TW201639855A - 改良之類鴉片合成方法 - Google Patents

改良之類鴉片合成方法 Download PDF

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Publication number
TW201639855A
TW201639855A TW105112605A TW105112605A TW201639855A TW 201639855 A TW201639855 A TW 201639855A TW 105112605 A TW105112605 A TW 105112605A TW 105112605 A TW105112605 A TW 105112605A TW 201639855 A TW201639855 A TW 201639855A
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TW
Taiwan
Prior art keywords
compound
formula
ppm
acid
less
Prior art date
Application number
TW105112605A
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English (en)
Chinese (zh)
Inventor
史都華 蓋比
約瑟華 其格里
凱斯 麥卡西
隆恩 萊德
Original Assignee
羅德科技公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 羅德科技公司 filed Critical 羅德科技公司
Publication of TW201639855A publication Critical patent/TW201639855A/zh

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D489/00Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08Oxygen atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10Laxatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12Antidiarrhoeals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/14Antitussive agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36Opioid-abuse
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
TW105112605A 2012-07-16 2013-07-15 改良之類鴉片合成方法 TW201639855A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261672265P 2012-07-16 2012-07-16
US201361762657P 2013-02-08 2013-02-08

Publications (1)

Publication Number Publication Date
TW201639855A true TW201639855A (zh) 2016-11-16

Family

ID=48916126

Family Applications (2)

Application Number Title Priority Date Filing Date
TW105112605A TW201639855A (zh) 2012-07-16 2013-07-15 改良之類鴉片合成方法
TW102125209A TWI588147B (zh) 2012-07-16 2013-07-15 改良之類鴉片合成方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
TW102125209A TWI588147B (zh) 2012-07-16 2013-07-15 改良之類鴉片合成方法

Country Status (21)

Country Link
US (4) US20150259355A1 (forum.php)
EP (1) EP2877473B1 (forum.php)
JP (1) JP6236446B2 (forum.php)
KR (1) KR101946104B1 (forum.php)
CN (1) CN104507947B (forum.php)
AR (1) AR091779A1 (forum.php)
AU (2) AU2013291723B2 (forum.php)
BR (1) BR112015000867A2 (forum.php)
CA (1) CA2879268C (forum.php)
CO (1) CO7180189A2 (forum.php)
EA (1) EA029925B1 (forum.php)
ES (1) ES2638178T3 (forum.php)
IL (1) IL236711B (forum.php)
IN (1) IN2015DN01164A (forum.php)
MX (1) MX362186B (forum.php)
NZ (2) NZ715111A (forum.php)
PH (1) PH12015500088B1 (forum.php)
SG (1) SG11201407986QA (forum.php)
TW (2) TW201639855A (forum.php)
UA (1) UA117226C2 (forum.php)
WO (1) WO2014013311A1 (forum.php)

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Also Published As

Publication number Publication date
ES2638178T3 (es) 2017-10-19
CO7180189A2 (es) 2015-02-09
EP2877473A1 (en) 2015-06-03
JP6236446B2 (ja) 2017-11-22
HK1210171A1 (en) 2016-04-15
AU2016204929A1 (en) 2016-08-04
AU2013291723B2 (en) 2016-07-28
AU2013291723A1 (en) 2014-12-18
PH12015500088A1 (en) 2015-03-02
JP2015524406A (ja) 2015-08-24
AR091779A1 (es) 2015-02-25
EA029925B1 (ru) 2018-05-31
IL236711A0 (en) 2015-02-26
US20210094964A1 (en) 2021-04-01
CN104507947A (zh) 2015-04-08
EP2877473B1 (en) 2017-06-14
US20190308986A1 (en) 2019-10-10
US10202396B2 (en) 2019-02-12
EA201590221A1 (ru) 2016-05-31
US11390627B2 (en) 2022-07-19
MX362186B (es) 2019-01-08
BR112015000867A2 (pt) 2019-10-15
CA2879268C (en) 2018-05-08
NZ628695A (en) 2016-02-26
UA117226C2 (uk) 2018-07-10
IL236711B (en) 2018-04-30
NZ715111A (en) 2016-12-23
KR101946104B1 (ko) 2019-02-08
SG11201407986QA (en) 2015-02-27
KR20150029753A (ko) 2015-03-18
IN2015DN01164A (forum.php) 2015-06-26
PH12015500088B1 (en) 2015-03-02
US20150259355A1 (en) 2015-09-17
MX2015000880A (es) 2016-09-07
US20180111946A1 (en) 2018-04-26
CA2879268A1 (en) 2014-01-23
WO2014013311A1 (en) 2014-01-23
CN104507947B (zh) 2017-06-27
TW201416368A (zh) 2014-05-01
TWI588147B (zh) 2017-06-21

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