WO2002067883A1 - Compositions de nettoyage pour la cavite buccale - Google Patents

Compositions de nettoyage pour la cavite buccale Download PDF

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Publication number
WO2002067883A1
WO2002067883A1 PCT/JP2002/001832 JP0201832W WO02067883A1 WO 2002067883 A1 WO2002067883 A1 WO 2002067883A1 JP 0201832 W JP0201832 W JP 0201832W WO 02067883 A1 WO02067883 A1 WO 02067883A1
Authority
WO
WIPO (PCT)
Prior art keywords
gel
oral cavity
composition
weight
sodium
Prior art date
Application number
PCT/JP2002/001832
Other languages
English (en)
Japanese (ja)
Inventor
Naomi Yasuda
Original Assignee
Sunstar Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sunstar Inc. filed Critical Sunstar Inc.
Publication of WO2002067883A1 publication Critical patent/WO2002067883A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides

Definitions

  • the present invention relates to a mouthwash composition containing a gel and a mouthwash method.
  • Landscape technology
  • Toothwash is usually required to be thoroughly rinsed in the mouth for about 20 to 30 seconds, but if it is used daily, it is generally exhaled in less than 10 seconds. In many cases.
  • An object of the present invention is to provide a mouthwash composition having the simplicity of a mouthwash, the feeling of use such as brushing, the cleaning effect, and the massaging effect on gingiva. Disclosure of the invention
  • the present inventor has found that, when the dosage form is in the form of a gel, it is easy to use, and there is a real feeling of use due to the stress that breaks down the gel by including it in the mouth and squeezing the gel.
  • the present inventors have found that dirt can be effectively removed, and have completed the present invention. That is, the present invention provides the inventions according to the following items.
  • Item 1 An oral cavity cleaning composition comprising a gel.
  • Item 2 The composition according to Item 1, comprising a gel formed from at least one selected from the group consisting of dielan gum, pectin, sodium alginate, carrageenan, agar, gelatin, and phaserelan. object.
  • Item 3 The composition according to Item 2, wherein the composition is a gel formed from a polyvalent cation and at least one member selected from the group consisting of dielan gum, pectin, sodium alginate, and larginan.
  • Item 4 The composition according to Item 3, wherein the polyvalent cation is a calcium ion.
  • Item 5 The composition according to Item 1, wherein the gel is a gel formed by mixing 30 to 90% by weight of water based on the total weight of the gel.
  • the gel contains at least one selected from the group consisting of hydroxyethyl cellulose, sodium carboxymethylcellulose, sodium polyacrylate, and a polyoxyethylene-polypropylene copolymer.
  • Item 2 The oral cavity cleaning composition according to Item 1, which is characterized in that:
  • Item 7 A method for washing the oral cavity, wherein the gel is used while being finely divided in the oral cavity.
  • Item 8 The washing method according to Item 7, wherein the gel is a gel formed from at least one selected from the group consisting of dielan gum, pectin, sodium alginate, carrageenan, agar, gelatin, and phaseleran. .
  • the present invention will be described in more detail.
  • the composition of the present invention is a gel itself or a gel-containing gel having a moderate hardness and a brittle touch, for example, crushing with a tongue and a hard palate without using teeth.
  • the hardness is such that
  • the gel of the present invention is not particularly limited as long as the desired effects of the present invention are exhibited.
  • a polymer selected from dielan gum, agar, gelatin, pectin, sodium alginate, carrageenan, and furcellane (Hereinafter, these may be referred to as "the specific polymer of the present invention.") It is preferable that the gel be a force-formed gel. No.
  • a gel formed from a polymer selected from dielan gum, pectin, sodium alginate and carrageenan is preferable, and a gel formed from a polymer selected from dielan gum, pectin and power raginan is more preferable. Further, a gel formed from a polymer selected from lactic acid and pectin is more preferable, and a gel formed from dielan gum is most preferable.
  • the amount of the gel formed by using the above-mentioned specific polymer of the present invention is not particularly limited as long as the intended effect of the present invention is achieved, and can be appropriately set. It is preferably about 0.005 to 5% by weight, particularly preferably about 0.05 to 3% by weight, and more preferably about 0.05 to 1% by weight based on the total weight. If the concentration of the specific polymer is 0.005% by weight or more, sufficient tactile sensation, practical feeling, and cleaning effect can be obtained when stuffed into the mouth. This is preferable because a gel having an appropriate hardness that can be broken is obtained.
  • the gel is preferably formed in the presence of a polyvalent cation. .
  • polyvalent cations examples include divalent cations (eg, alkaline earth metal ions such as Mg 2 + and Ca 2 + ), and trivalent cations (eg, Al 3 + ). Of these, divalent cations are preferred, and calcium ions are particularly preferred.
  • the cation source include, but are not limited to, organic acids such as calcium lactate, magnesium lactate, calcium dalconate, calcium glycerate phosphate, magnesium chloride, calcium chloride, magnesium sulfate, and aluminum lactate.
  • organic acids such as calcium lactate, magnesium lactate, calcium dalconate, calcium glycerate phosphate, magnesium chloride, calcium chloride, magnesium sulfate, and aluminum lactate.
  • a water-soluble polyvalent metal salt of an inorganic acid may be mentioned. Among them, a salt of an organic acid is preferable, and calcium lactate is particularly preferable.
  • These cation sources can be used alone or in combination of two or more.
  • the combination of at least one of the above-mentioned dielan gum, pectin, sodium alginate and carrageenan and a polyvalent cation is particularly useful as long as a desired gel can be obtained.
  • dielan gum and calcium ions, zinc and calcium ions, carrageenan and calcium ions are preferred.
  • the blending amount of the water-soluble polyvalent metal salt as a cation source is not particularly limited as long as a desired gel can be obtained, and at least one kind and amount of dielan gum, pectin, sodium alginate and carrageenan is used.
  • the amount of calcium lactate may be about 0.01 to 1% by weight, preferably about 0.05 to 0.5% by weight, based on the total weight of the composition. It is about.
  • the amount used when another cation source is used can be appropriately set with reference to the above range.
  • the amount of water used in preparing the gel of the composition of the present invention is not particularly limited as long as the desired effect of the present invention can be obtained, and can be appropriately set, but is usually based on the total weight of the gel. It is about 30 to 90% by weight, preferably about 50 to 90% by weight, and more preferably about 65 to 90% by weight.
  • the pH of the mouthwash composition of the present invention is preferably about 5.5 to 7.5, and more preferably about 6 to 7.
  • the pH is 5.5 or more, there is no risk of decarburization of the teeth when applied to the oral cavity, and when the pH is 7.5 or less, the hardened steel has sufficient stress to clean the oral cavity. This is preferable because a gel having a thickness of 10 ⁇ m can be formed.
  • a chelating agent so that the formed gel is homogeneous.
  • the chelating agent include sodium salts and potassium salts of cunic acid, malic acid, tartaric acid, acetic acid, phosphoric acid and the like.
  • the amount of the chelating agent is usually about 0.01 to 0.5% by weight based on the total amount of the composition.
  • the gel of the present invention contains a conventionally known component usually used in a mouthwash composition, for example, a wetting agent, a dispersing agent, a surfactant, an active ingredient, a flavoring agent, a coloring agent, a cleaning aid, and the like. Can be blended.
  • a wetting agent for example, a wetting agent, a dispersing agent, a surfactant, an active ingredient, a flavoring agent, a coloring agent, a cleaning aid, and the like.
  • wetting agent examples include ethanol, glycerin, sorbitol, ethylene glycol, propylene glycol, 1,3-butylendalcol, polyethylene glycol, polypropylene glycol, xylitol, maltitol, and lamellar.
  • the amount of the wetting agent is usually about 1 to 50% by weight, preferably about 5 to 30% by weight, based on the total amount of the composition.
  • dispersants examples include cellulose derivatives such as sodium carboxymethylcellulose, methylcellulose, and hydroxyethyl cellulose; gums such as tragacanth gum, karaya gum, arabic gum, xanthan gum, and mouth-to-cast bean gum; sodium polyacrylate; And synthetic water-soluble polymers such as oxyshethylene polyoxypropylene copolymer, polyvinyl alcohol, propyloxyvinyl polymer, and polyvinylpyrrolidone.
  • the amount of the dispersant is usually about 0.05 to 1% by weight based on the total amount of the composition.
  • hydroxyethyl cellulose sodium carboxymethylcellulose, sodium polyacrylate and polyoxyethylenepolypropylene copolymer are preferred.
  • Surfactants include anionic surfactants such as sodium lauryl sulfate, sodium myristyl sulfate, N-lauroyl sarcosinate, lauroyl methyl taurine salt, and acyl amino acid salt; sucrose fatty acid ester, decaglyceryl laurate, myristinic acid Examples include nonionic surfactants such as diethanolamide and polyoxyethylene hydrogenated castor oil.
  • the amount of the surfactant is usually from 0.05 to about 0% by weight, preferably from 0.1 to about 0% by weight, based on the total amount of the composition.
  • Active ingredients include fluorine compounds such as sodium fluoride, sodium monofluorophosphate, stannous fluoride; enzymes such as dextranase, mutanase, protease, and lysozyme; tranexamic acid, ⁇ -aminocaproic acid, Aluminum chloride hydroxy allantoin, allantoin, dihydrocholesterol, dalytileritic acid, bisabolol, isopropylmethylphenol, dali cerophosphate, chlorophyll, copper dalconate, sodium chloride, 7] ⁇ soluble inorganic phosphate compounds, chlorhexidine salts , Triclosan, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride; acetic acid d1- ⁇ -tocopherol, etc.
  • fluorine compounds such as sodium fluoride, sodium monofluorophosphate, stannous fluoride
  • enzymes such as dextranase
  • Vitamin E Vitamin E
  • Vitamin B such as pyridoxine acetate
  • Vitamin C such as ascorbic acid
  • plant extracts such as thyme extract and oegone extract, etc.
  • the amount of the active ingredient may be appropriately set according to the type of the active ingredient, but is usually 0.000 ;! with respect to the total amount of the composition. About 10% by weight.
  • the amount of the flavoring agent is usually about 0.001 to 5% by weight, preferably about 0.05 to 3% by weight, based on the total amount of the composition.
  • Red No. 3 As colorants, Red No. 3 (Acid Red 51), Red No. 105 (Acid Red 94), Red No. 106 (Acid Red 52), Yellow No. 4 (Acid Yellow 23), Blue No. 1 (Food Blue) 2), Blue No. 2 (Acid Blue 74), Green No. 3 (Food Green 3), Green No. 201 (Acid Green 25), etc.
  • the amount of the coloring agent may be appropriately set according to the type of the coloring agent so that the gel has a desired color.
  • a cleaning agent abrasive agent
  • precipitated silica, zirconosilicate, aluminosilicate, calcium phosphate, calcium carbonate, aluminum hydroxide, aluminum oxide and the like can be blended.
  • the amount of the cleaning aid is usually about 1 to 10% by weight based on the total amount of the composition.
  • the amounts of these optional components may be such that the effects of the present invention are not impaired, and are generally such that they are incorporated into a composition intended to clean the oral cavity.
  • the method for producing the mouthwash composition of the present invention is not particularly limited. For example, it can be manufactured as follows.
  • a component for forming a gel in water for example, the specific polymer of the present invention is added to water, and if necessary, heat is applied to dissolve the resultant to form an aqueous solution.Other components are added to the aqueous solution, and the mixture is stirred. Thereafter, if necessary, the gel can be obtained by cooling to about room temperature.
  • a polyvalent cation is used to form a gel
  • other components are added to the aqueous solution of the polymer, and after stirring, the mixture is cooled to about room temperature as needed, and an aqueous solution containing a polyvalent cation is added. Mixing can form a gel.
  • the mouthwash composition of the present invention the gel obtained as described above may be used as it is, or after gelation, cut into an appropriate size by stirring or passing through a mesh. Also included are free flowing gels.
  • the gel can be formed into a fluid gel by discharging the gel from a pump container or by squeezing the gel from a soft container having a narrow mouth.
  • the composition of the present invention can be used as described above, and the gel having fluidity obtained in this manner is also included in the composition for cleaning oral cavity of the present invention. If such a gel is used to remove plaque that is the cause of dental caries or periodontal disease, it can be contained in the oral cavity, broken down physically, and fragmented to form a gel. The dirt in the mouth can be removed by the stress.
  • the mass of the gel is further broken down, and the gel can move smoothly in the oral cavity, such as between teeth. It is convenient because you can know the standard between them. In addition to not only cleaning the oral cavity, it can also be expected to have a gingival massage effect.
  • the composition of the present invention also includes a composition containing a gel, water, and other components as described above in a range not to impair the intended effects of the present invention.
  • the intraoral cleansing composition of the present invention can be used to clean the inside of the mouth by physically squeezing the gel, as in a normal mouthwash, by physically squeezing the gel. It is exhaled from the mouth without swallowing after use.
  • the period of time for the oral cavity is not particularly limited, but is usually about 10 to 30 seconds, preferably about 20 to 30 seconds.
  • the amount of the oral cavity cleaning composition used is not particularly limited, but is usually about 5 to 25 ml, preferably about 10 to 2 Om1.
  • An oral cavity cleaning composition was prepared according to each composition shown below, and the cleanability and the feeling upon use were evaluated.
  • the gel thus obtained had a moderate hardness and a tactile sensation to wipe off dirt in the oral cavity, and became liquid by being physically subdivided in the oral cavity.
  • Mouthwash times were compared by 10 panelists who regularly use mouthwash.
  • the point when the gel was contained in the mouth was defined as the starting point, and the point when the gel was completely liquid was defined as the end point.
  • the mouthwash (Comparative Example 1) was measured with the mouth as the starting point, mouthwashed as usual, and the end point as spouted as the end point.
  • a panel of 10 panelists for evaluating the feeling of use performed a sensory evaluation on the feeling of stain removal in the oral cavity.
  • each of the mouthwash compositions of the present invention of Examples 1 and 2 and the mouthwash of Comparative Example 1 each containing 10 ml of the mouth were washed for 30 seconds.
  • the sensory evaluation was made on the feeling of dirt removal immediately after spitting.
  • the stain feeling was evaluated according to the following criteria.
  • Table 1 shows the results (average value) of the tests of the mouth washing time and the feeling of soiling by sensory evaluation according to the above test method.
  • table 1 Commercially available mouthwashes are usually used in the mouth for 20 to 30 seconds and then exhaled (rinsing) .In the liquid mouthwash of Comparative Example 1, the panelers average It was found that only 8 seconds remained in the oral cavity (Comparative Example 1).
  • the gel compositions of Examples 1 and 2 if the time when the gel becomes liquid in the oral cavity is the end point, it means that the gel has been cooked for 20 seconds or more, and the use time is reduced. Estimated end point is easily understood.
  • Examples 1 and 2 also have a better feeling of stain removal than Comparative Example 1.
  • the effect of indicating the end point (approximately 20 to 30 seconds) at the time of sucking in the mouth is easy and easy. It is also expected to have a gingival mass effect.

Abstract

L'invention concerne des compositions de nettoyage pour la cavité buccale qui peuvent être avantageusement utilisées comme bain de bouche. Ces compositions produisent une sensation lors de l'utilisation et un effet de nettoyage qui sont comparables à ceux que produisent les brosses à dents. En outre, ces compositions exercent un effet massant sur la gencive. L'invention concerne également un procédé de nettoyage de l'intérieur de la cavité buccale. Ces compositions de nettoyage pour la cavité buccale se caractérisent en ce qu'elles contiennent un gel tandis que le procédé de nettoyage de l'intérieur de la cavité buccale se caractérise en ce que le gel est finement réparti dans la cavité buccale pendant l'utilisation.
PCT/JP2002/001832 2001-02-28 2002-02-28 Compositions de nettoyage pour la cavite buccale WO2002067883A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001-053761 2001-02-28
JP2001053761A JP5084075B2 (ja) 2001-02-28 2001-02-28 口腔内洗浄用組成物

Publications (1)

Publication Number Publication Date
WO2002067883A1 true WO2002067883A1 (fr) 2002-09-06

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Application Number Title Priority Date Filing Date
PCT/JP2002/001832 WO2002067883A1 (fr) 2001-02-28 2002-02-28 Compositions de nettoyage pour la cavite buccale

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JP (1) JP5084075B2 (fr)
WO (1) WO2002067883A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014184083A1 (fr) 2013-05-15 2014-11-20 Unilever Plc Compositions de soin buccal
WO2014184084A2 (fr) 2013-05-15 2014-11-20 Unilever Plc Compositions de soin buccal

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4841146B2 (ja) * 2004-04-16 2011-12-21 佐藤歯材株式会社 歯垢染色用組成物
JP2006124362A (ja) * 2004-10-27 2006-05-18 Sunstar Inc 口腔内状態改善用組成物
KR100814250B1 (ko) 2006-11-01 2008-03-17 주식회사 엘지생활건강 동시 용해 및 겔화 정제형 구강 위생 조성물
JP5890097B2 (ja) * 2008-02-08 2016-03-22 ピュラック バイオケム ビー． ブイ． 金属ラクテート粉及び製造方法
KR101272225B1 (ko) * 2011-01-20 2013-06-11 이선정 젤리 치약 및 이의 제조방법
JP2013100305A (ja) * 2011-12-28 2013-05-23 Neige Corporation:Kk ゲル状、半固形状の洗浄料
JP5924998B2 (ja) * 2012-03-16 2016-05-25 日本ゼトック株式会社 ゲル状口腔用組成物
KR101305349B1 (ko) * 2013-05-16 2013-09-06 (주) 제이티 하이드로겔 비누 조성물, 하이드로겔 비누 및 이의 제조방법
CN108210385B (zh) * 2018-01-17 2020-08-18 山东大学 一种具有防龋抗菌和强根固齿功效的果冻状漱口水

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US5700449A (en) * 1994-10-18 1997-12-23 Kao Corporation Dentifrice composition
JP2000159646A (ja) * 1998-11-26 2000-06-13 Lion Corp 口腔用ポリビニルアルコールハイドロゲル組成物
JP2001031545A (ja) * 1999-07-16 2001-02-06 Lion Corp 口腔用ポリビニルアルコールハイドロゲル組成物
JP2001039843A (ja) * 1999-07-30 2001-02-13 Kao Corp 口腔用組成物

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US4705680A (en) * 1986-01-22 1987-11-10 Colgate-Palmolive Company Stable dental cream in polyethylene or polypropylene container
US5073368A (en) * 1991-05-15 1991-12-17 Colgate-Palmolive Company Sanguinaria mouthrinse having improved anti microbial activity and stability
JP3429065B2 (ja) * 1994-06-21 2003-07-22 サンスター株式会社 口腔用液体組成物
JP3753226B2 (ja) * 2000-06-30 2006-03-08 ライオン株式会社 口腔用組成物

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5700449A (en) * 1994-10-18 1997-12-23 Kao Corporation Dentifrice composition
JPH09110663A (ja) * 1995-10-20 1997-04-28 Lion Corp 油溶性成分配合ゲルカプセル、その製造方法及び口腔用組成物
JP2000159646A (ja) * 1998-11-26 2000-06-13 Lion Corp 口腔用ポリビニルアルコールハイドロゲル組成物
JP2001031545A (ja) * 1999-07-16 2001-02-06 Lion Corp 口腔用ポリビニルアルコールハイドロゲル組成物
JP2001039843A (ja) * 1999-07-30 2001-02-13 Kao Corp 口腔用組成物

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014184083A1 (fr) 2013-05-15 2014-11-20 Unilever Plc Compositions de soin buccal
WO2014184084A2 (fr) 2013-05-15 2014-11-20 Unilever Plc Compositions de soin buccal

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JP5084075B2 (ja) 2012-11-28

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