CO7180189A2 - Proceso de síntesis de opioides mejorado - Google Patents

Proceso de síntesis de opioides mejorado

Info

Publication number
CO7180189A2
CO7180189A2 CO15018246A CO15018246A CO7180189A2 CO 7180189 A2 CO7180189 A2 CO 7180189A2 CO 15018246 A CO15018246 A CO 15018246A CO 15018246 A CO15018246 A CO 15018246A CO 7180189 A2 CO7180189 A2 CO 7180189A2
Authority
CO
Colombia
Prior art keywords
synthesis process
compositions
compounds
enhanced opioid
apis
Prior art date
Application number
CO15018246A
Other languages
English (en)
Inventor
Keith Mccarthy
Joshua R Giguere
Stuart James Gebbie
Lonn S Rider
Original Assignee
Rhodes Technologies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhodes Technologies filed Critical Rhodes Technologies
Publication of CO7180189A2 publication Critical patent/CO7180189A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)

Abstract

Compuestos y composiciones para el uso como materiales de partida o materiales intermediarios en la preparación de opioides incluyendo, por ejemplo, base de oxicodona y/o una sal de oxicodona; procesos para preparar estos compuestos y composiciones; usos de estos compuestos y composiciones en la preparación de APIs y formas de dosis farmacéuticas; y usos de dichas APIs y formas de dosis farmacéuticas en el tratamiento de condiciones médicas.
CO15018246A 2012-07-16 2015-01-29 Proceso de síntesis de opioides mejorado CO7180189A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261672265P 2012-07-16 2012-07-16
US201361762657P 2013-02-08 2013-02-08

Publications (1)

Publication Number Publication Date
CO7180189A2 true CO7180189A2 (es) 2015-02-09

Family

ID=48916126

Family Applications (1)

Application Number Title Priority Date Filing Date
CO15018246A CO7180189A2 (es) 2012-07-16 2015-01-29 Proceso de síntesis de opioides mejorado

Country Status (22)

Country Link
US (4) US20150259355A1 (es)
EP (1) EP2877473B1 (es)
JP (1) JP6236446B2 (es)
KR (1) KR101946104B1 (es)
CN (1) CN104507947B (es)
AR (1) AR091779A1 (es)
AU (2) AU2013291723B2 (es)
BR (1) BR112015000867A2 (es)
CA (1) CA2879268C (es)
CO (1) CO7180189A2 (es)
EA (1) EA029925B1 (es)
ES (1) ES2638178T3 (es)
HK (1) HK1210171A1 (es)
IL (1) IL236711B (es)
IN (1) IN2015DN01164A (es)
MX (1) MX362186B (es)
NZ (2) NZ715111A (es)
PH (1) PH12015500088B1 (es)
SG (1) SG11201407986QA (es)
TW (2) TWI588147B (es)
UA (1) UA117226C2 (es)
WO (1) WO2014013311A1 (es)

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Publication number Priority date Publication date Assignee Title
KR101946103B1 (ko) 2012-07-16 2019-02-08 로드스 테크놀로지즈 개선된 오피오이드 합성을 위한 방법
AR091779A1 (es) 2012-07-16 2015-02-25 Rhodes Technologies Procedimiento para la sintesis mejorada de opioides
US8846923B1 (en) 2013-12-18 2014-09-30 Cody Laboratories, Inc. Preparation of 14-hydroxycodeinone sulfate
US9062062B1 (en) 2013-12-18 2015-06-23 Cody Laboratories, Inc. Synthesis of oxycodone hydrochloride
CN106164078A (zh) * 2013-12-18 2016-11-23 科迪实验室公司 氧可酮盐酸盐的合成
US10227354B2 (en) 2013-12-18 2019-03-12 Cody Laboratories, Inc. Conversion of oxycodone base to oxycodone hydrochloride
US9932348B2 (en) 2014-01-15 2018-04-03 Rhodes Technologies Process for improved oxycodone synthesis
MX2016009125A (es) 2014-01-15 2017-02-02 Rhodes Tech Proceso para la sintesis mejorada de oximorfona.
US20160052932A1 (en) * 2014-08-25 2016-02-25 Johnson Matthey Public Limited Company Processes for Making Opioids Including 14-Hydroxycodeinone and 14-hydroxymorphinone
US10941154B2 (en) 2017-06-20 2021-03-09 Johnson Matthey Public Limited Company Hydrogenation process for preparing oxycodone hydrochloride from 14-hydroxycodeinone
KR102120720B1 (ko) * 2018-07-16 2020-06-10 연성정밀화학(주) 날푸라핀 함유 구강붕해정
CN114573508B (zh) * 2020-12-01 2024-07-23 绍兴赜军生物医药科技有限公司 羟考酮类化合物、其中间体及制备方法
US11247999B1 (en) 2021-07-02 2022-02-15 Joseph DeGraw Facile conversion of morphine to normorphine
CN114276358B (zh) * 2022-01-07 2023-09-12 北京华素制药股份有限公司 羟考酮盐酸盐的多晶型物及其制备方法和用途

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Also Published As

Publication number Publication date
JP6236446B2 (ja) 2017-11-22
JP2015524406A (ja) 2015-08-24
CA2879268A1 (en) 2014-01-23
NZ628695A (en) 2016-02-26
PH12015500088A1 (en) 2015-03-02
SG11201407986QA (en) 2015-02-27
WO2014013311A1 (en) 2014-01-23
EP2877473B1 (en) 2017-06-14
EA029925B1 (ru) 2018-05-31
US20190308986A1 (en) 2019-10-10
BR112015000867A2 (pt) 2019-10-15
UA117226C2 (uk) 2018-07-10
NZ715111A (en) 2016-12-23
EP2877473A1 (en) 2015-06-03
AU2016204929A1 (en) 2016-08-04
HK1210171A1 (en) 2016-04-15
CN104507947B (zh) 2017-06-27
CA2879268C (en) 2018-05-08
PH12015500088B1 (en) 2015-03-02
US20150259355A1 (en) 2015-09-17
EA201590221A1 (ru) 2016-05-31
TWI588147B (zh) 2017-06-21
AU2013291723A1 (en) 2014-12-18
TW201639855A (zh) 2016-11-16
AU2013291723B2 (en) 2016-07-28
US10202396B2 (en) 2019-02-12
ES2638178T3 (es) 2017-10-19
IL236711A0 (en) 2015-02-26
US20210094964A1 (en) 2021-04-01
US20180111946A1 (en) 2018-04-26
CN104507947A (zh) 2015-04-08
AR091779A1 (es) 2015-02-25
US11390627B2 (en) 2022-07-19
TW201416368A (zh) 2014-05-01
MX2015000880A (es) 2016-09-07
KR101946104B1 (ko) 2019-02-08
MX362186B (es) 2019-01-08
IL236711B (en) 2018-04-30
IN2015DN01164A (es) 2015-06-26
KR20150029753A (ko) 2015-03-18

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