TW201700447A - Tgr5調控劑及其用法 - Google Patents

Info

Publication number

TW201700447A

TW201700447A TW105118959A TW105118959A TW201700447A TW 201700447 A TW201700447 A TW 201700447A TW 105118959 A TW105118959 A TW 105118959A TW 105118959 A TW105118959 A TW 105118959A TW 201700447 A TW201700447 A TW 201700447A

Authority

TW

Taiwan

Prior art keywords

mmol

compound

reduced pressure

under reduced

solution

Prior art date

2015-06-19

Links

• Espacenet
• Global Dossier
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• 102100025353 G-protein coupled bile acid receptor 1 Human genes 0.000 title claims abstract description 56
• 101000857733 Homo sapiens G-protein coupled bile acid receptor 1 Proteins 0.000 title claims abstract description 56
• IGRCWJPBLWGNPX-UHFFFAOYSA-N 3-(2-chlorophenyl)-n-(4-chlorophenyl)-n,5-dimethyl-1,2-oxazole-4-carboxamide Chemical compound C=1C=C(Cl)C=CC=1N(C)C(=O)C1=C(C)ON=C1C1=CC=CC=C1Cl IGRCWJPBLWGNPX-UHFFFAOYSA-N 0.000 title claims abstract description 49
• 150000001875 compounds Chemical class 0.000 claims abstract description 192
• -1 tautomer Chemical class 0.000 claims abstract description 81
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• 150000003839 salts Chemical class 0.000 claims abstract description 35
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• 238000000034 method Methods 0.000 claims description 44
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• ZVTQYRVARPYRRE-UHFFFAOYSA-N oxadiazol-4-one Chemical compound O=C1CON=N1 ZVTQYRVARPYRRE-UHFFFAOYSA-N 0.000 claims description 21
• ZOBPZXTWZATXDG-UHFFFAOYSA-N 1,3-thiazolidine-2,4-dione Chemical compound O=C1CSC(=O)N1 ZOBPZXTWZATXDG-UHFFFAOYSA-N 0.000 claims description 16
• 125000003831 tetrazolyl group Chemical group 0.000 claims description 16
• 229910052739 hydrogen Inorganic materials 0.000 claims description 14
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• WHLAXDUXKMECTM-UHFFFAOYSA-N oxadiazol-4-amine Chemical class NC1=CON=N1 WHLAXDUXKMECTM-UHFFFAOYSA-N 0.000 description 40
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• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 36
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• GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 description 31
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