TW202142243A - External composition for improving skin quality, cosmetic compostion and method for improving skin quality - Google Patents

Abstract

The present invention provides a topical composition for improving skin texture, the composition containing [beta]-1, 3-1, 6-glucan. The present invention also provides a cosmetic composition and a skin texture improving method using the same.

Description

External composition for skin quality improvement, cosmetic composition and skin quality improvement method

The present invention relates to an external composition for improving skin quality, a cosmetic composition and a method for improving skin quality.

The skin is sunburned due to ultraviolet (UV) radiation. The types of sunburn include inflammation of the skin and turn red, and melanocytes that are stimulated by UV to produce melanin. In addition, skin inflammation caused by sunburn can stimulate melanocytes, and thus produce melanin. Melanin may turn into pigmentation (dark spots) and remain on the skin and not easily fade away.

In order to prevent or improve dark spots, it can be considered to inhibit the production of melanin, or to lighten the melanin produced. In the past, various whitening agents have been proposed in the literature. Regarding β-glucan, there is a document report that β-glucan activates Langerhans cells and inhibits melanin synthesis by melanocytes (Patent Document 1). It is also known that after UV irradiation, coating β-glucan on pigmented skin increases the whiteness of the skin (Patent Document 2). It is also known that β-glucan is applied to skin that is irradiated with UV to induce erythema to exhibit a sunburn healing effect (Patent Document 2 and Patent Document 3). [Prior Technical Literature] [Patent Literature]

Patent Document 1: Japanese Patent Application Publication No. 2014-080386 Patent Document 2: Japanese Patent Laid-Open No. 11-313667 Patent Document 3: Japanese Patent Application Publication No. 11-501691

[The problem to be solved by the invention]

Although β-glucan is known to inhibit the synthesis of melanin or whiten pigmented skin, and have the effect of improving the skin condition of sunburn, the effect of β-glucan on improving skin quality for sunburn is still unknown.

Therefore, the object of the present invention is to provide an external composition for improving skin quality, which can be applied to the skin to improve the skin that is not prone to sunburn, and to suppress inflammation and swelling caused by sunburn, and to provide a cosmetic composition And skin quality improvement methods. [Means used to solve the problem]

The inventors of the present invention conducted various reviews in order to solve the above-mentioned problems, and found that by using β-1,3-1,6-glucan, the above-mentioned problems can be solved, that is, it can be improved before sunburn to be less susceptible to sunburn. skin. This is a surprising effect for β-1,3-1,6-glucan that has been used for the purpose of improving the skin after sunburn. That is, the present invention is an external composition for improving skin quality, which contains β-1,3-1,6-glucan.

In addition, the present invention is a cosmetic composition comprising the aforementioned external composition for improving skin quality, and containing the aforementioned external composition for improving skin quality relative to the total amount of the cosmetic composition, with β- 1,3-1,6-glucan is 0.0001 to 1% by mass.

In addition, the present invention is a method for improving skin quality, which includes the step of applying the above-mentioned cosmetic composition to the skin. In addition, the present invention is the use of a skin quality improving external composition or cosmetic composition containing β-1,3-1,6-glucan, which is used to improve skin quality. [Effects of the invention]

According to the present invention, by applying it to the skin, the skin that is not easily sunburned can be improved, and inflammation and swelling caused by sunburn can be suppressed.

According to the external composition for improving skin quality and the cosmetic composition of the present invention, β-1,3-1,6-glucan is applied to the skin to improve the skin quality to a state that is less prone to inflammation and swelling. This can suppress the inflammation and other symptoms caused by sunburn in advance, and can suppress the inflammation and swelling caused by sunburn. In addition, it can also inhibit the production of melanin caused by inflammation. In this way, the present invention can improve the skin to be less susceptible to sunburn, and can maintain this state.

The external composition for improving skin quality of the present invention contains β-1,3-1,6-glucan.

In the present invention, "improvement of skin quality" means applying to the skin to make the skin less prone to inflammation, or to maintain a less prone skin condition. In the present invention, the prevention of skin inflammation includes the suppression of redness and swelling, and specifically, the suppression of redness and swelling caused by sunburn.

In the present invention, "sunburn" means that the skin becomes inflamed and swollen due to ultraviolet radiation. "Before sunburn" refers to the state before the skin becomes inflamed and swollen due to ultraviolet radiation. "Sunburned" refers to the state when the skin becomes inflamed and swollen due to ultraviolet radiation. "Post-sunburn" refers to the state after the skin becomes inflamed and swollen due to ultraviolet radiation.

The external composition for improving skin quality of the present invention can be applied to any skin before sunburn, during sunburn, and after sunburn to improve skin, and it is preferably applied to unsunburned skin. This can effectively suppress inflammation and swelling caused by sunburn. In addition, the skin quality of the present invention is improved, so that it can behave better when the skin is sunburned. In this way, the skin texture will be improved before the sunburn, so it can effectively suppress the symptoms such as inflammation caused by the sunburn in advance.

The composition for external use for improving skin quality of the present invention is ideally applied to unsunburned skin, preferably to achieve skin quality improvement before sunburn, and does not need to be applied to the skin during UV irradiation. This is because the external composition for improving skin quality of the present invention can effectively suppress inflammation and swelling caused by sunburn even if it is not applied to the skin during ultraviolet irradiation, by applying it before sunburn.

The β-1,3-1,6-glucan contained in the external composition for improving skin quality of the present invention refers to glucose through β-1,3-glycosidic bond and β-1,6-glycosidic bond The β-glucose that is connected is known to have (1) the main chain is β-1,3-glycosidic bond and has β-1,6-glycosidic bond branches; (2) the main chain is composed of β-1,3 -Those formed by glycosidic bond and β-1,6-glycosidic bond, etc. In addition, the β-1,3-1,6-glucan used in the present invention may also have a part of the β-1,4-glycosidic bond and the like, β-1,3-glycosidic bond and β The content of glucosidic bonds other than 1,6-glycosidic bonds must be 10 mol% or less relative to the total of β-1,3-glycosidic bonds and β-1,6-glycosidic bonds.

In the external composition for improving skin quality of the present invention, any β-1,3-1,6-glucan can be used for β-1,3-1,6-glucan to prevent sunburn caused by It seems that the effect of redness and swelling is good, preferably β-1,3-1,6-glucan represented by the following general formula (1):

In the above general formula (1), R ¹ represents a hydrogen atom or a group represented by the following formula (A), and ^{among the plurality of R 1s} , one or more is the following formula (A). a indicates that the mass average molecular weight of β-1,3-1,6-glucan represented by the general formula (1) is determined to be 3,000 to 5,000,000. The β-1,3-1,6-glucan represented by the general formula (1) has hydroxyl groups at both ends, and * represents a bonding bond. In addition, ^{among the plurality of R 1} , 16 or more are preferably hydrogen atoms, and 20 or more are hydrogen atoms. That is, from the viewpoint of exerting the effect of the present invention, in the above general formula (1), R ¹ represents a hydrogen atom or a group represented by the following formula (A), and ¹ among a plurality of R 1 One or more is the following formula (A), and 20 or more of the ^{plurality of R 1 are preferably hydrogen atoms.}

(In formula (A), * means bonding bond)

When the mass average molecular weight of β-1,3-1,6-glucan represented by the general formula (1) is lower than 3,000 and higher than 5,000,000, the effect of suppressing redness and swelling caused by sunburn is insufficient Situation. The mass average molecular weight of β-1,3-1,6-glucan represented by the general formula (1) is preferably 5,000 to 3,000,000, more preferably 7,000 to 1,000,000, and most preferably 10,000 to 500,000. In addition, in the present invention, the mass average molecular weight of β-1,3-1,6-glucan refers to the case of gel permeation chromatography (Gel Permeation Chromatography, also known as GPC) analysis using water as a solvent , The mass average molecular weight in terms of pullulan. In addition, "mass average molecular weight" may also be called "weight average molecular weight".

The measurement method of the above-mentioned mass average molecular weight is not particularly limited. One example is to use several pullulans with known molecular weights (concentrations are arbitrary), and create a calibration curve with a differential refraction detector (x-axis is to maintain Time and y-axis are molecular weight). Next, measuring the sample (the concentration is arbitrary), using the previous calibration curve, and calculating the relative molecular weight (molecular weight in terms of pullulan) from the retention time is a general method. However, because pullulan has a different structure from β-1,3-1,6-glucan, even if the molecular weight is the same (the number of glucose units is the same), the molecular size will be different. Therefore, the use of molecular sieve gel penetration Only relative values can be obtained in chromatography, and inherent molecular weights approximate to absolute values can be calculated by calibration. The calibration can be calculated by measuring the concentration of the sample and measuring the three properties of differential pressure viscosity, differential refractive index, and light scattering. Specifically, first, the device constant k is obtained using a pullulan standard solution of known concentration, viscosity, and refractive index.

Next, the stock solution of the β-1,3-1,6-glucan concentration measured by the phenol-sulfuric acid method is accurately measured, and an aqueous solution of a known concentration is prepared as a sample. Then, the molecular weight is calculated from the values measured by the differential pressure viscosity detector, the differential refractive index detector, and the light scattering detector.

In the above general formula (1), R ¹ is the ratio of the unit of formula (A) to the unit in which R ¹ is a hydrogen atom. From the viewpoint of suppressing inflammation and swelling, 0.2 to 1 is preferable, 0.5 to 0.95 It is better, 0.6~0.9 is the best. In addition, in the general formula (1), ^{the unit in which R 1} is a hydrogen atom and the unit in which R ¹ is the formula (A) may be randomly bonded, or may be bonded in a block shape.

The ^ratio of the unit where R 1 is the formula (A) to the unit where R ¹ is a hydrogen atom can be obtained by the following method. First, after methylating the free hydroxyl groups of β-1,3-1,6-glucan, acid hydrolyze β-1,3-1,6-glucan into monosaccharides, The resulting hydroxyl group undergoes acetylation. Among the obtained glucose derivatives, the hydroxyl groups that contribute to the bonding are acetylated, and the hydroxyl groups that do not contribute to the bonding are methylated, which can be quantified by gas chromatography (GC), etc. Various glucose derivatives. From this, the ratio of β-1,3-bonded glucose derivatives to β-1,3-bonded and β-1,6-bonded glucose derivatives can be calculated. In addition, the β-1,3-1,6-glucan was analyzed in detail using 13C-NMR, etc., and the ratio of 2 glucose residues with 1 branch and 3 glucose residues with 1 branch was calculated. From these calculated values, the ratio of the above-mentioned units can be obtained.

The β-1,3-1,6-glucan represented by the general formula (1) can be obtained by well-known methods, such as yeast, lactic acid bacteria, natto bacteria, acetic acid bacteria, koji bacteria, Chlorococcus or spirulina It is obtained by extracting the cell walls or metabolites of algae, filamentous bacteria, etc. of the genus Algae. Especially from black yeast (Aureobasidium pullulans), β-1,3-1,6-glucan, which has a high moisturizing effect on the skin, can be extracted. The extraction method of β-1,3-1,6-glucan is not particularly limited, and it may be based on a well-known method.

As an example of the aforementioned black yeast, the deposit number FERM BP-8391 can be used in the present invention. In addition, the aforementioned deposit number FERM BP-8391 is described in detail in International Publication No. 2004/001053 (WO2004/001053), and it is deposited in the Chartered Bio Deposit Center of the Institute of Industrial Technology, Japan Independent Administrative Agency. The content of the deposited organism is detailed below.

(1) The name of the depository institution: The Institute of Industrial Technology Consortium (now the National Research and Development Corporation of Japan) Licensed Bio Deposit Center (Name of current depository organization: Japan Independent Administrative Agency Product Evaluation Technology Foundation Agency Licensed Bio Deposit Center) (2) Contact method: 〒305-8566 1st 1-chome, 1st Central, Tsukuba City, Ibaraki Prefecture, Japan 6th (Current contact method: 〒292-0818, Room 2-5-8122, Kazusa Kamazusa, Kisarazu City, Chiba Prefecture, Japan Phone Number 0438-20-5880) (3) Entrusted number: FERM BP-8391 (4) Identification mark: Aureobasidium pullulans ADK-34 (5) Original deposit date: July 11, Heisei 14 (2002) (6) Transfer date of deposit under the Budapest Treaty: June 2, 2003

In addition, in the case of concentrating the extracted β-1,3-1,6-glucan, as long as it is a method for removing water or powdering, it is not particularly limited. For example, spray drying, freeze drying, drying under reduced pressure, heat drying, precipitation recovery by solvent, etc. may be mentioned, and these methods may be appropriately combined.

The external composition for improving skin quality of the present invention can be used in medicines, quasi-drugs, cosmetics and the like. The external composition for improving skin quality of the present invention can also be blended with necessary additives to make products, and an appropriate amount of the external composition for improving skin quality of the present invention can also be added as the raw material of the product (β-1,3 -1,6-glucan pre-mixed composition) to be used.

The external composition for improving skin quality of the present invention contains, for example, the above-mentioned β-1,3-1,6-glucan from the viewpoint of the convenience of preparing the cosmetic composition described later, relative to the total amount of the external composition It is preferably 0.001% by mass or more in terms of solid content, preferably 0.01% by mass or more, more preferably 0.1% by mass or more, even more preferably 0.5% by mass or more, and most preferably 0.7% by mass or more. In addition, the upper limit of the aforementioned β-1,3-1,6-glucan is not particularly limited as long as the effects of the present invention can be obtained. From the viewpoint of high fluidity and good handleability, it is relative to The total amount of the external composition contains the above-mentioned β-1,3-1,6-glucan at a solid content of 20% by mass or less, preferably 10% by mass or less, and preferably contains 5.0% by mass or less More preferably, it is even more preferable to contain 3.0% by mass or less, and it is most preferable to contain 2.0% by mass or less.

In the external composition for improving skin quality of the present invention, when the above-mentioned β-1,3-1,6-glucan is in the form of an aqueous solution, the above-mentioned β-1,3-1,6-glucan is When the concentration is 2% by mass or more, it may not be completely dissolved and precipitation may easily occur. In this case, by containing a polyol having a carbon number of 2-6, the amount is 50-90% by mass relative to the external composition for improving skin quality, and it is easy to be used as an external composition.

The above-mentioned polyols with 2-6 carbon atoms include, for example, ethylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, propylene glycol, dipropylene glycol, 1,3-propanediol, 1,2-butanediol , 1,3-butanediol, 1,4-butanediol, 2,3-butanediol, 2-methyl-1,2-propanediol, 2-methyl-1,3-propanediol, 1,2 -Pentanediol, 1,3-pentanediol, 1,4-pentanediol, 1,5-pentanediol, 2,3-pentanediol, 2,4-pentanediol, 2-methyl- 1,2-butanediol, 2-methyl-2,3-butanediol, 2-methyl-1,4-butanediol, 3-methyl-1,2-butanediol, 3-methyl 1,3-butanediol, 2-ethyl-1,3-propanediol, 2,2-dimethyl-1,3-propanediol, 1,5-hexanediol, 1,6-hexanediol , 2,5-hexanediol, 3,3-hexanediol, 2-methyl-1,3-pentanediol, 2-methyl-1,5-pentanediol, 2-methyl-2, 4-pentanediol, 3-methyl-1,5-pentanediol, 3-methyl-2,3-pentanediol, 3-methyl-2,4-pentanediol, 2-ethyl- Diols such as 2-methyl-1,3-propanediol and 2,2-dimethyl-2,4-butanediol or their condensates; 1,2-cyclopentanediol, 1,3-cyclopentanediol, 1,2-cyclohexanediol, 1,3-cyclohexanediol, 1,4-cyclohexanediol and other alicyclic two Alcohol;

Glycerin, 1,2,3-butanetriol, 1,2,4-butanetriol, 2-methyl-1,2,3-propanetriol, 1,2,3-pentanetriol, 1,2 ,4-Pentanetriol, 1,3,5-Pentanetriol, 2,3,4-Pentanetriol, 2-Methyl-2,3,4-Butanetriol, 2,3,4-Hexane Alcohol, 2-ethyl-1,2,3-butanetriol and other triols; Erythritol, 1,2,3,4-butaneerythritol, 2,3,4,5-hexaneerythritol, 1,2,4,5-pentaerythritol, 1,3,4,5-hexane Tetrahydric alcohols such as tetraol, diglycerol and sorbitol; Pentahydric alcohols such as side marigold, arabitol, xylitol, triglycerin; hexahydric alcohols such as sorbitol, mannitol, iditol, inositol, galactitol, talose, and allose; 1-methyl glyceryl ether, 2-methyl glyceryl ether, 1-ethyl glyceryl ether, 2-ethyl glyceryl ether, 1-propyl glyceryl ether, 2-propyl glyceryl ether, 1-isopropyl glyceryl ether, Glycerin monoethers such as 2-isopropyl glyceryl ether, etc.

Among these polyols, in view of the excellent dispersion stability of β-1,3-1,6-glucan, diols or triols are preferred, propylene glycol, dipropylene glycol, 1,3-butanedi Alcohol and glycerin are preferred, and 1,3-butanediol is more preferred.

As described above, when 50 to 90% by mass of polyol is contained, from the viewpoint of the excellent dispersion stability of β-1,3-1,6-glucan in the composition for use outside of the present invention, the water It is better to set the blending amount of 5-27% by mass.

The external composition for improving skin quality of the present invention is preferably blended into a cosmetic composition. In the external composition for improving skin quality of the present invention, various blending ingredients commonly used in cosmetics can be blended according to the purpose of use, such as various surfactants, various enzymes, medicaments, antibacterial agents (preservatives), One or two or more of isotonic agents, buffers, stabilizers, chelating agents, dissolution aids, pH adjusters, fragrances, etc. are appropriately combined in the range of the usual amount of use.

In the external composition for improving skin quality of the present invention, the antibacterial agent (preservative) can be the same compound as the antibacterial agent contained in the cosmetic composition described later. From the viewpoint of exerting the effect of the present invention, Ether derivatives such as phenoxyethanol and ethylhexylglycerol are preferred. The antibacterial agent can be used in the same blending amount as in the case of the cosmetic composition.

Next, the cosmetic composition of the present invention will be described. The cosmetic composition of the present invention may be an aqueous solution, colloidal cosmetics, emulsified cosmetics, or any form in which solid components are dispersed, which are substantially free of oil. In the case of emulsified cosmetics, it can be provided in either an oil-in-water type or a water-in-oil-in-oil type emulsion. It is preferably an aqueous cosmetic such as an oil-in-water type or an oil-in-water type, that is, the continuous phase is the water phase.

The cosmetic composition of the present invention contains the above-mentioned external composition for improving skin quality, and from the viewpoint of the effect of improving the skin that is not prone to sunburn, in the cosmetic composition (relative to the total amount of the cosmetic composition), Calculated as β-1,3-1,6-glucan, the content is preferably 0.0001 to 1% by mass, preferably 0.0005 to 1% by mass, more preferably 0.001 to 1% by mass, and even more preferably 0.005 to 0.5% by mass, more preferably 0.005 to 0.2% by mass, still more preferably 0.005 to 0.1% by mass, most preferably 0.005 to 0.01% by mass.

From the point of view that the effects of the present invention can be fully exhibited, in the cosmetic composition, as an effective ingredient, for example, it is preferable to contain 0.0001% by mass or more of β-1,3-1,6-glucan in terms of solid content. . From the viewpoint of the ease of preparation of the cosmetic composition and the prevention of changes in the feeling of use, the cosmetic composition contains β-1,3-1,6-glucan as an effective ingredient, such as a solid component. The mass% or less is better.

In addition to the external composition for improving skin quality, the cosmetic composition of the present invention may contain optional ingredients that can be generally used in cosmetics. Examples include surfactants, chelating agents, low-molecular-weight polyols, plant-derived extracts, animal-derived extracts, microorganisms-derived extracts, cultures of microorganisms, zinc compounds, viscosity-increasing agents , Oils, pigments, pigments, antibacterial agents (preservatives), moisturizers, pH adjusters, antioxidants, ultraviolet absorbers, moisturizing ingredients, enzymes, fragrances, etc. The culture of microorganisms includes the whole culture liquid containing microorganisms and culture liquid, supernatant liquid, microorganisms, or whole culture liquid, supernatant liquid or freeze-dried products, concentrates, or extracts of microorganisms.

Surfactants include anionic surfactants, nonionic surfactants, cationic surfactants, and amphoteric surfactants. Anionic surfactants include, for example, higher fatty acid salts, higher alcohol sulfate ester salts, sulfated olefin salts, higher alkyl sulfonates, α-olefin sulfonates, sulfated fatty acid salts, sulfonated fatty acid salts, phosphoric acid Ester salt, fatty acid ester sulfate ester salt, glyceride sulfate ester salt, fatty acid ester sulfonate salt, α-sulfo fatty acid methyl ester salt, polyoxyalkylene ether sulfate ester salt, polyoxyalkylene ester Alkyl phenyl ether sulfate, polyoxyalkylene alkyl ether carboxylate, acylated peptide, fatty acid alkanol amide or its alkylene oxide adduct sulfate, sulfosuccinate, alkyl Benzene sulfonate, alkyl naphthalene sulfonate, alkyl benzimidazole sulfonate, polyoxyalkylene sulfosuccinate, salt of N-acyl-N-methyl taurine, N- Glutamic acid or its salt, oxyethane sulfonate, alkoxy ethane sulfonate, N-acyl-β-alanine or its salt, N-acyl-N-carboxyethyl Taurine or its salt, N-acyl-N-carboxymethylglycine or its salt, acyl lactate, N-acyl sarcosine and alkyl or alkenyl amino carboxymethyl sulfate Wait.

Nonionic surfactants include, for example, polyoxyalkylene ether, polyoxyalkylene alkenyl ether, polyethylene oxide polypropylene oxide alkyl ether (addition form of ethylene oxide and propylene oxide It can be random or block), polyethylene glycol propylene oxide adduct, polypropylene glycol ethylene oxide adduct, glycerin fatty acid ester or its ethylene oxide adduct, to Sorbitan fatty acid ester, polyethylene oxide sorbitan fatty acid ester, alkyl polyglucoside, fatty acid monoethanolamide or its ethylene oxide adduct, fatty acid-N-methylmonoethanolate Amine or its ethylene oxide adduct, fatty acid diethanolamide or its ethylene oxide adduct, sucrose fatty acid ester, alkyl (poly)glyceryl ether, polyglycerol fatty acid ester, polyethylene glycol fat Ester, ethoxylated fatty acid methyl ester, N-long chain alkyl dimethyl amine oxide, etc.

Cationic surfactants include, for example, alkyl (alkenyl) trimethyl ammonium salt, dialkyl (alkenyl) dimethyl ammonium salt, alkyl (alkenyl) quaternary ammonium salt, ether group or ester group-containing Or mono- or dialkyl (alkenyl) quaternary ammonium salt, alkyl (alkenyl) pyridinium salt, alkyl (alkenyl) dimethylbenzyl ammonium salt, alkyl (alkenyl) iso Quinolinium salt, dialkyl (alkenyl) morpholinium salt, polyethylene oxide alkyl (alkenyl) amine, alkyl (alkenyl) amine salt, polyamine fatty acid derivative, pentanol fatty acid derivative , Benzalkonium chloride, benzethonium chloride, etc.

The amphoteric surfactants include, for example, carboxybetaine, sultaine, phosphobetaine, amido acid, imidazolinium betaine-based surfactants, and the like.

The above-mentioned surfactant may be blended with one or two or more of the above. The blending amount is not particularly limited, and will vary according to the type of cosmetic composition. From the viewpoint of exerting the effects of the present invention, it is probably 0.01 to 80% by mass relative to the total amount of the cosmetic composition. , 0.05-60% by mass is preferred.

Examples of chelating agents include amino polycarboxylic acid chelating agents, aromatic or aliphatic carboxylic acid chelating agents, amino acid chelating agents, ether polycarboxylic acid chelating agents, phosphonic acid chelating agents, phosphoric acid chelating agents, Hydroxycarboxylic acid chelating agent, polymer electrolyte (including oligomer-electrolyte) chelating agent, dimethylglyoxime, ascorbic acid, thioglycolic acid, phytic acid, glyoxylic acid, glyoxylic acid, etc. Each of these chelating agents may be in the free acid form, or in the form of a salt such as a sodium salt, a potassium salt, or an ammonium salt. In addition, these chelating agents may also be in the form of hydrolyzable ester derivatives.

Amino polycarboxylic acid chelating agents include, for example, ethylenediaminetetraacetic acid, ethylenediaminediacetic acid, cyclohexanediaminetetraacetic acid, nitrotriacetic acid, iminodiacetic acid, N-(2-hydroxyethyl ) Iminodiacetic acid, diethylenetriaminepentaacetic acid, N-(2-hydroxyethyl)ethylenediaminetriacetic acid, glycol ether diaminetetraacetic acid, glutamic acid diacetic acid, aspartic acid diacetic acid and Its salts.

Aromatic or aliphatic carboxylic acid-based chelating agents, for example, oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, secreted acid, azaleaic acid, itaconic acid, aconitic acid, Pyruvate, salicylic acid, acetylsalicylic acid, hydroxybenzoic acid, aminobenzoic acid (including anthranilic acid), phthalic acid, fumaric acid, trimellitic acid, gallic acid, hexahydro Phthalic acid and its salts, methyl esters and ethyl esters.

Amino acid chelating agents include, for example, glycine, serine, alanine, lysine, cystine, cysteine, ethionine, tyrosine, methionine, and salts thereof Classes and derivatives. Examples of the phosphonic acid-based chelating agent include iminodimethylphosphonic acid, alkyl diphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid, and salts thereof. Examples of the phosphoric acid-based chelating agent include orthophosphoric acid, pyrophosphoric acid, triphosphoric acid, and polyphosphoric acid.

Examples of the hydroxycarboxylic acid chelating agent include malic acid, citric acid, glycolic acid, gluconic acid, heptanoic acid, tartaric acid, lactic acid, and salts thereof. Polymer electrolyte (including oligomer-electrolyte) chelating agent, for example, acrylic polymer, maleic anhydride polymer, α-hydroxy acrylic polymer, itaconic acid polymer, structure composed of two or more of these polymers Copolymers formed by monomers and epoxy succinic acid polymers.

Among these chelating agents, from the viewpoint of high safety and good chelating effect, ethylenediaminetetraacetic acid, ethylenediaminediacetic acid, nitrotriacetic acid, iminodiacetic acid, N-(2-hydroxyl (Ethyl) iminodiacetic acid, aspartic acid diacetic acid, succinic acid, salicylic acid, oxalic acid, lactic acid, fumaric acid, citric acid, tartaric acid, 1-hydroxyethane-1,1-diphosphonic acid and The salt is better.

The chelating agent may be blended with one or two or more of the above. The blending amount is not particularly limited and will vary depending on the type of cosmetic composition. From the viewpoint of exerting the effects of the present invention, it is probably preferably 0.01-30% by mass relative to the total amount of the cosmetic composition. , 0.05-20% by mass is preferred.

Low-molecular-weight polyols are polyols with a molecular weight of 50 to 1,000. From the viewpoint of exerting the effects of the present invention, they are preferably polyols with a molecular weight of 50 to 500. Examples include ethylene glycol, diethylene glycol, and triethylene glycol. , Tetraethylene glycol, propylene glycol, dipropylene glycol, tripropylene glycol, 1,3-propanediol, 1,2-butanediol, 1,3-butanediol, 1,4-butanediol, 2,3-butanediol Alcohol, 2-methyl-1,2-propanediol, 2-methyl-1,3-propanediol, 1,2-pentanediol, 1,3-pentanediol, 1,4-pentanediol, 1, 5-pentanediol, 2,3-pentanediol, 2,4-pentanediol, 2-methyl-1,2-butanediol, 2-methyl-2,3-butanediol, 2- Methyl-1,4-butanediol, 3-methyl-1,2-butanediol, 3-methyl-1,3-butanediol, 2-ethyl-1,3-propanediol, 2,2 -Dimethyl-1,3-propanediol, 1,2-hexanediol, 1,5-hexanediol, 1,6-hexanediol, 2,5-hexanediol, 3,3-hexanediol , 2-methyl-1,3-pentanediol, 2-methyl-1,5-pentanediol, 2-methyl-2,4-pentanediol, 3-methyl-1,5-pentane Glycol, 3-methyl-2,3-pentanediol, 3-methyl-2,4-pentanediol, 4-methyl-1,2-pentanediol, 2-ethyl-2-methyl 1,3-propanediol, 2,2-dimethyl-1,3-butanediol, 2,3-dimethyl-1,2-butanediol, 1,2-heptanediol, 1, 7-Heptanediol, 3,4-Heptanediol, 2-propyl-2-methyl-1,3-propanediol, 2-isopropyl-2-methyl-1,3-propanediol, 1,2 -Octanediol, 1,8-octanediol, 3,6-octanediol, 2-ethyl-1,3-hexanediol, 2-second butyl-2-butyl-1,3- Propylene glycol, 2,2-dimethyl-1,3-hexanediol, 2,5-dimethyl-2,5-hexanediol, 2,2,4-trimethyl-1,3-pentanediol Alcohol, 1,2-nonanediol, 1,3-nonanediol, 1,9-nonanediol, 3,6-octanediol, 2-ethyl-2-(2-methyl)propyl- 1,3-propanediol, 2,2,4-trimethyl-1,6-hexanediol, 2,4,4-trimethyl-1,6-hexanediol, 2-butyl-2-ethane 1,3-propanediol, 2,4-diethyl-1,5-pentanediol, 2-methyl-1,8-octanediol, 1,2-decanediol, 1,10-decane Diol, 5,6-decanediol, 3,6-dimethyl-3,6-octanediol, 3,7-dimethyl-1,6-octanediol, 3,7-dimethyl -1,7-octanediol, 1,2-undecanediol, 1,4-undecanediol, 1,11-undecanediol, 6-ethyl-3-methyl-1 ,6-octanediol, 1,2-dodecanediol, 1,10-dodecanediol, 1,12-dodecanediol, 2,4-diethyl-1,5-octane Diol, 2,8,8-trimethyl-2,7-nonanediol, 1,2-tetradecanediol, 1,14-tetradecanediol, 7,8-decane Tetradecanediol, 1,2-pentadecanediol, 1,2-hexadecanediol, 1,16-hexadecanediol, 1,17-hexadecanediol, 1,2-decanediol Octanediol, 1,12-octadecanediol, 1,2-eicosanediol, 1,2-docosanediol, 1,2-tetracosanediol, etc. Alcohol or its condensate;

2-butene-1,4-diol, 3-butene-1,2-diol, 2-methylene-1,3-propanediol, 2-butene-1,4-diol, 5- Hexene-1,2-diol, 3-methyl-2-pentene-1,5-diol, 3-methylenepentane-1,5-diol, 1,5-hexadiene- 3,4-diol, 7-octene-1,2-diol, 2,5-dimethyl-3-hexene-2,5-diol, 9-decene-1,2-diol , 2,6-Dimethyl-7-octene-2,6-diol, 3,7-dimethyl-7-octene-1,6-diol, 13-tetradecene-1,2 -Diol, 12-hydroxy-9-octadecenol, 2-pentyne-1,4-diol, 3-hexyne-2,5-diol, 4-methyl-2-pentyne-1 ,4-diol, 3-heptyne-2,5-diol, 4-methyl-2-pentyne-1,4-diol, 3,4-dimethyl-1-pentyne-3, 4-diol, 2,5-dimethyl-3-hexyne-2,5-diol, 5-decyne-4,7-diol, 2,6-dimethyl-7-octyne- 2,6-diol, 3,6-dimethyl-4-octyne-3,6-diol, 2,3,6,7-tetramethyl-4-octyne-3,6-diol , 2,4,7,9-tetramethyl-5-decyne-4,7-diol, 2,5,8,11-tetramethyl-6-dodecyne-5,8-diol, 1,1,4,4-Tetraisopropyl-4-octyne-3,6-diol, 5,10-diethyl-7-tetradecyne-6,9-diol, etc. alcohol;

1,2-cyclopentanediol, 1,3-cyclopentanediol, 1,2-cyclohexanediol, 1,3-cyclohexanediol, 1,4-cyclohexanediol, 1,2-cyclohexanediol Heptanediol, 2,3-norbornanediol, 2,5-norbornanediol, 2,7-norbornanediol, 1,2-cyclooctanediol, 1,4-cyclooctanediol Alcohol, 1,2-cyclodecanediol, 5-cyclooctene-1,2-diol, 1,5-decahydronaphthalenediol, azenediol, 1,2-terpenediol, 4,4 '-Dicyclohexanediol, 1,2-cyclododecanediol and other alicyclic diols;

Glycerin, 1,2,3-butanetriol, 1,2,4-butanetriol, 2-methyl-1,2,3-propanetriol, 1,2,3-pentanetriol, 1,2 ,4-Pentanetriol, 1,3,5-Pentanetriol, 2,3,4-Pentanetriol, 2-Methyl-2,3,4-Butanetriol, Trimethylolethane, 2 ,3,4-Hexanetriol, 2-ethyl-1,2,3-butanetriol, trimethylolpropane, 4-propyl-3,4,5-heptanetriol, 2,4-di Triols such as methyl-2,3,4-pentanetriol, triethanolamine, and triisopropanolamine;

Erythritol, pentaerythritol, 1,2,3,4-pentaerythritol, 2,3,4,5-hexaneerythritol, 1,2,4,5-pentaerythritol, 1,3,4,5 -Hexetriol, diglycerol, sorbitol, N,N,N',N'-four (2-hydroxypropyl) ethylene diamine, N,N,N',N'-four (hydroxyethyl) ) Tetrahydric alcohols such as ethylenediamine;

Pentahydric alcohols such as calendula, arabitol, xylitol, triglycerin; six such as dipentaerythritol, sorbitol, mannitol, iditol, inositol, galactitol, talose, allose, etc. Alcohol;

1-methyl glyceryl ether, 2-methyl glyceryl ether, 1-ethyl glyceryl ether, 2-ethyl glyceryl ether, 1-propyl glyceryl ether, 2-propyl glyceryl ether, 1-isopropyl glyceryl ether, 2-isopropyl glyceryl ether, 1-butyl glyceryl ether, 2-butyl glyceryl ether, 1-isobutyl glyceryl ether, 2-isobutyl glyceryl ether, 1-pentyl glycerol ether, 2-pentyl glycerol Ether, 1-hexyl glyceryl ether, 2-hexyl glyceryl ether, 1-heptyl glyceryl ether, 2-heptyl glyceryl ether, 1-octyl glyceryl ether, 2-octyl glyceryl ether, 1-(2-ethylhexyl) )Glyceryl ether, 2-(2-ethylhexyl) glyceryl ether, 1-nonyl glyceryl ether, 2-nonyl glyceryl ether, 1-decyl glyceryl ether, 2-decyl glyceryl ether, 1-undecyl Glyceryl ether, 2-undecyl glyceryl ether, 1-dodecyl glyceryl ether, 2-dodecyl glyceryl ether, 1-tridecyl glyceryl ether, 2-tridecyl glyceryl ether, 1- Tetradecyl glyceryl ether, 2-tetradecyl glyceryl ether, 1-hexadecyl glyceryl ether, 2-hexadecyl glyceryl ether, 1-octadecyl glyceryl ether, 2-octadecyl glycerol Ether, 1-branched stearyl glyceryl ether, 2-branched stearyl glyceryl ether, 1-eicosyl glyceryl ether, 2-eicosyl glyceryl ether, 1-allyl glyceryl ether, 2-allyl glyceryl ether, 1-undecenyl glyceryl ether, 2-undecenyl glyceryl ether, 1-oleyl glyceryl ether, 2-oleyl glyceryl ether, 1-phenylglyceryl ether, 2-benzene Glycerol monoethers such as glyceryl ether;

N-methyldiethanolamine, N-ethyldiethanolamine, N-propyldiethanolamine, N-isopropyldiethanolamine, N-butyldiethanolamine, N-cyclohexyldiethanolamine, N-(2-ethyl N-substituted diethanolamines such as hexyl)diethanolamine; N-methyldiisopropanolamine, N-ethyldiisopropanolamine, N-propyldiisopropanolamine, N-isopropyldiisopropanolamine, N-butyldiisopropanolamine , N-displaced diisopropanolamine such as N-cyclohexyl diisopropanolamine, N-(2-ethylhexyl) diisopropanolamine;

3-dimethylamino-1,2-propanediol, 3-diethylamino-1,2-propanediol, 3-dipropylamino-1,2-propanediol, 3-diisopropylamino -N,N-disubstituted-3-amino-1,2-propanediols such as 1,2-propanediol and 3-dibutylamino-1,2-propanediol.

Among these low-molecular-weight polyols, from the viewpoint of exerting the effects of the present invention, propylene glycol, dipropylene glycol, tripropylene glycol, 1,2-butanediol, 1,3-butanediol, and 2,3-butanediol Alcohol, 1,2-pentanediol, 3-methyl-1,3 butanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 2-ethyl -1,3-hexanediol, 1,2-nonanediol, 2-butyl-2-ethyl-1,3-propanediol, 1,2-decanediol, 1,10-decanediol, glycerin , Triethanolamine, triisopropanolamine, erythritol, diglycerol, sorbitol, N,N,N',N'-four (2-hydroxypropyl) ethylenediamine, N,N,N ',N'-Four (hydroxyethyl) ethylene diamine, sorbitol, 1-methyl glyceryl ether, 1-ethyl glyceryl ether, 1-propyl glyceryl ether, 1-butyl glyceryl ether, 1-octyl Glyceryl ether, 1-(2-ethylhexyl) glyceryl ether, 1-decyl glyceryl ether, 1-allyl glyceryl ether are preferred, propylene glycol, dipropylene glycol, tripropylene glycol, 1,3-butanediol, 3- Methyl-1,3-butanediol, 1,2-octanediol, glycerin, triethanolamine, diglycerol, sorbitol, N,N,N',N'-tetra-(2-hydroxypropyl)ethane Diamine, sorbitol, 1-allyl glycerol ether are preferred, propylene glycol, dipropylene glycol, 1,3-butanediol, 3-methyl-1,3-butanediol, glycerin, sorbitol, 1- Allyl glyceryl ether is more preferable.

The low-molecular-weight polyol may be blended with one or two or more of the above. The blending amount is not particularly limited, and will vary depending on the type of cosmetic composition. From the viewpoint of exerting the effects of the present invention, it is probably 0.01 to 90% by mass relative to the total amount of the cosmetic composition. , 0.05 to 70% by mass is preferable. However, when the cosmetic composition is water-based cosmetics such as lotions and oil-in-water emulsified cosmetics, the blending amount of low-molecular polyol is preferably 0.1-50% by mass relative to the total amount of the cosmetic composition, and 1-20% by mass % Is better. In addition, low-molecular-weight polyols will have moisturizing effects.

Plant-derived extracts refer to specific parts of plants, algae, or fungi as whole individuals or specific parts of flowers, leaves, stems, fruits, bark, roots, seeds, resins, etc., directly or after pressing, drying, crushing, or fermentation, etc. The extract obtained by solvent extraction at room temperature or under heating will dissolve in water, ethanol, propylene glycol or grease. Or it may be a product obtained by diluting, concentrating or drying the extract. In addition, steam distillation, extraction, chromatography, etc. can also be used to make essential oils.

The extraction solvent for plant-derived extracts, from the standpoint of exerting the effects of the present invention, is usually a solvent that can be used to extract natural components. Examples include water; methanol, ethanol, propanol, butanol, etc. Alcohols; polyols such as ethylene glycol, propylene glycol, butylene glycol, and glycerin: ketones such as acetone and methyl ethyl ketone; esters such as methyl acetate and ethyl acetate; tetrahydrofuran, diethyl ether, polyethylene Ethers such as glycols; halogenated hydrocarbons such as dichloroethane and chloroform; aliphatic hydrocarbons such as petroleum ether, n-hexane, and cyclohexane; aromatic hydrocarbons such as toluene; pyridines; sodium chloride solution Etc., especially water, ethanol, propylene glycol, and butylene glycol are preferred.

Plants that can be used for extracts derived from plants include, for example, cardoon, almond, polygonum blue, Eysenhardtia polystachya, millet grass, agave, mountain pepper, lebanon, Senegal Tea, Acacia, Acacia, Red Sunflower, Slippery Elm, Rehmannia glutinosa, Asafoetida, Dragon Sprout, Akebia vulgaris, Osmanthus fragrans, Thistle, Reed, Ashitaba, Xinjiang Ajuga, Red Bean, Luohan Cypress, Asparagus, South African Red Shrub (Aspalathus linearis), Acerola, Acinonyx, Catechin, Atlantic Cedar, Anise, Smooth Fruit Elm (Anogeissus leiocarpus), Crude Oats, Avocado, Flax, Glycine, Gancha Vine, Polygonatum, Glycyrrhiza, Amiga, Honey locust, American Zanthoxylum bungeanum, American Cohosh, American Ginseng, Cardamom, Green Quercus, Purple Cinnamon, May Burdock, Small Burdock, Arnica, Carmitus Golden car (Arnica Chamissonis), galangal, alfalfa (alias alfalfa), aloe vera, apricot, apricot, angelica, yellow alfalfa, snake grape, amla, epimedium, reeling flower, knotweed, Mediterranean cedar , Strawberry, Fig, Japanese Knotweed, Ginkgo, Yucca, Carob, Bistort, Asparagus, Bite Cat, Ylang-Ylang, Iris, Vetiver Iris, Rhodiola, Latifolia, Common Bean , Fennel, nightshade, turmeric, asarum, prunella vulgaris, nine-eyed livable, sea buckthorn, plum, black medicine, licorice, melon, ulva, black elm, uncaria, Wenzhou mandarin, Yingshi, Icelandic lichen, high mountain Edelweiss, Acanthopanax senticosus, wild strawberry, Lythrum chinensis, Echinacea angustifolia, Echinacea angustifolia, Echinacea purpurea, Gorse, Shrimp orchid, Bitter white hoof, Elm,

Luzon olive, locust tree, pea, juniper, wormwood, wormwood, coptis, milk thistle, umbellifera, Eurasian polypedum, vetch, root claw, Aldingland, orchid, oak Tree (also known as Quercus vulgaris), Elecampane, Atractylodes macrocephala, Cacao, Lagerstroemia grandiflora, Oukan, Palmyra sylvestris, Passiflora grandiflora, Barley, Allspice, Cnidium, Okra, Mirabilis, Koryo Ginseng, Forsythia, Ghost Poppy, Clary Sage, Cakile edentula, Formononetia, Twisted Cactus, Jinwu Fan Cactus, Watercress, Dutch Peony, Olive, Winter Oregano (Origanum Heracleoticum), Cat Asparagus, Moroccan Chamomile, Orange, Orobanche Rapum, Tahitian Gardenia, Carnation, Neem, Cocoa, Firethorn, Cinnamon, Cashew, American Buckthorn, Italian Senna, Long Heart Card Pazao, Cattleya orchid, Golden Seal Grass, Java Olive, Dog Rose, Valerian, Chaga, Turnip, Cattail (Typha), Chamomile (alias Jiami Lie), Holy Basil, Melaleuca, Cone Purple pansy, wild oats, oat stalk, angelica, guarana, French rose, cauliflower, papaya, heather (alias Scottish heather), garcinia cambogia, carrot, wormwood (alias Yinchen), licorice, aiyuzi, Rubus, kiwi fruit, trichosanthes, chicory, sausage tree, aloe vera, savory, cinchona, quinoa, phellodendron amurense (also known as cork), arugula, yellow lupin, millet, gymnema, acupuncture magnolia , Cassava, cabbage, caraway, cucumber (alias cucumber), turmeric, tamarisk, pine red plum, saponaria, paulownia, myrtle (alias honeysuckle), guar, guava, quince seed, white Quercus, stone chestnut, wolfberry, celandine, kudzu, camphor tree, passion fruit, gardenia, bearberry, mangosteen, verbena,

Yellow flower honey vegetable, cumin, Peruvian latani (Krameria Triandra), Sophora flavescens, cranberry, sea fennel, big gum grass, clintonia borealis, clintonia borealis, walnut, grapefruit, iron thread Lotus, black mustard, black walnut, scented tea, cloves, black currant, black mulberry, mulberry, spatholobi, cinnamon (alias cinnamon), Eurasian roadside green, purple calyx roadside green, Cape Aloe vera, poppy, night flower, laurel, moon peach, green hairy Willow chrysanthemum, yellow gentian, weeping gentian, Tong's geranium, northern hovenia, small leaf red sandalwood, red red sandalwood, holy Rhodiola, citronella , Grass, Japanese pineapple, coffee, scutellaria, red melon, black sandalwood, chrysanthemum, bilberry, coconut, palm leaf raspberry, pepper, white flower Bidens, nopal, butterfly dendrobium, phalaenopsis, quercus , Chickweed, burdock, sesame, wheat, rice, kola fruit tree, coriander, coleus, coleus forskohlii, carambola, fenugreek, South American milk vine (Marsdenia cundurango), healing power (alias polymer grass), small flower pinwheel , Sisal, asarum, sedge, cypress, coleus, snow lotus, Wei Lingxian, cherry blossom, cherry leaf viburnum, pomegranate, sugar maple, beautiful sugar cane, sugar pine, tea plum, sassafras, crocus , Saponaria, Salo, Black Willow, Lagerstroemia, Sanguinaria, Wild Hawthorn, Pansy, Panax notoginseng, Dogwood, American Pepper, Mountain Lentil, Pyrus sylvestris, Spider Silk Blue-ear Grass, Shea Butterwood, Inca Malachite , Water garlic mustard, Cistus (alias Rock Rose), Cistus Monspeliensis, Cistus Ladaniferus, Perilla, Lantana, East China Linden, Goose Guancao, Tonka Bean, Siberian Fir , Bitterwood, Cohosh, Mosquito, potato, peony, jasmine, Ophiopogon japonicus, Christmas heather, ginger flower, coix, panicle stone flower,

Mexican juniper, ulva, ginger, cardamom (also known as cardamom), calamus, rhubarb, white birch, purple orchid, white mustard, white frangipani, white lupin, grass cotton, platinum chicken, mysterious fruit, Cymbidium , Acacia, acacia, watermelon, honeysuckle, chervil, wattle, scutellaria, stevia, arborvitae, arborescens, arthrospira platensis, spirulina maxima, purslane, spelt Wheat, sour cherries, smilax, dyed madder, European red pine, buckthorn, divergent nettle, plantain, Hypericum perforatum, Valerian, Indian squash, Hawthorn, Artemisia serrata, Ivy, Persian walnut , Linsheng Scrophulariaceae, Primrose, Bright-leaf Crataegus, Western Linden, White Willow, Western Dandelion, Jin Ripe Boxwood, Horse Chestnut, European Ash Tree, Western Pear, Mosquito Leaf, European Sorbus, Ceylon Cinnamon, Western Elder Wood, vitex agnus, juniper, yarrow, hazel, peppermint, European holly, European sweet cherry, lotus root, burberry, mistletoe, European blackberry, Ceylon cinnamon, sage, polyant tree, Giant sequoia, sessile oak, purple eight treasures, mallow, Polygala tenuifolia, geranium, blue-flowered false bauhinia (Cercidium floridum), large-flowered cactus, celery, chuanxiong, rose scallion, coriander, coriander, amaranth, Inula, Rhizoma Atractylodes, White Mulberry, Saw Palmetto, Frangipani, Buckwheat, Wolfberry (Solanum Lycocarpum), Star Anise, White Radish, Giant Buddha Tripe Bamboo, Soybean, Jujube, Bitter Orange, Astragalus, Thyme , Taiwan cypress, Channa intestines, ordinary thyme, orange tangerine, red phoenix, purple campanula, resurrection, Turk rose, onion, damiana, tarragon, salvia,

Hairy leaf cup flower, Imperata cylindrica, tea tree (tea), wild passionflower, tuberose, clove, schisandra, butterfly pea, silver linden, Siegesbeckia, Gotu kola, Elaeagnus vulgaris, Polygonum multiflorum, bitter gourd, Australia Tea tree, chrysanthemum leaf yam, wild yam, Mexican tortoiseshell dragon, hand-beaten walnut, Tecoma Curialis (a kind of yellow bell flower in Central and South America), Tielimu, Lansa, Duboisia Leichardtii, olive kernel, sweet tea, German iris , European spruce, winter melon seeds, pepper, oriental angelica, marigold, peach kernel, female frame, fish scale spruce, corn, corn silk, ground root, horsetail, houttuynia cordata, poisonous ginseng, dodder (also known as bean yama), juniper , Tomato, Fenugreek, Potentilla, Sweet Sunflower, Savoy Sorrel, False Leaf Tree, Eggplant, Shepherd's Purse, Red Concanavali, Short-tongued Chrysanthemum, Tilia Latifolia, Date Tree, Date Palm, Galangal, Wood blue, gray edamame, sweet violet, geranium geranium, cedar, Central Asian artemisia, nutmeg, nigella, frankincense tree, elephant garlic, carrot, garlic, white water lily, root no kudzu, rose, Nasturtium, Viburnum, Briar, European Senecio, pineapple, Hibiscus, pine pine, Amaranthus, Lemon myrtle, Ophiopogon, Bacopa, Chrysanthemum, Lotus, Parsley, Patchouli, Ganoderma lucidum, Bacchus chrysanthemum, fragrant passion fruit, Taiwan's coix,

Banana, Oregano, Honeysuckle, Vanilla, Tahitian Vanilla, Cassia Pterocarpus, Papaya, Paphiopedilum, Haberlea Rhodopensis, Rose, Witch Hazel, Chayote, Rose, Wallweed, Robinia, Claw, Palmarosa, Barosma Betulina, Barosma Betulina, Bambara Bean, Beet, Oregon Grape, Shegan, Hairy Herb, Amiqin, Bitter almond, bitter orange, golden seal grass, daisy, poppy, Japanese schisandra, loblolly pine, Japanese cypress, brown algae, broad bud chrysanthemum, sea buckthorn, sunflower, winter green tree, kola nut, small vine vinca, Jatoba Beans, houttuynia cordata, white sandalwood, chickpeas, lentils, polygrass, hollyhock, Pilocarpus Pennatifolius, loquat, betel nut, Brazilian ginseng, bellflower, pueraria lobata, guppon awei ( Ferula Galbaniflua), Coltsfoot, Poria cocos, Daffodil, Red currant, Buddleia macrophylla, Ear sandalwood, Bitter Orange, Brazilian Mud, Hibiscus, False Leaf Tree, Palm Tree, Grape, Rose Apple, Japanese Beech , Bamboo leaf pepper, linden, cordyceps, Chilean strawberries, Brazil nuts, maritime pine, French lavender, Plantago Afra, Plantago ovata, Plantago Psyllium, Bellflower Spring, European plum, African pygeum, late flowering bird cherry, Burmese gardenia, Coleus forskohlii, purple blue flower Bletia Hyacinthina (Bletia Hyacinthina), propolis,

Rice, hay flowers, hazelnuts, pecans, vetiver, loofah, pulei mint, mahogany, safflower, Japanese hazel, American squash, plantain, Pelargonium Capitatum, sand helichrysum , Helichrysum, Helichrysum, Bergamot, Silver Bead, Peruvian Fragrance, Bergamot, Holly Barberry, Medicinal Granny, Henna, Ruta, Kochia Kochia, Lemon Verbena, Hope Spring Magnolia, Impatiens, Maidenhair fern, spinach, hill willow chrysanthemum, Japanese magnolia officinalis, spotted geranium, Bocoa Prouacensis (a kind of South American iron pigeon pea), Boswellia serrata, Senna angustifolia, Echinacea angustifolia, Nanjing linden, peony, snake Hemp, Ulmus pumila, Jojoba, Polygonatum, Bordeaux, Ponkan, Australian walnut, Magnolia officinalis, Wangchun Magnolia, White mulberry, Ganoderma lucidum, Holly euonymus, Hydrangea, Pine, Jasmine, Mate Tea, Virgin lily, marjoram, milk thistle, bright leaf acerola, quince, horse chestnut, mango, mangosteen, northeastern red antler, Chinese pine, maidenhair, orange, mandela grass, red Bupleurum , Water mint, camphor leaf passionflower, sagebrush, nymphaea, rough cap fruit, fine-flowered mimosa, camu fruit, myrrh (alias drug), milu (Myrothamnus Flabellifolia), myrobalan, sapindus, purple Grass, Japanese purple bead, tuberous swerve, echinacea, spice mulberry, basil, evening primrose, neem, melissa (also known as perfume mint), yellow vanilla smelt, thatch melon, cantaloupe, wild mint, mongolica, Mouera Fluviatilis (a tropical waterweed of the genus Muhaila), purple magnolia, rose musk, cowpea, myrrh, peach, olive tree, motherwort, cornflower, Alnus Firma, fragrant bayberry,

Hyssopus, Willow orchid, Chicken mulberry, Japanese mountain cherry, Japanese yam, Artemisia serrata, gourd, Eucalyptus, Eupatorium Ayapana, Stevia, Saxifraga, Orange, Guaiac, Camellia oleifera, Xiaosi Orchid (Yucca Glauca), Yucca Schidigera (Yucca Schidigera), Lily, Potentilla, Physalis, Pokeweed, Goldenrod, Raspberry, European Chestnut, Black Poplar, Birch, European Beech, Spicy Sedum , Silver fir, wormwood, artemisia chrysanthemum, lychee (alias lychee), emperor bean, lime, rye, lilac, radiata pine, latano palm, peanut, banyan buttercup, mixed lavender, apocynum, lavender , European larch, Chaparral shrub (Larrea Divaricata), Larrea Mexicana (a kind of Mexican shrub), rambutan, Lithothamnion Calcareum (Lithothamnion Calcareum), Liriosma ginger, longan, Liriosma Ovata (Brazilian tree) A kind of wood), apple, Rooibos, Texas lupin (Lupinus Subcarnosus), fluffy raspberry (Rubus Villosus), red ball ginger (Lempuyang), borage, field delphinium, lespede, yellow Mignonette, lettuce, chickpea, ginseng, Lebanese cedar, angelica, lemon, lemongrass, milk vetch, rosewood, rosemary, bush blueberry, fruit chrysanthemum, laurel (alias laurel), ink tree, Plants such as coffee, wild thyme, wasabi, horseradish, moringa, cotton cedar, serrata, sylvestris, sanguinum, etc.;

Phyllostachys vulgaris, Phyllostachys porphyratum, Pear-shaped macroalgae, Cladosiphon Okamuranus, Gigartina stellata, Kjellmaniella Gyrata, Sargassum Filipendula, Sheep Sargassum fusiforme, Sargassum Muticum, Sphacelaria Scoparia, Durvillaea Antarctica, Padina pavonica, Himanthalia Elongata ), Fucus serratus, Pelvetia canaliculata, Pear-shaped macroalgae, Hidaka kelp, Laminaria Ochroleuca, Laminaria cloustoni, Palmate kelp ( Laminaria digitata, Laminaria hyperborea, Wakame, Asparagopsis Armata, Xiancai, Hypnea japonica Tanaka, Betaphycus gelatinum, Gelidium cartilagineum , Ahnfeltiopsis Concinna, Gellidiela Acerosa, Rhodophyta, Porphyridium, Irish moss, Porphyridium Cruentum, Porphyra umbilicalis, Lithocarpus coralline (Lithothamnium corallioides), Ulva vulgaris, Chlorella Emersonii, Chlorella Pyrenoidosa, Dunaliella salina, Dunaliella bardawil, Flat stone Hair, Arthrospira platensis, Spirulina maxima, Haslea Ostrearia (a blue diatom), Delesseria Sanguinea (a red leaf alga), Pikea Robusta, Pleurochrysis carterae, rain Haematococcus pluvialis, cyanobacteria, carrageenan ( Chondrus crispus), coral algae, sea whip, red algae and other algae;

Tree moss (Evernia Furfuracea), oak moss, Usnea, Cynomorium, Chaga, Shiitake, Ground flower fungus, Brazilian mushroom, Cordyceps, Chaga, Polyporus umbellatus, Cordyceps and other lichens or mycelium.

The plant-derived extract can be blended with one or two or more of the above. The blending amount is not particularly limited and will vary depending on the type of cosmetic composition. From the viewpoint of exerting the effects of the present invention, it is probably 0.0001 to 5% by mass relative to the total amount of the cosmetic composition. , 0.001 to 1% by mass is preferable.

Extracts derived from animals, for example, bovine placenta extract (placenta), bovine neck ligament extract (elastin), bovine blood extract (hemoglobin), bovine pig stomach extract (mucopolysaccharide), bovine-pig Skin-fish extract (collagen), cockscomb extract, royal jelly (royal jelly), silk extract (silk protein, sericin), milk extract (whey, glycoprotein, lactoferrin), crab shell Extracts (chitin, chitosan), ceramide, squalene, etc.

The extracts from animals can be blended with one or more of the above. The blending amount is not particularly limited, and varies according to the type of cosmetic composition. From the viewpoint of exerting the effects of the present invention, it is preferably 0.0001 to 5% by mass relative to the total amount of the cosmetic composition. 0.001 to 1% by mass is preferable.

Extracts derived from microorganisms include, for example, bacterial metabolites, bacterial extracts, metabolites of molds or mushrooms, actinomycetes metabolites, extracts of molds or mushrooms, actinomycetes extracts, and metabolites of natto bacteria Fermented product, natto extract, fermented rice extract, fermented rice bran (red bran, white bran) extract, Euglena extract or its decomposition product or its water-soluble derivative, lactic acid fermentation product of fresh milk or skimmed milk powder, trehalose Or its derivatives, etc. In addition, the extract from microorganisms may also contain, for example, lipopolysaccharide (LPS).

The extracts from microorganisms can be blended with one or more of the above. The blending amount is not particularly limited, and varies according to the type of cosmetic composition. From the viewpoint of exerting the effects of the present invention, it is preferably 0.0001 to 5% by mass relative to the total amount of the cosmetic composition. 0.001 to 1% by mass is preferable.

Zinc compounds include, for example, zinc acetate, zinc laurate, zinc myristate, zinc palmitate, zinc ricinoleate, zinc undecylenate, zinc aspartate, zinc acetylmethionine, and gluconic acid Zinc, zinc citrate, zinc polypyrrolidone carboxylate, zinc picolinate and other organic acid zinc salts; zinc sulfonate such as zinc p-phenolsulfonate, zinc ascorbyl phosphate, sodium cetyl phosphate, zinc DNA, etc. Zinc phosphate; zinc complexes such as zinc pyrithione; zinc-supporting zeolites such as silver/zinc/ammonium zeolite, ammonium silicate/silver/zinc/aluminum, etc.; alumina/zinc, alumina/zinc/ Burned products of cerium, aluminum oxide/zinc/iron and aluminum hydroxide; zinc sulfate, zinc sulfide, zinc chloride, zinc bromide, zinc nitrate, zinc ammonium chloride, zinc aluminum sulfate, zinc potassium sulfate, iodine Inorganic zinc salts such as zinc oxide and alkaline zinc carbonate; (hydroxide/carbonate) magnesium/aluminum/zinc, zinc oxide, etc. Among these, compounds that are easily soluble in water and become zinc ions are preferred. The solubility in 100 g of water at 20°C is preferably 5 g or more, and the solubility is more preferably 10 g or more. Examples of such zinc compounds include zinc sulfate, zinc chloride, zinc gluconate, zinc bromide, zinc nitrate, zinc ammonium chloride, zinc aluminum sulfate, zinc potassium sulfate, and zinc iodide.

The zinc compound may be blended with one or two or more of the above. The blending amount is not particularly limited and will vary depending on the type of cosmetic composition. From the viewpoint of exerting the effects of the present invention, it is probably 0.001-10% by mass relative to the total amount of the cosmetic composition. , 0.01~3% by mass is preferable.

Tackifiers include, for example, dimethyldiallylammonium chloride-acrylamide copolymer, acrylamide-acrylic acid-dimethyldiallylammonium chloride copolymer, cellulose or its derivatives, and Protein and collagen or its derivatives, calcium alginate, pullulan, agar, gelatin, tamarind gum seed polysaccharides, xanthan gum, carrageenan, high methoxy pectin, low methoxy fruit Gum, guar gum, acacia gum, crystalline cellulose, arabinogalactan, karaya gum, tragacanth, alginic acid, protein, casein, Cattleya polysaccharide, β-1,3-1,6- Β-glucan other than glucan, β-glucan derivatives, gellan gum, polydextrose, α-glucose and α-glucose derivatives, glucomannan, galactomannan, arabinosyl wood Polysaccharides, cellulose derivatives, dextrin and dextrin derivatives, etc.

The tackifier may be blended with one or two or more of the above. The blending amount is not particularly limited, and varies depending on the type of cosmetic composition. From the viewpoint of exerting the effects of the present invention, it is probably 0.01-20% by mass relative to the total amount of the cosmetic composition. , 0.05-10% by mass is preferable.

Examples of the oil agent include volatile and non-volatile oil agents, solvents, and resins commonly used in cosmetic compositions. They may be liquids, pastes, or solids at room temperature, and liquids with excellent handling properties are preferred. Examples of oils include higher alcohols such as cetyl alcohol, isostearyl alcohol, lauryl alcohol, cetyl alcohol, and octyldodecanol; lauric acid, undecylenic acid, myristic acid, palmitic acid, Stearic acid, behenic acid, isostearic acid, 12-hydroxystearic acid, oleic acid, linoleic acid, linolenic acid, arachidonic acid, eicosapentaenoic acid, docosahexaenoic acid, High-carbon fatty acids such as isostearic acid, 12-hydroxystearic acid and lanolin fatty acid; myristyl myristate, hexyl laurate, decyl oleate, isopropyl myristate, hexyl dimethylcaprylate Decyl ester, glycerol monostearate, diethyl phthalate, ethylene glycol monostearate, octyl hydroxystearate, diisopropyl adipate, cetyl caprylate, isononyl isononanoate Esters, isopropyl palmitate, stearyl stearate, isotridecyl myristate, 2-ethylhexyl palmitate, octyl dodecyl ricinoleate, carbon number 10-30 Fatty acid cholesterol/lanosterol ester, cetyl lactate, lanolin acetate, ethylene glycol di-2-ethylhexanoate, pentaerythritol fatty acid ester, dipentaerythritol fatty acid ester, cetyl caprylate, three Glyceryl caprylate, diisostearyl malate, dioctyl succinate, and cetyl 2-ethylhexanoate; hydrocarbons such as liquid paraffin, petrolatum, squalane, etc.; lanolin, reduced wool Oil, carnauba wax and other waxes; mink oil, cocoa butter, coconut oil, palm kernel oil, camellia oil, sesame oil, castor oil, olive oil and other oils; dimethyl polysiloxane, methyl hydrogen polysiloxane Alkyl, methylphenyl polysiloxane, polyether modified organopolysiloxane, fluoroalkyl/polyoxyalkylene co-modified organopolysiloxane, alkyl modified organopolysiloxane, terminal Modified organopolysiloxane, fluorine-modified organopolysiloxane, amino-terminated dimethylpolysiloxane, amino-modified organopolysiloxane, polysiloxane colloid, acrylic polysiloxane, three Polysiloxane compounds such as methyl siloxy silicate and polysiloxane RTV rubber; fluorine compounds such as perfluoropolyether, fluorinated pitch, fluorocarbon, fluoroalcohol, etc.; polybutene, polyisobutylene, hydrogenated poly Polyolefins or olefin oligomers such as isobutylene, ethylene-α-olefin-co-oligomer; hydrocarbons such as mineral oil, light mobile isoparaffin, petrolatum, squalane, etc.

The oil agent may be blended with one or two or more of the above. The blending amount is not particularly limited and will vary depending on the type of cosmetic composition. From the viewpoint of exerting the effects of the present invention, it is probably 0.1 to 90% by mass relative to the total amount of the cosmetic composition. , 0.5 to 70% by mass is preferred.

Examples of pigments include pigments such as red No. 201, yellow No. 4, blue No. 1, and black No. 401, yellow No. 4 Al lake, yellow No. 203 Ba lake, and the like.

Examples of the pigment include white pigments such as titanium oxide, extender pigments such as silica, talc, mica, sericite, and kaolin, and pearl pigments such as titanium mica. The shape of these pigments (spherical, rod-shaped, needle-shaped, plate-shaped, indeterminate shape, scale-shaped, spindle-shaped, etc.) is not particularly limited. These pigments can be treated by well-known surface treatments, such as fluorine compound treatment, silicone treatment, silicone resin treatment, side chain treatment, silane coupling agent treatment, titanium coupling agent treatment, oil treatment, N-acid treatment Chemical lysine treatment, polyacrylic acid treatment, metal soap treatment, amino acid treatment, inorganic compound treatment, plasma treatment, mechanochemical treatment, etc., surface treatment in advance. It can also be used as an ultraviolet scattering agent.

The coloring matter and/or the pigment may be blended with one or two or more of the above. The blending amount is not particularly limited and will vary depending on the type of cosmetic composition. From the viewpoint of exerting the effects of the present invention, it is probably 0.1 to 90% by mass relative to the total amount of the cosmetic composition. , 0.5 to 70% by mass is preferred.

Antibacterial agents (preservatives) include, for example, paraben-based antibacterial agents such as methyl paraben and ethyl paraben; thiabendazole, methyl 2-benzimidazolyl carbamate Imidazole-based antibacterial agents such as Preventol; stilbene urea-based antibacterial agents such as triclosan and chlorflubenzuron; Thiazole-based antibacterial agents such as benzothiazole; triazine-based antibacterial agents such as tebuconazole and Kabinon Agents; biguanide-based antibacterial agents such as chlorhexidine hydrochloride, polyhexamethylene biguanide, ether derivative-based antibacterial agents such as phenoxyethanol, ethylhexylglycerol, ethylene glycol, diethylene glycol, three Glycol-based antibacterial agents such as ethylene glycol, butylene glycol, propylene glycol, dipropylene glycol, pentanediol, and octanediol, and benzoic acid-based antibacterial agents such as sodium benzoate, potassium benzoate, and calcium benzoate. As the antibacterial agent, from the viewpoint of exerting the effects of the present invention, it is preferable to use an ether derivative-based antibacterial agent, a glycol-based antibacterial agent, or the like.

Antibacterial agents can be blended with one or two or more of the above. When these antibacterial agents are used in combination, they should be used with caution in consideration of irritation to the human body. From the viewpoint of exerting the effects of the present invention, the blending amount is preferably 0.01-10% by mass relative to the total amount of the cosmetic composition, preferably 0.03-6% by mass, and more preferably 0.03-3% by mass. .

Examples of pH adjusters include potassium carbonate, sodium hydrogen carbonate, ammonium hydrogen carbonate, ascorbic acid, hydrochloric acid, gluconic acid, acetic acid, lactic acid, phosphoric acid, sulfuric acid, citric acid, anionic surfactants, and the like. These pH adjusters may be the same as or different from the acid group used when preparing the cationic surfactant composed of the aforementioned tertiary amine and amidoamine.

The pH adjusting agent may be blended with one or two or more of the above. The blending amount is not particularly limited and will vary depending on the type of cosmetic composition. From the viewpoint of exerting the effects of the present invention, it is probably 0.001-10% by mass relative to the total amount of the cosmetic composition. , 0.01~5 mass% is preferable. In addition, the pH adjuster varies according to the type of cosmetic composition. From the viewpoint of exerting the effects of the present invention, the cosmetic composition should preferably have a pH of 3.0 to 13.0, and preferably a pH of 4.0 to 12.0. , More preferably pH5.0~10.0, most preferably pH6.0~7.0.

Examples of antioxidants include tocopherol, butylhydroxyanisole, dibutylhydroxytoluene, and phytic acid. The antioxidant may be blended with one or two or more of the above. The blending amount is not particularly limited and will vary depending on the type of cosmetic composition. From the viewpoint of exerting the effects of the present invention, it is probably 0.001-10% by mass relative to the total amount of the cosmetic composition. , 0.01~5 mass% is preferable.

UV absorbers include, for example, salicylic acids such as trimethylcyclohexyl salicylate, octyl salicylate, triethanolamine salicylate; p-aminobenzoic acid, dihydroxypropyl p-aminobenzoic acid ethyl ester, PABA series such as p-aminobenzoic acid glyceride, dimethyl p-aminobenzoic acid octyl ester, p-dimethylaminobenzoic acid amyl ester, p-dimethylaminobenzoic acid 2-ethylhexyl ester, etc.; 4- (2-β-Glucopyranosyloxy)propoxy-2-hydroxybenzophenone, dihydroxydimethoxybenzophenone, dihydroxydimethoxybenzophenone sodium disulfonate, 2-hydroxy- 4-methoxybenzophenone, hydroxymethoxybenzophenone sulfonic acid and its trihydrate, sodium hydroxymethoxybenzophenone sulfonate, 2-hydroxy-4-methoxybenzophenone-5- Sulfuric acid, 2,2'-dihydroxy-4-methoxybenzophenone, 2,4-dihydroxybenzophenone, 2,2'4,4'-tetrahydroxybenzophenone, 2,2'-di Benzophenone series such as hydroxy-4,4'-dimethoxybenzophenone and 2-hydroxy-4-N-octyloxybenzophenone; 2-ethylhexyl p-methoxycinnamic acid (alias ：P-methoxycinnamate octyl ester), two-p-methoxycinnamate mono-2-ethylhexanoic acid glyceride, 2,5-diisopropyl cinnamate methyl ester, 2,4,6-see [4 -(2-Ethylhexyloxycarbonyl)aniline]-1,3,5-triazine, trimethoxycinnamate, methyl bis(trimethylsiloxy) silyl isoamyl ester, p-methoxy Cinnamic acid series such as isopropyl cinnamic acid, diisopropyl cinnamic acid ester mixture, p-methoxyhydroxycinnamic acid diethanolamine salt, etc.; 2-phenyl-benzimidazole-5-sulfuric acid, 4-isopropyl two Benzoyl methane series such as benzyl methane and 4-tert-butyl-4'-methoxydibenzyl methane; 2-cyano-3-diphenylprop-2-enoic acid 2-Ethylhexyl ester (alias: octocrylene), 2-ethylhexyl dimethoxybenzylidene dioxoimidazolidinium propionate, 1-(3,4-dimethoxy) (Phenyl)-4,4-dimethyl-1,3-pentanedione, Cinoxate, methyl anthranilate, 2-cyano-3,3-diphenylacrylic acid 2 -Ethylhexyl ester, 3-(4-methylbenzylidene) camphor, octyl triazone, 4-(3,4-dimethoxyphenylmethylene)-2,5-dioxo -1-imidazolidinyl propionic acid 2-ethylhexyl ester, its polymer derivatives and silane derivatives.

The ultraviolet absorber may be blended with one or two or more of the above. The blending amount is not particularly limited and will vary depending on the type of cosmetic composition. From the viewpoint of exerting the effects of the present invention, it is probably 0.01-10% by mass relative to the total amount of the cosmetic composition. , 0.1~1% by mass is preferred.

Moisturizing ingredients include, for example, mucopolysaccharides such as deoxyribonucleic acid, hyaluronic acid and its sodium, potassium, and derivatives, chondroitin sulfate, collagen, elastin, chitin, chitosan, and hydrolyzed eggshell Membrane, polyethylene oxide methyl glucoside, polypropylene oxide methyl glucoside, sodium lactate, urea, sodium pyrrolidone carboxylate, betaine, whey, ceramide, squalene, squalane and its derivatives, Mevalonate lactone and so on.

The moisturizing ingredient may be blended with one or two or more of the above. The blending amount is not particularly limited and will vary depending on the type of cosmetic composition. From the viewpoint of exerting the effects of the present invention, it is probably 0.001 to 30% by mass relative to the total amount of the cosmetic composition. , 0.01-20% by mass is preferable.

Enzymes include, for example, acetyl-CoA desaturase, aminopeptidase, amyloglucosidase, oxidoreductase, catalase, glucose oxidase, superoxide dismutase, soybean peroxidase, polydextrose Immobilized protease, transglutaminase, hyaluronidase, protease, hesperidinase, lactoperoxidase, lipase, etc.

Enzymes can be blended with one or two or more of the above. The blending amount is not particularly limited and will vary depending on the type of cosmetic composition. From the viewpoint of exerting the effects of the present invention, it is probably 0.001-10% by mass relative to the total amount of the cosmetic composition. , 0.01~5 mass% is preferable.

Fragrance is blended for the purpose of imparting aroma and fragrance to the cosmetic composition, or for masking unpleasant odors. As long as they are generally blended into cosmetic compositions, they are not particularly limited, and include various extracts exemplified by the aforementioned physiologically active ingredients, etc., and exemplified fragrances extracted from flowers, seeds, leaves, roots, etc. of various plants , Spices extracted from seaweeds, spices extracted from various parts or secretions of animals (e.g. musk, ambergris), synthetic flavors (e.g. menthol, synthetic musk, acetate, vanilla extract) .

The fragrance can be blended with one or two or more of the above. The blending amount is not particularly limited and will vary depending on the type of cosmetic composition. From the viewpoint of exerting the effects of the present invention, it is probably 0.001-10% by mass relative to the total amount of the cosmetic composition. , 0.01~3% by mass is preferable.

Specific uses of the cosmetic composition of the present invention include, for example, scalp care cosmetics; creams (hand creams, body creams), lotions (body lotions, sunscreen lotions, etc.), lotions, and lotions (Emulsion for sunscreen, etc.), beauty lotion, beauty lotion for facial mask, beauty lotion for flake-shaped processed products (e.g., thin sheet with microneedles), facial patch, shaving cream, after-sun lotion, after-sun Skin care cosmetics such as repair lotion; cleansing cosmetics such as facial cleanser, makeup remover, shampoo and shower gel; makeup cosmetics such as foundation, barrier cream, lip balm, etc.; bathing agent, especially body lotion, body Creams, lotions for sunscreen, lotions, lotions (emulsions for sunscreen, etc.), and beauty lotions are particularly preferred.

Next, the manufacturing method of the cosmetic composition of the present invention will be described. The cosmetic composition of the present invention can be manufactured according to a conventional method, and it is preferable that the above-mentioned external composition is contained in the water phase.

Next, the method of using the cosmetic composition containing the composition for external use of the present invention will be described. The method of using the cosmetic composition of the present invention can be adjusted in accordance with the skin condition, age, sex, etc. of the subject to be used, and may be, for example, the following method. That is, several times a day (for example, about 1 to 5 times, preferably 1 to 3 times), apply an appropriate amount (for example, about 0.02 mg to 20 mg on an area of, for example, 6 cm × 10 cm). , The skin of the whole body starting with hands and feet. The coating period is not particularly limited. From the viewpoint of the skin renewal cycle and the effective exertion of the effects of the present invention, for example, about 1 to 110 days is preferable, about 15 to 80 days is more preferable, and about 25 to 60 days For better. The cosmetic composition of the present invention has the effect of improving skin quality that is not prone to sunburn and inhibiting inflammation and swelling caused by sunburn. The object of use is not limited, and for people who are particularly prone to sunburn, the effect of improving the skin to a state that is not prone to sunburn is well exerted. In addition, for people whose skin is not prone to sunburn, the degree of easy sunburn can also be suppressed, and the state of being less prone to sunburn can be maintained.

Next, the skin quality improvement method of the present invention will be described. The skin quality improvement method of the present invention includes the step of applying the cosmetic composition of the present invention to the skin. This can improve the skin that is not prone to sunburn or maintain its state, so it can suppress inflammation and swelling caused by sunburn. The coating environment of the cosmetic composition of the present invention, such as temperature, is not particularly limited.

In the skin quality improvement method of the present invention, it is preferable to apply the cosmetic composition of the present invention before the skin is sunburned. Specifically, it is applied before the skin is irradiated ^{with ultraviolet rays of 2.0 mJ/cm 2} or more for 1 minute or more. Cloth is preferable, and ^{it is better to carry out before irradiating ultraviolet rays of 5.0 mJ/cm 2} or more for 1 minute or more, and it is more preferable to carry out before irradiating ^{ultraviolet rays of 10.0 mJ/cm 2} or more for 1 minute or more. This can effectively suppress inflammation and swelling caused by sunburn.

If the cosmetic composition of the present invention is applied before sunburn, the external composition for improving skin quality of the present invention may be applied or not applied to the skin during ultraviolet irradiation. By applying the cosmetic composition of the present invention at least before sunburn, inflammation and swelling caused by sunburn can be effectively suppressed. In addition, the cosmetic composition of the present invention can exert a skin quality improvement effect even if it is applied to sunburned skin. [Example]

The following examples illustrate the present invention in detail. In addition, in the following examples and the like, unless otherwise stated, "%" is the "quality criterion".

<Examples 1 to 4 (Preparation of samples A to D)> The black yeast (deposit number FERM BP-8391) was cultivated as a preservation strain with potato dextrose agar slant medium, and inoculated into a 500 ml Erlenmeyer flask containing 100 ml of YM liquid medium (manufactured by Difco) at 28°C Cultivate 3 days before. The culture solution was transferred to a 30-liter fermentation tank containing 15 liters of Czapeak's medium (manufactured by Difco), and cultured at 28°C for 3 days. After the culture solution was sterilized by heating at 90°C for 30 minutes, the cells were removed by centrifugation to obtain a culture supernatant (β-1,3-1,6-glucan 1% by mass).

This culture supernatant was diluted with water to 0.8%, and it was designated as sample A (Example 1) (β-1,3-1,6-glucan contained in sample A was 0.008% by mass). In addition, the above-mentioned culture supernatant was diluted with water to 80%, and it was designated as sample B (Example 2) (β-1,3-1,6-glucan contained in sample B was 0.8% by mass ). In addition, the above-mentioned culture supernatant was designated as sample C (Example 3). In addition, phenoxyethanol and ethylhexylglycerol as antibacterial agents were added to the above-mentioned culture supernatant, and water was further added to dilute the culture supernatant to 80%, which was designated as sample D (Example 4) (Sample The β-1,3-1,6-glucan contained in D is 0.8% by mass, phenoxyethanol is 0.5% by mass, and ethylhexylglycerol is 0.3% by mass). In addition, the above-mentioned samples A to D correspond to the external composition for improving skin quality of the present invention.

The β-1,3-1,6-glucan contained in samples A, B, C and D is β-1,3-1,6-glucan represented by general formula (1), which The mass average molecular weight is 300,000, and ^{the ratio of the unit in which R 1} is the formula (A) to the unit in which R ¹ is a hydrogen atom is 0.85. The measurement method of the mass average molecular weight and the calculation method of the unit ratio are disclosed below.

(Determination of mass average molecular weight) Add 3 times the amount of ethanol to the culture supernatant, cool to -20°C, and leave for 10 minutes to obtain a precipitate. Take 5 mg of the β-1,3-1,6-glucan precipitate into a tube, add 1 ml of distilled water, and dissolve it in boiling water. The solution was passed through a 0.22 μm filter to prepare a sample for high-speed liquid chromatography. The separation was performed using Shodex packed column KS-805, 804 (manufactured by Showa Denko Corporation) using a high-speed liquid chromatograph colloidal filtration column, a flow rate of 0.5 ml/min., a temperature of 80°C, and an RI detector for detection. And use water as the separation solvent to implement. The molecular weight marker was measured by obtaining the device constant k using Shodex pullulan standard solution P-82 (manufactured by Showa Denko Corporation).

(Calculation of unit ratio) The analysis of the bonding pattern of β-1,3-1,6-glucan is based on a general method for methylation analysis. That is, the sample is dissolved in distilled water at a concentration of 1 mg/ml, 3 times the amount of ethanol is added to precipitate β-1,3-1,6-glucan, the supernatant is removed, and the sample is again in distilled water melt. This operation was repeated three times to remove components other than β-1,3-1,6-glucan to prepare a purified sample. Add 2ml of DMSO to 1mg of the purified sample after freeze-drying to dissolve it, and add 0.5ml of carbanion reagent. After stirring at room temperature for 4 hr, CH ₃ I was added, and stirring was carried out under water cooling for 1 hr to react to methylate free hydroxyl groups. After blowing N ₂ to remove residual CH ₃ I, the reaction solution was transferred to a dialysis tube and dialyzed with water. After drying the sample, add concentrated sulfuric acid (72%), continue to dilute with water, and perform acid hydrolysis to obtain monosaccharides. After the reaction is completed, it is _{neutralized with BaCO 3} and the supernatant is added to the ion exchange resin for desalination. 2N ammonia water was added to the sample, _{1 mg of NaBH 4 was} added for reduction, acetic anhydride and 0.1 ml of pyridine were added to react for 2 hours, and then the acetylation of the hydroxyl group that contributed to the bonding was completed. The acetylated sample was dissolved in acetone and detected by gas chromatography. In addition, β-1,3-1,6-glucan was analyzed in detail using 13C-NMR. From these calculated values, R ¹ is the ratio of the unit of formula (A) to the unit in which R ^{1 is a hydrogen atom.}

＜Evaluation example 1 (Review of improvement of skin quality)＞ Use Multiport Solar UV Simulator Model 601 (Solar Light Co. Inc.) as a light source, and its irradiation intensity is measured using a multi-function measuring system Model PMA2100 (Solar Light Co. Inc.) to determine the minimum amount of erythema (MED: Minimal Erythema Dose) .

First, the inner sides of the left and right upper arms of 9 subjects were irradiated ^{with ultraviolet light of 13.4, 16.8, 21.0, 26.3, 32.8, 41.0mJ/cm 2} equivalent to 0.64, 0.80, 1.00, 1.25, 1.56, 1.95 MED/min for 1 minute. . The MED was determined by the erythema that appeared 24 hours after the irradiation.

Next, samples A and B were applied to other parts of the inner left upper arm of each subject, twice a day, 2 ml each in the morning and evening, for 4 weeks. In addition, pullulan (manufactured by Hayashibara Co., Ltd., 90% by mass) was similarly applied to another part of the inner left upper arm of each subject. Pullulan is diluted with water to 0.008% by mass and used. The inner side of the right upper arm where nothing was applied among the subjects was designated as the control group. Then, the same irradiation was performed on the inner sides of the left and right upper arms of the subject again, and the MED was determined 24 hours after the irradiation. In addition, the case without coating was regarded as Comparative Example 1, and the case where pullulan was applied was regarded as Comparative Example 2 for evaluation.

Table 1 shows the change in MED (△MED) of the subjects before the start of application and 4 weeks after application. The values in Table 1 are the average values of MED measurements of 9 subjects.

It can be seen from Table 1 that the MED value of the uncoated area decreases after 4 weeks, that is, it is prone to erythema due to sunburn. On the other hand, the coated area of Sample A or B showed an increase in MED value after 4 weeks of application compared with before the start of application, that is, there is a tendency that erythema due to sunburn is less likely to occur. In addition, the area where pullulan is applied is likely to cause erythema due to sunburn, which is equivalent to the area without application. It can be seen from this that even if the uncoated part is in an environment prone to sunburn, by applying sample A or B to the skin, inflammation and swelling caused by sunburn can be suppressed. That is to say, by applying sample A or B to the unsunburned skin, the skin that is not easily sunburned can be significantly improved, and the redness and swelling caused by sunburn can be suppressed.

＜Evaluation example 2 (Review of improvement of skin quality in low MED group)＞ In the above evaluation example 1, 4 subjects whose MED was 1.25 or less compared to the MED before the start of application were classified as the low MED group (sunburn-prone group), and data analysis was performed. Table 2 shows the changes in MED of the low MED group before the start of coating and 4 weeks after coating. The values in Table 2 are the average values of the MED measurements of the subjects. The p value represents the significance before the start of coating (corresponding t test). The smaller the p-value, the more significant it is, especially when the p-value does not reach 0.05, it is considered statistically significant.

It can be seen from Table 2 that 4 weeks after sample A was applied in the low MED group, the MED increased significantly compared with the non-coated part and the pullulan-coated part, which was significant before the start of the application. From this, it can be seen that the sample A has a good effect of improving the skin to a state that is not easily sunburned for the group that is particularly susceptible to sunburn.

＜Evaluation example 3 (Review of improvement of skin quality)＞ According to the formula shown in Table 3, cosmetic compositions (Examples 5 to 8, Comparative Examples 3 and 4) were prepared. The cosmetic compositions of Examples 5 to 8 and Comparative Examples 3 and 4 were applied by the same method as Evaluation Example 1, and the MED was measured. The results are shown in Table 4.

Comparing the application areas of the cosmetic compositions of Examples 5 to 8 with the application areas of the cosmetic compositions of Comparative Examples 3 and 4, the value of MED increased after 4 weeks of application compared to before the start of application . That is, it was observed that the cosmetic composition of Examples 5 to 8 had a tendency to be less likely to develop erythema due to sunburn at the application site. [Biological Material Deposit]

主張利用生物材料：

須寄存生物材料者： 國外生物材料　[格式請依：寄存國家、機構、日期、號碼　順序註記] 1.日本　　　　　　 ; NITE-IPOD ; 2002/07/11 ; FERM BP-8391

Advocating the use of biological materials:

Those who need to deposit biological materials: foreign biological materials [format please follow: deposit country, institution, date, number order note] 1. Japan; NITE-IPOD; 2002/07/11; FERM BP-8391

Claims (13)

An external composition for improving skin quality, which contains β-1,3-1,6-glucan. For example, the external composition for improving skin quality of claim 1, wherein β-1,3-1,6-glucan is represented by the following general formula (1),

(In formula (1), R ¹ represents a hydrogen atom or a group represented by the following formula (A), ^{one or more of the plural R 1} is the following formula (A), and a represents that it will be represented by the general formula (1) The mass average molecular weight of the β-1,3-1,6-glucan expressed is set at a number of 3,000 to 5,000,000, and the two β-1,3-1,6-glucans represented by the general formula (1) The end is a hydroxyl group, * means a bonding bond)

(In formula (A), * represents a bonding bond). For example, the external composition for skin quality improvement of claim 2, wherein in the general formula (1), ^{more than one} of the plurality of R 1 is the aforementioned formula (A), and more than 20 of the ^{plurality of R 1 are hydrogen} atom. As the skin 2 or 3 for external use request entry improved composition, wherein in the general formula (1), R ¹ is a unit of formula (A) with respect to the ratio of the units R ¹ is a hydrogen atom is 0.2 to 1. A cosmetic composition comprising the external composition for improving skin quality according to any one of claims 1 to 4, and containing the aforementioned external composition for improving skin quality relative to the total amount of the cosmetic composition The content of β-1,3-1,6-glucan is 0.0001 to 1% by mass. A cosmetic composition comprising the external composition for improving skin quality according to any one of claims 1 to 4, and containing the aforementioned external composition for improving skin quality relative to the total amount of the cosmetic composition The content of β-1,3-1,6-glucan is 0.001 to 1% by mass. A method for improving skin quality, comprising the step of applying the cosmetic composition of claim 5 or 6 to the skin. The method for improving skin quality according to claim 7, wherein the aforementioned coating step is performed before the skin is sunburned. The skin quality improvement method of claim 7 or 8, wherein β-1,3-1,6-glucan is β-1,3-1,6-glucan represented by the following general formula (1) ,

(In formula (1), R ¹ represents a hydrogen atom or a group represented by the following formula (A), ^{one or more of the plural R 1} is the following formula (A), and a represents that it will be represented by the general formula (1) The mass average molecular weight of the β-1,3-1,6-glucan expressed is set at a number of 3,000 to 5,000,000, and the two β-1,3-1,6-glucans represented by the general formula (1) The end is a hydroxyl group, * means a bonding bond)

(In formula (A), * represents a bonding bond). Such as the skin quality improvement method of claim 9, wherein in the general formula (1), ^{more than one} of the plurality of R 1 is the aforementioned formula (A), and more than 20 of the ^{plurality of R 1 are hydrogen atoms.} According to the skin quality improvement method of claim 9 or 10, in the general formula (1), ^{the ratio of the unit in which R 1} is the formula (A) to the unit in which R ¹ is a hydrogen atom is 0.2 to 1. The use of an external composition for improving skin quality containing β-1,3-1,6-glucan or a cosmetic composition containing the aforementioned external composition for improving skin quality is used to improve skin quality. A use of β-1,3-1,6-glucan to prepare an external composition for improving skin quality, or to prepare a cosmetic composition containing a former composition for external use.