TW202216780A - 抗ｎｏｔｃｈ２抗體及其使用方法 - Google Patents

抗ｎｏｔｃｈ２抗體及其使用方法 Download PDF

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Publication number
TW202216780A
TW202216780A TW110126288A TW110126288A TW202216780A TW 202216780 A TW202216780 A TW 202216780A TW 110126288 A TW110126288 A TW 110126288A TW 110126288 A TW110126288 A TW 110126288A TW 202216780 A TW202216780 A TW 202216780A
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Taiwan
Prior art keywords
seq
amino acid
acid sequence
antibody
sequence
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TW110126288A
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English (en)
Chinese (zh)
Inventor
珮芝 趙
雁 吳
艾德爾 馬赫茂德 艾索利
丹尼爾 喬治 拉夫卡
建 梅爾 迪恩 帕揚德
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美商建南德克公司
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Publication of TW202216780A publication Critical patent/TW202216780A/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW110126288A 2020-07-17 2021-07-16 抗ｎｏｔｃｈ２抗體及其使用方法 TW202216780A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063053034P 2020-07-17 2020-07-17
US63/053,034 2020-07-17

Publications (1)

Publication Number Publication Date
TW202216780A true TW202216780A (zh) 2022-05-01

Family

ID=77338798

Family Applications (1)

Application Number Title Priority Date Filing Date
TW110126288A TW202216780A (zh) 2020-07-17 2021-07-16 抗ｎｏｔｃｈ２抗體及其使用方法

Country Status (18)

Country Link
US (1) US20230303682A1 (https=)
EP (1) EP4182348A1 (https=)
JP (1) JP7829547B2 (https=)
KR (1) KR20230038735A (https=)
CN (1) CN116406377A (https=)
AR (1) AR123001A1 (https=)
AU (1) AU2021308653A1 (https=)
BR (1) BR112023000839A2 (https=)
CA (1) CA3185122A1 (https=)
CL (3) CL2023000129A1 (https=)
CO (1) CO2023000505A2 (https=)
CR (1) CR20230087A (https=)
IL (1) IL299799A (https=)
MX (1) MX2023000617A (https=)
PE (1) PE20231300A1 (https=)
PH (1) PH12023550112A1 (https=)
TW (1) TW202216780A (https=)
WO (1) WO2022016037A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230322958A1 (en) * 2022-01-19 2023-10-12 Genentech, Inc. Anti-Notch2 Antibodies and Conjugates and Methods of Use
WO2024216505A1 (zh) * 2023-04-18 2024-10-24 上海洛启生物医药技术有限公司 抗Notch2纳米抗体及其应用

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Publication number Publication date
WO2022016037A1 (en) 2022-01-20
CN116406377A (zh) 2023-07-07
US20230303682A1 (en) 2023-09-28
PE20231300A1 (es) 2023-08-24
CO2023000505A2 (es) 2023-04-05
CA3185122A1 (en) 2022-01-20
AR123001A1 (es) 2022-10-19
CL2023000129A1 (es) 2023-07-07
AU2021308653A1 (en) 2023-02-16
CL2024003786A1 (es) 2025-04-21
IL299799A (en) 2023-03-01
JP2023534458A (ja) 2023-08-09
EP4182348A1 (en) 2023-05-24
BR112023000839A2 (pt) 2023-02-07
JP7829547B2 (ja) 2026-03-13
MX2023000617A (es) 2023-02-13
KR20230038735A (ko) 2023-03-21
CL2023003151A1 (es) 2024-05-03
CR20230087A (es) 2023-03-20
PH12023550112A1 (en) 2024-06-24

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