TW202014420A - Nlrp3 調節劑 - Google Patents

Nlrp3 調節劑 Download PDF

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Publication number
TW202014420A
TW202014420A TW108114491A TW108114491A TW202014420A TW 202014420 A TW202014420 A TW 202014420A TW 108114491 A TW108114491 A TW 108114491A TW 108114491 A TW108114491 A TW 108114491A TW 202014420 A TW202014420 A TW 202014420A
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TW
Taiwan
Prior art keywords
alkyl
substituted
independently selected
independently
cancer
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TW108114491A
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English (en)
Chinese (zh)
Inventor
後補後補
阿斯凡尼克瑪 V 高法
安德魯 F 唐尼爾
舒米爾 高許
威廉 R 羅許
普拉撒那 斯華拉卡山姆
史蒂芬 P 賽斯
杰 A 馬克華德勒
Original Assignee
美商英能腫瘤免疫股份有限公司
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Publication of TW202014420A publication Critical patent/TW202014420A/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
TW108114491A 2018-04-25 2019-04-25 Nlrp3 調節劑 TW202014420A (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201862662240P 2018-04-25 2018-04-25
US62/662,240 2018-04-25
US201862764818P 2018-08-16 2018-08-16
US62/764,818 2018-08-16
US201962825044P 2019-03-28 2019-03-28
US62/825,044 2019-03-28

Publications (1)

Publication Number Publication Date
TW202014420A true TW202014420A (zh) 2020-04-16

Family

ID=66677224

Family Applications (1)

Application Number Title Priority Date Filing Date
TW108114491A TW202014420A (zh) 2018-04-25 2019-04-25 Nlrp3 調節劑

Country Status (19)

Country Link
US (1) US12037344B2 (enExample)
EP (2) EP3784670B1 (enExample)
JP (2) JP7351850B2 (enExample)
KR (1) KR102711180B1 (enExample)
CN (2) CN112521387B (enExample)
AU (1) AU2019261582A1 (enExample)
BR (1) BR112020021539A2 (enExample)
CA (1) CA3097865A1 (enExample)
CL (1) CL2020002719A1 (enExample)
CO (2) CO2021006672A2 (enExample)
ES (1) ES2971122T3 (enExample)
IL (1) IL278173A (enExample)
MX (1) MX2020011234A (enExample)
NZ (1) NZ769136A (enExample)
PE (1) PE20210160A1 (enExample)
SG (1) SG11202010463TA (enExample)
TW (1) TW202014420A (enExample)
WO (1) WO2019209896A1 (enExample)
ZA (1) ZA202007307B (enExample)

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CN114539095A (zh) * 2020-11-26 2022-05-27 乐凯化学材料有限公司 3-(4-羟基-3-甲氧基-苯基)-2-氰基-2-丙烯酸乙酯的制备方法
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WO2023283213A1 (en) 2021-07-07 2023-01-12 Incyte Corporation Tricyclic compounds as inhibitors of kras
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CA3097865A1 (en) 2019-10-31
KR20210005106A (ko) 2021-01-13
JP7351850B2 (ja) 2023-09-27
PE20210160A1 (es) 2021-01-26
BR112020021539A2 (pt) 2021-01-19
WO2019209896A1 (en) 2019-10-31
US20210267964A1 (en) 2021-09-02
CO2021006672A2 (es) 2021-06-10
EP4353235A2 (en) 2024-04-17
AU2019261582A1 (en) 2020-11-12
US12037344B2 (en) 2024-07-16
CN112074516A (zh) 2020-12-11
SG11202010463TA (en) 2020-11-27
JP2021522249A (ja) 2021-08-30
IL278173A (en) 2020-11-30
EP3784670A1 (en) 2021-03-03
ZA202007307B (en) 2023-01-25
EP4353235A3 (en) 2024-07-31
EP3784670B1 (en) 2023-11-29
JP2024001030A (ja) 2024-01-09
CN112521387B (zh) 2023-08-22
MX2020011234A (es) 2020-11-11
KR102711180B1 (ko) 2024-09-26
ES2971122T3 (es) 2024-06-03
NZ769136A (en) 2024-04-26
CL2020002719A1 (es) 2020-12-18
CO2020013155A2 (es) 2021-06-10
CN112521387A (zh) 2021-03-19
JP7660634B2 (ja) 2025-04-11

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