獲得其效果之範圍則未被特別限制。一般而言，相對於本口腔用組成物，可含有0.01％～5％左右。清涼化劑可一種單獨或組合二種以上而使用。
作為甜味劑，只要能適用於口腔內則未被特別限定。可列舉例如糖精鈉、乙醯磺胺酸鉀、甜菊苷、山梨醇、異麥芽糖醇（Palatinit）、木糖醇、赤藻糖醇、新橘皮苷二氫查酮、甘草酸苷、紫蘇糖、索馬甜、天冬胺醯基苯丙胺醯甲酯（asparatylphenylalanyl methyl ester）、對甲氧桂皮醛。
甜味劑的含量只要為能獲得其效果之範圍則未被特別限制。一般而言，相對於本口腔用組成物，可含有0.01％～30％左右。甜味劑可一種單獨或組合二種以上而使用。
作為本發明的口腔用組成物的製備方法，可列舉例如以下方法：首先將（A）成分與（B）成分進行攪拌並混合後，一邊持續攪拌一邊在該混合物中添加（C）成分並進行混合。混合可藉由習知的攪拌機而進行。
又，藉由進一步含有固體油分，可做成為固體或半固體。作為此情形的製備方法，可列舉以下方法：將（A）、（B）與固體油分一起加熱至熔點以上，均勻混合後添加（C）成分，維持著熔融狀態而注入指定的容器等，進行冷卻或放置冷卻。
作為固體油分，只要能適用於口腔內且熔點為50～120℃則未被特別限定。可列舉例如：合成烴蠟、聚乙烯蠟、乙烯－丙烯共聚物、微晶蠟、地蠟、石蠟、地石蠟（ozokerite）、費－托石蠟（Fischer-Tropsch wax）等烴；木蠟（Japan wax）、棕櫚蠟、小燭樹蠟、米糠蠟、蜂蠟、氫化荷荷芭油、硬化油、高級醇、聚矽氧蠟（silicone wax）。
相對於本口腔用組成物，固體油分的含量可含有1％～30％，較佳為2～20％，更佳為3～15％。相對於本口腔用組成物，固體油分的含量可為5％以上、8％以上或10％以上，且可為15％以下、12％以下或10％以下。不包含固體油分的含量之情形，因組成物的形狀保持性變得不充分，故無法成為固體狀的形狀。相反地，固體油分的含量過多之情形，使用於口腔內時的分散性降低。固體油分可一種單獨或組合二種以上而使用。
相對於本口腔用組成物，液狀油分及固體油分的合計的含量為40％～95％，較佳為50～90％，更佳為70～90％。相對於本口腔用組成物，液狀油分的含量可為55％以上、60％以上、65％以上、70％以上、75％以上或80％以上，且可為95％以下、90％以下或88％以下。
本發明的口腔用組成物雖亦可包含水，但水的含量可為50％以下、40％以下、35％以下、30％以下、25％以下、20％以下、15％以下、10％以下或5％以下，且可為1％以上、3％以上、5％以上或10％以上。
本發明的口腔用組成物的相態及分散狀態未被特別限制。相態可列舉例如O（油）相單獨、W／O、O／W、W／O／W、O／W／O、雙連續（Bicontinuous）、高內相比乳化。分散狀態可列舉可溶化、乳化、二相分離、三相分離、多相分離、固液分散，亦可為在使用時因振動等外力而分散者。但是，本發明的口腔用組成物較佳為實質上由油性成分所構成之單相的油性組成物。本發明的口腔用組成物含有水之情形，可成為藉由非離子界面活性劑而將水分散在液狀油分及／或固體油分中之狀態。
本發明的口腔用組成物的劑型及形狀未被特別限制。可列舉例如液體（溶液、乳液、懸浮液、黏性液等）、半固體（凝膠、軟膏、霜、糊等）、固體（錠劑、粒狀劑、膠囊劑、薄膜劑、混練物、熔融固體、蠟狀固體、彈性固體、軟膠囊劑等）。但是，本發明的口腔用組成物較佳為半固體狀的組成物。
本發明的口腔用組成物可廣泛利用於口腔用途。作為固體的劑型的口腔用組成物，可列舉例如口含錠、軟糖、口香糖、牙膏。作為半固體的劑型的口腔用組成物，可列舉例如牙膏、塗布劑。作為液體的劑型的口腔用組成物，可列舉例如漱口水、牙膏、口中清涼劑（噴霧等）。此等之中，由有效性及穩定性的觀點而言，較佳為牙膏、塗布劑、漱口水、口中清涼劑。口腔用組成物的製造方法並未被特別限定，能因應劑型而利用各自的通常方法製備。
在本發明的口腔用組成物中，在不損及本發明的效果之範圍內，亦可包含可使口腔用組成物含有之習知成分。添加此種成分之本發明的口腔用組成物，例如可藉由在混合（A）成分與（B）成分後與（C）成分一起添加該成分並進行混合之方法而製備。
作為此種習知成分，可列舉例如濕潤劑、發泡劑、增黏劑、研磨劑、矯味劑、收斂劑、pH調整劑、染色劑、防腐劑、有效成分等。此外，此種習知成分可一種單獨或組合二種以上而使用。
作為濕潤劑，可列舉例如乙醇、乙二醇、丙二醇（propanediol）、聚乙二醇、丙二醇（propylene glycol）、1,3－丁二醇、甘油、山梨醇。
作為發泡劑，可列舉例如月桂基硫酸鈉、月桂醯基肌胺酸鈉、十二烷基苯磺酸鈉、月桂基磺酸乙酸鈉、N－月桂基二胺基乙基甘胺酸、月桂基磺酸丁二酸鈉、N－棕櫚醯基麩胺酸鈉、N－甲基－N－醯基牛磺酸鈉、α－烯烴磺酸鈉、月桂基二甲基胺基乙酸甜菜鹼、椰子油脂肪酸醯胺丙基二甲基胺基乙酸甜菜鹼、N－椰子油脂肪酸醯基－N－羧甲基－N－羥乙基咪唑啉甜菜鹼、椰子油脂肪酸醯胺丙基甜菜鹼等。
作為增黏劑，可列舉例如羧甲基纖維素鈉、羥丙基纖維素、羥乙基纖維素、結蘭膠、黃原膠、阿拉伯膠、鹿角菜膠、增黏性矽石等。
作為研磨劑，可列舉例如二氧化矽、矽酸鈣、碳酸鈣、焦磷酸鈣、磷酸鈣、氧化鋁、氫氧化鋁、膨土、羥磷灰石等。
作為矯味劑，可列舉例如茶萃取物、茶干餾液、氯化鎂、蜂膠萃取物、麩胺酸鈉等。
作為收斂劑，可列舉例如乳酸鋁、碳酸氫鈉、氯化鋅、氧化鋅、氯化鈉等。
作為pH調整劑，可列舉例如：檸檬酸、磷酸、乳酸、焦磷酸、蘋果酸、植酸、酒石酸、甘油磷酸、硝酸、乙酸或此等化學上可能的鹽；氫氧化鈉、矽酸鈉等。
作為染色劑，可列舉例如藍色1號、綠色3號、黃色4號、群青、紺青、氧化鈦、雲母鈦等。
作為防腐劑，可列舉例如對羥苯甲酸甲酯、對羥苯甲酸乙酯、對羥苯甲酸丙酯、對羥苯甲酸丁酯、苯甲酸鈉、烷基二胺基乙基甘胺酸鹽酸鹽、苯氧乙醇等。
作為有效成分，可列舉消炎劑、乳化助劑、殺菌消毒劑、維生素類、吸附劑、美白劑、再礦化促進劑、感覺過敏抑制劑、牙結石去除劑、酵素、成骨劑（osteogenic agent）、象牙質塗層劑等。作為消炎劑，可列舉例如甘菊磺酸鈉、ε－胺基己酸、尿囊素、氯羥基尿囊素鋁、甘草酸苷類、甘草次酸、氯化溶菌酶、葉綠酸銅鈉、傳明酸（tranexamic acid）等。又，作為乳化助劑，可列舉二氫膽固醇等。作為殺菌消毒劑，可列舉異丙基甲酚、氯化十六烷基吡啶、地喹氯銨（dequalinium chloride）、氯化苯二甲烴銨、氯化本索寧、洛赫西定鹽類、三氯沙、檜酚酮、月桂醯基肌胺酸鈉、組胺酸等。又，精胺酸、離胺酸、瓜胺酸、鳥胺酸、肌酸、二胺基丁酸、二胺基丙酸等鹼性胺基酸作為致齲性細菌（cariogenic bacteria）用的殺菌劑為有用。作為維生素類，可列舉抗壞血酸或其鹽、鹽酸吡多辛、乙酸－dl－α－生育酚、菸鹼酸－dl－α－生育酚等。作為吸附劑，可列舉沸石、環糊精類、葡萄糖酸銅等。作為美白劑，可列舉焦磷酸鈉、聚磷酸鈉、偏磷酸鹽等縮合磷酸鹽、過氧化氫等。作為再礦化促進劑，可列舉氟化鈉、單氟磷酸鈉、氟化亞錫、氯化溶菌酶、葉綠酸銅鈉等。作為感覺過敏抑制劑，可列舉硝酸鉀、氯化鉀、乳酸鋁、乙酸鍶等。作為牙結石去除劑，可列舉聚葡萄糖酶、葡聚醣變構水解酶（mutanase）等。作為酵素，可列舉澱粉酶、蛋白酶、分解酵素等。作為成骨劑，可列舉生物活性玻璃等。作為象牙質塗層劑，可列舉吡咯啶酮羧酸等。另外，可列舉類黃酮、植物萃取物、乳酸菌等作為有效成分。
本發明的口腔用組成物可進一步包含具有染色去除效果及或漂白效果之水溶性高分子。藉由包含此等，可進一步提高本發明的組成物的美白效果，因此非常有效。具有染色去除效果及或漂白效果之水溶性高分子可一種單獨或組合二種以上而使用。
作為具有染色去除效果及或漂白效果之水溶性高分子，可列舉：聚乙二醇等多元醇類；聚乙烯吡咯啶酮等聚乙烯基聚合物類等。
本發明進一步關於一種去除牙齒的著色之方法，其係由併用口腔用組成物與牙刷所致。藉由將本發明的組成物與牙刷組合使用，可效率佳地去除牙齒的著色。牙刷可為一般的牙刷，但較佳為電動牙刷。
[實施例]
以下，更具體地說明本發明，但本發明並未受限於下述的例子。各表所記載之各成分的摻合量值亦只要未特別說明則表示「質量％」。
《口腔用組成物的製備1》
遵循表1所示之組成（數值表示質量％）並藉由通常方法而製備固體組成物。將所得之牙膏組成物使用作為樣品，並利用下述方法進行評價。將結果一併記載於表中。
（牙齒表面塗層的實際感覺 評價方法）
藉由4位受驗者品評小組（subject panel）而評價口腔用組成物的牙齒表面塗層的實際感覺。將樣品的固體組成物0.5g取至牙刷，將口腔整體刷洗3分鐘後吐出。針對刷洗中（將固體組成物遍布於口腔內的期間）的牙齒表面塗層的實際感覺，分別藉由下述所示之評點基準而進行判定。求取4位的點數的平均，並藉由下述的評價基準而進行評價。此外，於此，所謂牙齒表面塗層的實際感覺，係指已分散於口腔內之組成物緊附於牙齒表面之實際感覺。
[評價基準]
4點：相當有塗層的實際感覺
3點：稍微有塗層的實際感覺
2點：幾乎沒有塗層的實際感覺
1點：無塗層的實際感覺
[4階段判定基準]
◎：平均點為3.5點以上
○：平均點為3.0點以上且小於3.5點
△：平均點為2.0點以上且小於3.0點
×：平均點為小於2.0點
（香味使用感 評價方法）
藉由4位受驗者品評小組而評價口腔用組成物的使用感。將樣品的固體組成物0.5g取至牙刷，將口腔整體刷洗3分鐘後吐出。針對刷洗中（將固體組成物遍布於口腔內的期間）的香味，分別藉由下述所示之評點基準而進行判定。求取4位的點數的平均，藉由下述的評價基準而進行評價。
[評價基準]
4點：口腔內未感覺到不舒服感（異味、不舒服的氣味）
3點：口腔內幾乎未感覺到不舒服感（異味、不舒服的氣味）
2點：口腔內稍微地感覺到不舒服感（異味、不舒服的氣味）
1點：口腔內相當地感覺到不舒服感（異味、不舒服的氣味）
[4階段判定基準]
◎：平均點為3.5點以上
○：平均點為3.0點以上且小於3.5點
△：平均點為2.0點以上且小於3.0點
×：平均點為小於2.0點
[表1]
| 液狀組成物 | 實施例 | 比較例 | ||||||||||
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 1 | 2 | ||
| 液狀油分 | 棕櫚酸乙基己酯 | 60 | 60 | 60 | 60 | 60 | 60 | 60 | 60 | 60 | 60 | 10 |
| 三（辛癸酸）甘油酯 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | ||
| 異壬酸異十三酯 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | ||
| 非離子性 界面活性劑 | 異硬脂酸POE甘油酯 （PEG-20，HLB:13） | 10 | 6 | 8 | 6 | 10 | 10 | 10 | 10 | |||
| 異硬脂酸POE甘油酯 （PEG-3，HLB:6） | 2 | 6 | 4 | 3 | 2 | 2 | 2 | 2 | ||||
| POE氫化蓖麻油 （PEG-20，HLB:10.5） | 8 | 8 | 2 | |||||||||
| 山梨醇酐單油酸酯 （HLB:4.3） | 4 | 4 | ||||||||||
| 清涼化劑/ 甜味劑 | l-薄荷醇 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0.3 | 1 | 1 | |
| 木糖醇 | 0.1 | 1 | 0.1 | 0.1 | ||||||||
| 其他基劑 | 純化水（殘餘量） | 殘餘量 | 殘餘量 | 殘餘量 | 殘餘量 | 殘餘量 | 殘餘量 | 殘餘量 | 殘餘量 | 殘餘量 | 殘餘量 | 殘餘量 |
| 評價 | 牙齒表面塗層的實際感覺 | ◎ | ◎ | ◎ | ◎ | ◎ | ◎ | ◎ | ◎ | ◎ | △ | × |
| 使用感 | ○ | ○ | ○ | ○ | ○ | ○ | ◎ | ○ | × | ○ | ◎ |
如表1所示，實施例1～8的口腔用組成物顯示良好的牙齒表面塗層的實際感覺、使用感。實施例9的口腔用組成物因未包含清涼化劑等，故使用感雖不佳，但顯示良好的牙齒表面塗層的實際感覺。
《口腔用組成物的製備2》
遵循表2所示之組成（數值表示質量％）並藉由通常方法而製備液狀組成物。將所得之牙膏組成物使用作為樣品，並利用下述方法進行評價。將結果一併記載於表中。
（牙齒表面塗層的實際感覺 評價方法）
藉由4位受驗者品評小組而評價口腔用組成物的牙齒表面塗層的實際感覺。將樣品的液狀組成物10mL含於口中，漱口20秒鐘後吐出。針對在漱口中（將液狀組成物遍布於口腔內的期間）的牙齒表面塗層的實際感覺，分別藉由下述所示之評點基準而進行判定。求取4位的點數的平均，藉由下述的評價基準而進行評價。此外，於此，所謂牙齒表面塗層的實際感覺，係指已分散於口腔內之組成物緊附於牙齒表面之實際感覺。
（香味使用感 評價方法）
藉由4位受驗者品評小組而評價口腔用組成物的使用感。將樣品的液狀組成物10mL含於口中，漱口20秒鐘後吐出。針對在漱口中（將液狀組成物遍布於口腔內的期間）的香味，分別藉由下述所示之評點基準而進行判定。求取4位的點數的平均，藉由下述的評價基準而進行評價。
此等評價基準及4階段判定基準係與口腔用組成物的製備1所使用之基準相同。
[表2]
| 固體組成物 | 實施例 | 比較例 | ||||||||||||
| 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 3 | 4 | ||
| 液狀油分 | 棕櫚酸2-乙基己酯 | 55 | 55 | 55 | 55 | 55 | 55 | 55 | 55 | 55 | 55 | 55 | 60 | 15 |
| 三（辛癸酸）甘油酯 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 25 | ||
| 異壬酸異十三酯 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 5 | ||
| 非離子性 界面活性劑 | 異硬脂酸POE甘油酯 （PEG-20，HLB:13） | 10 | 6 | 10 | 10 | 10 | 50 | |||||||
| 異硬脂酸POE甘油酯 （PEG-3，HLB:6） | 2 | 6 | 4 | 2 | 2 | 2 | 25 | |||||||
| 異硬脂酸POE甘油酯 （PEG-60，HLB:16） | 8 | 12 | ||||||||||||
| POE鯨蠟基醚 （HLB:5.7） | 12 | |||||||||||||
| 聚甘油單油酸酯 （HLB:12） | 12 | |||||||||||||
| POE氫化蓖麻油 （PEG-20，HLB:10.5） | 12 | |||||||||||||
| POE氫化蓖麻油 （PEG-80，HLB:15） | 12 | |||||||||||||
| 清涼化劑/ 甜味劑 | l-薄荷醇 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0.3 | 1 | 1 | |
| 糖精鈉 | 0.1 | 0.5 | 0.1 | 0.1 | ||||||||||
| 固體油分 | 聚乙烯蠟 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 9 | 9 | 8 | 8 |
| 其他基劑 | 純化水（殘餘量） | 殘餘量 | 殘餘量 | 殘餘量 | 殘餘量 | 殘餘量 | 殘餘量 | 殘餘量 | 殘餘量 | 殘餘量 | 殘餘量 | 殘餘量 | 殘餘量 | 殘餘量 |
| 評價 | 牙齒表面塗層的實際感覺 | ◎ | ◎ | ◎ | ◎ | ◎ | ◎ | ◎ | ◎ | ◎ | ◎ | ◎ | × | △ |
| 使用感 | ◎ | ◎ | ◎ | ◎ | ◎ | ◎ | ◎ | ◎ | ◎ | ◎ | × | △ | × |
如表2所示，實施例10～19的口腔用組成物顯示良好的牙齒表面塗層的實際感覺、使用感。實施例20的口腔用組成物因未包含清涼化劑等，故雖使用感不佳，但顯示良好的牙齒表面塗層的實際感覺。
以下揭示本發明的口腔用組成物的處方例。此外，各處方例的摻合量（％）表示質量％。下述處方顯示良好的牙齒表面塗層的實際感覺、使用感。
[表3]
| 處方例1 | 摻合比 [%] | 處方例2 | 摻合比 [%] | 處方例3 | 摻合比 [%] | |
| 液狀油分 | 棕櫚酸2-乙基己酯 | 50 | 硬脂酸2-乙基己酯 | 40 | 2-乙基己酸鯨蠟酯 | 40 |
| 三（辛癸酸）甘油酯 | 15 | 液態石蠟 | 15 | 異壬酸異壬酯 | 10 | |
| 非離子性 界面活性劑 | 異硬脂酸POE甘油酯 | 12 | 聚甘油十油酸酯 | 8 | 聚甘油二異硬脂酸酯 | 10 |
| 聚乙二醇單油酸酯 | 2 | 烷基糖苷 | 2 | 聚氧乙烯氫化蓖麻油 | 5 | |
| 清涼化劑/ 甜味劑 | l-薄荷醇 | 1 | 赤藻糖醇 | 7 | 異麥芽糖醇 | 5 |
| 甜菊苷 | 0.3 | 薄荷油 | 0.2 | 瑞香酚 | 0.01 | |
| 固體油分 | 聚乙烯蠟 | 8 | 微晶蠟 | 9 | 氫化荷荷芭油 | 8 |
| 有效成分 | 聚乙二醇 | 5 | 硝酸鉀 | 5 | 單氟磷酸鈉 | 0.7 |
| 氟化鈉 | 0.21 | 聚磷酸鈉 | 2 | 聚乙烯吡咯啶酮 | 0.5 | |
| 乙酸-dl-α-生育酚 | 0.05 | 檜酚酮 | 0.02 | β-甘草次酸 | 0.1 | |
| 其他基劑 | 羥磷灰石 | 5 | 二氧化矽 | 10 | 碳酸鈣 | 20 |
| 月桂基硫酸鈉 | 0.5 | 氧化鈦 | 1 | α-烯烴磺酸鈉 | 0.3 | |
| 椰子油脂肪酸醯胺丙基甜菜鹼 | 0.3 | 月桂醯基肌胺酸鈉 | 0.4 | 焦磷酸鈉 | 0.1 | |
| 檸檬酸鈉 | 0.1 | β-環糊精 | 0.2 | 藍色1號 | 微量 | |
| 必要基劑 | 純化水（殘餘量） | 殘餘量 | 純化水（殘餘量） | 殘餘量 | 純化水（殘餘量） | 殘餘量 |
[表4]
| 處方例4 | 摻合比 [%] | 處方例5 | 摻合比 [%] | |
| 液狀油分 | 肉豆蔻酸異十三酯 | 60 | 鯊烷 | 60 |
| 甲基苯基聚矽氧烷 | 5 | 三（辛癸酸）甘油酯 | 18 | |
| - | - | 鰐梨油 | 5 | |
| 非離子性 界面活性劑 | POE硬脂基醚 | 6 | 聚氧乙烯氫化蓖麻油 | 6 |
| 聚甘油五油酸酯 | 6 | 異硬脂酸POE甘油酯 | 2 | |
| 清涼化劑/ 甜味劑 | 山梨醇 | 8 | 綠薄荷油 | 0.5 |
| 薄荷油 | 0.5 | 糖精鈉 | 0.3 | |
| 固體油分 | 合成烴蠟 | 3 | - | - |
| 有效成分 | 氯化鈉 | 5 | 抗壞血酸鈉 | 0.1 |
| 甘草酸苷二鉀 | 0.05 | 尿囊素 | 0.1 | |
| 氯化十六烷基吡啶 | 0.05 | 異丙基甲酚 | 0.05 | |
| 其他基劑 | 甘油 | 3 | 乙醇 | 2 |
| N-月桂基二胺基乙基甘胺酸 | 1 | 十二烷基苯磺酸鈉 | 0.5 | |
| 碳酸氫鈉 | 0.5 | 黃原膠 | 0.3 | |
| 植酸 | 0.1 | 對羥苯甲酸甲酯 | 0.1 | |
| - | - | 茶萃取物 | 0.01 | |
| 必要基劑 | 純化水（殘餘量） | 殘餘量 | 純化水（殘餘量） | 殘餘量 |
無
無
Claims (11)
- 一種口腔用組成物，其含有： （A）30～95質量％的液狀油分； （B）一種以上的非離子界面活性劑。
- 如請求項1之口腔用組成物，其中，液狀油分為酯化合物。
- 如請求項2之口腔用組成物，其中，液狀油分為飽和脂肪酸酯化合物。
- 如請求項1之口腔用組成物，其中，非離子性界面活性劑的一種以上為HLB值5～13。
- 如請求項1之口腔用組成物，其中，進一步含有1～30質量％的熔點為50～120℃的固體油分。
- 如請求項5之口腔用組成物，其中，固體油分為烴。
- 如請求項1之口腔用組成物，其中，進一步含有（C）能適用於口腔內的清涼化劑及／或甜味劑。
- 如請求項1之口腔用組成物，其中，進一步含有縮合磷酸鹽，縮合磷酸鹽係選自由焦磷酸鹽、三聚磷酸鹽及偏磷酸鹽所組成之群組的一種以上。
- 如請求項1之口腔用組成物，其中，進一步含有殺菌消毒劑、消炎劑及／或維生素類，殺菌消毒劑為異丙基甲酚或氯化十六烷基吡啶，消炎劑為甘草酸苷類或甘草次酸。
- 如請求項1之口腔用組成物，其中，進一步含有一種以上的具有牙齒硬組織的染色去除效果及／或漂白效果之水溶性高分子。
- 一種去除牙齒的著色之方法，其係由併用如請求項1至9中任一項之口腔用組成物與電動牙刷所致。
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| WO (1) | WO2023234379A1 (zh) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012124533A1 (ja) * | 2011-03-11 | 2012-09-20 | ライオン株式会社 | ２層分離型液体口腔用組成物 |
| JP2014051444A (ja) * | 2012-09-06 | 2014-03-20 | Lion Corp | ２層分離型液体口腔用組成物 |
| JP6031902B2 (ja) * | 2012-09-06 | 2016-11-24 | ライオン株式会社 | ２層分離型液体口腔用組成物 |
| JP6795406B2 (ja) * | 2017-01-12 | 2020-12-02 | アース製薬株式会社 | ２相液体口腔用組成物 |
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2023
- 2023-05-31 TW TW112120269A patent/TW202406531A/zh unknown
- 2023-06-01 WO PCT/JP2023/020395 patent/WO2023234379A1/ja unknown
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| Publication number | Publication date |
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| WO2023234379A1 (ja) | 2023-12-07 |
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