SG11201407986QA - Process for improved opioid synthesis - Google Patents
Process for improved opioid synthesisInfo
- Publication number
- SG11201407986QA SG11201407986QA SG11201407986QA SG11201407986QA SG11201407986QA SG 11201407986Q A SG11201407986Q A SG 11201407986QA SG 11201407986Q A SG11201407986Q A SG 11201407986QA SG 11201407986Q A SG11201407986Q A SG 11201407986QA SG 11201407986Q A SG11201407986Q A SG 11201407986QA
- Authority
- SG
- Singapore
- Prior art keywords
- improved opioid
- opioid synthesis
- synthesis
- improved
- opioid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261672265P | 2012-07-16 | 2012-07-16 | |
| US201361762657P | 2013-02-08 | 2013-02-08 | |
| PCT/IB2013/001538 WO2014013311A1 (en) | 2012-07-16 | 2013-07-15 | Process for improved opioid synthesis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201407986QA true SG11201407986QA (en) | 2015-02-27 |
Family
ID=48916126
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201407986QA SG11201407986QA (en) | 2012-07-16 | 2013-07-15 | Process for improved opioid synthesis |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US20150259355A1 (en) |
| EP (1) | EP2877473B1 (en) |
| JP (1) | JP6236446B2 (en) |
| KR (1) | KR101946104B1 (en) |
| CN (1) | CN104507947B (en) |
| AR (1) | AR091779A1 (en) |
| AU (2) | AU2013291723B2 (en) |
| BR (1) | BR112015000867A2 (en) |
| CA (1) | CA2879268C (en) |
| CO (1) | CO7180189A2 (en) |
| EA (1) | EA029925B1 (en) |
| ES (1) | ES2638178T3 (en) |
| HK (1) | HK1210171A1 (en) |
| IL (1) | IL236711B (en) |
| IN (1) | IN2015DN01164A (en) |
| MX (1) | MX362186B (en) |
| NZ (2) | NZ628695A (en) |
| PH (1) | PH12015500088B1 (en) |
| SG (1) | SG11201407986QA (en) |
| TW (2) | TWI588147B (en) |
| UA (1) | UA117226C2 (en) |
| WO (1) | WO2014013311A1 (en) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6236447B2 (en) | 2012-07-16 | 2017-11-22 | ローズ テクノロジーズ | Improved opioid synthesis method |
| CN104507947B (en) | 2012-07-16 | 2017-06-27 | 罗德科技公司 | For the method for improved opioid synthesis |
| US10227354B2 (en) | 2013-12-18 | 2019-03-12 | Cody Laboratories, Inc. | Conversion of oxycodone base to oxycodone hydrochloride |
| CN106164078A (en) * | 2013-12-18 | 2016-11-23 | 科迪实验室公司 | The synthesis of oxycodone hydrochloride |
| US9062062B1 (en) | 2013-12-18 | 2015-06-23 | Cody Laboratories, Inc. | Synthesis of oxycodone hydrochloride |
| US8846923B1 (en) | 2013-12-18 | 2014-09-30 | Cody Laboratories, Inc. | Preparation of 14-hydroxycodeinone sulfate |
| WO2015107472A1 (en) | 2014-01-15 | 2015-07-23 | Rhodes Technologies | Process for improved oxymorphone synthesis |
| JP2017502991A (en) | 2014-01-15 | 2017-01-26 | ローズ テクノロジーズ | Method for improved oxycodone synthesis |
| US20160052932A1 (en) | 2014-08-25 | 2016-02-25 | Johnson Matthey Public Limited Company | Processes for Making Opioids Including 14-Hydroxycodeinone and 14-hydroxymorphinone |
| EP3642207B1 (en) | 2017-06-20 | 2022-08-31 | Johnson Matthey Public Limited Company | Hydrogenation process for preparing oxycodone hydrochloride from 14-hydroxycodeinone |
| KR102120720B1 (en) * | 2018-07-16 | 2020-06-10 | 연성정밀화학(주) | Orally Disintegrating Tablet Comprising Nalfurafine |
| CN114573508A (en) * | 2020-12-01 | 2022-06-03 | 中国科学院上海有机化学研究所 | Oxycodone compounds, intermediates and preparation method thereof |
| US11247999B1 (en) | 2021-07-02 | 2022-02-15 | Joseph DeGraw | Facile conversion of morphine to normorphine |
| CN114276358B (en) * | 2022-01-07 | 2023-09-12 | 北京华素制药股份有限公司 | Polymorphs of oxycodone hydrochloride, preparation method and application thereof |
Family Cites Families (58)
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| US2772270A (en) | 1954-10-21 | 1956-11-27 | M J Lewenstein | 14-hydroxymorphinone and 8, 14-dihydroxydihydromorphinone |
| US3173876A (en) | 1960-05-27 | 1965-03-16 | John C Zobrist | Cleaning methods and compositions |
| NL271831A (en) | 1960-11-29 | |||
| US3276586A (en) | 1963-08-30 | 1966-10-04 | Rosaen Filter Co | Indicating means for fluid filters |
| NL6714885A (en) | 1967-11-02 | 1969-05-06 | ||
| US3541006A (en) | 1968-07-03 | 1970-11-17 | Amicon Corp | Ultrafiltration process |
| US3541005A (en) | 1969-02-05 | 1970-11-17 | Amicon Corp | Continuous ultrafiltration of macromolecular solutions |
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| GB1478759A (en) | 1974-11-18 | 1977-07-06 | Alza Corp | Process for forming outlet passageways in pills using a laser |
| US4077407A (en) | 1975-11-24 | 1978-03-07 | Alza Corporation | Osmotic devices having composite walls |
| US4063064A (en) | 1976-02-23 | 1977-12-13 | Coherent Radiation | Apparatus for tracking moving workpiece by a laser beam |
| US4285987A (en) | 1978-10-23 | 1981-08-25 | Alza Corporation | Process for manufacturing device with dispersion zone |
| US4200098A (en) | 1978-10-23 | 1980-04-29 | Alza Corporation | Osmotic system with distribution zone for dispensing beneficial agent |
| US4861598A (en) | 1986-07-18 | 1989-08-29 | Euroceltique, S.A. | Controlled release bases for pharmaceuticals |
| DE3812567A1 (en) | 1988-04-15 | 1989-10-26 | Basf Ag | METHOD FOR PRODUCING PHARMACEUTICAL MIXTURES |
| US5215758A (en) | 1991-09-11 | 1993-06-01 | Euroceltique, S.A. | Controlled release matrix suppository for pharmaceuticals |
| US5472712A (en) | 1991-12-24 | 1995-12-05 | Euroceltique, S.A. | Controlled-release formulations coated with aqueous dispersions of ethylcellulose |
| US5273760A (en) | 1991-12-24 | 1993-12-28 | Euroceltigue, S.A. | Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer |
| US5286493A (en) | 1992-01-27 | 1994-02-15 | Euroceltique, S.A. | Stabilized controlled release formulations having acrylic polymer coating |
| US5324351A (en) | 1992-08-13 | 1994-06-28 | Euroceltique | Aqueous dispersions of zein and preparation thereof |
| DE60230632D1 (en) * | 2001-07-18 | 2009-02-12 | Euro Celtique Sa | PHARMACEUTICAL COMBINATIONS OF OXYCODONE AND NALOXONE |
| US6864370B1 (en) * | 2003-06-05 | 2005-03-08 | Zhaiwei Lin | Process for manufacturing oxycodone |
| US20050203115A1 (en) * | 2004-03-10 | 2005-09-15 | Sancilio Frederick D. | Narcotic-NSAID ion pairs |
| TWI365880B (en) * | 2004-03-30 | 2012-06-11 | Euro Celtique Sa | Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone and oxycodone hydrochloride composition,pharmaceutical dosage form,sustained release oeal dosage form and pharmaceutically acceptable package having less than 25 pp |
| SK286087B6 (en) | 2004-08-18 | 2008-03-05 | Zentiva, A. S. | Method of preparation of oxycodone |
| GB0421149D0 (en) | 2004-09-23 | 2004-10-27 | Johnson Matthey Plc | Preparation of oxycodone |
| SK286233B6 (en) | 2004-11-15 | 2008-05-06 | Zentiva, A. S. | Isolation process of 14-hydroxycodeinone |
| CA2614223A1 (en) * | 2005-02-24 | 2006-08-31 | Dr Pharma Nova, Llc | A registry method and control system for dea schedule ii-v medicines |
| EP1893616B1 (en) | 2005-06-16 | 2010-12-29 | Mallinckrodt, Inc. | A synthetic route to 14-hydroxyl opiates through 1-halo-thebaine or analogs |
| KR100753432B1 (en) | 2005-11-08 | 2007-08-31 | 경희대학교 산학협력단 | Apparatus and crystallization method for polycrystalline silicon |
| US20070117826A1 (en) * | 2005-11-23 | 2007-05-24 | Forest Laboratories, Inc. | Pharmaceutical formulations comprising ibuprofen, oxycodone, and 14-hydroxycodeinone |
| CA2644095A1 (en) | 2006-03-02 | 2007-09-13 | Mallinckrodt Inc. | Processes for preparing morphinan-6-one products with low levels of alpha, beta-unsaturated ketone compounds |
| AU2007329453B2 (en) * | 2006-12-04 | 2013-04-04 | Noramco, Llc | Process for preparing oxycodone having reduced levels of 14-hydroxycodeinone |
| CN101652369A (en) | 2006-12-04 | 2010-02-17 | 诺拉姆科有限公司 | Reduce the method for impurity in the oxycodone base |
| GB0624880D0 (en) | 2006-12-14 | 2007-01-24 | Johnson Matthey Plc | Improved method for making analgesics |
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| GB2450691A (en) | 2007-07-02 | 2009-01-07 | Alpharma Aps | One-pot preparation of oxycodone from thebaine |
| US8217204B2 (en) | 2009-06-03 | 2012-07-10 | Takasago International Corporation | Catalyst for asymmetric hydrogenation |
| EP2477984B1 (en) | 2009-09-16 | 2016-08-03 | Monash University | A method for the n-demethylation of n-methyl heterocycles |
| EP2377866B1 (en) * | 2010-03-23 | 2014-02-26 | Siegfried AG | Preparation of low impurity opiates in a continuous flow reactor |
| AU2011263416B2 (en) | 2010-06-11 | 2014-04-10 | Rhodes Technologies | Process for N-dealkylation of tertiary amines |
| ES2659168T3 (en) * | 2010-07-02 | 2018-03-14 | Johnson Matthey Public Limited Company | Process for the synthesis and purification of oxycodone |
| AU2011276978B2 (en) | 2010-07-08 | 2015-01-29 | Alkermes Pharma Ireland Limited | Process for the synthesis of substituted morphinans |
| JP5780933B2 (en) | 2010-12-01 | 2015-09-16 | 高砂香料工業株式会社 | Method for producing optically active menthol |
| WO2013188418A1 (en) | 2012-06-11 | 2013-12-19 | Jianguang Sun | Improved method of preparing oxymorphone |
| JP6236447B2 (en) | 2012-07-16 | 2017-11-22 | ローズ テクノロジーズ | Improved opioid synthesis method |
| CN104507947B (en) | 2012-07-16 | 2017-06-27 | 罗德科技公司 | For the method for improved opioid synthesis |
| CN103113378B (en) | 2013-02-20 | 2016-04-06 | 北京华素制药股份有限公司 | A kind of synthetic method of oxymorphone hydrochloride |
| CN103433076B (en) | 2013-09-02 | 2015-06-24 | 浙江新和成股份有限公司 | Immobilized asymmetric catalyst and application thereof in asymmetric hydrogenation reaction |
| US9060620B1 (en) | 2013-12-04 | 2015-06-23 | Yogi Realty LLC | Baby restraining article |
| US8846923B1 (en) | 2013-12-18 | 2014-09-30 | Cody Laboratories, Inc. | Preparation of 14-hydroxycodeinone sulfate |
| US10227354B2 (en) | 2013-12-18 | 2019-03-12 | Cody Laboratories, Inc. | Conversion of oxycodone base to oxycodone hydrochloride |
| CN106164078A (en) | 2013-12-18 | 2016-11-23 | 科迪实验室公司 | The synthesis of oxycodone hydrochloride |
| US9062062B1 (en) | 2013-12-18 | 2015-06-23 | Cody Laboratories, Inc. | Synthesis of oxycodone hydrochloride |
| WO2015107472A1 (en) | 2014-01-15 | 2015-07-23 | Rhodes Technologies | Process for improved oxymorphone synthesis |
| JP2017502991A (en) | 2014-01-15 | 2017-01-26 | ローズ テクノロジーズ | Method for improved oxycodone synthesis |
-
2013
- 2013-07-15 CN CN201380037927.6A patent/CN104507947B/en active Active
- 2013-07-15 EP EP13745177.9A patent/EP2877473B1/en active Active
- 2013-07-15 AR ARP130102526 patent/AR091779A1/en unknown
- 2013-07-15 TW TW102125209A patent/TWI588147B/en active
- 2013-07-15 ES ES13745177.9T patent/ES2638178T3/en active Active
- 2013-07-15 UA UAA201501304A patent/UA117226C2/en unknown
- 2013-07-15 EA EA201590221A patent/EA029925B1/en not_active IP Right Cessation
- 2013-07-15 TW TW105112605A patent/TW201639855A/en unknown
- 2013-07-15 KR KR1020157003909A patent/KR101946104B1/en active IP Right Grant
- 2013-07-15 NZ NZ628695A patent/NZ628695A/en unknown
- 2013-07-15 JP JP2015522181A patent/JP6236446B2/en active Active
- 2013-07-15 AU AU2013291723A patent/AU2013291723B2/en active Active
- 2013-07-15 BR BR112015000867A patent/BR112015000867A2/en not_active Application Discontinuation
- 2013-07-15 MX MX2015000880A patent/MX362186B/en active IP Right Grant
- 2013-07-15 SG SG11201407986QA patent/SG11201407986QA/en unknown
- 2013-07-15 WO PCT/IB2013/001538 patent/WO2014013311A1/en active Application Filing
- 2013-07-15 US US14/413,360 patent/US20150259355A1/en not_active Abandoned
- 2013-07-15 NZ NZ715111A patent/NZ715111A/en unknown
- 2013-07-15 CA CA2879268A patent/CA2879268C/en active Active
-
2015
- 2015-01-13 IL IL236711A patent/IL236711B/en active IP Right Grant
- 2015-01-14 PH PH12015500088A patent/PH12015500088B1/en unknown
- 2015-01-29 CO CO15018246A patent/CO7180189A2/en unknown
- 2015-02-12 IN IN1164DEN2015 patent/IN2015DN01164A/en unknown
- 2015-11-09 HK HK15111025.9A patent/HK1210171A1/en unknown
-
2016
- 2016-07-14 AU AU2016204929A patent/AU2016204929A1/en not_active Abandoned
-
2017
- 2017-09-11 US US15/700,345 patent/US10202396B2/en active Active
-
2019
- 2019-02-08 US US16/270,969 patent/US20190308986A1/en not_active Abandoned
-
2020
- 2020-09-08 US US17/014,134 patent/US11390627B2/en active Active
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