SG11201407986QA - Process for improved opioid synthesis - Google Patents

Process for improved opioid synthesis

Info

Publication number
SG11201407986QA
SG11201407986QA SG11201407986QA SG11201407986QA SG11201407986QA SG 11201407986Q A SG11201407986Q A SG 11201407986QA SG 11201407986Q A SG11201407986Q A SG 11201407986QA SG 11201407986Q A SG11201407986Q A SG 11201407986QA SG 11201407986Q A SG11201407986Q A SG 11201407986QA
Authority
SG
Singapore
Prior art keywords
improved opioid
opioid synthesis
synthesis
improved
opioid
Prior art date
Application number
SG11201407986QA
Other languages
English (en)
Inventor
Keith Mccarthy
Joshua R Giguere
Stuart James Gebbie
Lonn S Rider
Original Assignee
Rhodes Technologies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhodes Technologies filed Critical Rhodes Technologies
Publication of SG11201407986QA publication Critical patent/SG11201407986QA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
SG11201407986QA 2012-07-16 2013-07-15 Process for improved opioid synthesis SG11201407986QA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261672265P 2012-07-16 2012-07-16
US201361762657P 2013-02-08 2013-02-08
PCT/IB2013/001538 WO2014013311A1 (en) 2012-07-16 2013-07-15 Process for improved opioid synthesis

Publications (1)

Publication Number Publication Date
SG11201407986QA true SG11201407986QA (en) 2015-02-27

Family

ID=48916126

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201407986QA SG11201407986QA (en) 2012-07-16 2013-07-15 Process for improved opioid synthesis

Country Status (21)

Country Link
US (4) US20150259355A1 (forum.php)
EP (1) EP2877473B1 (forum.php)
JP (1) JP6236446B2 (forum.php)
KR (1) KR101946104B1 (forum.php)
CN (1) CN104507947B (forum.php)
AR (1) AR091779A1 (forum.php)
AU (2) AU2013291723B2 (forum.php)
BR (1) BR112015000867A2 (forum.php)
CA (1) CA2879268C (forum.php)
CO (1) CO7180189A2 (forum.php)
EA (1) EA029925B1 (forum.php)
ES (1) ES2638178T3 (forum.php)
IL (1) IL236711B (forum.php)
IN (1) IN2015DN01164A (forum.php)
MX (1) MX362186B (forum.php)
NZ (2) NZ715111A (forum.php)
PH (1) PH12015500088B1 (forum.php)
SG (1) SG11201407986QA (forum.php)
TW (2) TW201639855A (forum.php)
UA (1) UA117226C2 (forum.php)
WO (1) WO2014013311A1 (forum.php)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10316042B2 (en) 2012-07-16 2019-06-11 Rhodes Technologies Process for improved opioid synthesis
WO2014013311A1 (en) 2012-07-16 2014-01-23 Rhodes Technologies Process for improved opioid synthesis
CA2934527A1 (en) * 2013-12-18 2015-06-25 Cody Laboratories, Inc. Synthesis of oxycodone hydrochloride
US9062062B1 (en) 2013-12-18 2015-06-23 Cody Laboratories, Inc. Synthesis of oxycodone hydrochloride
US10227354B2 (en) 2013-12-18 2019-03-12 Cody Laboratories, Inc. Conversion of oxycodone base to oxycodone hydrochloride
US8846923B1 (en) 2013-12-18 2014-09-30 Cody Laboratories, Inc. Preparation of 14-hydroxycodeinone sulfate
EP3094634A1 (en) 2014-01-15 2016-11-23 Rhodes Technologies Process for improved oxycodone synthesis
WO2015107472A1 (en) 2014-01-15 2015-07-23 Rhodes Technologies Process for improved oxymorphone synthesis
US20160052932A1 (en) 2014-08-25 2016-02-25 Johnson Matthey Public Limited Company Processes for Making Opioids Including 14-Hydroxycodeinone and 14-hydroxymorphinone
EP3642207B1 (en) 2017-06-20 2022-08-31 Johnson Matthey Public Limited Company Hydrogenation process for preparing oxycodone hydrochloride from 14-hydroxycodeinone
KR102445512B1 (ko) 2018-03-30 2022-09-21 삼성디스플레이 주식회사 지문 센서 패키지 및 이를 포함하는 표시 장치
KR102120720B1 (ko) * 2018-07-16 2020-06-10 연성정밀화학(주) 날푸라핀 함유 구강붕해정
CN114573508B (zh) * 2020-12-01 2024-07-23 绍兴赜军生物医药科技有限公司 羟考酮类化合物、其中间体及制备方法
US11247999B1 (en) 2021-07-02 2022-02-15 Joseph DeGraw Facile conversion of morphine to normorphine
CN114276358B (zh) * 2022-01-07 2023-09-12 北京华素制药股份有限公司 羟考酮盐酸盐的多晶型物及其制备方法和用途

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2772270A (en) 1954-10-21 1956-11-27 M J Lewenstein 14-hydroxymorphinone and 8, 14-dihydroxydihydromorphinone
US3173876A (en) 1960-05-27 1965-03-16 John C Zobrist Cleaning methods and compositions
NL271831A (forum.php) 1960-11-29
US3276586A (en) 1963-08-30 1966-10-04 Rosaen Filter Co Indicating means for fluid filters
NL6714885A (forum.php) 1967-11-02 1969-05-06
US3541006A (en) 1968-07-03 1970-11-17 Amicon Corp Ultrafiltration process
US3541005A (en) 1969-02-05 1970-11-17 Amicon Corp Continuous ultrafiltration of macromolecular solutions
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
GB1478759A (en) 1974-11-18 1977-07-06 Alza Corp Process for forming outlet passageways in pills using a laser
US4077407A (en) 1975-11-24 1978-03-07 Alza Corporation Osmotic devices having composite walls
US4063064A (en) 1976-02-23 1977-12-13 Coherent Radiation Apparatus for tracking moving workpiece by a laser beam
US4285987A (en) 1978-10-23 1981-08-25 Alza Corporation Process for manufacturing device with dispersion zone
US4200098A (en) 1978-10-23 1980-04-29 Alza Corporation Osmotic system with distribution zone for dispensing beneficial agent
US4861598A (en) 1986-07-18 1989-08-29 Euroceltique, S.A. Controlled release bases for pharmaceuticals
DE3812567A1 (de) 1988-04-15 1989-10-26 Basf Ag Verfahren zur herstellung pharmazeutischer mischungen
US5215758A (en) 1991-09-11 1993-06-01 Euroceltique, S.A. Controlled release matrix suppository for pharmaceuticals
US5472712A (en) 1991-12-24 1995-12-05 Euroceltique, S.A. Controlled-release formulations coated with aqueous dispersions of ethylcellulose
US5273760A (en) 1991-12-24 1993-12-28 Euroceltigue, S.A. Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer
US5286493A (en) 1992-01-27 1994-02-15 Euroceltique, S.A. Stabilized controlled release formulations having acrylic polymer coating
US5324351A (en) 1992-08-13 1994-06-28 Euroceltique Aqueous dispersions of zein and preparation thereof
ATE419039T1 (de) * 2001-07-18 2009-01-15 Euro Celtique Sa Pharmazeutische kombinationen von oxycodon und naloxon
US6864370B1 (en) * 2003-06-05 2005-03-08 Zhaiwei Lin Process for manufacturing oxycodone
US20050203115A1 (en) * 2004-03-10 2005-09-15 Sancilio Frederick D. Narcotic-NSAID ion pairs
TW201509943A (zh) * 2004-03-30 2015-03-16 Euro Celtique Sa 含有小於２５ｐｐｍ１４-羥可待因酮之羥可酮鹽酸鹽之組成物、醫藥劑型、延遲釋出口服劑型及醫藥上可以接受的包裝
SK286087B6 (sk) 2004-08-18 2008-03-05 Zentiva, A. S. Spôsob prípravy oxykodonu
GB0421149D0 (en) 2004-09-23 2004-10-27 Johnson Matthey Plc Preparation of oxycodone
SK286233B6 (sk) 2004-11-15 2008-05-06 Zentiva, A. S. Spôsob izolácie 14-hydroxykodeinonu
US8703099B2 (en) * 2005-02-24 2014-04-22 Dr Pharma Nova, Llc Registry method and control system for DEA schedule II-V medicines
WO2006138020A2 (en) 2005-06-16 2006-12-28 Mallinckrodt Inc. A synthetic route to 14-hydroxyl opiates through 1-halo-thebaine or analogs
KR100753432B1 (ko) 2005-11-08 2007-08-31 경희대학교 산학협력단 다결정 실리콘 및 그의 결정화 방법
US20070117826A1 (en) * 2005-11-23 2007-05-24 Forest Laboratories, Inc. Pharmaceutical formulations comprising ibuprofen, oxycodone, and 14-hydroxycodeinone
AU2007224221B2 (en) 2006-03-02 2013-02-14 SpecGx LLC Processes for preparing morphinan-6-one products with low levels of alpha, beta-unsaturated ketone compounds
ES2393221T3 (es) * 2006-12-04 2012-12-19 Noramco, Inc. Procedimiento de preparación de oxicodona con niveles reducidos de 14-hidroxicodeinona
WO2008070656A2 (en) 2006-12-04 2008-06-12 Noramco, Inc Process for reducing impurities in oxycodone base
GB0624880D0 (en) 2006-12-14 2007-01-24 Johnson Matthey Plc Improved method for making analgesics
WO2008118654A1 (en) 2007-03-23 2008-10-02 Mallinckrodt Inc. Improved preparation of oxymorphone from oripavine
US8309727B2 (en) 2007-04-16 2012-11-13 Mallinckrodt Llc Opiate reduction utilizing catalytic hydrogen transfer reaction
GB2450691A (en) 2007-07-02 2009-01-07 Alpharma Aps One-pot preparation of oxycodone from thebaine
US8217204B2 (en) 2009-06-03 2012-07-10 Takasago International Corporation Catalyst for asymmetric hydrogenation
WO2011032214A1 (en) 2009-09-16 2011-03-24 Monash University A method for the n-demethylation of n-methyl heterocycles
EP2377866B1 (en) * 2010-03-23 2014-02-26 Siegfried AG Preparation of low impurity opiates in a continuous flow reactor
CA2802294C (en) 2010-06-11 2016-05-10 Rhodes Technologies Process for n-dealkylation of tertiary amines
PL2588481T3 (pl) * 2010-07-02 2018-05-30 Johnson Matthey Public Limited Company Sposób syntezy i oczyszczania oksykodonu
EP2590649B1 (en) 2010-07-08 2018-11-28 Alkermes Pharma Ireland Limited Process for the synthesis of substituted morphinans
JP5780933B2 (ja) 2010-12-01 2015-09-16 高砂香料工業株式会社 光学活性メントールの製造方法
AU2013274407B2 (en) 2012-06-11 2017-06-22 Siegfried Ag Improved method of preparing oxymorphone
WO2014013311A1 (en) 2012-07-16 2014-01-23 Rhodes Technologies Process for improved opioid synthesis
US10316042B2 (en) 2012-07-16 2019-06-11 Rhodes Technologies Process for improved opioid synthesis
CN103113378B (zh) 2013-02-20 2016-04-06 北京华素制药股份有限公司 一种盐酸羟吗啡酮的合成方法
CN103433076B (zh) 2013-09-02 2015-06-24 浙江新和成股份有限公司 一种固载型不对称催化剂及其在不对称氢化反应中的应用
US9060620B1 (en) 2013-12-04 2015-06-23 Yogi Realty LLC Baby restraining article
CA2934527A1 (en) 2013-12-18 2015-06-25 Cody Laboratories, Inc. Synthesis of oxycodone hydrochloride
US10227354B2 (en) 2013-12-18 2019-03-12 Cody Laboratories, Inc. Conversion of oxycodone base to oxycodone hydrochloride
US8846923B1 (en) 2013-12-18 2014-09-30 Cody Laboratories, Inc. Preparation of 14-hydroxycodeinone sulfate
US9062062B1 (en) 2013-12-18 2015-06-23 Cody Laboratories, Inc. Synthesis of oxycodone hydrochloride
EP3094634A1 (en) 2014-01-15 2016-11-23 Rhodes Technologies Process for improved oxycodone synthesis
WO2015107472A1 (en) 2014-01-15 2015-07-23 Rhodes Technologies Process for improved oxymorphone synthesis

Also Published As

Publication number Publication date
ES2638178T3 (es) 2017-10-19
CO7180189A2 (es) 2015-02-09
EP2877473A1 (en) 2015-06-03
JP6236446B2 (ja) 2017-11-22
HK1210171A1 (en) 2016-04-15
AU2016204929A1 (en) 2016-08-04
AU2013291723B2 (en) 2016-07-28
AU2013291723A1 (en) 2014-12-18
PH12015500088A1 (en) 2015-03-02
JP2015524406A (ja) 2015-08-24
AR091779A1 (es) 2015-02-25
EA029925B1 (ru) 2018-05-31
IL236711A0 (en) 2015-02-26
US20210094964A1 (en) 2021-04-01
CN104507947A (zh) 2015-04-08
EP2877473B1 (en) 2017-06-14
US20190308986A1 (en) 2019-10-10
US10202396B2 (en) 2019-02-12
EA201590221A1 (ru) 2016-05-31
US11390627B2 (en) 2022-07-19
MX362186B (es) 2019-01-08
BR112015000867A2 (pt) 2019-10-15
CA2879268C (en) 2018-05-08
NZ628695A (en) 2016-02-26
UA117226C2 (uk) 2018-07-10
IL236711B (en) 2018-04-30
NZ715111A (en) 2016-12-23
KR101946104B1 (ko) 2019-02-08
KR20150029753A (ko) 2015-03-18
IN2015DN01164A (forum.php) 2015-06-26
PH12015500088B1 (en) 2015-03-02
US20150259355A1 (en) 2015-09-17
MX2015000880A (es) 2016-09-07
US20180111946A1 (en) 2018-04-26
CA2879268A1 (en) 2014-01-23
WO2014013311A1 (en) 2014-01-23
CN104507947B (zh) 2017-06-27
TW201639855A (zh) 2016-11-16
TW201416368A (zh) 2014-05-01
TWI588147B (zh) 2017-06-21

Similar Documents

Publication Publication Date Title
IL236711A0 (en) A process for improved synthesis of opioids
ZA201500664B (en) Process for making isoquinoline compounds
IL236710A0 (en) A process for improved synthesis of opioids
PT2875062T (pt) Processo de síntese de poliarilétercetonas
GB201111595D0 (en) Improved process
AP3450A (en) Process for the synthesis of methanol
GB201103499D0 (en) Process
IL230594A0 (en) Process for the preparation of nitrogen-substituted 1h-pyrazole-5-carbonyl chloride compounds
GB201101370D0 (en) Process
IL227872A0 (en) A process for the preparation of n-converted phenylhydroxylamines
EP2628647A4 (en) INFLATABLE CUSHION DEVICE
GB2509659B (en) Process for the 3-O-demethylation of morphinan compounds
ZA201409261B (en) Process for making hydroxylated cyclopentylpyrimidine compounds
IL235714A0 (en) A process for preparing hydroxylated cyclopentylpyrimidine compounds
GB2488894B (en) Process for producing V-Coelenterazine compounds
GB201115218D0 (en) Novel process
SG11201501831WA (en) Aminoethylation process for producing aryloxyalkylene amine compounds
IL233433A0 (en) A process for preparing affluents
EP2852607A4 (en) IMPROVED SYNTHESIS
GB201103092D0 (en) Process
GB201116359D0 (en) Novel synthesis method
EP2831054A4 (en) IMPROVED PROCESS FOR THE PRODUCTION OF (S) -EQUOL
HUP1200614A2 (en) Process for development catalayzer
GB201111381D0 (en) Process for the synthesis of prodrugs of opioids
EP2917309A4 (en) PROCESS FOR RECOVERING OLIGOMERATE